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公开(公告)号：US20110287106A1
公开(公告)日：2011-11-24
申请号：US12672768
申请日：2009-06-16
申请人： Kikuji Yamaguchi , Yasushi Ohizumi , Tohru Yamakuni , Akira Nakajima , Yoshiharu Iwabuchi , Masatoshi Shibuya
发明人： Kikuji Yamaguchi , Yasushi Ohizumi , Tohru Yamakuni , Akira Nakajima , Yoshiharu Iwabuchi , Masatoshi Shibuya
IPC分类号： A61K35/64 , C07D311/30 , A61P25/00 , A61K36/41
CPC分类号： A61K35/644 , A61K31/352 , A61K31/353 , A61K36/16 , A61K36/41 , A61K2300/00
摘要： A cognitive impairment ameliorant is provided that is useful for the prevention or treatment of cognitive impairment, and particularly Alzheimer's disease. The cognitive impairment ameliorant contains royal jelly as an active ingredient thereof.
摘要翻译： 提供了一种认知障碍改善剂，其用于预防或治疗认知障碍，特别是阿尔茨海默氏病。 认知障碍改善剂含有蜂王浆作为其活性成分。
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公开(公告)号：US08669367B2
公开(公告)日：2014-03-11
申请号：US13585592
申请日：2012-08-14
申请人： Toshimasa Hamada , Noriaki Nagahama , Masami Kozawa , Yoshiharu Iwabuchi , Masatoshi Shibuya , Masaki Tomizawa , Yusuke Sasano
发明人： Toshimasa Hamada , Noriaki Nagahama , Masami Kozawa , Yoshiharu Iwabuchi , Masatoshi Shibuya , Masaki Tomizawa , Yusuke Sasano
IPC分类号： C07D451/14 , C07C61/29 , C07C211/41 , C07C247/00 , C07C271/24
CPC分类号： C07D451/14
摘要： To provide a method whereby a 2-azaadamantane can easily be obtained in good yield.A method for producing a 2-azaadamantane represented by the formula (1), which comprises cyclizing a compound represented by the following formula (2) in the presence of an acid.
摘要翻译： 提供可以容易地以良好的产率获得2-氮杂金刚烷的方法。 一种制备由式（1）表示的2-氮杂金刚烷的方法，其包括在酸存在下环化下式（2）表示的化合物。
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公开(公告)号：US20070232838A1
公开(公告)日：2007-10-04
申请号：US11570756
申请日：2005-06-24
IPC分类号： C07D487/00 , B01J31/02 , C07C29/00
CPC分类号： C07D471/08 , B01J31/006 , B01J31/0235 , B01J31/0237 , B01J2231/70 , C07C45/29
摘要： An organic oxidation catalyst for alcohols which is environmentally less harmful and with which efficient oxidation can be conducted. The oxidation catalyst for alcohols is a 1-alkyl-2-azadamantan-N-oxyl which has a nitroxyl group incorporated in the adamantane skeleton and was synthesized from as a base material a bicyclic compound obtained by the Grob-type ring-opening reaction of 1,3-adamantanediol. Due to the nitroxyl group on the adamantane skeleton, the α-position hydrogen is stabilized based on Bredt's rule and the stability of the oxoammonium group generated by the oxidation thereof is ensured. Compared to TEMPO, which is a conventional oxidation catalyst, this catalyst is reduced in steric hindrance and is usable in a wide range of reaction fields. Because of this, not only a primary alcohol but a secondary alcohol having a sterically complicated structure, which has been difficult to oxidize with TEMPO, can be oxidized at a high efficiency.
摘要翻译： 用于醇的有机氧化催化剂，其对环境无害且能够进行有效的氧化。 醇的氧化催化剂是在金刚烷骨架中具有硝酰基的1-烷基-2-氮杂金刚烷-N-氧基，其作为基材通过由Grob型开环反应获得的双环化合物合成， 1,3-金刚烷二醇 由于金刚烷骨架上的硝酰基，基于Bredt规则使α位氢稳定，并且确保了通过其氧化产生的氧代铵基团的稳定性。 与作为常规氧化催化剂的TEMPO相比，该催化剂的空间位阻减小，可用于广泛的反应领域。 因此，不仅可以高效地氧化难以用TEMPO氧化的伯醇和具有空间复杂结构的仲醇。
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公开(公告)号：US20100311977A1
公开(公告)日：2010-12-09
申请号：US12744015
申请日：2008-11-20
申请人： Toshimasa Hamada , Noriaki Nagahama , Masami Kozawa , Yoshiharu Iwabuchi , Masatoshi Shibuya , Masaki Tomizawa , Yusuke Sasano
发明人： Toshimasa Hamada , Noriaki Nagahama , Masami Kozawa , Yoshiharu Iwabuchi , Masatoshi Shibuya , Masaki Tomizawa , Yusuke Sasano
IPC分类号： C07D451/14 , C07C271/24 , C07C211/41 , C07C61/29 , C07C247/00
CPC分类号： C07D451/14
摘要： To provide a method whereby a 2-azaadamantane can easily be obtained in good yield.A method for producing a 2-azaadamantane represented by the formula (1), which comprises cyclizing a compound represented by the following formula (2) in the presence of an acid.
