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公开(公告)号：US20050237604A1
公开(公告)日：2005-10-27
申请号：US11095518
申请日：2005-04-01
CPC分类号： G02B21/26 , A61B90/20 , A61B90/50 , G02B21/0012 , G02B21/082 , G02B21/24
摘要： An in-vivo examination apparatus in which the examination angle can be changed while keeping an examination site in focus to carry out accurate in-vivo examination is provided. The in-vivo examination apparatus includes a stage on which a living organism is mounted, a measurement head that irradiates the living organism on the stage with light emitted from a light source and detects light returning from the living organism, and a rotation mechanism that rotates the measurement head about a fixed point on the stage.
摘要翻译： 提供一种体内检查装置，其中可以在保持检查部位聚焦的同时改变检查角度，以进行准确的体内检查。 体内检查装置包括安装有活体的台，测量头，用从光源发出的光照射舞台上的活体，并检测从活体返回的光;旋转机构，其旋转 测量头围绕舞台上的一个固定点。
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公开(公告)号：US07268938B2
公开(公告)日：2007-09-11
申请号：US11095518
申请日：2005-04-01
CPC分类号： G02B21/26 , A61B90/20 , A61B90/50 , G02B21/0012 , G02B21/082 , G02B21/24
摘要： An in-vivo examination apparatus in which the examination angle can be changed while keeping an examination site in focus to carry out accurate in-vivo examination is provided. The in-vivo examination apparatus includes a stage on which a living organism is mounted, a measurement head that irradiates the living organism on the stage with light emitted from a light source and detects light returning from the living organism, and a rotation mechanism that rotates the measurement head about a fixed point on the stage.
摘要翻译： 提供一种体内检查装置，其中可以在保持检查部位聚焦的同时改变检查角度，以进行准确的体内检查。 体内检查装置包括安装有活体的台，测量头，用从光源发出的光照射舞台上的活体，并检测从活体返回的光;旋转机构，其旋转 测量头围绕舞台上的固定点。
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公开(公告)号：US20050187441A1
公开(公告)日：2005-08-25
申请号：US11035075
申请日：2005-01-14
CPC分类号： G01N21/6458
摘要： A laser-scanning examination apparatus includes a laser light source; an optical fiber through which laser light generated in the laser light source is transmitted; a scan head including a casing for housing a laser scanning unit that scans the laser light transmitted by the optical fiber on a specimen, an objective unit for imaging the laser light scanned by the laser scanning unit onto the specimen; an optical detector for detecting returning light that returns from the specimen to the interior of the casing via the objective unit; a stage for mounting the specimen; and an arm that supports the scan head so that the position and orientation of the objective unit with respect to the stage can be adjusted. The optical detector is provided on an outer surface of the casing except for the surface located in the opposite direction from the direction in which the arm extends from the casing. The laser-scanning examination apparatus has a compact head unit and allows improved ease-of-use by securing a large space around the head unit.
摘要翻译： 激光扫描检查装置包括激光光源; 在激光光源中产生的激光透过的光纤; 扫描头，包括用于容纳将由所述光纤透射的激光扫描在检体上的激光扫描单元的外壳，用于将由所述激光扫描单元扫描的激光成像到所述样本上的目标单元; 光检测器，用于检测经由所述物镜单元从所述样本返回到所述壳体内部的返回光; 安装样品的阶段; 以及支撑扫描头的臂，使得可以调节物镜单元相对于平台的位置和取向。 光检测器设置在壳体的外表面上，除了位于与臂从壳体延伸的方向相反的方向上的表面之外。 激光扫描检查装置具有紧凑的头部单元，并且通过确保头部单元周围的大空间来允许改进的易于使用。
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公开(公告)号：US20050281476A1
公开(公告)日：2005-12-22
申请号：US11080561
申请日：2005-03-16
CPC分类号： A61B5/0059 , A61B5/0066 , A61B5/0068 , A61B5/0402 , A61B8/06 , H04N5/23212
摘要： An examination apparatus that can acquire detailed images from a specimen exhibiting dynamic behavior is provided. The examination apparatus comprises an imaging unit that images a specimen exhibiting dynamic behavior; a behavior detecting unit that detects the dynamic behavior of the specimen; an image storing unit that stores the dynamic behavior of the specimen detected by the behavior detecting unit and images of the specimen imaged by the imaging unit so as to be associated with each other; and a still-image extraction unit that extracts an image of the specimen when the specimen is substantially still based on the dynamic behavior of the specimen from the images of the specimen stored in the image storing unit.
