Mucosal adjuvant composition
    1.
    发明授权
    Mucosal adjuvant composition 有权
    粘膜佐剂组合物

    公开(公告)号:US09381241B2

    公开(公告)日:2016-07-05

    申请号:US13876439

    申请日:2011-09-27

    摘要: Problem to be Solved: The present invention provides a novel mucosal adjuvant.Solution: The present invention provides a mucosal adjuvant composition containing at least a composition comprising molecules having a molecular weight in a range of 100 to 300 kDa obtained from cells or culture fluid of Bordetella bronchiseptica. Administration of the mucosal adjuvant composition to a non-human animal at a surface of the mucous membrane can enhance immunity at the surface of mucous membrane. Therefore preventive effects against trans-mucosal infection can be increased by administering an inactivated vaccine against trans-mucosal infection and the mucosal adjuvant composition to a non-human animal at a surface of mucous membrane. The present invention is effective for preventing trans-mucosal infections, including one or more infections of e.g., canine parainfluenza, canine adenovirus, canine coronavirus, canine parvovirus, canine distemper virus, canine herpesvirus, reovirus and pneumovirus.

    摘要翻译: 待解决的问题:本发明提供一种新型粘膜佐剂。 解决方案:本发明提供一种粘膜佐剂组合物,其至少含有由支气管炎博德特氏菌的细胞或培养液获得的分子量为100-300kDa的分子的组合物。 在粘膜表面向非人动物施用粘膜佐剂组合物可提高粘膜表面的免疫力。 因此,可以通过在粘膜表面施用针对反粘膜感染的灭活疫苗和粘膜佐剂组合物至非人动物来增加对反粘膜感染的预防效果。 本发明对于预防反粘膜感染,包括一种或多种例如副流感病毒,犬腺病毒,犬冠状病毒,犬细小病毒,犬瘟热病毒,犬疱疹病毒,呼肠孤病毒和肺病毒感染是有效的。

    MUCOSAL ADJUVANT COMPOSITION
    2.
    发明申请
    MUCOSAL ADJUVANT COMPOSITION 有权
    粘膜补充剂组合物

    公开(公告)号:US20130302360A1

    公开(公告)日:2013-11-14

    申请号:US13876439

    申请日:2011-09-27

    IPC分类号: A61K39/39

    摘要: Problem to be Solved: The present invention provides a novel mucosal adjuvant.Solution: The present invention provides a mucosal adjuvant composition containing at least a composition comprising molecules having a molecular weight in a range of 100 to 300 kDa obtained from cells or culture fluid of Bordetella bronchiseptica. Administration of the mucosal adjuvant composition to a non-human animal at a surface of the mucous membrane can enhance immunity at the surface of mucous membrane. Therefore preventive effects against trans-mucosal infection can be increased by administering an inactivated vaccine against trans-mucosal infection and the mucosal adjuvant composition to a non-human animal at a surface of mucous membrane. The present invention is effective for preventing trans-mucosal infections, including one or more infections of e.g., canine parainfluenza, canine adenovirus, canine coronavirus, canine parvovirus, canine distemper virus, canine herpesvirus, reovirus and pneumovirus.

    摘要翻译: 待解决的问题:本发明提供一种新型粘膜佐剂。 解决方案:本发明提供一种粘膜佐剂组合物,其至少含有由支气管炎博德特氏菌的细胞或培养液获得的分子量为100-300kDa的分子的组合物。 在粘膜表面向非人动物施用粘膜佐剂组合物可增强粘膜表面的免疫力。 因此,可以通过在粘膜表面施用针对反粘膜感染的灭活疫苗和粘膜佐剂组合物至非人动物来增加对反粘膜感染的预防效果。 本发明对于预防反粘膜感染,包括一种或多种例如副流感病毒,犬腺病毒,犬冠状病毒,犬细小病毒,犬瘟热病毒,犬疱疹病毒,呼肠孤病毒和肺病毒感染是有效的。

    Recombinant feline herpesvirus type 1 and polyvalent vaccine using the same
    3.
    发明授权
    Recombinant feline herpesvirus type 1 and polyvalent vaccine using the same 有权
    重组猫疱疹病毒1型和使用其的多价疫苗

    公开(公告)号:US07659114B2

    公开(公告)日:2010-02-09

    申请号:US11869896

    申请日:2007-10-10

    IPC分类号: A61A48/00 C12N15/63

    摘要: An attenuated feline recombinant herpesvirus 1 (FHV-1), which is prepared by identifying gene regions in the genome wherein inserted foreign genes can be expressed without affecting the replication of FHV-1 and has least two types of foreign nucleic acid sequences inserted thereinto, usable as a vector virus or a vaccine. In this attenuated recombinant FHV-1, at least two types of foreign genes are inserted in such a manner as allowing the expression into two different gene regions exerting no lethal effect on the proliferation of the virus in the feline herpesvirus 1 genome.