摘要翻译： 提供可以容易地以良好的产率获得2-氮杂金刚烷的方法。 一种制备由式（1）表示的2-氮杂金刚烷的方法，其包括在酸存在下环化下式（2）表示的化合物。
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公开(公告)号：US08273889B2
公开(公告)日：2012-09-25
申请号：US12744015
申请日：2008-11-20
申请人： Toshimasa Hamada , Noriaki Nagahama , Masami Kozawa , Yoshiharu Iwabuchi , Masatoshi Shibuya , Masaki Tomizawa , Yusuke Sasano
发明人： Toshimasa Hamada , Noriaki Nagahama , Masami Kozawa , Yoshiharu Iwabuchi , Masatoshi Shibuya , Masaki Tomizawa , Yusuke Sasano
IPC分类号： C07D451/14 , C07C61/29 , C07C211/41 , C07C247/00 , C07C271/24
CPC分类号： C07D451/14
摘要： The invention provides a method for producing 2-azaadamantanes represented by formula (1) in good yields. The method includes cyclizing a compound represented by formula (2) in the presence of an acid.
摘要翻译： 本发明提供以良好的产率制备由式（1）表示的2-氮杂金刚烷的方法。 该方法包括在酸存在下环化由式（2）表示的化合物。
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公开(公告)号：US07705152B2
公开(公告)日：2010-04-27
申请号：US11943836
申请日：2007-11-21
IPC分类号： C07D453/06
CPC分类号： C07D453/06 , C07C45/30 , C07C2601/14 , C07D487/04 , C07D493/20 , C07C47/228 , C07C49/657 , C07C49/603 , C07C49/76 , C07C49/04
摘要： An alcohol oxidation catalyst which is an organic oxidation catalyst to oxidize an alcohol, which contains azabicyclo[3.3.1]nonane N-oxyl represented by the following formula (1) having an N-oxyl group incorporated in a bicycle[3.3.1]nonane skeleton: wherein X is H2, O or NOH.
摘要翻译： 作为氧化醇的有机氧化催化剂的醇氧化催化剂，其含有结合在自行车中的具有N-氧基的由下式（1）表示的氮杂双环[3.3.1]壬烷N-氧基[3.3.1] 壬烷骨架：其中X是H 2，O或NOH。
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7.发明授权Catalytic antibodies hydrolyzing acylated carbohydrates in a regioselective and stereoselective manner 失效催化抗体以区域选择性和立体选择性方式水解酰化碳水化合物
公开(公告)号：US5672489A
公开(公告)日：1997-09-30
申请号：US602595
申请日：1996-02-16
IPC分类号： C07K16/00 , C07H3/06 , C07H13/12 , C07H15/04 , C12N5/10 , C12N9/00 , C12N15/02 , C12P19/26 , C12P21/08 , C12R1/91 , C12P19/00
CPC分类号： C07H15/04 , C07H13/12 , C07H3/06 , C12N9/0002
摘要： A method of regio-and stereoselective hydrolysis to deprotect an acylated hydroxy group in acylated carbohydrates, which contributes to synthesis of complex oligosaccharides, is provided. The method utilizes catalytic antibodies as hydrolase.
摘要翻译： 提供了一种区域和立体选择性水解方法，使酰化的碳水化合物中的酰化羟基脱保护，这有助于复合寡糖的合成。 该方法利用催化抗体作为水解酶。
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公开(公告)号：US08871981B2
公开(公告)日：2014-10-28
申请号：US13809753
申请日：2011-05-30
申请人： Yoshiharu Iwabuchi , Masaki Hayashi
发明人： Yoshiharu Iwabuchi , Masaki Hayashi
IPC分类号： C07C45/29 , C07D493/20 , C07D213/50 , C07H19/16 , C07C269/06 , C07C45/39 , C07C201/12 , C07H9/04 , C07C45/30 , C07B53/00 , C07H19/167
CPC分类号： C07H19/16 , B01J31/0235 , B01J2231/70 , C07B53/00 , C07B2200/07 , C07C45/29 , C07C45/30 , C07C45/39 , C07C201/12 , C07C269/06 , C07C2601/14 , C07C2603/74 , C07D213/50 , C07D493/20 , C07H9/04 , C07H19/167 , C07C271/24 , C07C205/44 , C07C47/228 , C07C49/213 , C07C49/407 , C07C49/437 , C07C49/76 , C07C49/04 , C07C49/657 , C07C49/453 , C07C47/235 , C07C47/575 , C07C49/784
摘要： A method for oxidizing an alcohol, wherein oxidation is performed in the presence of a compound represented by the following formula (I) and a bulk oxidant, which enables efficient oxidation of secondary alcohols as well as primary alcohols, and can attain high reaction efficiency even when air is used as a bulk oxidant.
