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    Transcription factor RNA interference reagents and methods of use thereof
    1.
    发明申请
    Transcription factor RNA interference reagents and methods of use thereof 审中-公开
    转录因子RNA干扰试剂及其使用方法

    公开(公告)号：US20050197312A1

    公开(公告)日：2005-09-08

    申请号：US11070767

    申请日：2005-03-02

    申请人： Kevin Fitzgerald ,  Donald Jackson ,  Qi Guo

    发明人： Kevin Fitzgerald ,  Donald Jackson ,  Qi Guo

    IPC分类号： A61K48/00 ,  C12N9/00 ,  C12N15/113 ,  C12N15/85

    CPC分类号： C12N15/1137 ,  C12N15/113 ,  C12N2310/14

    摘要： The present invention concerns methods and reagents useful in modulating transcription factor gene expression in a variety of applications, including methods of use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siRNA), short interfering RNA (siRNA), and doublestranded RNA (dsRNA) molecules capable of mediating RNA interference (RNAi) against E2F1, NFkB, CREB-1, and/or CDC2A gene expression, useful in the treatment of cell cycle disorders, inflammatory conditions, reproductive disorders, cancers and any other condition that responds to modulation of E2F1, NFkB, CREB-1, and/or CDC2A expression and/or activity.

    摘要翻译： 本发明涉及可用于调节多种应用中的转录因子基因表达的方法和试剂，包括在治疗，诊断，靶标验证和基因组发现应用中使用的方法。 具体而言，本发明涉及能够介导针对E2F1，NFkB，CREB-1的RNA干扰（RNAi）的短干扰核酸（siRNA），短干扰RNA（siRNA）和双链RNA（dsRNA）分子的小核酸分子， 1和/或CDC2A基因表达，其可用于治疗细胞周期障碍，炎性病症，生殖障碍，癌症以及对E2F1，NFkB，CREB-1和/或CDC2A表达的调节作出响应的任何其它病症和/或 活动。

    Transcription factor RNA interference reagents and methods of use thereof
    2.
    发明申请
    Transcription factor RNA interference reagents and methods of use thereof 审中-公开
    转录因子RNA干扰试剂及其使用方法

    公开(公告)号：US20060234973A1

    公开(公告)日：2006-10-19

    申请号：US11402608

    申请日：2006-04-12

    申请人： Kevin Fitzgerald ,  Donald Jackson ,  Qi Guo

    发明人： Kevin Fitzgerald ,  Donald Jackson ,  Qi Guo

    IPC分类号： A61K48/00 ,  C12N15/09

    CPC分类号： C12N15/113 ,  C12N2310/14

    摘要： The present invention concerns methods and reagents useful in modulating transcription factor gene expression in a variety of applications, including methods of use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), and doublestranded RNA (dsRNA) molecules capable of mediating RNA interference (RNAi) against E2F1 gene expression, useful in the treatment of cell cycle disorders, inflammatory conditions, reproductive disorders, cancers and any other condition that responds to modulation of E2F1 expression and/or activity.

    摘要翻译： 本发明涉及可用于调节多种应用中的转录因子基因表达的方法和试剂，包括在治疗，诊断，靶标验证和基因组发现应用中使用的方法。 具体地，本发明涉及能够介导针对E2F1基因表达的RNA干扰（RNAi）的短核酸（siNA），短干扰RNA（siRNA）和双链RNA（dsRNA）分子的小核酸分子，其可用于 治疗细胞周期障碍，炎性病症，生殖障碍，癌症以及任何其它对E2F1表达和/或活性调节作用的病症。

    Biomarkers and Methods for Determining Sensitivity to Epidermal Growth Factor Receptor Modulators in Non-Small Cell Lung Cancer
    3.
    发明申请
    Biomarkers and Methods for Determining Sensitivity to Epidermal Growth Factor Receptor Modulators in Non-Small Cell Lung Cancer 审中-公开
    用于测定非小细胞肺癌中表皮生长因子受体调节剂敏感性的生物标志物和方法

    公开(公告)号：US20070259375A1

    公开(公告)日：2007-11-08

    申请号：US10594211

    申请日：2005-03-28

    申请人： Shirin Ford ,  Nancy-Anne Perkins ,  Donald Jackson ,  Shirin Ford ,  Nancy-Anne Perkins ,  Donald Jackson

    发明人： Shirin Ford ,  Nancy-Anne Perkins ,  Donald Jackson ,  Shirin Ford ,  Nancy-Anne Perkins ,  Donald Jackson

    IPC分类号： G01N33/53

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

    摘要： EGFR biomarkers useful in a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) exposing a biological sample from the mammal to the EGFR modulator and (b) measuring in the biological sample the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the EGFR modulator indicates that the mammal will respond therapeutically to the method of treating cancer.

