公开(公告)号：US20140044694A1

公开(公告)日：2014-02-13

申请号：US14114122

申请日：2012-04-27

申请人： Keiichi Ozono ,  Takanobu Otomo ,  Norio Sakai

发明人： Keiichi Ozono ,  Takanobu Otomo ,  Norio Sakai

IPC分类号： A61K38/47

CPC分类号： A61K38/47 ,  A61K38/48 ,  A61K38/4813 ,  A61K38/488 ,  C12N5/06 ,  C12Y302/0102 ,  C12Y302/01021 ,  C12Y302/01022 ,  C12Y302/01023 ,  C12Y302/01024 ,  C12Y302/01031 ,  C12Y302/01046 ,  C12Y302/01051 ,  C12Y302/01052 ,  C12Y304/14001 ,  C12Y304/16005 ,  C12Y304/22001 ,  C12Y304/22038 ,  C12Y304/23005 ,  C12Y304/23034 ,  A61K2300/00

摘要： The purpose of the present invention is to provide, in a simple and also inexpensive manner, a pharmaceutical composition which comprises a plurality of lysosomal enzymes and is effective in treating lysosomal storage disease caused by a deficiency in a plurality of lysosomal enzymes. Provided is a pharmaceutical composition for treating lysosomal storage disease, the composition comprising as an active ingredient a lysosomal enzyme group obtained from cells derived from a subject who does not suffer from lysosomal storage disease.

摘要翻译： 本发明的目的是以简单且便宜的方式提供包含多种溶酶体酶的药物组合物，并且有效地治疗由多种溶酶体酶缺乏引起的溶酶体贮积病。 本发明提供一种用于治疗溶酶体贮积病的药物组合物，该组合物含有从不患有溶酶体贮积病的受试者的细胞获得的溶酶体酶组分作为活性成分。

公开(公告)号：US09138465B2

公开(公告)日：2015-09-22

申请号：US14114122

申请日：2012-04-27

申请人： Keiichi Ozono ,  Takanobu Otomo ,  Norio Sakai

发明人： Keiichi Ozono ,  Takanobu Otomo ,  Norio Sakai

IPC分类号： A61K38/54 ,  A61K38/47 ,  A61K38/48 ,  C12N5/07

CPC分类号： A61K38/47 ,  A61K38/48 ,  A61K38/4813 ,  A61K38/488 ,  C12N5/06 ,  C12Y302/0102 ,  C12Y302/01021 ,  C12Y302/01022 ,  C12Y302/01023 ,  C12Y302/01024 ,  C12Y302/01031 ,  C12Y302/01046 ,  C12Y302/01051 ,  C12Y302/01052 ,  C12Y304/14001 ,  C12Y304/16005 ,  C12Y304/22001 ,  C12Y304/22038 ,  C12Y304/23005 ,  C12Y304/23034 ,  A61K2300/00

摘要： The purpose of the present invention is to provide, in a simple and also inexpensive manner, a pharmaceutical composition which comprises a plurality of lysosomal enzymes and is effective in treating lysosomal storage disease caused by a deficiency in a plurality of lysosomal enzymes. Provided is a pharmaceutical composition for treating lysosomal storage disease, the composition comprising as an active ingredient a lysosomal enzyme group obtained from cells derived from a subject who does not suffer from lysosomal storage disease.

摘要翻译： 本发明的目的是以简单且便宜的方式提供包含多种溶酶体酶的药物组合物，并且有效地治疗由多种溶酶体酶缺乏引起的溶酶体贮积病。 本发明提供一种用于治疗溶酶体贮积病的药物组合物，该组合物含有从不患有溶酶体贮积病的受试者的细胞获得的溶酶体酶组分作为活性成分。

公开(公告)号：US20140329950A1

公开(公告)日：2014-11-06

申请号：US14240229

申请日：2012-08-10

申请人： Mutsuhiro Shimoguchi ,  Michiya Nakashima ,  Keiichi Ozono ,  Hidemi Nakamura ,  Hiroko Sakurai

发明人： Mutsuhiro Shimoguchi ,  Michiya Nakashima ,  Keiichi Ozono ,  Hidemi Nakamura ,  Hiroko Sakurai

IPC分类号： C09J11/04 ,  C09J7/00

CPC分类号： C09J11/04 ,  B32B7/12 ,  B32B27/08 ,  B32B27/302 ,  B32B27/306 ,  B32B27/32 ,  B32B27/34 ,  B32B27/36 ,  B32B2307/518 ,  B32B2307/7242 ,  B32B2439/70 ,  C08G18/10 ,  C08G18/42 ,  C08K3/04 ,  C08K3/22 ,  C08K3/346 ,  C08K2003/2213 ,  C08K2003/2237 ,  C08K2003/2244 ,  C08K2003/2265 ,  C08K2003/2296 ,  C09J7/00 ,  C09J175/04 ,  C09J175/06 ,  C08G18/7642

摘要： An object of the present invention is to provide a resin composition for adhesives, the resin composition mainly containing a resin that has a good adhesive strength or a good oxygen-barrier property, and an adhesive obtained by applying the resin composition onto a film. The object is achieved by providing a resin composition for adhesives, the resin composition containing (A) a resin that has, as functional groups, two or more hydroxyl groups per molecule, (B) an isocyanate compound that has, as functional groups, two or more isocyanate groups per molecule, and (C1) a plate-like inorganic compound or (C2) a light-blocking agent that can block light having a wavelength of 350 nm or less, and an adhesive obtained by curing the resin composition for adhesives.

