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公开(公告)号:US20120101040A1
公开(公告)日:2012-04-26
申请号:US13319289
申请日:2010-05-07
申请人: Kazutaka Ogiwara , Noriko Ishikawa
发明人: Kazutaka Ogiwara , Noriko Ishikawa
CPC分类号: A61K38/39 , C07K5/0806 , C07K5/0817 , C07K5/10
摘要: An object of the present invention is to provide a biologically safe and highly bioadhesive angiogenesis inducing agent. The present invention provides an angiogenesis inducing agent which comprises a recombinant gelatin having an amino acid sequence derived from a partial amino acid sequence of collagen.
摘要翻译: 本发明的目的是提供一种生物安全和高生物粘附性血管生成诱导剂。 本发明提供一种血管生成诱导剂,其包含具有衍生自胶原的部分氨基酸序列的氨基酸序列的重组明胶。
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公开(公告)号:US20100227866A1
公开(公告)日:2010-09-09
申请号:US12600894
申请日:2008-05-26
申请人: Hiroyuki Hisamichi , Itsuro Shimada , Tsukasa Ishihara , Tomofumi Takuwa , Takafumi Shimizu , Noriko Ishikawa , Kyoichi Maeno , Norio Seki
发明人: Hiroyuki Hisamichi , Itsuro Shimada , Tsukasa Ishihara , Tomofumi Takuwa , Takafumi Shimizu , Noriko Ishikawa , Kyoichi Maeno , Norio Seki
IPC分类号: A61K31/4725 , C07D401/12 , C07D401/14 , A61K31/53 , A61K31/506 , A61P1/00 , A61P35/00
CPC分类号: A61K31/4725 , A61K31/435 , A61K31/439 , A61K31/445 , A61K31/472 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/695 , C07D217/26 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04
摘要: [Problems] To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS).[Means for Solving Problems] It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.
摘要翻译: [问题]提供药物,特别是可用作肠易激综合征(IBS)治疗剂的化合物。 [解决问题的手段]发现在4-位具有酰胺基的四氢异喹啉-1-酮衍生物或其药学上可接受的盐具有优异的铃蟾肽2(BB2)受体拮抗作用。 还发现四氢异喹啉-1-酮衍生物对肠运动障碍是高度有效的。 从上述可以看出,本发明的四氢异喹啉-1-酮衍生物可用作与BB2受体,特别是IBS相关疾病的治疗剂。
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公开(公告)号:US06653320B2
公开(公告)日:2003-11-25
申请号:US10087717
申请日:2002-03-01
申请人: Masahiko Hayakawa , Hiroyuki Kaizawa , Ken-Ichi Kawaguchi , Koyo Matsuda , Noriko Ishikawa , Tomonobu Koizumi , Mayumi Yamano , Minoru Okada , Mitsuaki Ohta
发明人: Masahiko Hayakawa , Hiroyuki Kaizawa , Ken-Ichi Kawaguchi , Koyo Matsuda , Noriko Ishikawa , Tomonobu Koizumi , Mayumi Yamano , Minoru Okada , Mitsuaki Ohta
IPC分类号: A61K31437
CPC分类号: C07D471/04 , A61K31/435 , C07D487/04
摘要: The present invention relates to novel compounds having a phosphatidylinositol 3 kinase (PI3K) inhibiting activity which are useful as medicaments, more particularly as antitumor agent. Novel 3-(imidazo[1,2-a]pyridin-3-yl) derivatives or salts thereof exhibit an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity, and are thus useful as medicaments, especially as PI3K inhibitors and antitumor agents.
