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    3-heteroaralkylthio carbacephem compounds and antibacterial pharmaceutical composition
    1.
    发明授权
    3-heteroaralkylthio carbacephem compounds and antibacterial pharmaceutical composition 失效
    3-杂芳烷硫基碳化合物和抗菌药物组成

    公开(公告)号：US4760060A

    公开(公告)日：1988-07-26

    申请号：US798320

    申请日：1985-11-15

    申请人： Kenichi Mochida ,  Takehiro Ogasa ,  Junichi Shimada ,  Tadahi Hirata ,  Kiyoshi Sato ,  Ryo Okachi

    发明人： Kenichi Mochida ,  Takehiro Ogasa ,  Junichi Shimada ,  Tadahi Hirata ,  Kiyoshi Sato ,  Ryo Okachi

    IPC分类号： A61K31/435 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D463/00 ,  C07D501/59 ,  C07D487/06 ,  C07D501/14

    CPC分类号： C07D463/22 ,  Y02P20/55

    摘要： Carbacephem and cephem compounds represented by the formula: ##STR1## [Wherein X is S or CH.sub.2 ; n is an integer of 1 to 5; R.sub.1 is an unsubstituted or substituted heterocyclic group (where the heterocyclic group is a 5- or 6-membered heterocyclic group having 1 to 4 of O, S and N); R.sub.2 is a group represented by the formula: ##STR2## (where R.sub.4 is an unsubstituted or substituted phenyl or 2-aminothiazolyl) or a group represented by the formula: ##STR3## (where R.sub.5 is an unsubstituted or substituted lower alkyl); R.sub.3 is hydrogen, an alkali metal, an alkaline earth metal, an organic ammonium group or an ester residue, and R.sub.1 may be a quaternary ammonium group, where --CO.sub.2 R.sub.3 represents --CO.sub.2.sup.- ] have strong antibacterial activity against Gram-positive and Gram-negative bacteria, and are useful for treating various infections.

    摘要翻译： 碳水化合物和头孢烯化合物，其由下式表示：其中X是S或CH 2; n为1〜5的整数， R1是未取代或取代的杂环基（其中杂环基是具有1至4个O，S和N的5或6元杂环基）; R2是由下式表示的基团：其中R 4是未取代或取代的苯基或2-氨基噻唑基）或由下式表示的基团：其中R5是未取代或取代的低级烷基; R3是氢，碱金属，碱土金属，有机铵基或酯残基，R1可以是季铵基，其中-CO 2 R 3表示-CO 2 - ]对革兰氏阳性和革兰氏阳性菌具有很强的抗菌活性， 阴性细菌，可用于治疗各种感染。

    3-substituted carbacepem compounds having antibacterial effect
    2.
    发明授权
    3-substituted carbacepem compounds having antibacterial effect 失效
    具有抗菌作用的3-取代的碳水化合物

    公开(公告)号：US4640919A

    公开(公告)日：1987-02-03

    申请号：US702623

    申请日：1985-02-19

    申请人： Kenichi Mochida ,  Takehiro Ogasa ,  Junichi Shimada ,  Tadashi Hirata ,  Kiyoshi Sato ,  Ryo Okachi

    发明人： Kenichi Mochida ,  Takehiro Ogasa ,  Junichi Shimada ,  Tadashi Hirata ,  Kiyoshi Sato ,  Ryo Okachi

    IPC分类号： A61K31/435 ,  A61P31/04 ,  C07D463/00 ,  C07D493/14 ,  A61K31/53 ,  C07D251/00 ,  C07D253/00

    CPC分类号： C07D493/14 ,  C07D463/22

    摘要： Carbacephem compounds represented by the formula: ##STR1## [wherein R.sub.1 is a lower alkylsulfonyloxy, unsubstituted or substituted arylsulfonyloxy, azido, cyano, carbamoyloxy, unsubstituted or substituted heterocyclic thio ("heterocyclic" means a 5- or 6-membered heterocyclic group having 1 to 4 O, S or N atoms), unsubstituted or substituted lower alkylthio, or unsubstituted or substituted arylthio group; R.sub.2 and R.sub.3 are groups frequently used in the cephalosporin chemistry] have strong antibacterial activity against Gram-positive and Gram-negative bacteria, and are useful for curing various infections.