摘要翻译： 本发明的目的是提供一种用于粘合剂的树脂组合物，该树脂组合物主要含有具有良好的粘合强度或良好的阻氧性的树脂，以及通过将该树脂组合物涂布在膜上获得的粘合剂。 该目的通过提供粘合剂用树脂组合物来实现，该树脂组合物含有（A）每分子具有两个以上羟基作为官能团的树脂，（B）作为官能团的异氰酸酯化合物， 或更多的异氰酸酯基团，和（C1）板状无机化合物或（C2）可以阻挡波长为350nm以下的光的遮光剂，以及通过固化用于粘合剂的树脂组合物获得的粘合剂 。

公开(公告)号：US09676976B2

公开(公告)日：2017-06-13

申请号：US13805596

申请日：2011-06-16

申请人： Hiroyuki Takeda ,  Keiichi Ozono ,  Michiya Nakashima ,  Yoshinori Kanagawa

发明人： Hiroyuki Takeda ,  Keiichi Ozono ,  Michiya Nakashima ,  Yoshinori Kanagawa

IPC分类号： B32B7/12 ,  B32B27/08 ,  B32B27/36 ,  B32B27/40 ,  C08G18/42 ,  C08G18/76 ,  C08G18/78 ,  C08G18/80 ,  C09D175/06 ,  C09J167/00 ,  C09J167/02 ,  C09J175/04 ,  C09J175/06

CPC分类号： C09J175/04 ,  B32B7/12 ,  B32B27/08 ,  B32B27/36 ,  B32B27/40 ,  B32B2307/7244 ,  B32B2439/70 ,  C08G18/4213 ,  C08G18/4236 ,  C08G18/7642 ,  C08G18/7831 ,  C08G18/8029 ,  C09D175/06 ,  C09J167/00 ,  C09J167/02 ,  C09J175/06

摘要： An oxygen-barrier film and an adhesive used therefor. Provided are an adhesive, which can be used for packaging foodstuffs and contains mainly a polyester having excellent oxygen-barrier properties, and an oxygen-barrier film that uses the adhesive. The oxygen-barrier film is prepared using an adhesive that includes: an amorphous polyester polyol, which is obtained by polycondensation of a polyvalent carboxylic acid component including at least one type of ortho-oriented aromatic dicarboxylic acid or anhydride thereof, and a polyhydric alcohol including at least one compound selected from the group consisting of ethylene glycol, propylene glycol, butylene glycol, neopentyl glycol and cyclohexanedimethanol, and a curing agent capable of reacting with the amorphous polyester polyol.

公开(公告)号：US20130158186A1

公开(公告)日：2013-06-20

申请号：US13805596

申请日：2011-06-16

申请人： Hiroyuki Takeda ,  Keiichi Ozono ,  Michiya Nakashima ,  Yoshinori Kanagawa

发明人： Hiroyuki Takeda ,  Keiichi Ozono ,  Michiya Nakashima ,  Yoshinori Kanagawa

IPC分类号： C09J175/04 ,  C09J167/00

CPC分类号： C09J175/04 ,  B32B7/12 ,  B32B27/08 ,  B32B27/36 ,  B32B27/40 ,  B32B2307/7244 ,  B32B2439/70 ,  C08G18/4213 ,  C08G18/4236 ,  C08G18/7642 ,  C08G18/7831 ,  C08G18/8029 ,  C09D175/06 ,  C09J167/00 ,  C09J167/02 ,  C09J175/06

摘要： An oxygen-barrier film and an adhesive used therefor. Provided are an adhesive, which can be used for packaging foodstuffs and contains mainly a polyester having excellent oxygen-barrier properties, and an oxygen-barrier film that uses the adhesive. The oxygen-barrier film is prepared using an adhesive that includes: an amorphous polyester polyol, which is obtained by polycondensation of a polyvalent carboxylic acid component including at least one type of ortho-oriented aromatic dicarboxylic acid or anhydride thereof, and a polyhydric alcohol including at least one compound selected from the group consisting of ethylene glycol, propylene glycol, butylene glycol, neopentyl glycol and cyclohexanedimethanol, and a curing agent capable of reacting with the amorphous polyester polyol.

摘要翻译： 氧隔离膜和用于其的粘合剂。 提供一种粘合剂，其可以用于包装食品并且主要包含具有优异的阻氧性的聚酯和使用该粘合剂的氧阻隔膜。 使用粘合剂制备氧阻隔膜，所述粘合剂包括：通过包含至少一种类型的邻位取向的芳族二羧酸或其酸酐的多元羧酸组分与包含以下的多元醇的多元醇缩聚得到的无定形聚酯多元醇： 至少一种选自乙二醇，丙二醇，丁二醇，新戊二醇和环己烷二甲醇的化合物，以及能够与无定形聚酯多元醇反应的固化剂。