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公开(公告)号：US07118918B2
公开(公告)日：2006-10-10
申请号：US09931513
申请日：2001-08-16
申请人： Keith G. Copeland , Thomas M. Grogan , Charles Hassen , William Ross Humphreys , Charles D. Lemme , Phillip C. Miller , William L. Richards , Wayne A. Showalter
发明人： Keith G. Copeland , Thomas M. Grogan , Charles Hassen , William Ross Humphreys , Charles D. Lemme , Phillip C. Miller , William L. Richards , Wayne A. Showalter
IPC分类号： G01N35/00
CPC分类号： G01N35/10 , B01F5/0057 , B01F13/0059 , B01F13/02 , B01F13/0272 , B01F2215/0037 , G01N1/312 , G01N35/025 , G01N35/1002 , G01N2001/317 , G01N2035/00079 , G01N2035/00386 , G01N2035/00544 , G01N2035/00752 , Y10T436/11 , Y10T436/111666 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initiating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.
摘要翻译： 一种具有试剂施用区和试剂供应区的自动免疫染色装置。 该装置具有支撑其上的多个滑动支架的转盘滑动支架，并且驱动器接合转盘滑动支架，以连续地将多个滑动支架中的每一个放置在试剂应用区域中。 该装置还具有在其上具有多个试剂容器支架的转盘试剂支架，驱动器接合转盘以旋转圆盘传送带并将预先选定的试剂容器支架定位在试剂供应区中。 该装置还具有定位用于接合位于试剂输送区域中的容器支架上的试剂容器并启动试剂从试剂容器输送到支撑在试剂接收区域中的载玻片支架上的载玻片的试剂递送致动器。
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公开(公告)号：US06827901B2
公开(公告)日：2004-12-07
申请号：US10137169
申请日：2002-05-02
申请人： Keith G. Copeland , Thomas M. Grogan , Charles Hassen , William Ross Humphreys , Charles D. Lemme , Phillip C. Miller , William L. Richards , Wayne A. Showalter
发明人： Keith G. Copeland , Thomas M. Grogan , Charles Hassen , William Ross Humphreys , Charles D. Lemme , Phillip C. Miller , William L. Richards , Wayne A. Showalter
IPC分类号： G01N3500
CPC分类号： G01N35/10 , B01F5/0057 , B01F13/0059 , B01F13/02 , B01F13/0272 , B01F2215/0037 , G01N1/312 , G01N35/025 , G01N35/1002 , G01N2001/317 , G01N2035/00079 , G01N2035/00386 , G01N2035/00544 , G01N2035/00752 , Y10T436/11 , Y10T436/111666 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive means engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive means engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator means positioned for engaging a reagent container positioned on a container support.
摘要翻译： 一种具有试剂施用区和试剂供应区的自动免疫染色装置。 该装置具有支撑其上的多个滑动支架的转盘滑动支撑件，以及接合转盘滑动支架的驱动装置，用于将多个滑动支架中的每一个连续地定位在试剂应用区域中。 该装置还具有其上具有多个试剂容器支架的转盘试剂支架，以及接合转盘的驱动装置，用于旋转转盘，并将预选的试剂容器支架定位在试剂供应区中。 该装置还具有定位用于接合位于容器支架上的试剂容器的试剂输送致动器装置。
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公开(公告)号：US5654200A
公开(公告)日：1997-08-05
申请号：US479415
申请日：1995-06-06
申请人： Keith G. Copeland , Thomas M. Grogan , Charles Hassen , William Ross Humphreys , Charles D. Lemme , Phillip C. Miller , William L. Richards , Wayne A. Showalter
发明人： Keith G. Copeland , Thomas M. Grogan , Charles Hassen , William Ross Humphreys , Charles D. Lemme , Phillip C. Miller , William L. Richards , Wayne A. Showalter
CPC分类号： G01N35/10 , B01F13/02 , B01F13/0272 , B01F5/0057 , G01N1/312 , G01N35/025 , G01N35/1002 , B01F13/0059 , B01F2215/0037 , G01N2001/317 , G01N2035/00079 , G01N2035/00386 , G01N2035/00544 , G01N2035/00752 , Y10T436/11 , Y10T436/111666 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive device engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive device engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator device positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.