摘要翻译： 提供了一种能够从表现动态行为的样本获得详细图像的检查装置。 该检查装置包括成像单元，其对表现出动态行为的样本进行成像; 行为检测单元，其检测所述检体的动态行为; 图像存储单元，其存储由所述行为检测单元检测到的样本的动态行为和由所述成像单元成像的所述样本的图像以使得彼此相关联; 以及静止图像提取单元，其基于来自存储在图像存储单元中的样本的图像的样本的动态行为，基本上静止时，提取样本的图像。
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公开(公告)号：US07564621B2
公开(公告)日：2009-07-21
申请号：US11975385
申请日：2007-10-18
CPC分类号： G02B21/002 , G02B21/245
摘要： A focusing method for an examination apparatus that can quickly and easily perform focusing for fluoroscopy is provided. The focusing method, for an examination apparatus that can observe fluorescence emitted from a specimen, includes a first step of irradiating the specimen with light via an objective lens to generate reflected light and fluorescence; a second step of performing focusing with respect to the surface of the specimen using the reflected light from the specimen; and a third step of performing focusing for the fluorescence based on the focal position of the specimen surface in the second step.
摘要翻译： 提供了一种用于能够快速且容易地执行用于荧光透视的聚焦的检查装置的聚焦方法。 对于可以观察从样本发出的荧光的检查装置的聚焦方法包括：通过物镜用光照射样本以产生反射光和荧光的第一步骤; 使用来自样本的反射光对样本的表面进行聚焦的第二步骤; 以及在第二步骤中基于样品表面的焦点位置进行荧光聚焦的第三步骤。
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公开(公告)号：US20080049215A1
公开(公告)日：2008-02-28
申请号：US11975385
申请日：2007-10-18
IPC分类号： G01N21/00
CPC分类号： G02B21/002 , G02B21/245
摘要： A focusing method for an examination apparatus that can quickly and easily perform focusing for fluoroscopy is provided. The focusing method, for an examination apparatus that can observe fluorescence emitted from a specimen, includes a first step of irradiating the specimen with light via an objective lens to generate reflected light and fluorescence; a second step of performing focusing with respect to the surface of the specimen using the reflected light from the specimen; and a third step of performing focusing for the fluorescence based on the focal position of the specimen surface in the second step.
摘要翻译： 提供了一种用于能够快速且容易地执行用于荧光透视的聚焦的检查装置的聚焦方法。 对于可以观察从样本发出的荧光的检查装置的聚焦方法包括：通过物镜用光照射样本以产生反射光和荧光的第一步骤; 使用来自样本的反射光对样本的表面进行聚焦的第二步骤; 以及在第二步骤中基于样品表面的焦点位置进行荧光聚焦的第三步骤。
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公开(公告)号：US07301626B2
公开(公告)日：2007-11-27
申请号：US11182782
申请日：2005-07-18
IPC分类号： G01J3/30
CPC分类号： G01N21/6458 , G02B21/002 , G02B21/0064 , G02B21/0076 , G02B21/0084 , G02B21/16
摘要： The invention reduces the loss of fluorescence intensity obtained from a specimen to acquire clear fluorescence images when irradiating the specimen with ultrashort-pulse laser light produced by a laser light source. The invention provides a laser-scanning examination apparatus including a laser light source for producing ultrashort-pulse laser light; a laser light source for producing continuous-wave laser light; a measurement head including an optical scanning unit for scanning the laser light on a specimen and an objective optical system; an imaging unit for detecting return light from the specimen in response to the ultrashort-pulse laser light; and an imaging unit for detecting return light from the specimen in response to the continuous-wave laser light. The laser light sources and one imaging unit are connected to the measurement head by an optical fiber, and the other imaging unit is connected to the measurement head by another optical fiber with a larger core diameter.
