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公开(公告)号：US20050187441A1
公开(公告)日：2005-08-25
申请号：US11035075
申请日：2005-01-14
CPC分类号： G01N21/6458
摘要： A laser-scanning examination apparatus includes a laser light source; an optical fiber through which laser light generated in the laser light source is transmitted; a scan head including a casing for housing a laser scanning unit that scans the laser light transmitted by the optical fiber on a specimen, an objective unit for imaging the laser light scanned by the laser scanning unit onto the specimen; an optical detector for detecting returning light that returns from the specimen to the interior of the casing via the objective unit; a stage for mounting the specimen; and an arm that supports the scan head so that the position and orientation of the objective unit with respect to the stage can be adjusted. The optical detector is provided on an outer surface of the casing except for the surface located in the opposite direction from the direction in which the arm extends from the casing. The laser-scanning examination apparatus has a compact head unit and allows improved ease-of-use by securing a large space around the head unit.
摘要翻译： 激光扫描检查装置包括激光光源; 在激光光源中产生的激光透过的光纤; 扫描头，包括用于容纳将由所述光纤透射的激光扫描在检体上的激光扫描单元的外壳，用于将由所述激光扫描单元扫描的激光成像到所述样本上的目标单元; 光检测器，用于检测经由所述物镜单元从所述样本返回到所述壳体内部的返回光; 安装样品的阶段; 以及支撑扫描头的臂，使得可以调节物镜单元相对于平台的位置和取向。 光检测器设置在壳体的外表面上，除了位于与臂从壳体延伸的方向相反的方向上的表面之外。 激光扫描检查装置具有紧凑的头部单元，并且通过确保头部单元周围的大空间来允许改进的易于使用。
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公开(公告)号：US20050237604A1
公开(公告)日：2005-10-27
申请号：US11095518
申请日：2005-04-01
CPC分类号： G02B21/26 , A61B90/20 , A61B90/50 , G02B21/0012 , G02B21/082 , G02B21/24
摘要： An in-vivo examination apparatus in which the examination angle can be changed while keeping an examination site in focus to carry out accurate in-vivo examination is provided. The in-vivo examination apparatus includes a stage on which a living organism is mounted, a measurement head that irradiates the living organism on the stage with light emitted from a light source and detects light returning from the living organism, and a rotation mechanism that rotates the measurement head about a fixed point on the stage.
摘要翻译： 提供一种体内检查装置，其中可以在保持检查部位聚焦的同时改变检查角度，以进行准确的体内检查。 体内检查装置包括安装有活体的台，测量头，用从光源发出的光照射舞台上的活体，并检测从活体返回的光;旋转机构，其旋转 测量头围绕舞台上的一个固定点。
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公开(公告)号：US07268938B2
公开(公告)日：2007-09-11
申请号：US11095518
申请日：2005-04-01
CPC分类号： G02B21/26 , A61B90/20 , A61B90/50 , G02B21/0012 , G02B21/082 , G02B21/24
摘要： An in-vivo examination apparatus in which the examination angle can be changed while keeping an examination site in focus to carry out accurate in-vivo examination is provided. The in-vivo examination apparatus includes a stage on which a living organism is mounted, a measurement head that irradiates the living organism on the stage with light emitted from a light source and detects light returning from the living organism, and a rotation mechanism that rotates the measurement head about a fixed point on the stage.
摘要翻译： 提供一种体内检查装置，其中可以在保持检查部位聚焦的同时改变检查角度，以进行准确的体内检查。 体内检查装置包括安装有活体的台，测量头，用从光源发出的光照射舞台上的活体，并检测从活体返回的光;旋转机构，其旋转 测量头围绕舞台上的固定点。
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公开(公告)号：US08110394B2
公开(公告)日：2012-02-07
申请号：US12776182
申请日：2010-05-07
CPC分类号： C12M41/14 , C12M23/50 , C12M41/46 , G02B21/0088 , G02B21/06 , G02B21/24 , Y10S435/809
摘要： A culture microscope apparatus has an illumination unit to apply excitation light to the specimen, a specimen observing portion to observe light generated from the specimen due to the excitation light, and a dimmer unit to dim the excitation light that has penetrated the specimen.
摘要翻译： 培养显微镜装置具有对试样施加激发光的照明单元，用于观察由于激发光而产生的试样的光的试样观察部，以及使透过试样的激发光变暗的调光单元。
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5.发明授权公开(公告)号：US07612316B2
公开(公告)日：2009-11-03
申请号：US11876676
申请日：2007-10-22
IPC分类号： G02B7/04
CPC分类号： G02B21/0088 , G02B21/16 , G02B21/244 , G02B21/245
摘要： A focus detection device which is applied to a fluorescent observation device for observing a fluorescent image to be emitted from an observation sample on the basis of an evanescent light, includes an image pickup unit which detects a contrast of the fluorescent image by imaging the fluorescent image, and a detector which detects a focus on the basis of the detection result.
摘要翻译： 应用于荧光观察装置的焦点检测装置包括通过对荧光图像进行成像来检测荧光图像的对比度的图像拾取单元，该荧光观察装置用于观察从观察样本发射的荧光图像 以及基于检测结果检测焦点的检测器。
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6.发明授权公开(公告)号：US07304282B2
公开(公告)日：2007-12-04
申请号：US11328028
申请日：2006-01-09
IPC分类号： G02B7/04
CPC分类号： G02B21/0088 , G02B21/16 , G02B21/244 , G02B21/245
摘要： A focus detection device which is applied to a fluorescent observation device for observing a fluorescent image to be emitted from an observation sample on the basis of an evanescent light, includes an image pickup unit which detects a contrast of the fluorescent image by imaging the fluorescent image, and a detector which detects a focus on the basis of the detection result.