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公开(公告)号:US07585878B2
公开(公告)日:2009-09-08
申请号:US10560282
申请日:2004-06-10
申请人: Takahiro Kuramochi , Norio Asai , Kazuhiro Ikegai , Seijiro Akamatsu , Hironori Harada , Noriko Ishikawa , Shohei Shirakami , Satoshi Miyamoto , Toshihiro Watanabe , Tetsuo Kiso
发明人: Takahiro Kuramochi , Norio Asai , Kazuhiro Ikegai , Seijiro Akamatsu , Hironori Harada , Noriko Ishikawa , Shohei Shirakami , Satoshi Miyamoto , Toshihiro Watanabe , Tetsuo Kiso
IPC分类号: C07D413/02 , C07D403/02 , A61K31/538 , A61K31/404
CPC分类号: C07C237/40 , A61K31/167 , A61K31/428 , A61K31/4453 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/538 , A61K31/55 , C07D209/08 , C07D209/34 , C07D213/75 , C07D215/38 , C07D217/04 , C07D223/16 , C07D231/56 , C07D235/06 , C07D241/42 , C07D249/18 , C07D263/58 , C07D265/36 , C07D277/64 , C07D277/82 , C07D279/16 , C07D295/155 , C07D307/79 , C07D317/66 , C07D333/54 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要: There is provided a compound having a capsaicin receptor VR1 inhibitory activity and useful as a therapeutic agent for various pains including inflammatory pain and neurogenic pain, migraine, cluster headache, bladder diseases including overactive bladder, and the like.A benzamide derivative or a salt thereof wherein a benzene ring is attached to a D ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring) through an amide bond, the benzene ring is directly bonded to an E ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring), and the benzene ring is further bonded to A (an amino moiety, a monocyclic or bicyclic heterocycle) through L (a lower alkylene).
摘要翻译: 提供了具有辣椒素受体VR1抑制活性的化合物,并且可用作各种疼痛的治疗剂,包括炎性疼痛和神经源性疼痛,偏头痛,丛集性头痛,包括膀胱活动过度的膀胱疾病等。 一种苯甲酰胺衍生物或其盐,其中苯环通过酰胺键连接到D环(单环或双环烃环或单环或双环杂芳族环),苯环直接键合到E环(单环 或双环烃环或单环或双环杂芳族环),并且苯环通过L(低级亚烷基)进一步与A(氨基部分,单环或双环杂环)键合。
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公开(公告)号:US06403588B1
公开(公告)日:2002-06-11
申请号:US09843610
申请日:2001-04-26
申请人: Masahiko Hayakawa , Hiroyuki Kaizawa , Ken-Ichi Kawaguchi , Koyo Matsuda , Noriko Ishikawa , Tomonobu Koizumi , Mayumi Yamano , Minoru Okada , Mitsuaki Ohta
发明人: Masahiko Hayakawa , Hiroyuki Kaizawa , Ken-Ichi Kawaguchi , Koyo Matsuda , Noriko Ishikawa , Tomonobu Koizumi , Mayumi Yamano , Minoru Okada , Mitsuaki Ohta
IPC分类号: A61K31435
CPC分类号: C07D471/04 , A61K31/435 , C07D487/04
摘要: The present invention relates to novel compounds having a phosphatidylinositol 3 kinase (PI3K) inhibiting activity which are useful as medicaments, more particularly as antitumor agent. Novel 3-(imidazo[1,2-a]pyridin-3-yl) derivatives or salts thereof exhibit an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity, and are thus useful as medicaments, especially as PI3K inhibitors and antitumor agents.
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公开(公告)号:US08486970B2
公开(公告)日:2013-07-16
申请号:US12600894
申请日:2008-05-26
申请人: Hiroyuki Hisamichi , Itsuro Shimada , Tsukasa Ishihara , Tomofumi Takuwa , Takafumi Shimizu , Noriko Ishikawa , Kyoichi Maeno , Norio Seki
发明人: Hiroyuki Hisamichi , Itsuro Shimada , Tsukasa Ishihara , Tomofumi Takuwa , Takafumi Shimizu , Noriko Ishikawa , Kyoichi Maeno , Norio Seki
IPC分类号: A01N43/40 , A61K31/445
CPC分类号: A61K31/4725 , A61K31/435 , A61K31/439 , A61K31/445 , A61K31/472 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/695 , C07D217/26 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04
摘要: [Problems] To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS).[Means for Solving Problems] It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.
