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29 条记录 (耗时 0.034 秒)

    Fiber optic illumination and detection patterns, shapes, and locations for use in spectroscopic analysis
    3.
    发明授权
    Fiber optic illumination and detection patterns, shapes, and locations for use in spectroscopic analysis 失效
    用于光谱分析的光纤照明和检测图案，形状和位置

    公开(公告)号：US06411373B1

    公开(公告)日：2002-06-25

    申请号：US09415389

    申请日：1999-10-08

    申请人： Jeffrey J. Garside ,  Stephen Monfre ,  Barry C. Elliott ,  Timothy L. Ruchti ,  Glenn Aaron Kees ,  Frank S. Grochocki

    发明人： Jeffrey J. Garside ,  Stephen Monfre ,  Barry C. Elliott ,  Timothy L. Ruchti ,  Glenn Aaron Kees ,  Frank S. Grochocki

    IPC分类号： G01N3348

    CPC分类号： G01N21/474

    摘要： The invention provides a design process that is used in the determination of the pattern of detector and illumination optical fibers at the sampling area of a subject. Information about the system, specifically a monochromator (e.g. to determine the optimal number of fibers at an output slit) and the bundle termination at a detector optics stack (e.g. to determine the optimal number of fibers at the bundle termination), is of critical importance to this design. It is those numbers that determine the ratio and number of illumination to detection fibers, significantly limiting and constraining the solution space. Additional information about the estimated signal and noise in the skin is necessary to maximize the signal-to-noise ratio in the wavelength range of interest. Constraining the fibers to a hexagonal perimeter and prescribing a hex-packed pattern, such that alternating columns contain illumination and detection fibers, yields optimal results. In the preferred embodiment of the invention, two detectors share the totality of the detection fibers at the sampling interface. A third group of detection fibers is used for classification purposes.

    摘要翻译： 本发明提供了一种设计过程，其用于确定被检体的取样区域处的检测器和照明光纤的图案。 关于系统的信息，特别是单色仪（例如，确定输出狭缝处的光纤的最佳数量）和检测器光学堆叠处的束终止（例如，以确定束终止时的最佳光纤数量）是至关重要的 到这个设计。 这些数字决定了对检测光纤的照射比例和数量，显着限制和限制了解决方案的空间。 关于皮肤估计的信号和噪声的附加信息对于使感兴趣的波长范围内的信噪比最大化是必要的。 将纤维限制在六边形周边，并规定六方填充图案，使得交替的列包含照明和检测纤维，产生最佳结果。 在本发明的优选实施例中，两个检测器在采样接口处共享检测光纤的总体。 第三组检测纤维用于分类目的。

    Optical sampling interface system for in vivo measurement of tissue
    7.
    发明申请
    Optical sampling interface system for in vivo measurement of tissue 审中-公开
    用于体内测量组织的光学取样界面系统

    公开(公告)号：US20050267341A1

    公开(公告)日：2005-12-01

    申请号：US11178084

    申请日：2005-07-08

    申请人： Thomas Blank ,  George Acosta ,  Mutua Mattu ,  Stephen Monfre

    发明人： Thomas Blank ,  George Acosta ,  Mutua Mattu ,  Stephen Monfre

    IPC分类号： A61B5/01 ,  A61B20060101 ,  A61B1/00 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/145 ,  A61B5/1455 ,  A61K9/00 ,  G01N21/01 ,  G01N21/35

    CPC分类号： A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/01 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6824 ,  A61B5/6833 ,  A61B5/6843 ,  A61B2560/0233 ,  A61B2562/12 ,  A61B2562/146

    摘要： An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: an optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement. Separate components of system can be individually deployed.

