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公开(公告)号：US07344852B1
公开(公告)日：2008-03-18
申请号：US10659055
申请日：2003-09-09
申请人： Kathleen Aertgeerts , Ciaran N. Cronin , David J. Hosfield , Mark W. Knuth , Duncan E. McRee , Sridhar Prasad , Bi Ching Sang , Robert J. Skene , Robert A. Wijnands , Sheng Ye
发明人： Kathleen Aertgeerts , Ciaran N. Cronin , David J. Hosfield , Mark W. Knuth , Duncan E. McRee , Sridhar Prasad , Bi Ching Sang , Robert J. Skene , Robert A. Wijnands , Sheng Ye
CPC分类号： C12N9/48 , C07K2299/00 , C12Q1/37 , C12Y304/14005 , G01N2800/00
摘要： Provided are crystals relating to DPPIV and its various uses.
摘要翻译： 提供与DPPIV及其各种用途有关的晶体。
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公开(公告)号：US07319016B1
公开(公告)日：2008-01-15
申请号：US10646470
申请日：2003-08-22
申请人： Ellen Chien , Douglas R. Dougan , Mark W. Knuth , Duncan E. McRee , Bi Ching Sang , Robert J. Skene , Ronald V. Swanson , Leslie W. Tari , Robert A. Wijnands
发明人： Ellen Chien , Douglas R. Dougan , Mark W. Knuth , Duncan E. McRee , Bi Ching Sang , Robert J. Skene , Ronald V. Swanson , Leslie W. Tari , Robert A. Wijnands
CPC分类号： C12Y304/22027 , C07K2299/00 , C12N9/6472 , G01N2333/96466
摘要： Provided are crystals relating to Cathepsin S and its various uses.
摘要翻译： 提供与组织蛋白酶S及其各种用途有关的晶体。
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公开(公告)号：US07444273B1
公开(公告)日：2008-10-28
申请号：US10601011
申请日：2003-06-20
申请人： Ciaran N. Cronin , Mark W. Knuth , Duncan E. McRee , Jacek Nowakowski , Nikola P. Pavletich , Devon A. Thompson , Robert A. Wijnands
发明人： Ciaran N. Cronin , Mark W. Knuth , Duncan E. McRee , Jacek Nowakowski , Nikola P. Pavletich , Devon A. Thompson , Robert A. Wijnands
CPC分类号： C12N9/1205 , G06F19/16
摘要： Provided are crystals relating to Aurora/LPL1P-related kinase and its various uses.
摘要翻译： 提供与Aurora / LPL1P相关激酶相关的晶体及其各种用途。
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公开(公告)号：US07507552B1
公开(公告)日：2009-03-24
申请号：US10826170
申请日：2004-04-16
申请人： Ciaran N. Cronin , Mark T. Hilgers , Mark W. Knuth , Marc E. Navre , Bi Ching Sang , Robert J. Skene , Leslie W. Tari , Keith P. Wilson , Darbi Witmer , Hua Zou
发明人： Ciaran N. Cronin , Mark T. Hilgers , Mark W. Knuth , Marc E. Navre , Bi Ching Sang , Robert J. Skene , Leslie W. Tari , Keith P. Wilson , Darbi Witmer , Hua Zou
IPC分类号： C12Q1/34 , C12N9/78 , G01N33/483 , G01N31/00 , G06G7/58
CPC分类号： C12Q1/34 , C07K2299/00 , C12N9/1029 , G01N2500/02 , G01N2500/04 , G01N2500/10 , G01N2500/20
摘要： Provided are crystals relating to histone deacetylase 2 (HDAC-2) and its various uses.
摘要翻译： 提供与组蛋白脱乙酰酶2（HDAC-2）相关的晶体及其各种用途。
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公开(公告)号：US07368269B1
公开(公告)日：2008-05-06
申请号：US11075058
申请日：2005-03-07
申请人： Ciaran N. Cronin , Douglas R. Dougan , Mark W. Knuth , Michelle L. Kraus , Kheng Lim , Clifford D. Mol , Gyorgy Snell , Hua Zou
发明人： Ciaran N. Cronin , Douglas R. Dougan , Mark W. Knuth , Michelle L. Kraus , Kheng Lim , Clifford D. Mol , Gyorgy Snell , Hua Zou
CPC分类号： C12N9/1205 , C07K2299/00
摘要： Provided are crystals relating to human mitogen-activated protein kinase kinase2 (MAPKK2), also known as MAPK/ERK Kinase2 (MEK2) and its various uses.
摘要翻译： 提供与人丝裂素活化蛋白激酶激酶2（MAPKK2）（也称为MAPK / ERK激酶2（MEK2））及其各种用途相关的晶体。
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公开(公告)号：US07303892B1
公开(公告)日：2007-12-04
申请号：US10601311
申请日：2003-06-20
申请人： Eric Adam , Oleg Brodsky , Mark W. Knuth , Jacek Nowakowski , Nikola P. Pavletich , Devon A. Thompson , Robert A. Wijnands
发明人： Eric Adam , Oleg Brodsky , Mark W. Knuth , Jacek Nowakowski , Nikola P. Pavletich , Devon A. Thompson , Robert A. Wijnands
CPC分类号： C07K14/82 , C07K2299/00 , C12N9/12 , G01N2333/9121
摘要： Provided are crystals relating to AKT3 and its various uses.