摘要翻译： 本发明减少了从样品获得的荧光强度的损失，以便在用激光光源产生的超短脉冲激光照射样品时获得清晰的荧光图像。 本发明提供了一种激光扫描检查装置，其包括用于产生超短脉冲激光的激光光源; 用于产生连续波激光的激光源; 测量头，包括用于扫描样本上的激光的光学扫描单元和物镜光学系统; 用于响应于超短脉冲激光来检测来自样本的返回光的成像单元; 以及用于响应于连续波激光来检测来自样本的返回光的成像单元。 激光光源和一个成像单元通过光纤连接到测量头，另一个成像单元通过具有较大芯直径的另一光纤连接到测量头。
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公开(公告)号：US20060017920A1
公开(公告)日：2006-01-26
申请号：US11182782
申请日：2005-07-18
IPC分类号： G01J3/30
CPC分类号： G01N21/6458 , G02B21/002 , G02B21/0064 , G02B21/0076 , G02B21/0084 , G02B21/16
摘要： The invention reduces the loss of fluorescence intensity obtained from a specimen to acquire clear fluorescence images when irradiating the specimen with ultrashort-pulse laser light produced by a laser light source. The invention provides a laser-scanning examination apparatus including a laser light source for producing ultrashort-pulse laser light; a laser light source for producing continuous-wave laser light; a measurement head including an optical scanning unit for scanning the laser light on a specimen and an objective optical system; an imaging unit for detecting return light from the specimen in response to the ultrashort-pulse laser light; and an imaging unit for detecting return light from the specimen in response to the continuous-wave laser light. The laser light sources and one imaging unit are connected to the measurement head by an optical fiber, and the other imaging unit is connected to the measurement head by another optical fiber with a larger core diameter.
摘要翻译： 本发明减少了从样品获得的荧光强度的损失，以便在用激光光源产生的超短脉冲激光照射样品时获得清晰的荧光图像。 本发明提供了一种激光扫描检查装置，其包括用于产生超短脉冲激光的激光光源; 用于产生连续波激光的激光源; 测量头，包括用于扫描样本上的激光的光学扫描单元和物镜光学系统; 用于响应于超短脉冲激光来检测来自样本的返回光的成像单元; 以及用于响应于连续波激光来检测来自样本的返回光的成像单元。 激光光源和一个成像单元通过光纤连接到测量头，另一个成像单元通过具有较大芯直径的另一光纤连接到测量头。
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公开(公告)号：US20050219688A1
公开(公告)日：2005-10-06
申请号：US11090036
申请日：2005-03-28
CPC分类号： G02B21/002 , G02B21/245
摘要： A focusing method for an examination apparatus that can quickly and easily perform focusing for fluoroscopy is provided. The focusing method, for an examination apparatus that can observe fluorescence emitted from a specimen, includes a first step of irradiating the specimen with light via an objective lens to generate reflected light and fluorescence; a second step of performing focusing with respect to the surface of the specimen using the reflected light from the specimen; and a third step of performing focusing for the fluorescence based on the focal position of the specimen surface in the second step.
摘要翻译： 提供了一种用于能够快速且容易地执行用于荧光透视的聚焦的检查装置的聚焦方法。 对于可以观察从样本发出的荧光的检查装置的聚焦方法包括：通过物镜用光照射样本以产生反射光和荧光的第一步骤; 使用来自样本的反射光对样本的表面进行聚焦的第二步骤; 以及在第二步骤中基于样品表面的焦点位置进行荧光聚焦的第三步骤。
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公开(公告)号：US07304790B2
公开(公告)日：2007-12-04
申请号：US11090036
申请日：2005-03-28
IPC分类号： G02B21/00
CPC分类号： G02B21/002 , G02B21/245
摘要： A focusing method for an examination apparatus that can quickly and easily perform focusing for fluoroscopy is provided. The focusing method, for an examination apparatus that can observe fluorescence emitted from a specimen, includes a first step of irradiating the specimen with light via an objective lens to generate reflected light and fluorescence; a second step of performing focusing with respect to the surface of the specimen using the reflected light from the specimen; and a third step of performing focusing for the fluorescence based on the focal position of the specimen surface in the second step.
摘要翻译： 提供了一种用于能够快速且容易地执行用于荧光透视的聚焦的检查装置的聚焦方法。 对于可以观察从样本发出的荧光的检查装置的聚焦方法包括：通过物镜用光照射样本以产生反射光和荧光的第一步骤; 使用来自样本的反射光对样本的表面进行聚焦的第二步骤; 以及在第二步骤中基于样品表面的焦点位置进行荧光聚焦的第三步骤。
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