摘要:
A novel and very elegant method is proposed for the preparation of N.sub.1 -(2-tetrahydrofuryl)-5-substituted or -unsubstituted uracil, especially, N.sub.1 -(2-tetrahydrofuryl)-5-fluorouracil, by the reaction of the corresponding 5-substituted uracil compound with 2,3-dihydrofuran. The reaction is performed in the presence of a chlorosilane compound, e.g. dimethyldichlorosilane, and a catalytic amount of an organic amine compound and can proceed very rapidly without disadvantageous side reactions to give the objective compound with high purity in a high yield.
摘要:
A novel and efficient method is proposed for the preparation of isosorbide-5-nitrate which is a promising medicinal compound for several diseases due to disorder in heart. The method comprises direct nitration of isosorbide with a concentrated nitric acid in a specific reaction medium containing an aromatic hydrocarbon solvent, e.g. benzene, in addition to conventional acetic acid and acetic anhydride. After neutralization of the reaction mixture and removal of the dinitrate as a byproduct therefrom, the reaction mixture is admixed with an aqueous solution of sodium hydroxide so that a sodium salt of isosorbide-5-nitrate is precipitated in the form of a hydrate, which is a novel compound not known in the prior art. This hydrate sodium salt is then decomposed with an acid to give the desired isosorbide-5-nitrate in a high yield.
摘要:
The present invention provides a combination product which comprises: (1) a polyaldehyde obtained by introducing an aldehyde group into a branched glucose in a β-1,3-glucan, and (2) a polyamine obtained by increasing the molecular weight of a poly-L-lysine. The combination product according to the present invention is useful as a material for a tissue adhesive hydrogel which can be used as a hemostatic agent or the like which exhibits low risks for viral infections and the like, high biodegradability and biocompatibility, excellent safety, a good adhesion rate and a good adhesion strength.
摘要:
There is provided an aluminum-alloy material having sufficient electric conductivity and tensile strength as a wiring material and excellent in wire-drawing property, and an electric wire or cable using the same. An electric wire or cable includes an aluminum-alloy strand formed of an aluminum-alloy including Fe: 0.1% by mass or more to less than 1.0% by mass, Zr: 0 to 0.08% by mass, Si: 0.02 to 2.8% by mass, at least one of Cu: 0.05 to 0.63% by mass and Mg: 0.04 to 0.45% by mass, and the remainder being aluminum and unavoidable impurities.
摘要:
It is an object of the present invention to provide a protein having a drug transport activity, a method for screening a compound that promotes or inhibits the activity of the drug transporter, a compound obtained by the method, an antibody against the drug transporter, a pharmaceutical composition comprising the same, or the like. The protein with a drug transport activity of the present invention has an amino acid sequence represented by SEQ ID NO: 1.
摘要翻译:本发明的目的是提供具有药物转运活性的蛋白质,用于筛选促进或抑制药物转运蛋白活性的化合物的方法,通过该方法获得的化合物,针对药物转运蛋白的抗体, 包含其的药物组合物等。 具有本发明的药物转运活性的蛋白质具有SEQ ID NO:1所示的氨基酸序列。
摘要:
A semiconductor integrated circuit system having a function of automatically adjusting an output resistance value with reference to a temperature of an LSI which is operating. When a count value obtained from a counter by counting the output of a timer becomes equal to a predetermined value, a temperature sensor measures temperatures of LSIs. If a temperature fluctuation measured from a previous measured value is greater than a predetermined width, then a control apparatus issues an output resistance value adjustment request signal to output resistance adjustment units of the LSIs. When receiving the output resistance value adjustment request signal, the output resistance value adjustment units stop the signal transmission between the LSIs, adjust output resistance values of output circuits in such a manner that the output resistance values are matched with a characteristic impedance of a transmission line, and maintains the adjusted output resistance values until the output resistance value adjustment units receive next output resistance value adjustment request signal.
摘要:
Data is transmitted from any one of a plurality of transmitters in synchronism with a first clock. A receiver receives the data in synchronism with the first clock and a second clock having a predetermined phase relationship with the first clock. Control information is previously held in the receiver regarding data reception conditions associated with the plurality of transmitters to control reception conditions of the receiver on the basis of the control information.
摘要:
Apparatus for interconnecting logic boards is provided with a backplane, a plurality of logic boards connected to the backplane, and a plurality of interconnecting boards, connected to the backplane, for interconnecting the plurality of logic boards. In the apparatus, the plurality of logic boards are connected to the backplane with the logic boards in vertical position at right angles with the interconnecting boards and a specified distance away from the interconnecting boards.
摘要:
Apparatus for interconnecting logic boards is provided with a backplane, a plurality of logic boards connected to the backplane, and a plurality of interconnecting boards, connected to the backplane, for interconnecting the plurality of logic boards. In the apparatus, the plurality of logic boards are connected to the backplane with the logic boards in vertical position at right angles with the interconnecting boards and a specified distance away from the interconnecting boards.
摘要:
A semiconductor integrated circuit comprising a clock pulse generator, peripheral function blocks and bus master modules. The peripheral function blocks are commonly supplied with a first system clock signal of a constant frequency generated on the basis of the output from the clock pulse generator. The bus master modules are fed with a second system clock signal generated on the basis of the pulse generator output. The frequency of the second system clock signal is variable and lower than that of the first system clock signal. The function blocks supplied with the first system clock signal are connected to a data bus separate from the one connected to the function blocks fed with the second system clock signal.