摘要翻译： 一种具有试剂施用区和试剂供应区的自动免疫染色装置。 该装置具有支撑其上的多个滑动支架的转盘滑动支架，以及与转盘滑动支架接合的驱动装置，用于将多个滑动支架中的每一个连续地定位在试剂应用区域中。 该装置还具有其上具有多个试剂容器支架的转盘试剂支架，以及与转盘相啮合的驱动装置，用于旋转转盘，并将预选的试剂容器支架定位在试剂供应区中。 该装置还具有定位用于接合位于试剂输送区域中的容器支架上的试剂容器的试剂输送致动器装置，以及试剂从试剂容器向支撑在试剂接收区的滑动支架上的载玻片的输送。
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公开(公告)号：US06943029B2
公开(公告)日：2005-09-13
申请号：US10054535
申请日：2002-01-22
申请人： Keith G. Copeland , Thomas M. Grogan , Charles Hassen , William Ross Humphreys , Charles D. Lemme , Phillip C. Miller , William L. Richards , Wayne A. Showalter
发明人： Keith G. Copeland , Thomas M. Grogan , Charles Hassen , William Ross Humphreys , Charles D. Lemme , Phillip C. Miller , William L. Richards , Wayne A. Showalter
IPC分类号： B01F5/00 , B01F13/00 , B01F13/02 , G01N1/30 , G01N1/31 , G01N35/00 , G01N35/02 , G01N35/10 , B01L3/02 , B01L9/00 , G01N1/00 , G01N1/10
CPC分类号： G01N35/10 , B01F5/0057 , B01F13/0059 , B01F13/02 , B01F13/0272 , B01F2215/0037 , G01N1/312 , G01N35/025 , G01N35/1002 , G01N2001/317 , G01N2035/00079 , G01N2035/00386 , G01N2035/00544 , G01N2035/00752 , Y10T436/11 , Y10T436/111666 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive means engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive means engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator means positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initiating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.
摘要翻译： 一种具有试剂施用区和试剂供应区的自动免疫染色装置。 该装置具有支撑其上的多个滑动支架的转盘滑动支撑件，以及接合转盘滑动支架的驱动装置，用于将多个滑动支架中的每一个连续地定位在试剂应用区域中。 该装置还具有其上具有多个试剂容器支架的转盘试剂支架，以及接合转盘的驱动装置，用于旋转转盘，并将预选的试剂容器支架定位在试剂供应区中。 该装置还具有试剂递送致动器装置，其被定位用于接合位于试剂输送区域中的容器支架上的试剂容器，并且启动试剂从试剂容器递送到支撑在试剂接收区域中的载玻片支架上的载玻片。
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公开(公告)号：US07470541B2
公开(公告)日：2008-12-30
申请号：US10991050
申请日：2004-11-17
申请人： Keith G. Copeland , Thomas M. Grogan , Charles Hassen , William Ross Humphreys , Charles D. Lemme , Philip C. Miller , William L. Richards , Wayne A. Showalter
发明人： Keith G. Copeland , Thomas M. Grogan , Charles Hassen , William Ross Humphreys , Charles D. Lemme , Philip C. Miller , William L. Richards , Wayne A. Showalter
CPC分类号： G01N35/10 , B01F5/0057 , B01F13/0059 , B01F13/02 , B01F13/0272 , B01F2215/0037 , G01N1/312 , G01N35/025 , G01N35/1002 , G01N2001/317 , G01N2035/00079 , G01N2035/00386 , G01N2035/00544 , G01N2035/00752 , Y10T436/11 , Y10T436/111666 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive means engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive means engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator means positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initiating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.
摘要翻译： 一种具有试剂施用区和试剂供应区的自动免疫染色装置。 该装置具有支撑其上的多个滑动支架的转盘滑动支撑件，以及接合转盘滑动支架的驱动装置，用于将多个滑动支架中的每一个连续地定位在试剂应用区域中。 该装置还具有其上具有多个试剂容器支架的转盘试剂支架，以及接合转盘的驱动装置，用于旋转转盘，并将预选的试剂容器支架定位在试剂供应区中。 该装置还具有试剂递送致动器装置，其被定位用于接合位于试剂输送区域中的容器支架上的试剂容器，并且启动试剂从试剂容器递送到支撑在试剂接收区域中的载玻片支架上的载玻片。
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公开(公告)号：US06352861B1
公开(公告)日：2002-03-05
申请号：US09452309
申请日：1999-12-01
申请人： Keith G. Copeland , Thomas M. Grogan , Charles Hassen , William Ross Humphreys , Charles E. Lemme , Phillip C. Miller , William L. Richards , Wayne A. Showalter
发明人： Keith G. Copeland , Thomas M. Grogan , Charles Hassen , William Ross Humphreys , Charles E. Lemme , Phillip C. Miller , William L. Richards , Wayne A. Showalter
IPC分类号： G01N100
CPC分类号： G01N35/10 , B01F5/0057 , B01F13/0059 , B01F13/02 , B01F13/0272 , B01F2215/0037 , G01N1/312 , G01N35/025 , G01N35/1002 , G01N2001/317 , G01N2035/00079 , G01N2035/00386 , G01N2035/00544 , G01N2035/00752 , Y10T436/11 , Y10T436/111666 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive means engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive means engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator means positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initiating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.