摘要翻译： 应用于荧光观察装置的焦点检测装置包括通过对荧光图像进行成像来检测荧光图像的对比度的图像拾取单元，该荧光观察装置用于观察从观察样本发射的荧光图像 以及基于检测结果检测焦点的检测器。
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公开(公告)号：US06226118B1
公开(公告)日：2001-05-01
申请号：US09098064
申请日：1998-06-16
IPC分类号： G02B2100
CPC分类号： G02B7/16
摘要： An optical microscope has a revolver for selectively inserting a plurality of objective lenses including a low-magnification (very-low-magnification) objective lens on an optical axis for observation light. In fluorescence observation using the low-magnification objective lens, the effective diameter of an observation optical system is set larger than that of an illumination optical system. With this arrangement, fluorescence observation using the low-magnification objective lens can be stably performed. A cube unit having a plurality of cubes corresponding to the respective microscopic methods is arranged in the optical microscope. An auxiliary lens serving as a very-low-magnification objective lens is mounted in this cube unit. The auxiliary lens can be automatically used in observation using the very-low-magnification objective lens. With this arrangement, a compact optical microscope excellent in operability can be realized.
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8.发明授权公开(公告)号：US07816126B2
公开(公告)日：2010-10-19
申请号：US11312114
申请日：2005-12-20
申请人： Akitsugu Kagayama , Ryuichi Hirano , Atsuhiro Tsuchiya , Kenichi Koyama , Kazuhiro Hasegawa , Katsuyoshi Yamaguchi , Hideaki Endo
发明人： Akitsugu Kagayama , Ryuichi Hirano , Atsuhiro Tsuchiya , Kenichi Koyama , Kazuhiro Hasegawa , Katsuyoshi Yamaguchi , Hideaki Endo
摘要： A culture observation apparatus, which is used for observing a cultured cell while culturing the cell, includes a culture device that forms a culture space which is controlled to be an environment suitable for culturing the cultured cell; a sample tray that holds a container housing the cultured cell and a culture medium; a microscope that serves for observing the cultured cell; a tray holding mechanism that holds the sample tray in the culture space in a detachable manner with good reproducibility; and a shifting mechanism that relatively shifts the sample tray held by the tray holding mechanism and a light axis of the microscope along a plane that is orthogonal to the light axis, wherein the sample tray has a heater used for heating the sample tray, and is electrically connectable to an energy supplying unit that supplies energy to the sample tray.
摘要翻译： 用于在培养细胞时观察培养细胞的培养观察装置包括形成培养空间的培养装置，该培养装置被控制为适于培养培养细胞的环境; 容纳容纳培养细胞的容器和培养基的样品盘; 用于观察培养细胞的显微镜; 托盘保持机构，以可拆卸的方式将样品盘保持在培养空间中，具有良好的再现性; 以及移动机构，其使由所述托盘保持机构保持的所述检体托盘和所述显微镜的光轴沿着与所述光轴正交的平面相对移动，所述检体托盘具有用于加热所述检体托盘的加热器， 电连接到向样品托盘供应能量的能量供应单元。
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公开(公告)号：US07595188B2
公开(公告)日：2009-09-29
申请号：US11302591
申请日：2005-12-12
申请人： Kazuhiro Hasegawa , Akitsugu Kagayama , Hideaki Endo , Ryuichi Hirano , Atsuhiro Tsuchiya , Kenichi Koyama , Katsuyoshi Yamaguchi
发明人： Kazuhiro Hasegawa , Akitsugu Kagayama , Hideaki Endo , Ryuichi Hirano , Atsuhiro Tsuchiya , Kenichi Koyama , Katsuyoshi Yamaguchi
IPC分类号： C12M3/00
摘要： An observation apparatus includes a sample tray that holds a container housing a cultured cell and a culture medium and covered with a lid; an observation unit that serves for observation of the cultured cell; and a shifting unit that relatively shifts the sample tray and a light axis of the observation unit along a plane that is orthogonal to the light axis of the observation unit, wherein the sample tray includes a container holding unit that holds the container by utilizing an elastic force, and at least one of the lid and one portion of the lid is made detachable, with the container being held in the sample tray by the container holding unit.
摘要翻译： 观察装置包括：样本托盘，其容纳容纳培养细胞和培养基并容纳盖子的容器; 用于观察培养细胞的观察单元; 以及移动单元，其沿着与所述观察单元的光轴正交的平面相对地移动所述样本托盘和所述观察单元的光轴，其中，所述样本托盘包括容器保持单元，所述容器保持单元通过利用弹性 并且盖子和盖子的一部分中的至少一个是可拆卸的，容器通过容器保持单元保持在样品盘中。
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10.发明申请公开(公告)号：US20080179491A1
公开(公告)日：2008-07-31
申请号：US11876676
申请日：2007-10-22
IPC分类号： G02B7/09
CPC分类号： G02B21/0088 , G02B21/16 , G02B21/244 , G02B21/245
摘要： A focus detection device which is applied to a fluorescent observation device for observing a fluorescent image to be emitted from an observation sample on the basis of an evanescent light, includes an image pickup unit which detects a contrast of the fluorescent image by imaging the fluorescent image, and a detector which detects a focus on the basis of the detection result.
摘要翻译： 应用于荧光观察装置的焦点检测装置包括通过对荧光图像进行成像来检测荧光图像的对比度的图像拾取单元，该荧光观察装置用于观察从观察样本发射的荧光图像 以及基于检测结果检测焦点的检测器。
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