    摘要翻译： EGFR生物标志物可用于鉴定将对治疗癌症治疗的治疗反应的哺乳动物的方法，其包括施用EGFR调节剂，其中所述方法包括（a）将生物样品从哺乳动物暴露于EGFR调节剂和（b） 所述生物样品中所述至少一种生物标志物的水平，其中在（b）中测量的所述至少一种生物标志物的水平与未暴露于EGFR调节剂的哺乳动物中的生物标志物水平相比的差异表明： 哺乳动物将对治疗癌症的方法进行治疗反应。

    Global visualization process (GVP) and system for implementing a GVP
    5.
    发明授权
    Global visualization process (GVP) and system for implementing a GVP 失效
    全球可视化过程（GVP）和实施GVP的系统

    公开(公告)号：US07239311B2

    公开(公告)日：2007-07-03

    申请号：US10255413

    申请日：2002-09-26

    申请人： Richard S. Dunn ,  Walter P. Gatewood, Jr. ,  Wayne Erchak ,  Donald Jackson ,  Christopher S. Allport ,  Joseph A. Hamilton

    发明人： Richard S. Dunn ,  Walter P. Gatewood, Jr. ,  Wayne Erchak ,  Donald Jackson ,  Christopher S. Allport ,  Joseph A. Hamilton

    IPC分类号： G06T15/00 ,  G06T17/00

    CPC分类号： G06T17/05 ,  G06T19/003 ,  G06T2210/36

    摘要： A system and process that incorporates hardware and software as elements to be combined with procedures and processes to obtain, format, store, combine, control, display, record, and visualize dynamic scenarios by interacting with accurate, realistic models and actual events within, on, and above a three-dimensional surface to be observed or modeled. One application provides a user-manipulated large-scale dynamic display of systems testing in a real world environment for real time visualization by test personnel. The Global Visualization Process (GVP) system is an integrated software solution for high-performance visualization. GVP software and process is capable of displaying extremely high resolution terrain models and imagery in real time over the entire surface of the planet, as well as a large number of moving entities and their associated graphical models. The system can display imagery at 2 cm/pixel, and infinitely detailed terrain in real time over the whole surface of a planet. All displayed data is referenced to the World Geodetic System 1984 (WGS-84) ellipsoid for true round-earth effects, and can be rendered in correct asymmetric stereo. These features, combined with a network application progamming interface (API), make GVP suitable for flight simulation out-the-window displays, command and control scenarios, and mission review or rehearsal.

    摘要翻译： 将硬件和软件作为要素组合的系统和过程，与程序和过程相结合，以通过与准确，现实的模型和实际事件进行交互来获取，格式化，存储，组合，控制，显示，记录和可视化动态场景 ，以及待观察或建模的三维表面以上。 一个应用程序提供用户操纵的大规模动态显示在现实世界环境中的系统测试，由测试人员进行实时可视化。 全球可视化过程（GVP）系统是用于高性能可视化的集成软件解决方案。 GVP软件和过程能够在地球的整个表面以及大量移动实体及其相关的图形模型上实时显示极高分辨率的地形模型和图像。 该系统可以在地球的整个表面上实时显示2厘米/像素的图像和无限细节的地形。 所有显示的数据参考世界大地测量系统1984（WGS-84）椭圆体，用于真正的圆球效应，并且可以以正确的非对称立体声渲染。 这些功能与网络应用程序编程接口（API）相结合，使GVP适用于飞行模拟窗外显示，命令和控制场景以及任务回顾或排练。

    METHOD AND APPARATUS FOR LOCALIZED VOICE OVER INTERNET PROTOCOL USAGE
    7.
    发明申请
    METHOD AND APPARATUS FOR LOCALIZED VOICE OVER INTERNET PROTOCOL USAGE 有权
    通过互联网协议使用本地化语音的方法和装置

    公开(公告)号：US20080095147A1

    公开(公告)日：2008-04-24

    申请号：US11877556

    申请日：2007-10-23

    申请人： Donald Jackson ,  Michael Epstein ,  John Giannandrea ,  Mark Verber

    发明人： Donald Jackson ,  Michael Epstein ,  John Giannandrea ,  Mark Verber

    IPC分类号： H04L12/66

    CPC分类号： H04M3/4938 ,  H04M7/1245

    摘要： An approach to abstracting the circuit switched nature of the public switched telephone network (PSTN) by using VoIP to provide voice actuated services is disclosed. By carrying a telephone call using VoIP technology for a short distance (frequently within a server room) significant benefits to call handling and capacity management can be obtained. Specifically, a PSTN-to-IP gateway is used to receive (and place) calls over the PSTN and route those calls internally to servers over an IP network in a packet switched format. A number of computer systems can receive and handle the calls in the IP format, including: translating the packets into an audio format suitable for speech recognition and creating suitable packets from computer sound files for transmission back over the PSTN.

    摘要翻译： 公开了一种通过使用VoIP提供语音驱动服务来抽象公共交换电话网（PSTN）的电路交换特性的方法。 通过使用VoIP技术短时间（通常在服务器机房内）进行电话呼叫，可以获得呼叫处理和容量管理的显着优点。 具体来说，PSTN到IP网关用于通过PSTN接收（并放置）呼叫，并以数据包交换格式通过IP网络将这些呼叫内部路由到服务器。 许多计算机系统可以接收和处理IP格式的呼叫，包括：将分组转换成适合于语音识别的音频格式，并从计算机声音文件创建合适的分组，以便通过PSTN传输。

    Novel human histone deacetylases
    8.
    发明申请
    Novel human histone deacetylases 有权

    公开(公告)号：US20060269559A1

    公开(公告)日：2006-11-30

    申请号：US11497205

    申请日：2006-08-01

    申请人： Donald Jackson ,  Matthew Lorenzi ,  Ricardo Attar ,  Marco Gottardis

    发明人： Donald Jackson ,  Matthew Lorenzi ,  Ricardo Attar ,  Marco Gottardis

    IPC分类号： A61K48/00 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395 ,  C07K14/82 ,  C07K16/30

    CPC分类号： C12N9/16

    摘要： The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.