摘要翻译： 提供与AKT3有关的晶体及其各种用途。
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7.发明授权Isolated agarase enzyme from flavobacterium SP. strain NR19, cloned genes therefor, and expression thereof in transformed host cells 失效来自黄杆菌SP的分离的琼脂糖酶。 NR19株，克隆基因及其在转化宿主细胞中的表达
公开(公告)号：US6001636A
公开(公告)日：1999-12-14
申请号：US107755
申请日：1998-06-30
CPC分类号： C12Y302/01081 , C08B37/0039 , C12N15/1003 , C12N9/24 , C12N9/2468 , C12P19/34 , Y10S435/85
摘要： Novel purified agarase enzymes from Flavobacterium sp. strain NR19 and cloned genes encoding the agarase enzymes are disclosed. Transformed host cells which express the novel agarase enzymes in isolatable quantities are also described. Also disclosed are antibodies specifically reactive with the novel agarases.
摘要翻译： 来自黄杆菌属的新型纯化琼脂糖酶 公开了NR19菌株和编码琼脂糖酶的克隆基因。 还描述了以可分离的量表达新型琼脂糖酶的转化的宿主细胞。 还公开了与新型琼脂特异性反应的抗体。
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公开(公告)号：US06586575B1
公开(公告)日：2003-07-01
申请号：US08447381
申请日：1995-05-23
申请人： Timothy W. Evans , Mark W. Knuth
发明人： Timothy W. Evans , Mark W. Knuth
IPC分类号： C07K1700
CPC分类号： C07K1/1133 , C07K14/61
摘要： This invention discloses a commercially advantageous process for extraction and purification of protein from microorganisms. The initial steps of the process are useful for purifying many insoluble proteins while later steps are designed to renature denatured somatotropins produced by transformed microorganisms. The process is especially useful for purifying recombinantly-produced bovine somatotropin.
摘要翻译： 本发明公开了一种从微生物中提取和纯化蛋白质的商业上有利的方法。 该方法的初始步骤对于纯化许多不溶性蛋白质是有用的，而后来的步骤被设计为使转化的微生物产生的变性生长激素变性。 该方法对于纯化重组产生的牛生长激素特别有用。
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9.发明授权Isolated agarase enzyme from flavobacterium sp. strain NR19, cloned genes therefor, and expression thereof in transformed host cells 失效来自黄杆菌的分离的琼脂糖酶 NR19株，克隆基因及其在转化宿主细胞中的表达
公开(公告)号：US5869310A
公开(公告)日：1999-02-09
申请号：US655704
申请日：1996-06-03
CPC分类号： C12Y302/01081 , C08B37/0039 , C12N15/1003 , C12N9/24 , C12N9/2468 , C12P19/34 , Y10S435/85
摘要： Novel purified agarase enzymes from Flavobacterium sp. strain NR19 and cloned genes encoding the agarase enzymes are disclosed. Transformed host cells which express the novel agarase enzymes in isolatable quantities are also described. Also disclosed are antibodies specifically reactive with the novel agarases.
摘要翻译： 来自黄杆菌属的新型纯化琼脂糖酶 公开了NR19菌株和编码琼脂糖酶的克隆基因。 还描述了以可分离的量表达新型琼脂糖酶的转化的宿主细胞。 还公开了与新型琼脂特异性反应的抗体。
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10.发明授权High level expression and facile purification of proteins, peptides and conjugates for immunization, purification and detection applications 失效用于免疫，纯化和检测应用的蛋白质，肽和缀合物的高水平表达和易于纯化
公开(公告)号：US6069230A
公开(公告)日：2000-05-30
申请号：US338382
申请日：1994-11-10
IPC分类号： G01N33/531 , A61K38/00 , A61K39/00 , A61P37/02 , A61P43/00 , C07K14/00 , C07K14/01 , C07K16/18 , C07K16/28 , C07K19/00 , C12N1/21 , C12N15/09 , C12N15/62 , C12P21/02 , C12Q1/25 , G01N33/543
CPC分类号： C07K14/005 , C07K16/18 , C07K16/2866 , C12N15/625 , A61K39/00 , C07K2317/11 , C07K2317/23 , C07K2319/02 , C07K2319/09 , C07K2319/10 , C07K2319/40 , C12N2795/10222
摘要： A process for pro and purifying peptides and for producing peptide/protein antigens for antibody production is described. The process utilizes fusion proteins and specifically fusion proteins in which the fusion protein carrier segment includes an amino acid sequence at least about 65 amino acids long and in which the amino acid sequence does not contain negative or positive charged side chains of amino acids.
摘要翻译： 描述了用于促进和纯化肽和产生用于抗体生产的肽/蛋白质抗原的方法。 该方法利用融合蛋白和特异性融合蛋白，其中融合蛋白载体片段包含至少约65个氨基酸长的氨基酸序列，其中氨基酸序列不含有负氨基酸或带正电荷的氨基酸侧链。
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