    摘要翻译： 由下式表示的碳水化合物化合物[其中R1是低级烷基磺酰氧基，未取代或取代的芳基磺酰氧基，叠氮基，氰基，氨基甲酰氧基，未取代或取代的杂环硫基（“杂环”是指具有1 至4 O，S或N原子），未取代或取代的低级烷硫基，或未取代或取代的芳硫基; R2和R3是头孢菌素化学中经常使用的基团]对革兰氏阳性和革兰氏阴性菌具有很强的抗菌活性，可用于治疗各种感染。

    Optically active cephalosporin analogs
    3.
    发明授权
    Optically active cephalosporin analogs 失效
    光学活性头孢菌素类似物

    公开(公告)号：US4663450A

    公开(公告)日：1987-05-05

    申请号：US788660

    申请日：1985-10-17

    申请人： Tadashi Hirata ,  Yukio Hashimoto ,  Takehiro Ogasa ,  Shigeru Kobayashi ,  Akira Sato ,  Kiyoshi Sato ,  Seigo Takasawa

    发明人： Tadashi Hirata ,  Yukio Hashimoto ,  Takehiro Ogasa ,  Shigeru Kobayashi ,  Akira Sato ,  Kiyoshi Sato ,  Seigo Takasawa

    IPC分类号： C07D463/00 ,  C07F9/568 ,  C12P17/18 ,  C07D471/04 ,  A61K31/435

    CPC分类号： C12P17/184 ,  C07D463/22 ,  C07F9/5683

    摘要： Optically active cephalosporin analogs of the formula ##STR1## wherein R.sub.2 represents a hydrogen or a group represented by the formula ##STR2## wherein R.sub.3 is a straight or branched lower alkyl group having 1 to 6 carbon atoms, a straight or branched lower alkoxy group having 1 to 6 carbon atoms or a phenyl group and R.sub.4 is a hydrogen or a straight or branched lower alkyl group having 1 to 6 carbon atoms; and A.sub.2 represents a straight or branched lower alkyl group having 1 to 6 carbon atoms or a straight or branched lower alkyl group having 1 to 6 carbon atoms which is substituted with one or two carboxyl groups, are useful as antibacterial agents.

    摘要翻译： 其中R2代表氢或由下式表示的基团的光学活性头孢菌素类似物：其中R 3是具有1-6个碳原子的直链或支链低级烷基，具有直链或支链的低级烷氧基， 1〜6个碳原子或苯基，R4为氢或碳原子数为1〜6的直链或支链的低级烷基; A2表示碳原子数1〜6的直链或支链的低级烷基或碳原子数1〜6的直链或支链的低级烷基，被一个或两个羧基取代，可用作抗菌剂。

    .beta.-lactam compound and a pharmaceutical composition containing the same
    5.
    发明授权
    .beta.-lactam compound and a pharmaceutical composition containing the same 失效
    β-内酰胺化合物和含有该β-内酰胺的药物组合物

    公开(公告)号：US4694001A

    公开(公告)日：1987-09-15

    申请号：US674710

    申请日：1984-11-26

    申请人： Tadashi Hirata ,  Kenichi Mochida ,  Chihiro Shiraki ,  Kiyoshi Sato

    发明人： Tadashi Hirata ,  Kenichi Mochida ,  Chihiro Shiraki ,  Kiyoshi Sato

    IPC分类号： C07D277/20 ,  A61K31/435 ,  A61K31/535 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/38 ,  C07D277/40 ,  C07D277/46 ,  C07D463/00 ,  C07D501/20 ,  C07D501/22 ,  C07D501/34 ,  C07D501/59 ,  C07D505/00 ,  C07D205/12 ,  A61K31/395

    CPC分类号： C07D505/00 ,  C07D277/46 ,  C07D463/22 ,  Y02P20/55

    摘要： .beta.-Lactam compounds represented by the general formula: ##STR1## (wherein X represents CH.sub.2, S or O; Y represents a hydroxyl group, a lower alkanoyloxy group or a lower alkoxycarbonyloxy group; W is a group represented by CH.sub.2, NH, ##STR2## A is a phenyl group, a naphthyl group, or a monocyclic or dicyclic heterocyclic group, respectively substituted by (Y).sub.n ; R.sub.4 and R.sub.5 each are a hydrogen atom, a lower alkyl group, or a cycloalkylidene group with a carbon atom combined therewith; l is 0 or an integer of 1, 2 or 3; m is 0 or 1; n is an integer of 1, 2, 3, 4 or 5; and R.sub.1, R.sub.2 and R.sub.3 are groups often used in the conventional .beta.-lactam compounds) have strong antimicrobial activities against a wide range of Gram positive and negative bacteria; particularly Gram negative bacteria including Pseudomonas aeruginosa, Pseudomonas sepatia and various Enterobacters.

