-
公开(公告)号：US6094943A
公开(公告)日：2000-08-01
申请号：US104361
申请日：1998-06-25
申请人： Katsuji Okuda , Shinichi Kita , Masahide Ishibashi
发明人： Katsuji Okuda , Shinichi Kita , Masahide Ishibashi
IPC分类号： B60J1/00 , C03B23/025 , C03B27/00 , C03B27/04 , C03B27/044 , C03C4/08
CPC分类号： C03B27/044 , C03B27/00 , C03B27/0404 , C03B27/0413
摘要： A toughened glass sheet for use as a windowpane of an automotive vehicle. The toughened glass sheet has a thickness ranging from 2.5 mm to 3.1 mm and has a first characteristic that a number of fragments is not less than 40 within an area of 50 mm.times.50 mm in a fragmentation test in which an impact is applied to a predetermined position of the glass sheet with a hammer or a punch, and a second characteristic that a specified height is not less than 2 m in an impact resistance test in which the specified height is a value at which the glass sheet is broken upon dropping a steel ball having a weight of 227 g.
摘要翻译： 用作机动车辆窗玻璃的钢化玻璃板。 钢化玻璃板的厚度范围为2.5mm〜3.1mm，并且在将冲击施加于规定位置的破碎试验中，具有在50mm×50mm的范围内碎片数为40个以上的第一特征 的冲击强度试验中规定的高度不小于2μm的第二特性，其中指定的高度是在钢球落下时玻璃板断裂的值 重量为227克。
-
公开(公告)号：US20100322968A1
公开(公告)日：2010-12-23
申请号：US12449377
申请日：2008-02-07
申请人： Keiko Udaka , Masahide Ishibashi
发明人： Keiko Udaka , Masahide Ishibashi
CPC分类号： A61K39/099 , A61K39/0011 , A61K2039/521 , A61K2039/55505 , A61K2039/55594 , C07K14/4747 , C07K14/4748 , Y02A50/386
摘要： The present invention provides an adjuvant for cancer antigen peptide vaccines and virus antigen peptides, containing a pertussis vaccine as a primary ingredient. The present invention also provides a therapeutic agent for a cancer or viral infectious disease, and a prophylactic agent for metastasis or recurrence of cancer or onset of virus-induced tumor, containing a cancer antigen peptide or virus antigen peptide and a pertussis vaccine. A pertussis vaccine that can be suitably used is a whole cell body pertussis vaccine. The agents of the present invention can be safely administered in a plurality of doses.
摘要翻译： 本发明提供了含有百日咳疫苗作为主要成分的癌抗原肽疫苗和病毒抗原肽的佐剂。 本发明还提供了癌症或病毒感染性疾病的治疗剂，以及含有癌抗原肽或病毒抗原肽和百日咳疫苗的癌症转移或复发或病毒诱导肿瘤发病的预防剂。 可以适当使用的百日咳疫苗是全细胞体百日咳疫苗。 可以以多个剂量安全地施用本发明的药剂。
-
3.发明授权Attenuated chimeric flavivirus bearing attenuated Japanese encephalitis virus gene as backbone 失效具有减毒的日本脑炎病毒基因的减毒嵌合黄病毒作为骨架公开(公告)号：US07749734B2
公开(公告)日：2010-07-06
申请号：US11793277
申请日：2005-12-22
申请人： Morita Kouichi , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
发明人： Morita Kouichi , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
CPC分类号： A61K39/12 , A61K2039/5254 , C12N7/00 , C12N2770/24134 , C12N2770/24161 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.
摘要翻译： 含有编码日本脑炎病毒的衣壳蛋白，膜前蛋白质和非结构蛋白质的核苷酸序列的核酸分子和编码第二黄病毒的包膜蛋白的核苷酸序列，其中编码的核苷酸序列 日本脑炎病毒的膜前蛋白质和/或非结构蛋白质含有产生一种或多种减弱病毒的氨基酸突变的核苷酸突变。
-
4.发明申请Attenuated Chimeric Flavivirus Bearing Attenuated Japanese Encephalitis Virus Gene as Backbone 失效减毒的嵌合黄病毒携带减毒的日本脑炎病毒基因作为骨干公开(公告)号：US20080138363A1
公开(公告)日：2008-06-12
申请号：US11793277
申请日：2005-12-22
申请人： Morita Kouichi , Takeshi Nabeshima , Shinichi Miyake , Toshiuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
发明人： Morita Kouichi , Takeshi Nabeshima , Shinichi Miyake , Toshiuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
CPC分类号： A61K39/12 , A61K2039/5254 , C12N7/00 , C12N2770/24134 , C12N2770/24161 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.