    摘要翻译: 一种减毒的猫重组疱疹病毒1(FHV-1),其通过鉴定基因组中的基因区域而制备,其中可以表达插入的外来基因而不影响FHV-1的复制,并且其中插入有至少两种类型的外来核酸序列, 可用作载体病毒或疫苗。 在这种减毒的重组FHV-1中,插入至少两种类型的外来基因,使得能够表达两个不同的基因区域,对猫疱疹病毒1基因组中病毒的增殖没有致死作用。

    Novel Recombinant Feline Herpesvirus Type I and Polyvalent Vaccine Using the Same
    4.
    发明申请
    Novel Recombinant Feline Herpesvirus Type I and Polyvalent Vaccine Using the Same 有权
    新型重组犬疱疹病毒I型和使用其的多价疫苗

    公开(公告)号:US20080152670A1

    公开(公告)日:2008-06-26

    申请号:US11869896

    申请日:2007-10-10

    IPC分类号: A61K39/245 A61P31/22

    摘要: An attenuated feline recombinant herpesvirus 1 (FHV-1), which is prepared by identifying gene regions in the genome wherein inserted foreign genes can be expressed without affecting the replication of FHV-1 and has least two types of foreign nucleic acid sequences inserted thereinto, usable as a vector virus or a vaccine. In this attenuated recombinant FHV-1, at least two types of foreign genes are inserted in such a manner as allowing the expression into two different gene regions exerting no lethal effect on the proliferation of the virus in the feline herpesvirus 1 genome.

    摘要翻译: 一种减毒的猫重组疱疹病毒1(FHV-1),其通过鉴定基因组中的基因区域而制备,其中可以表达插入的外来基因而不影响FHV-1的复制,并且其中插入有至少两种类型的外源核酸序列, 可用作载体病毒或疫苗。 在这种减毒的重组FHV-1中,插入至少两种类型的外来基因,使得能够表达两个不同的基因区域,对猫疱疹病毒1基因组中病毒的增殖没有致死作用。

    Recombinant feline herpesvirus type 1 and polyvalent vaccine using the same
    5.
    发明授权
    Recombinant feline herpesvirus type 1 and polyvalent vaccine using the same 有权
    重组猫疱疹病毒1型和使用其的多价疫苗

    公开(公告)号:US07297533B2

    公开(公告)日:2007-11-20

    申请号:US10398696

    申请日:2001-10-05

    IPC分类号: C12N15/63 A61K48/00

    摘要: An attenuated feline recombinant herpesvirus 1 (FHV-1), which is prepared by identifying gene regions in the genome wherein inserted foreign genes can be expressed without affecting the replication of FHV-1 and has least two types of foreign nucleic acid sequences inserted thereinto, usable as a vector virus or a vaccine. In this attenuated recombinant FHV-1, at least two types of foreign genes are inserted in such a manner as allowing the expression into two different gene regions exerting no lethal effect on the proliferation of the virus in the feline herpesvirus 1 genome.

    摘要翻译: 一种减毒的猫重组疱疹病毒1(FHV-1),其通过鉴定基因组中的基因区域而制备,其中可以表达插入的外来基因而不影响FHV-1的复制,并且其中插入有至少两种类型的外源核酸序列, 可用作载体病毒或疫苗。 在这种减毒的重组FHV-1中,插入至少两种类型的外来基因,使得能够表达两个不同的基因区域,对猫疱疹病毒1基因组中病毒的增殖没有致死作用。

    Surface acoustic wave device using beveled substrate
    9.
    发明授权
    Surface acoustic wave device using beveled substrate 失效
    表面声波装置采用斜面基板

    公开(公告)号:US4603275A

    公开(公告)日:1986-07-29

    申请号:US672144

    申请日:1984-11-16

    CPC分类号: H03H9/02629 H03H9/02842

    摘要: A surface acoustic device is formed by cutting a piezoelectric wafer having a number of input and output electrodes on one surface thereof such that at least one end of the device has a bevel adjacent the upper surface. The bevel suppresses the reflection of surface waves. The bevel may be formed by a rotating cutter having a central disc and opposite frustoconical cutters.

    摘要翻译: 表面声学装置通过在其一个表面上切割具有多个输入和输出电极的压电晶片形成,使得装置的至少一端具有邻近上表面的斜面。 斜面抑制了表面波的反射。 斜面可以由具有中心盘和相对的截头圆锥形切割器的旋转切割器形成。

    HARMFUL BACTERIUM CONTROL AGENT CONTAINING BACILLUS THURINGIENSIS
    10.
    发明申请
    HARMFUL BACTERIUM CONTROL AGENT CONTAINING BACILLUS THURINGIENSIS 审中-公开
    含有BACILLUS THURINGIENSIS的有害的细菌控制剂

    公开(公告)号:US20090257995A1

    公开(公告)日:2009-10-15

    申请号:US12092275

    申请日:2006-10-05

    申请人: Masami Mochizuki

    发明人: Masami Mochizuki

    IPC分类号: A61K35/74 C12N1/20 A61P43/00

    摘要: Through inhibition of the multiplication of pathogenic bacteria and inactivation of bacterial self-induced factors, the balance of intestinal flora is improved to thereby promote regulation of animal intestinal functions and enable prevention/treatment of infection disease caused by such pathogenic bacteria. Accordingly, a pharmaceutical containing Bacillus thuringiensis is administered to animals, and animals are allowed to ingest food or feed containing Bacillus thuringiensis.

    摘要翻译: 通过抑制病原菌的繁殖和细菌自身诱导因子的失活,肠道菌群的平衡得到改善,从而促进动物肠道功能的调节,并能够预防/治疗由这种致病菌引起的感染疾病。 因此,向动物施用含有苏云金芽孢杆菌的药物,并允许动物摄取含有苏云金芽孢杆菌的食物或饲料。