公开(公告)号：US20050120496A1

公开(公告)日：2005-06-09

申请号：US11032532

申请日：2005-01-10

申请人： Kevin Miller ,  John Pace ,  Aafke Koster

发明人： Kevin Miller ,  John Pace ,  Aafke Koster

IPC分类号： A61C17/22 ,  A61C17/34 ,  H02K7/06 ,  H02K7/14

CPC分类号： A61C17/3445 ,  A61C17/22 ,  A61C17/3481

摘要： The power toothbrush, which has a rotating brushhead movement, includes a housing with a motor mounted therein having an armature which in operation rotates through an arc of predetermined magnitude. The toothbrush also includes a brushhead mounted on a shaft which is connected to an output mass. A spring assembly couples the armature to the output mass, the spring assembly including two spring portions with a node point therebetween, wherein when the armature rotates, the brushhead moves in an opposite direction. The frequency of the movement of the armature is set equal to the resonant frequency of the spring coupling system and the output assembly.

摘要翻译： 具有旋转刷头运动的动力牙刷包括具有安装在其中的电动机的壳体，其具有操作中的电枢旋转预定大小的弧度。 牙刷还包括安装在连接到输出质量块的轴上的刷头。 弹簧组件将电枢耦合到输出质量块，弹簧组件包括两个在其间具有节点的弹簧部分，其中当衔铁旋转时，刷头沿相反方向移动。 电枢的运动频率设定为等于弹簧联接系统和输出组件的共振频率。

公开(公告)号：US20100186179A1

公开(公告)日：2010-07-29

申请号：US11993744

申请日：2006-06-30

申请人： Kevin Miller ,  John Pace ,  Patrick Headstrom ,  Wolter Benning

发明人： Kevin Miller ,  John Pace ,  Patrick Headstrom ,  Wolter Benning

IPC分类号： A61C17/34 ,  H02K49/10 ,  H02K7/065

CPC分类号： H02K49/108 ,  A61C1/07 ,  A61C17/34 ,  H02K7/06

摘要： A workpiece system with a reciprocating motion which includes a motor assembly for producing an output drive signal with a periodic force pulse. The drive signal is coupled to a driven member assembly through a magnetic arrangement, wherein the driven member assembly has a workpiece mounted thereon with a return spring assembly. The driven member assembly has a resonant mechanical frequency. As the RPM of the motor increases from zero following startup, the drive signal frequency increases to the point very near resonance, where the energy from the drive signal is transferred into the reciprocating motion of the driven assembly, producing an effective amplitude of workpiece motion.

摘要翻译： 一种具有往复运动的工件系统，其包括用于产生具有周期性力脉冲的输出驱动信号的马达组件。 驱动信号通过磁性装置联接到从动构件组件，其中从动构件组件具有安装在其上的具有复位弹簧组件的工件。 从动构件组件具有谐振机械频率。 随着起动后马达的RPM从零增加，驱动信号频率增加到非常接近谐振的点，其中来自驱动信号的能量被转移到从动组件的往复运动，产生工件运动的有效振幅。

公开(公告)号：US10004368B2

公开(公告)日：2018-06-26

申请号：US15496231

申请日：2017-04-25

申请人： John Pace

发明人： John Pace

IPC分类号： E03D9/00 ,  E03D11/00 ,  A47K13/02 ,  E03C1/304

CPC分类号： A47K13/02 ,  E03C1/304 ,  E03D9/00

摘要： A splash shield for a toilet plunger or brush includes a membrane that fits over the top of a toilet bowl. The membrane seals tightly around the toilet bowl rim and has an aperture proximate the center so the user can slide the plunger or brush handle up through the aperture and affix the edges of the membrane around the toilet bowl, and then plunge or clean the toilet. After use, the user can remove the membrane from the toilet bowl and wrap the contaminated head of the plunger or brush within the membrane and take it away to be cleaned. A new membrane may be placed on the cleaned plunger or brush to act as a sanitary cover until its next use.

公开(公告)号：US20080175664A1

公开(公告)日：2008-07-24

申请号：US11657335

申请日：2007-01-24

申请人： John Pace

发明人： John Pace

IPC分类号： E01C11/02

CPC分类号： E01D19/06

摘要： A roadway-support bird protection arrangement and method for preventing birds from entering and damaging hollow cores of elongated roadway support structures. The elongated roadway support structures are longitudinally spaced apart to allow for expansion and contraction therebetween. The inventive arrangement includes an elongated foraminous web of material having generally parallel side edges, a reinforcement arrangement on its side edges, an attachment member spaced along the reinforcement member to permit the foraminous web to be supportively hung between adjacent, longitudinally spaced apart roadway support structures so as to keep birds from entering the support structures. The elongated foraminous web is preferably formed in a “V” shape with elongated side wings thereon for disposition between and attachment to the roadway support structures.

摘要翻译： 一种用于防止鸟类进入并损坏细长巷道支撑结构的空心岩心的道路支护鸟类保护装置和方法。 细长的道路支撑结构纵向间隔开以允许它们之间的膨胀和收缩。 本发明的布置包括具有大致平行的侧边缘的细长的多孔材料网，在其侧边缘上的加强装置，沿着加强构件间隔开的附接构件，以允许多孔腹板被支撑地悬挂在相邻的纵向间隔开的道路支撑结构 以防止鸟类进入支撑结构。 细长的多孔网优选地形成为“V”形，其上具有细长的侧翼，用于配置在道路支撑结构之间并附接到道路支撑结构。

公开(公告)号：US20070196859A1

公开(公告)日：2007-08-23

申请号：US11603329

申请日：2006-11-21

申请人： Burton Christensen ,  Edmund Moran ,  John Griffin ,  J. Judice ,  YongQi Mu ,  John Pace ,  Mathai Mammen ,  James Aggen