摘要翻译: [问题]提供药物,特别是可用作肠易激综合征(IBS)治疗剂的化合物。 [解决问题的手段]发现在4-位具有酰胺基的四氢异喹啉-1-酮衍生物或其药学上可接受的盐具有优异的铃蟾肽2(BB2)受体拮抗作用。 还发现四氢异喹啉-1-酮衍生物对肠运动障碍是高度有效的。 从上述可以看出,本发明的四氢异喹啉-1-酮衍生物可用作与BB2受体,特别是IBS相关疾病的治疗剂。
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公开(公告)号:US20070167444A1
公开(公告)日:2007-07-19
申请号:US10560282
申请日:2004-06-10
申请人: Takahiro Kuramochi , Norio Asai , Kazuhiro Ikegai , Seijiro Akamatsu , Hironori Harada , Noriko Ishikawa , Shohei Shirakami , Satoshi Miyamoto , Toshihiro Watanabe , Tetsuo Kiso
发明人: Takahiro Kuramochi , Norio Asai , Kazuhiro Ikegai , Seijiro Akamatsu , Hironori Harada , Noriko Ishikawa , Shohei Shirakami , Satoshi Miyamoto , Toshihiro Watanabe , Tetsuo Kiso
IPC分类号: A61K31/538 , A61K31/404 , C07D413/02 , C07D403/02
CPC分类号: C07C237/40 , A61K31/167 , A61K31/428 , A61K31/4453 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/538 , A61K31/55 , C07D209/08 , C07D209/34 , C07D213/75 , C07D215/38 , C07D217/04 , C07D223/16 , C07D231/56 , C07D235/06 , C07D241/42 , C07D249/18 , C07D263/58 , C07D265/36 , C07D277/64 , C07D277/82 , C07D279/16 , C07D295/155 , C07D307/79 , C07D317/66 , C07D333/54 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要: There is provided a compound having a capsaicin receptor VR1 inhibitory activity and useful as a therapeutic agent for various pains including inflammatory pain and neurogenic pain, migraine, cluster headache, bladder diseases including overactive bladder, and the like. A benzamide derivative or a salt thereof wherein a benzene ring is attached to a D ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring) through an amide bond, the benzene ring is directly bonded to an E ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring), and the benzene ring is further bonded to A (an amino moiety, a monocyclic or bicyclic heterocycle) through L (a lower alkylene).
摘要翻译: 提供了具有辣椒素受体VR1抑制活性的化合物,并且可用作各种疼痛的治疗剂,包括炎性疼痛和神经源性疼痛,偏头痛,丛集性头痛,包括膀胱活动过度的膀胱疾病等。 一种苯甲酰胺衍生物或其盐,其中苯环通过酰胺键连接到D环(单环或双环烃环或单环或双环杂芳族环),苯环直接键合到E环(单环 或双环烃环或单环或双环杂芳族环),并且苯环通过L(低级亚烷基)进一步与A(氨基部分,单环或双环杂环)键合。
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公开(公告)号:US07855198B2
公开(公告)日:2010-12-21
申请号:US12496993
申请日:2009-07-02
申请人: Takahiro Kuramochi , Norio Asai , Kazuhiro Ikegai , Seijiro Akamatsu , Hironori Harada , Noriko Ishikawa , Shohei Shirakami , Satoshi Miyamoto , Toshihiro Watanabe , Tetsuo Kiso
发明人: Takahiro Kuramochi , Norio Asai , Kazuhiro Ikegai , Seijiro Akamatsu , Hironori Harada , Noriko Ishikawa , Shohei Shirakami , Satoshi Miyamoto , Toshihiro Watanabe , Tetsuo Kiso
IPC分类号: C07D413/10 , C07D413/14 , A61K31/538
CPC分类号: C07C237/40 , A61K31/167 , A61K31/428 , A61K31/4453 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/538 , A61K31/55 , C07D209/08 , C07D209/34 , C07D213/75 , C07D215/38 , C07D217/04 , C07D223/16 , C07D231/56 , C07D235/06 , C07D241/42 , C07D249/18 , C07D263/58 , C07D265/36 , C07D277/64 , C07D277/82 , C07D279/16 , C07D295/155 , C07D307/79 , C07D317/66 , C07D333/54 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要: There is provided a compound having a capsaicin receptor VR1 inhibitory activity and useful as a therapeutic agent for various pains including inflammatory pain and neurogenic pain, migraine, cluster headache, bladder diseases including overactive bladder, and the like.A benzamide derivative or a salt thereof wherein a benzene ring is attached to a D ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring) through an amide bond, the benzene ring is directly bonded to an E ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring), and the benzene ring is further bonded to A (an amino moiety, a monocyclic or bicyclic heterocycle) through L (a lower alkylene).
摘要翻译: 提供了具有辣椒素受体VR1抑制活性的化合物,并且可用作各种疼痛的治疗剂,包括炎性疼痛和神经源性疼痛,偏头痛,丛集性头痛,包括膀胱活动过度的膀胱疾病等。 一种苯甲酰胺衍生物或其盐,其中苯环通过酰胺键连接到D环(单环或双环烃环或单环或双环杂芳族环),苯环直接键合到E环(单环 或双环烃环或单环或双环杂芳族环),并且苯环通过L(低级亚烷基)进一步与A(氨基部分,单环或双环杂环)键合。
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