    摘要翻译： 光采样接口系统最小化并补偿由采样变化和测量位置状态波动引起的误差。 组件包括：具有孔的光学探针放置引导件，其中接收光学探针，在组织测量位置的表面上有助于对表面组织具有最小的，可重复的干扰的可重复放置精度。 孔径产生组织弯月面，其最小化由于表面不规则性引起的干扰并控制采集的组织体积的变化; 放置在组织半月板上方的闭塞元件将半月板与环境波动隔离，稳定了现场的水化，从而表现出张力; 光学耦合介质消除皮肤表面和光学探针之间的气隙; 偏置校正元件对光谱测量和相关的分析物测量应用偏差校正。 当导向器被更换时，新的偏置校正被确定用于新放置的测量。 可以单独部署系统的单独组件。

    Photostimulation method and apparatus in combination with glucose determination
    8.
    发明申请
    Photostimulation method and apparatus in combination with glucose determination 审中-公开
    结合葡萄糖测定的光刺激方法和装置

    公开(公告)号：US20050054908A1

    公开(公告)日：2005-03-10

    申请号：US10841200

    申请日：2004-05-06

    申请人： Thomas Blank ,  Stephen Monfre ,  Marcy Makarewicz ,  Mutua Mattu ,  Kevin Hazen ,  James Henderson

    发明人： Thomas Blank ,  Stephen Monfre ,  Marcy Makarewicz ,  Mutua Mattu ,  Kevin Hazen ,  James Henderson

    IPC分类号： A61B5/00 ,  G01N21/27 ,  G01N21/35 ,  A61B6/00

    CPC分类号： A61B5/1455 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1491 ,  A61B2562/146 ,  G01N21/274 ,  G01N21/359

    摘要： A method and apparatus using photo-stimulation to treat or pretreat a sample site prior to analyte concentration determination is presented. More particularly, photo-stimulation at or near at least one sample site is used to enhance perfusion of the sample site leading to reduced errors associated with sampling. Increased perfusion of the sample site leads to increased volume percentages of the target analyte and/or allows the blood or tissue constituent concentrations to more accurately and/or precisely track corresponding sample constituents in more well perfused body compartments or sites such as arteries, veins, or fingertips. In one embodiment, analysis of the photo-stimulated site is used in conjunction with glucose analyzers to determine the analyte concentration with greater ease, accuracy, or precision and may allow determination of the analyte concentration of another non-sampled body part or compartment.

    摘要翻译： 提出了使用光刺激在分析物浓度测定之前处理或预处理样品位点的方法和装置。 更具体地，使用至少一个样品位点处或附近的光刺激来增强样品位点的灌注，导致与采样相关的减少的误差。 样品位点的增加的灌注导致目标分析物的体积百分比增加和/或允许血液或组织成分浓度更准确地和/或精确地跟踪更好灌注的身体隔室或部位如动脉，静脉中的相应样品组分， 或指尖。 在一个实施方案中，将光刺激位点的分析与葡萄糖分析仪结合使用以更容易，准确或精确地确定分析物浓度，并且可以允许确定另一非取样体部分或隔室的分析物浓度。

    Optical sampling interface system for in vivo measurement of tissue
    9.
    发明申请
    Optical sampling interface system for in vivo measurement of tissue 有权
    用于体内测量组织的光学取样界面系统

    公开(公告)号：US20070060805A9

    公开(公告)日：2007-03-15

    申请号：US10917802

    申请日：2004-08-12

    申请人： Thomas Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen Monfre ,  Alexander Lorenz ,  Timothy Ruchti

    发明人： Thomas Blank ,  George Acosta ,  Mutua Mattu ,  Marcy Makarewicz ,  Stephen Monfre ,  Alexander Lorenz ,  Timothy Ruchti

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/01 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6824 ,  A61B5/6833 ,  A61B5/6843 ,  A61B2560/0233 ,  A61B2562/12 ,  A61B2562/146

    摘要： An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement. Separate components of system can be individually deployed.

    摘要翻译： 光采样接口系统最小化并补偿由采样变化和测量位置状态波动引起的误差。 组件包括：具有孔的光学探针放置引导件，其中接收光学探针，在组织测量位置的表面上促进对表面组织具有最小的，可重复的干扰的可重复放置精度。 孔径产生组织弯月面，其最小化由于表面不规则性引起的干扰并控制采集的组织体积的变化; 放置在组织半月板上方的闭塞元件将半月板与环境波动隔离，稳定了现场的水化，从而表现出张力; 光学耦合介质消除皮肤表面和光学探针之间的气隙; 偏置校正元件对光谱测量和相关的分析物测量应用偏差校正。 当导向器被更换时，新的偏置校正被确定用于新放置的测量。 可以单独部署系统的单独组件。