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公开(公告)号：US5595707A
公开(公告)日：1997-01-21
申请号：US352966
申请日：1994-12-09
申请人： Keith G. Copeland , Thomas M. Grogan , Charles Hassen , William R. Humphreys , Charles D. Lemme , Phillip C. Miller , William L. Richards , Wayne A. Showalter
发明人： Keith G. Copeland , Thomas M. Grogan , Charles Hassen , William R. Humphreys , Charles D. Lemme , Phillip C. Miller , William L. Richards , Wayne A. Showalter
CPC分类号： G01N35/10 , B01F13/02 , B01F13/0272 , B01F5/0057 , G01N1/312 , G01N35/025 , G01N35/1002 , B01F13/0059 , B01F2215/0037 , G01N2001/317 , G01N2035/00079 , G01N2035/00386 , G01N2035/00544 , G01N2035/00752 , Y10T436/11 , Y10T436/111666 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support supporting a plurality of slide supports thereon, and drive means engaging the carousel slide support for consecutively positioning each of a plurality of slide supports in the reagent application zone. The apparatus also has a carousel reagent support having a plurality of reagent container supports thereon, and drive means engaging the carousel for rotating the carousel and positioning a preselected reagent container support in the reagent supply zone. The apparatus also has a reagent delivery actuator means positioned for engaging a reagent container positioned on a container support in the reagent delivery zone and initiating reagent delivery from the reagent container to a slide supported on a slide support in the reagent receiving zone.
摘要翻译： 一种具有试剂施用区和试剂供应区的自动免疫染色装置。 该装置具有支撑其上的多个滑动支架的转盘滑动支撑件，以及接合转盘滑动支架的驱动装置，用于将多个滑动支架中的每一个连续地定位在试剂应用区域中。 该装置还具有其上具有多个试剂容器支架的转盘试剂支架，以及接合转盘的驱动装置，用于旋转转盘，并将预选的试剂容器支架定位在试剂供应区中。 该装置还具有试剂递送致动器装置，其被定位用于接合位于试剂输送区域中的容器支架上的试剂容器，并且启动试剂从试剂容器递送到支撑在试剂接收区域中的载玻片支架上的载玻片。
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公开(公告)号：US5654199A
公开(公告)日：1997-08-05
申请号：US474359
申请日：1995-06-06
申请人： Keith G. Copeland , Thomas M. Grogan , Phillip C. Miller , William L. Richards , Wayne A. Showalter
发明人： Keith G. Copeland , Thomas M. Grogan , Phillip C. Miller , William L. Richards , Wayne A. Showalter
IPC分类号： B01F5/00 , B01F13/00 , B01F13/02 , G01N1/30 , G01N1/31 , G01N35/00 , G01N35/02 , G01N35/10 , G01N1/38
CPC分类号： G01N35/10 , B01F13/02 , B01F13/0272 , B01F5/0057 , G01N1/312 , G01N35/025 , G01N35/1002 , B01F13/0059 , B01F2215/0037 , G01N2001/317 , G01N2035/00079 , G01N2035/00386 , G01N2035/00544 , G01N2035/00752 , Y10T436/11 , Y10T436/111666 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support (24) supporting a plurality of slide supports (26) thereon, and drive means (48) engaging the carousel slide support (24) for consecutively positioning each of a plurality of slide supports (26) in the reagent application zone. The apparatus also has a carousel reagent support (10) having a plurality of reagent container supports (11) thereon, and drive means (14) engaging the carousel for rotating the carousel and positioning a preselected reagent container support (11) in the reagent supply zone. The apparatus also has a reagent delivery actuator means (18) positioned for engaging a reagent container (12) positioned on a container support (11) in the reagent delivery zone and initiating reagent delivery from the reagent container (12) to a slide supported on a slide support (26) in the reagent receiving zone.