    摘要翻译： 由以下通式表示的β-内酰胺化合物：其中X表示CH 2，S或O; Y表示羟基，低级烷酰氧基或低级烷氧基羰氧基; W表示为CH 2，NH， 图像A是分别被（Y）n取代的苯基，萘基或单环或二环杂环基; R 4和R 5各自为氢原子，低级烷基或具有碳原子的亚环烷基 l是0或1,2或3的整数; m是0或1; n是1,2,3,4或5的整数; R 1，R 2和R 3是通常用于常规的基团 β-内酰胺化合物）对广泛的革兰氏阳性和阴性细菌具有很强的抗微生物活性; 特别是革兰氏阴性细菌，包括铜绿假单胞菌，假单胞菌分离菌和各种肠道特征。

    4-alkylresorcinol derivative and external preparation for skin containing the same
    6.
    发明授权
    4-alkylresorcinol derivative and external preparation for skin containing the same 有权
    4-烷基间苯二酚衍生物和含有其的皮肤外用剂

    公开(公告)号：US08486919B2

    公开(公告)日：2013-07-16

    申请号：US13809696

    申请日：2011-06-01

    申请人： Hirotada Fukunishi ,  Rikako Suzuki ,  Kiyoshi Sato ,  Masaru Suetsugu

    发明人： Hirotada Fukunishi ,  Rikako Suzuki ,  Kiyoshi Sato ,  Masaru Suetsugu

    IPC分类号： A61K31/6615 ,  C07F9/12

    CPC分类号： C07F9/09 ,  A61K8/55 ,  A61K2800/782 ,  A61Q19/02 ,  C07F9/12

    摘要： The present invention provides a compound that has a high whitening effect and is excellent in safety and stability and provides an external preparation for skin comprising the same. The compound of the present invention is a 4-alkylresorcinol derivative represented by formula (1) or a salt thereof: wherein R1 is a branched or cyclic alkyl group of 3 to 7 carbon atoms or a linear alkyl group of 2 to 5 carbon atoms; R2 and R3 are each independently a hydrogen atom or a group represented by —P(O)(OR4)(OR5), and at least one of R2 and R3 is a group represented by —P(O)(OR4)(OR5); and R4 and R5 are each independently a hydrogen atom or a linear or branched alkyl group of 2 to 5 carbon atoms.

    摘要翻译： 本发明提供了具有高白化效果并且安全性和稳定性优异的化合物，并且提供了包含其的皮肤外用剂。 本发明的化合物是式（1）表示的4-烷基间苯二酚衍生物或其盐：其中，R 1为碳原子数3〜7的支链或环状烷基或碳原子数2〜5的直链烷基; R 2和R 3各自独立地为氢原子或由-P（O）（OR 4）（OR 5）表示的基团，R 2和R 3中的至少一个为-P（O）（OR 4）（OR 5） ; R 4和R 5各自独立地为氢原子或2〜5个碳原子的直链或支链烷基。

    SKIN-WHITENING AGENT AND COSMETIC METHOD FOR WHITENING SKIN
    8.
    发明申请
    SKIN-WHITENING AGENT AND COSMETIC METHOD FOR WHITENING SKIN 审中-公开
    用于白化皮肤的皮肤白化剂和化妆方法

    公开(公告)号：US20120122951A1

    公开(公告)日：2012-05-17

    申请号：US13138787

    申请日：2010-03-04

    申请人： Rikako Suzuki ,  Yosuke Tojo ,  Chieko Mizumoto ,  Kiyotaka Hasegawa ,  Yutaka Ashida ,  Jun-ichi Hosoi ,  Kiyoshi Sato