摘要翻译： 含有编码日本脑炎病毒的衣壳蛋白，膜前蛋白质和非结构蛋白质的核苷酸序列的核酸分子和编码第二黄病毒的包膜蛋白的核苷酸序列，其中编码的核苷酸序列 日本脑炎病毒的膜前蛋白质和/或非结构蛋白质含有产生一种或多种减弱病毒的氨基酸突变的核苷酸突变。
-
5.发明申请Attenuated chimeric flavivirus bearing attenuated Japanese encephalitis virus gene as backbone 失效具有减毒的日本脑炎病毒基因的减毒嵌合黄病毒作为骨架公开(公告)号：US20090104702A1
公开(公告)日：2009-04-23
申请号：US12292518
申请日：2008-11-20
申请人： Morita Kouichi , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
发明人： Morita Kouichi , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
CPC分类号： A61K39/12 , A61K2039/5254 , C12N7/00 , C12N2770/24134 , C12N2770/24161 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.
摘要翻译： 含有编码日本脑炎病毒的衣壳蛋白，膜前蛋白质和非结构蛋白质的核苷酸序列的核酸分子和编码第二黄病毒的包膜蛋白的核苷酸序列，其中编码的核苷酸序列 日本脑炎病毒的膜前蛋白质和/或非结构蛋白质含有产生一种或多种减弱病毒的氨基酸突变的核苷酸突变。
-
公开(公告)号：US09045556B2
公开(公告)日：2015-06-02
申请号：US12449377
申请日：2008-02-07
申请人： Keiko Udaka , Masahide Ishibashi
发明人： Keiko Udaka , Masahide Ishibashi
CPC分类号： A61K39/099 , A61K39/0011 , A61K2039/521 , A61K2039/55505 , A61K2039/55594 , C07K14/4747 , C07K14/4748 , Y02A50/386
摘要： The present invention provides an adjuvant for cancer antigen peptide vaccines and virus antigen peptides, containing a pertussis vaccine as a primary ingredient. The present invention also provides a therapeutic agent for a cancer or viral infectious disease, and a prophylactic agent for metastasis or recurrence of cancer or onset of virus-induced tumor, containing a cancer antigen peptide or virus antigen peptide and a pertussis vaccine. A pertussis vaccine that can be suitably used is a whole cell body pertussis vaccine. The agents of the present invention can be safely administered in a plurality of doses.
摘要翻译： 本发明提供了含有百日咳疫苗作为主要成分的癌抗原肽疫苗和病毒抗原肽的佐剂。 本发明还提供了癌症或病毒感染性疾病的治疗剂，以及含有癌抗原肽或病毒抗原肽和百日咳疫苗的癌症转移或复发或病毒诱导肿瘤发病的预防剂。 可以适当使用的百日咳疫苗是全细胞体百日咳疫苗。 可以以多个剂量安全地施用本发明的药剂。
-
7.发明授权Attenuated chimeric flavivirus bearing attenuated japanese encephalitis virus gene as backbone 失效减毒的日本脑炎病毒基因的减毒嵌合黄病毒为骨架公开(公告)号：US08492532B2
公开(公告)日：2013-07-23
申请号：US12292518
申请日：2008-11-20
申请人： Kouichi Morita , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
发明人： Kouichi Morita , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
CPC分类号： A61K39/12 , A61K2039/5254 , C12N7/00 , C12N2770/24134 , C12N2770/24161 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.
摘要翻译： 含有编码日本脑炎病毒的衣壳蛋白，膜前蛋白质和非结构蛋白质的核苷酸序列的核酸分子和编码第二黄病毒的包膜蛋白的核苷酸序列，其中编码的核苷酸序列 日本脑炎病毒的膜前蛋白质和/或非结构蛋白质含有产生一种或多种减弱病毒的氨基酸突变的核苷酸突变。
-
8.发明授权公开(公告)号：US06841374B1
公开(公告)日：2005-01-11
申请号：US09555704
申请日：1999-06-02
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/70 , C12N2770/24134 , C12N2770/24151 , C12N2770/24163 , Y02A50/39
摘要： The present invention provides a novel inactivated virus particle and a reinforced immunogen which have a reinforced titer about twice to about 10 times that of a conventional vaccine, as well as a method for producing the same. The inactivated virus particle is produced by inactivating and then purifying a culture by physical means. The inactivated virus particle of the present invention is useful in a diagnostic agent for infectious disease caused by a group of Japanese encephalitis virus.
摘要翻译： 本发明提供了一种新型灭活病毒颗粒和增强免疫原，其具有约为常规疫苗的约2倍至约10倍的增强滴度，以及其制备方法。 灭活的病毒颗粒是通过灭活然后通过物理方法纯化培养物产生的。 本发明的灭活病毒颗粒可用于由一组日本脑炎病毒引起的感染性疾病的诊断剂。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.019 秒)