摘要翻译： 一种具有试剂施用区和试剂供应区的自动免疫染色装置。 该装置具有支撑其上的多个滑动支撑件（26）的转盘滑动支撑件（24）和与圆盘传送带滑动支架（24）接合的驱动装置（48），用于将多个滑动支架（26）中的每一个连续地定位在 试剂应用区。 该装置还具有在其上具有多个试剂容器支架（11）的转盘试剂支架（10）和与圆盘传送带接合的驱动装置（14），用于旋转圆盘传送带并将预先选定的试剂容器支架（11） 区。 该装置还具有定位用于接合位于试剂输送区域中的容器支架（11）上的试剂容器（12）的试剂输送致动器装置（18），并且启动试剂从试剂容器（12）输送至支撑在 在试剂接收区中的滑动支架（26）。
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公开(公告)号：US5650327A
公开(公告)日：1997-07-22
申请号：US469577
申请日：1995-06-06
申请人： Keith G. Copeland , Thomas M. Grogan , Phillip C. Miller , William L. Richards , Wayne A. Showalter
发明人： Keith G. Copeland , Thomas M. Grogan , Phillip C. Miller , William L. Richards , Wayne A. Showalter
IPC分类号： B01F5/00 , B01F13/00 , B01F13/02 , G01N1/30 , G01N1/31 , G01N35/00 , G01N35/02 , G01N35/10 , G01N1/38
CPC分类号： G01N35/10 , B01F13/02 , B01F13/0272 , B01F5/0057 , G01N1/312 , G01N35/025 , G01N35/1002 , B01F13/0059 , B01F2215/0037 , G01N2001/317 , G01N2035/00079 , G01N2035/00386 , G01N2035/00544 , G01N2035/00752 , Y10T436/11 , Y10T436/111666 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/2575
摘要： An automated immunostaining apparatus having a reagent application zone and a reagent supply zone. The apparatus has a carousel slide support (24) supporting a plurality of slide supports (26) thereon, and drive means (48) engaging the carousel slide support (24) for consecutively positioning each of a plurality of slide supports (26) in the reagent application zone. The apparatus also has a carousel reagent support (10) having a plurality of reagent container supports (11) thereon, and drive means (14) engaging the carousel for rotating the carousel and positioning a preselected reagent container support (11) in the reagent supply zone. The apparatus also has a reagent delivery actuator means (18) positioned for engaging a reagent container (12) positioned on a container support (11) in the reagent delivery zone and initiating reagent delivery from the reagent container (12) to a slide supported on a slide support (26) in the reagent receiving zone.
摘要翻译： 一种具有试剂施用区和试剂供应区的自动免疫染色装置。 该装置具有支撑其上的多个滑动支撑件（26）的转盘滑动支撑件（24）和与圆盘传送带滑动支架（24）接合的驱动装置（48），用于将多个滑动支架（26）中的每一个连续地定位在 试剂应用区。 该装置还具有在其上具有多个试剂容器支架（11）的转盘试剂支架（10）和与圆盘传送带接合的驱动装置（14），用于旋转圆盘传送带并将预先选定的试剂容器支架（11） 区。 该装置还具有定位用于接合位于试剂输送区域中的容器支架（11）上的试剂容器（12）的试剂输送致动器装置（18），并且启动试剂从试剂容器（12）输送至支撑在 在试剂接收区中的滑动支架（26）。
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公开(公告)号：US07468161B2
公开(公告)日：2008-12-23
申请号：US11116676
申请日：2005-04-27
申请人： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William L. Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon C. Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall B. Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
发明人： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William L. Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon C. Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall B. Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
CPC分类号： G01N35/00029 , B01L9/52 , B01L2300/0822 , G01N1/30 , G01N1/312 , G01N1/36 , G01N35/00732 , G01N35/0099 , G01N2035/00039 , G01N2035/00138 , Y10T436/11 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.
摘要翻译： 提供了一种自动化系统，用于对载有生物样品的载玻片进行滑动加工操作。 在一个实施例中，所公开的系统包括容纳大致水平位置的多个滑块的滑动盘和接收滑动盘的工作站。 在一个具体实施方案中，工作站递送试剂以滑动表面，而不会将试剂（和试剂携带的污染物，例如脱落的细胞）基本上从一个载玻片转移到另一个载体。 还提供了一种用于自动处理幻灯片的方法。
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