摘要翻译： 一种氧化醇的方法，其中在由下式（I）表示的化合物和本体氧化剂的存在下进行氧化，其能够有效地氧化仲醇以及伯醇，并且甚至可以获得高的反应效率，甚至 当空气用作体积氧化剂时。
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9.发明授权Bis(arylmethylidene)acetone compound, anti-cancer agent, carcinogenesis-preventive agent, inhibitor of expression of Ki-Ras, ErbB2, c-Myc and Cycline D1, β-catenin-degrading agent, and p53 expression enhancer 有权双（芳基亚甲基）丙酮化合物，抗癌剂，致癌作用预防剂，Ki-Ras，ErbB2，c-Myc和Cycline D1，b-cadherin降解剂和p53表达增强子表达抑制剂公开(公告)号：US08178727B2
公开(公告)日：2012-05-15
申请号：US11993840
申请日：2006-06-27
IPC分类号： C07C49/217 , A61K31/12
CPC分类号： C07C247/04 , C07C49/223 , C07C49/248 , C07C49/255 , C07C205/45
摘要： It has been demanded to improve the poor solubility of curcumin to develop an anti-tumor compound capable of inhibiting the growth of various cancer cells at a low concentration. Thus, disclosed is a novel synthetic compound, a bis(arylmethylidene)acetone, which has both of an excellent anti-tumor activity and a chemo-preventive activity. A bis(arylmethylidene)acetone (i.e., a derivative having a curcumin skeleton) which is an anti-tumor compound and has a chemo-preventive activity is synthesized and screened. A derivative having enhanced anti-tumor activity and chemo-preventive activity can be synthesized.
摘要翻译： 已经要求提高姜黄素的溶解性差，开发能够抑制各种癌细胞生长低浓度的抗肿瘤化合物。 因此，公开了具有优异的抗肿瘤活性和化学预防活性的新型合成化合物双（芳基亚甲基）丙酮。 合成并筛选作为抗肿瘤化合物并具有化学预防活性的双（芳基亚甲基）丙酮（即具有姜黄素骨架的衍生物）。 可以合成具有增强的抗肿瘤活性和化学预防活性的衍生物。
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10.发明申请BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, BETA-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER 有权BIS（ARYLMETHYLIDENE）ACETONE化合物，抗癌剂，致癌作用剂，Ki-Ras，ErbB2，c-Myc和CYCLINE D1表达抑制剂，β-CATENIN降解剂和p53表达增强剂公开(公告)号：US20100152493A1
公开(公告)日：2010-06-17
申请号：US11993840
申请日：2006-06-27
IPC分类号： C07C49/217
CPC分类号： C07C247/04 , C07C49/223 , C07C49/248 , C07C49/255 , C07C205/45
摘要： It has been demanded to improve the poor solubility of curcumin to develop an anti-tumor compound capable of inhibiting the growth of various cancer cells at a low concentration. Thus, disclosed is a novel synthetic compound, a bis(arylmethylidene)acetone, which has both of an excellent anti-tumor activity and a chemo-preventive activity. A bis(arylmethylidene)acetone (i.e., a derivative having a curcumin skeleton) which is an anti-tumor compound and has a chemo-preventive activity is synthesized and screened. A derivative having enhanced anti-tumor activity and chemo-preventive activity can be synthesized.
摘要翻译： 已经要求提高姜黄素的溶解性差，开发能够抑制各种癌细胞生长低浓度的抗肿瘤化合物。 因此，公开了具有优异的抗肿瘤活性和化学预防活性的新型合成化合物双（芳基亚甲基）丙酮。 合成并筛选作为抗肿瘤化合物并具有化学预防活性的双（芳基亚甲基）丙酮（即具有姜黄素骨架的衍生物）。 可以合成具有增强的抗肿瘤活性和化学预防活性的衍生物。
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