    发明人： Rikako Suzuki ,  Yosuke Tojo ,  Chieko Mizumoto ,  Kiyotaka Hasegawa ,  Yutaka Ashida ,  Jun-ichi Hosoi ,  Kiyoshi Sato

    IPC分类号： A61K31/40 ,  A61Q19/02 ,  C07D207/16

    CPC分类号： A61K31/401 ,  A23L33/175 ,  A23V2002/00 ,  A61K8/0212 ,  A61K8/0216 ,  A61K8/4913 ,  A61K2800/92 ,  A61Q19/02 ,  A23V2200/318

    摘要： The development of a skin-whitening agent which has a lower molecular weight, can be synthesized through a fewer steps and can be produced at low cost has been demanded. Thus, it is provided by the present invention a skin-whitening agent including one or more compounds selected from the group consisting of 4-cis-hydroxyproline and its derivative and/or its salt, a skin-whitening composition for external formulation to the skin, a cosmetic composition and a pharmaceutical composition, each of which contains the skin-whitening agent of the invention, and a cosmetic method for whitening the skin, which includes a step of administering one or more compounds selected from the group consisting of 4-cis-hydroxyproline and its derivative and/or its salt. In the skin-whitening agent and the cosmetic method for whitening the skin of the invention, the 4-cis-hydroxyproline may be 4-cis-L-hydroxyproline and/or 4-cis-D-hydroxyproline.

    摘要翻译： 需要开发具有较低分子量的皮肤增白剂，可以通过较少的步骤合成并且可以以低成本生产。 因此，本发明提供一种皮肤增白剂，其包含一种或多种选自4-顺式 - 羟基脯氨酸及其衍生物和/或其盐的化合物，用于皮肤外用制剂的皮肤增白组合物 ，化妆品组合物和药物组合物，其含有本发明的皮肤增白剂和美白化妆品的方法，其包括给予一种或多种选自4-顺式 - 羟脯氨酸及其衍生物和/或其盐。 在本发明的皮肤美白剂和美白化妆品的美白方法中，4-顺式 - 羟基脯氨酸可以是4-顺式-L-羟基脯氨酸和/或4-顺式-D-羟基脯氨酸。

    Connector unit for differential transmission
    9.
    发明授权
    Connector unit for differential transmission 失效
    用于差速传动的连接器单元

    公开(公告)号：US08152539B2

    公开(公告)日：2012-04-10

    申请号：US12346951

    申请日：2008-12-31

    申请人： Satoshi Moriyama ,  Tadashi Kumamoto ,  Masahiro Hamazaki ,  Mitsuru Kobayashi ,  Kiyoshi Sato

    发明人： Satoshi Moriyama ,  Tadashi Kumamoto ,  Masahiro Hamazaki ,  Mitsuru Kobayashi ,  Kiyoshi Sato

    IPC分类号： H01R4/66 ,  H01R13/648

    CPC分类号： H01R13/26 ,  H01R13/6471 ,  H01R13/6585

    摘要： A differential transmission connector unit is disclosed that includes a first differential transmission connector including a first electrically insulating block body; and first signal contact pairs and first ground contacts arranged alternately in a row in the first block body; and a second differential transmission connector including a second electrically insulating block body; and second signal contact pairs and second ground contacts arranged alternately in a row in the second block body. The first differential transmission connector is connected to the second differential transmission connector with the first signal contact pairs and the second signal contact pairs being in contact with each other and the first ground contacts and the second ground contacts being in contact with each other. One of the contact surface of each first ground contact and the contact surface of the corresponding second ground contact is a rolled surface, the contact surfaces contacting each other.

    摘要翻译： 公开了一种差分传输连接器单元，其包括：第一差分传输连接器，包括第一电绝缘块体; 以及在所述第一块体中交替布置的第一信号触点对和第一接地触点; 以及包括第二电绝缘块体的第二差分传输连接器; 以及第二信号接触对和第二接地触头，其在第二块体中交替布置成一行。 第一差分传输连接器与第二差分传输连接器连接，其中第一信号接触对和第二信号接触对彼此接触，并且第一接地触点和第二接地触点彼此接触。 每个第一接地触点的接触表面和相应的第二接地触点的接触表面之一是轧制表面，接触表面彼此接触。