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    Novel antibacterial agents
    4.
    发明申请
    Novel antibacterial agents 审中-公开
    新型抗菌剂

    公开(公告)号：US20070196859A1

    公开(公告)日：2007-08-23

    申请号：US11603329

    申请日：2006-11-21

    申请人： Burton Christensen ,  Edmund Moran ,  John Griffin ,  J. Judice ,  YongQi Mu ,  John Pace ,  Mathai Mammen ,  James Aggen

    发明人： Burton Christensen ,  Edmund Moran ,  John Griffin ,  J. Judice ,  YongQi Mu ,  John Pace ,  Mathai Mammen ,  James Aggen

    IPC分类号： A61K38/14 ,  A61K31/43 ,  A61K31/545 ,  A61K31/407

    CPC分类号： C07D477/12 ,  C07D499/32 ,  C07D499/44 ,  C07D501/56

    摘要： This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked ) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, penicillinase enzyme, cephalosporinase enzyme, a transglycosylase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

    摘要翻译： 本发明涉及作为抗菌剂的新型多结合化合物（试剂）。 本发明的多相结合化合物包含2-10个配体，其通过连接体或连接体共价连接，其中所述各单体（即，未连接）状态的所述配体具有结合涉及细胞壁生物合成和代谢的酶的能力 用于合成细菌细胞壁和/或细菌细胞表面的前体因而干扰细胞壁的合成和/或代谢。 特别地，本发明的多相结合化合物包含通过接头或接头共价连接的2-10个配体，其中每个所述配体具有能够结合青霉素结合蛋白的配体结构域，转肽酶，转肽酶的底物， β-内酰胺酶，青霉素酶，头孢菌素酶，转糖基酶或转糖基酶酶底物; 优选地，配体选自β-内酰胺或糖肽类抗菌剂。

    Splash shield for toilet plunger or brush
    7.
    发明授权
    Splash shield for toilet plunger or brush 有权

    公开(公告)号：US10004368B2

    公开(公告)日：2018-06-26

    申请号：US15496231

    申请日：2017-04-25

    申请人： John Pace

    发明人： John Pace

    IPC分类号： E03D9/00 ,  E03D11/00 ,  A47K13/02 ,  E03C1/304

    CPC分类号： A47K13/02 ,  E03C1/304 ,  E03D9/00

    摘要： A splash shield for a toilet plunger or brush includes a membrane that fits over the top of a toilet bowl. The membrane seals tightly around the toilet bowl rim and has an aperture proximate the center so the user can slide the plunger or brush handle up through the aperture and affix the edges of the membrane around the toilet bowl, and then plunge or clean the toilet. After use, the user can remove the membrane from the toilet bowl and wrap the contaminated head of the plunger or brush within the membrane and take it away to be cleaned. A new membrane may be placed on the cleaned plunger or brush to act as a sanitary cover until its next use.

    Roadway expansion joint bird protection arrangement
    8.
    发明申请
    Roadway expansion joint bird protection arrangement 审中-公开
    道路扩张联鸟保护安排

    公开(公告)号：US20080175664A1

    公开(公告)日：2008-07-24

    申请号：US11657335

    申请日：2007-01-24

    申请人： John Pace

    发明人： John Pace

    IPC分类号： E01C11/02

    CPC分类号： E01D19/06

    摘要： A roadway-support bird protection arrangement and method for preventing birds from entering and damaging hollow cores of elongated roadway support structures. The elongated roadway support structures are longitudinally spaced apart to allow for expansion and contraction therebetween. The inventive arrangement includes an elongated foraminous web of material having generally parallel side edges, a reinforcement arrangement on its side edges, an attachment member spaced along the reinforcement member to permit the foraminous web to be supportively hung between adjacent, longitudinally spaced apart roadway support structures so as to keep birds from entering the support structures. The elongated foraminous web is preferably formed in a “V” shape with elongated side wings thereon for disposition between and attachment to the roadway support structures.

    摘要翻译： 一种用于防止鸟类进入并损坏细长巷道支撑结构的空心岩心的道路支护鸟类保护装置和方法。 细长的道路支撑结构纵向间隔开以允许它们之间的膨胀和收缩。 本发明的布置包括具有大致平行的侧边缘的细长的多孔材料网，在其侧边缘上的加强装置，沿着加强构件间隔开的附接构件，以允许多孔腹板被支撑地悬挂在相邻的纵向间隔开的道路支撑结构 以防止鸟类进入支撑结构。 细长的多孔网优选地形成为“V”形，其上具有细长的侧翼，用于配置在道路支撑结构之间并附接到道路支撑结构。

    Nodal mounted system for driving a power appliance
    9.
    发明申请
    Nodal mounted system for driving a power appliance 有权
    用于驱动电力设备的节点安装系统

    公开(公告)号：US20050120496A1

    公开(公告)日：2005-06-09

    申请号：US11032532

    申请日：2005-01-10

    申请人： Kevin Miller ,  John Pace ,  Aafke Koster

    发明人： Kevin Miller ,  John Pace ,  Aafke Koster

    IPC分类号： A61C17/22 ,  A61C17/34 ,  H02K7/06 ,  H02K7/14

    CPC分类号： A61C17/3445 ,  A61C17/22 ,  A61C17/3481

    摘要： The power toothbrush, which has a rotating brushhead movement, includes a housing with a motor mounted therein having an armature which in operation rotates through an arc of predetermined magnitude. The toothbrush also includes a brushhead mounted on a shaft which is connected to an output mass. A spring assembly couples the armature to the output mass, the spring assembly including two spring portions with a node point therebetween, wherein when the armature rotates, the brushhead moves in an opposite direction. The frequency of the movement of the armature is set equal to the resonant frequency of the spring coupling system and the output assembly.

    摘要翻译： 具有旋转刷头运动的动力牙刷包括具有安装在其中的电动机的壳体，其具有操作中的电枢旋转预定大小的弧度。 牙刷还包括安装在连接到输出质量块的轴上的刷头。 弹簧组件将电枢耦合到输出质量块，弹簧组件包括两个在其间具有节点的弹簧部分，其中当衔铁旋转时，刷头沿相反方向移动。 电枢的运动频率设定为等于弹簧联接系统和输出组件的共振频率。