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    .gamma.-chain humaninterleukin-2 receptor polypeptide and method of making
    4.
    发明授权
    .gamma.-chain humaninterleukin-2 receptor polypeptide and method of making 失效
    γ链人类白细胞介素-2受体多肽及其制备方法

    公开(公告)号：US5856140A

    公开(公告)日：1999-01-05

    申请号：US636936

    申请日：1996-04-24

    申请人： Toshiro Shimamura ,  Junji Hamuro ,  Harumi Nakazawa ,  Yuka Kanayama ,  Kazuo Sugamura ,  Toshikazu Takeshita

    发明人： Toshiro Shimamura ,  Junji Hamuro ,  Harumi Nakazawa ,  Yuka Kanayama ,  Kazuo Sugamura ,  Toshikazu Takeshita

    IPC分类号： A61K38/00 ,  C07K14/715 ,  C07K16/28 ,  C12N1/21 ,  C12N15/13 ,  C12P21/08 ,  C12P21/04 ,  C12N1/20 ,  C12N15/00 ,  C12P21/06

    CPC分类号： C07K14/7155 ,  C07K16/2866 ,  A61K38/00

    摘要： A polypeptide which specifically binds to the .gamma.-chain of the human interleukin-2 receptor and selectively inhibits the binding of the .gamma.-chain of human interleukin-2 receptor to the .beta.-chain of the same is provided. The polypeptide has an activity of blocking the human interleukin-2 response. Also provided are an immunosuppressant containing the polypeptide, a DNA gene coding for the polypeptide, a recombinant DNA having the gene, a transformant having the recombinant DNA, and a method for producing the intended polypeptide by incubating the transformant. The novel polypeptide can be used independently, or with substances capable of inhibiting the binding of interleukin-2 to the interleukin-2 receptor, as a medicine for preventing the rejection of grafts after transplantation and also for curing inflammatory diseases such as allergic diseases and autoimmune diseases.

    摘要翻译： 提供了特异性结合人白细胞介素-2受体的γ-链的多肽，并选择性地抑制人白细胞介素-2受体的γ-链与β-链的结合。 该多肽具有阻断人白介素-2应答的活性。 还提供了含有多肽的免疫抑制剂，编码该多肽的DNA基因，具有该基因的重组DNA，具有该重组DNA的转化体，以及通过温育该转化体来制备该多肽的方法。 该新型多肽可以独立使用，也可以与能够抑制白介素-2与白细胞介素-2受体结合的物质用作防止移植后移植物排斥的药物，还可用于治疗炎性疾病如过敏性疾病和自身免疫性 疾病

    Monoclonal antibodies which bind the gamma chain of human interleukin-2 receptor
    5.
    发明授权
    Monoclonal antibodies which bind the gamma chain of human interleukin-2 receptor 失效
    结合人白细胞介素2受体γ链的单克隆抗体

    公开(公告)号：US5582826A

    公开(公告)日：1996-12-10

    申请号：US230843

    申请日：1994-04-21

    申请人： Toshiro Shimamura ,  Junji Hamuro ,  Harumi Nakazawa ,  Yuka Kanayama ,  Kazuo Sugamura ,  Toshikazu Takeshita

    发明人： Toshiro Shimamura ,  Junji Hamuro ,  Harumi Nakazawa ,  Yuka Kanayama ,  Kazuo Sugamura ,  Toshikazu Takeshita

    IPC分类号： A61K38/00 ,  C07K14/715 ,  C07K16/28 ,  C12N1/21 ,  C12N15/13 ,  C12P21/08 ,  A61K39/395 ,  C07K16/24 ,  C12N5/12

    CPC分类号： C07K14/7155 ,  C07K16/2866 ,  A61K38/00

    摘要： A polypeptide which specifically binds to the .gamma.-chain of the human interleukin-2 receptor and selectively inhibits the binding of the .gamma.-chain of human interleukin-2 receptor to the .beta.-chain of the same is provided. The polypeptide has an activity of blocking the human interleukin-2 response. Also provided are an immunosuppressant containing the polypeptide, a DNA gene coding for the polypeptide, a recombinant DNA having the gene, a transformant having the recombinant DNA, and a method for producing the intended polypeptide by incubating the transformant. The novel polypeptide can be used independently, or with substances capable of inhibiting the binding of interleukin-2 to the interleukin-2 receptor, as a medicine for preventing the rejection of grafts after transplantation and also for curing inflammatory diseases such as allergic diseases and autoimmune diseases.

    摘要翻译： 提供了特异性结合人白细胞介素-2受体的γ-链的多肽，并选择性地抑制人白细胞介素-2受体的γ-链与β-链的结合。 该多肽具有阻断人白介素-2应答的活性。 还提供了含有多肽的免疫抑制剂，编码该多肽的DNA基因，具有该基因的重组DNA，具有该重组DNA的转化体，以及通过温育该转化体来制备该多肽的方法。 该新型多肽可以独立使用，也可以与能够抑制白介素-2与白细胞介素-2受体结合的物质用作防止移植后移植物排斥的药物，还可用于治疗炎性疾病如过敏性疾病和自身免疫性 疾病