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1.发明申请公开(公告)号：US20170037359A1
公开(公告)日：2017-02-09
申请号：US15299059
申请日：2016-10-20
发明人： Robert Doebler , Ali Nadim , James D. Sterling , Anna Hickerson , Barbara Erwin , Denice Woyski , Ryan P. Talbot , Bruce Irvine
CPC分类号： C12M47/06 , C12M23/28 , C12M27/00 , C12N1/066 , G01N1/286 , G01N1/4077 , G01N2001/4083 , G01N2001/4088 , G01N2001/4094
摘要： Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency.
摘要翻译： 摆动角度旋转包含材料的容器可能导致材料分离。 可能意外地将吸收剂或较重的物质收集得相对靠近旋转轴线收集，而较不致密或轻质材料倾向于相对远离旋转轴线收集。 沿弧形路径的振荡提供了高裂解效率。 或者，微型马达可以驱动可拆卸地容纳在容器中的叶轮。 裂解可以分批模式，流通停止或半分批模式或流通连续模式来实现。 裂解颗粒材料可能超过待裂解的材料或裂解的材料和/或空气可以基本上从室中除去以增加裂解效率。
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2.发明申请SYSTEMS AND DEVICES FOR ISOTHERMAL BIOCHEMICAL REACTIONS AND/OR ANALYSIS 审中-公开用于同位素生物化学反应和/或分析的系统和装置公开(公告)号：US20160151785A1
公开(公告)日：2016-06-02
申请号：US14806438
申请日：2015-07-22
CPC分类号： B01L7/52 , B01L2200/147 , B01L2300/0609 , B01L2300/0654 , B01L2300/0681 , B01L2300/18 , B01L2300/1805 , B01L2300/1827 , C12Q1/6844 , G01N21/0332 , G01N21/6428 , G01N21/6486 , G01N2201/06153 , Y10T436/12 , Y10T436/25
摘要： An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.
摘要翻译： 等温反应和分析系统可以包括用于接收样品架的接收器，用于控制接收器的温度的热控制子系统，激励子系统，检测子系统和分析子系统。 定位激励源和/或检测器以增强数据收集。 样品保持器可以包括滤光器，选择性地阻挡和通过电磁辐射的波长或带。
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3.发明申请公开(公告)号：US20150024480A1
公开(公告)日：2015-01-22
申请号：US14451015
申请日：2014-08-04
发明人： Robert Doebler , Ali Nadim , James D. Sterling , Anna Hickerson , Barbara Erwin , Denice Woyski , Ryan P. Talbot , Bruce Irvine
CPC分类号： C12M47/06 , C12M23/28 , C12M27/00 , C12N1/066 , G01N1/286 , G01N1/4077 , G01N2001/4083 , G01N2001/4088 , G01N2001/4094
摘要： Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency.
摘要翻译： 摆动角度旋转包含材料的容器可能导致材料分离。 可能意外地将吸收剂或较重的物质收集得相对靠近旋转轴线收集，而较不致密或较轻的材料倾向于相对于旋转轴线收集。 沿弧形路径的振荡提供了高裂解效率。 或者，微型马达可以驱动可拆卸地容纳在容器中的叶轮。 裂解可以分批模式，流通停止或半分批模式或流通连续模式来实现。 裂解颗粒材料可能超过待裂解的材料或裂解的材料和/或空气可以基本上从室中除去以增加裂解效率。
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公开(公告)号：US20130291965A1
公开(公告)日：2013-11-07
申请号：US13859680
申请日：2013-04-09
发明人： Anna Hickerson
IPC分类号： F16K15/00
CPC分类号： F16K15/00 , F16K15/142 , Y10T137/7837
摘要： A valve has a generally hollow core with one open end and one closed end, and at least one side port in a sidewall of the core. The valve also includes a sleeve that fits over the core and covers the side port(s). The cracking pressure of the valve is tunable by varying the parameters of the sleeve.
摘要翻译： 阀具有通常为中空的芯，其具有一个开口端和一个封闭端，以及在该芯的侧壁中的至少一个侧端口。 该阀还包括套筒，该套筒套在芯部上并覆盖侧面端口。 阀的开启压力可通过改变套筒的参数来调节。
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公开(公告)号：US20200002663A1
公开(公告)日：2020-01-02
申请号：US16565206
申请日：2019-09-09
发明人： Robert Doebler , Ali Nadim , James D. Sterling , Anna Hickerson , Barbara Erwin , Denice Woyski , Ryan P. Talbot , Bruce Irvine
摘要： Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency.
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公开(公告)号：US20180023121A1
公开(公告)日：2018-01-25
申请号：US15699718
申请日：2017-09-08
发明人： Angelika Niemz , Anna Hickerson , Kristina Roskos , Hsiang-Wei Lu
CPC分类号： C12Q1/686 , B01L3/502723 , B01L3/50273 , B01L7/00 , B01L2300/0663 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , F04B17/00
摘要： A disposable and inexpensive biological diagnostic cartridge for the amplification and detection of nucleic acids includes a configuration having a reaction pouch for amplification which is compressed by a flexible pump pouch for detection of the amplified reaction.
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公开(公告)号：US09797006B2
公开(公告)日：2017-10-24
申请号：US13860453
申请日：2013-04-10
发明人： Angelika Niemz , Anna Hickerson , Kristina Roskos , Hsiang-Wei Lu
CPC分类号： C12Q1/686 , B01L3/502723 , B01L3/50273 , B01L7/00 , B01L2300/0663 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , F04B17/00
摘要： A disposable and inexpensive biological diagnostic cartridge for the amplification and detection of nucleic acids includes a configuration having a reaction pouch for amplification which is compressed by a flexible pump pouch for detection of the amplified reaction.
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公开(公告)号：US09358540B1
公开(公告)日：2016-06-07
申请号：US14806438
申请日：2015-07-22
CPC分类号： B01L7/52 , B01L2200/147 , B01L2300/0609 , B01L2300/0654 , B01L2300/0681 , B01L2300/18 , B01L2300/1805 , B01L2300/1827 , C12Q1/6844 , G01N21/0332 , G01N21/6428 , G01N21/6486 , G01N2201/06153 , Y10T436/12 , Y10T436/25
摘要： An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.
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公开(公告)号：US10428301B2
公开(公告)日：2019-10-01
申请号：US15299059
申请日：2016-10-20
发明人： Robert Doebler , Ali Nadim , James D. Sterling , Anna Hickerson , Barbara Erwin , Denice Woyski , Ryan P. Talbot , Bruce Irvine
摘要： Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency.
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10.发明授权公开(公告)号：US09115393B2
公开(公告)日：2015-08-25
申请号：US14307253
申请日：2014-06-17
CPC分类号： B01L7/52 , B01L2200/147 , B01L2300/0609 , B01L2300/0654 , B01L2300/0681 , B01L2300/18 , B01L2300/1805 , B01L2300/1827 , C12Q1/6844 , G01N21/0332 , G01N21/6428 , G01N21/6486 , G01N2201/06153 , Y10T436/12 , Y10T436/25
摘要： An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.
摘要翻译： 等温反应和分析系统可以包括用于接收样品架的接收器，用于控制接收器的温度的热控制子系统，激励子系统，检测子系统和分析子系统。 定位激励源和/或检测器以增强数据收集。 样品保持器可以包括滤光器，选择性地阻挡和通过电磁辐射的波长或带。
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