发明人： Burton Christensen ,  Edmund Moran ,  John Griffin ,  J. Judice ,  YongQi Mu ,  John Pace ,  Mathai Mammen ,  James Aggen

IPC分类号： A61K38/14 ,  A61K31/43 ,  A61K31/545 ,  A61K31/407

CPC分类号： C07D477/12 ,  C07D499/32 ,  C07D499/44 ,  C07D501/56

摘要： This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked ) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, penicillinase enzyme, cephalosporinase enzyme, a transglycosylase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

摘要翻译： 本发明涉及作为抗菌剂的新型多结合化合物（试剂）。 本发明的多相结合化合物包含2-10个配体，其通过连接体或连接体共价连接，其中所述各单体（即，未连接）状态的所述配体具有结合涉及细胞壁生物合成和代谢的酶的能力 用于合成细菌细胞壁和/或细菌细胞表面的前体因而干扰细胞壁的合成和/或代谢。 特别地，本发明的多相结合化合物包含通过接头或接头共价连接的2-10个配体，其中每个所述配体具有能够结合青霉素结合蛋白的配体结构域，转肽酶，转肽酶的底物， β-内酰胺酶，青霉素酶，头孢菌素酶，转糖基酶或转糖基酶酶底物; 优选地，配体选自β-内酰胺或糖肽类抗菌剂。

公开(公告)号：US20050048557A1

公开(公告)日：2005-03-03

申请号：US10931779

申请日：2004-09-01

申请人： W. Jackson ,  John Pace

发明人： W. Jackson ,  John Pace

IPC分类号： G01N33/563 ,  A61K31/711 ,  A61K38/00 ,  A61K39/00 ,  A61K39/118 ,  A61K39/395 ,  A61K39/40 ,  A61K48/00 ,  A61P31/04 ,  A61P43/00 ,  C07K14/295 ,  C07K16/12 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/569 ,  G01N33/571 ,  A61K39/02 ,  C07H21/04

CPC分类号： G01N33/56927 ,  A61K38/00 ,  A61K39/00 ,  C07K14/295 ,  C07K16/125 ,  G01N2333/295 ,  Y10S514/885 ,  Y10S514/931 ,  Y10S514/937 ,  Y10S530/811 ,  Y10S530/814 ,  Y10S530/82

摘要： A high molecular weight (“HMW”) protein of Chlamydia, the amino acid sequence thereof, and antibodies that specifically bind the HMW protein are disclosed as well as the nucleic acid sequence encoding the same. Also disclosed are prophylactic and therapeutic compositions, comprising the HMW protein, a fragment thereof, or an antibody that specifically binds the HMW protein or a portion thereof, or the nucleotide sequence encoding the HMW protein or a fragment thereof, including vaccines.

摘要翻译： 公开了衣原体的高分子量（“HMW”）蛋白，其氨基酸序列和特异性结合HMW蛋白的抗体以及编码该HMW蛋白的核酸序列。 还公开了包含HMW蛋白，其片段或特异性结合HMW蛋白或其部分的抗体或编码HMW蛋白或其片段（包括疫苗）的核苷酸序列的预防和治疗组合物。

公开(公告)号：US20050026820A1

公开(公告)日：2005-02-03

申请号：US10930585

申请日：2004-08-31

申请人： J. Judice ,  Jeng Shaw ,  YongQi Mu ,  Michael Conner ,  John Pace

发明人： J. Judice ,  Jeng Shaw ,  YongQi Mu ,  Michael Conner ,  John Pace

IPC分类号： A61K38/00 ,  A61K9/00 ,  A61K9/02 ,  A61K9/14 ,  A61K9/19 ,  A61K9/20 ,  A61K9/48 ,  A61K47/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/40 ,  A61K47/48 ,  A61K51/08 ,  A61P31/04 ,  C07F9/38 ,  C07K1/113 ,  C07K9/00 ,  A61K38/17 ,  A61K31/724

CPC分类号： B82Y5/00 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/02 ,  A61K9/19 ,  A61K9/2018 ,  A61K9/4858 ,  A61K31/724 ,  A61K38/14 ,  A61K47/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/40 ,  A61K47/6951 ,  C07K9/008

摘要： Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical compositions.

公开(公告)号：US5115461A

公开(公告)日：1992-05-19

申请号：US663748

申请日：1991-03-04

申请人： Robert E. Kranz ,  John Pace

发明人： Robert E. Kranz ,  John Pace

IPC分类号： G03B42/04

CPC分类号： G03B42/047

摘要： An X-ray label includes a substrate that is transparent to X-ray radiation and X-ray absorbing pigment deposited on the substrate in images that provide identification data under visible light and that create corresponding images in an X-ray film emulsion layer when the film is exposed to X-ray radiation. Preferably, the X-ray absorbing pigment is deposited on the substrate using a thermal print process to quickly and consistently transfer X-ray absorbing pigment characters from the ribbon to the X-ray transparent substrate.

摘要翻译： X射线标签包括对X射线辐射透明的基底和在基底上沉积的X射线吸收颜料的图像，其在可见光下提供识别数据，并且当在X射线胶片乳剂层中产生相应的图像时 膜暴露于X射线辐射。 优选地，使用热打印方法将X射线吸收颜料沉积在基底上，以快速且一致地将X射线吸收颜料特征从带传送到X射线透明基底。

公开(公告)号：USD273698S

公开(公告)日：1984-05-01

申请号：US224741

申请日：1981-01-13

申请人： John Pace

设计人： John Pace

公开(公告)号：USD848590S1

公开(公告)日：2019-05-14

申请号：US29601665

申请日：2017-04-25

申请人： John Pace

设计人： John Pace