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    Anti-glypican 3 antibody having modified sugar chain
    1.
    发明授权
    Anti-glypican 3 antibody having modified sugar chain 有权
    具有修饰糖链的抗磷脂酰肌醇蛋白聚糖3抗体

    公开(公告)号：US07867734B2

    公开(公告)日：2011-01-11

    申请号：US11577944

    申请日：2005-10-26

    申请人： Kiyotaka Nakano ,  Izumi Sugo ,  Masamichi Sugimoto ,  Takahiro Ishiguro ,  Megumi Tanaka ,  Shigeyuki Iijima

    发明人： Kiyotaka Nakano ,  Izumi Sugo ,  Masamichi Sugimoto ,  Takahiro Ishiguro ,  Megumi Tanaka ,  Shigeyuki Iijima

    IPC分类号： C12P21/04 ,  C07K16/00

    CPC分类号： C07K16/303 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/72 ,  C07K2317/732

    摘要： An anti-glypican 3 antibody with modified sugar chains, more specifically, an anti-glypican 3 antibody lacking fucose is provided. The anti-glypican 3 antibody with modified sugar chains of the present invention may be produced by a process comprising introducing a nucleic acid encoding an anti-glypican 3 antibody into host cells with reduced fucose addition capability, such as YB2/0 cells and cells lacking a fucose transporter. The anti-glypican 3 antibody with modified sugar chains of the present invention has a high level of cytotoxic activity and therefore is useful as a cell growth inhibitor such as an anticancer agent.

    摘要翻译： 提供了具有修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体，更具体地，提供了缺乏岩藻糖的磷脂酰肌醇蛋白聚糖3抗体。 具有本发明的修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体可以通过包括将编码抗磷脂酰肌醇蛋白聚糖3抗体的核酸引入具有降低的岩藻糖加成能力的宿主细胞中的方法来生产，例如YB2 / 0细胞和缺乏细胞的细胞 岩藻糖转运蛋白 具有本发明的修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体具有高水平的细胞毒活性，因此可用作细胞生长抑制剂如抗癌剂。

    Anti-Glypican 3 Antibody Having Modified Sugar Chain
    2.
    发明申请
    Anti-Glypican 3 Antibody Having Modified Sugar Chain 审中-公开
    具有改性糖链的抗磷脂酰肌醇蛋白3抗体

    公开(公告)号：US20110033452A1

    公开(公告)日：2011-02-10

    申请号：US12852950

    申请日：2010-08-09

    申请人： Kiyotaka Nakano ,  Izumi Sugo ,  Masamichi Sugimoto ,  Takahiro Ishiguro ,  Megumi Tanaka ,  Shigeyuki Iijima

    发明人： Kiyotaka Nakano ,  Izumi Sugo ,  Masamichi Sugimoto ,  Takahiro Ishiguro ,  Megumi Tanaka ,  Shigeyuki Iijima

    IPC分类号： A61K39/395 ,  C07K16/00 ,  C12P21/08 ,  C12N5/071 ,  A61P35/00

    CPC分类号： C07K16/303 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/72 ,  C07K2317/732

    摘要： An anti-glypican 3 antibody with modified sugar chains, more specifically, an anti-glypican 3 antibody lacking fucose is provided. The anti-glypican 3 antibody with modified sugar chains of the present invention may be produced by a process comprising introducing a nucleic acid encoding an anti-glypican 3 antibody into host cells with reduced fucose addition capability, such as YB2/0 cells and cells lacking a fucose transporter. The anti-glypican 3 antibody with modified sugar chains of the present invention has a high level of cytotoxic activity and therefore is useful as a cell growth inhibitor such as an anticancer agent.

    摘要翻译： 提供了具有修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体，更具体地，提供了缺乏岩藻糖的磷脂酰肌醇蛋白聚糖3抗体。 具有本发明的修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体可以通过包括将编码抗磷脂酰肌醇蛋白聚糖3抗体的核酸引入具有降低的岩藻糖加成能力的宿主细胞中的方法来生产，例如YB2 / 0细胞和缺乏细胞的细胞 岩藻糖转运蛋白 具有本发明的修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体具有高水平的细胞毒活性，因此可用作细胞生长抑制剂如抗癌剂。

    Anti-Glypican 3 Antibody Having Modified Sugar Chain
    3.
    发明申请
    Anti-Glypican 3 Antibody Having Modified Sugar Chain 有权
    具有改性糖链的抗磷脂酰肌醇蛋白3抗体

    公开(公告)号：US20080124330A1

    公开(公告)日：2008-05-29

    申请号：US11577944

    申请日：2005-10-26

    申请人： Kiyotaka Nakano ,  Izumi Sugo ,  Masamichi Sugimoto ,  Takahiro Ishiguro ,  Megumi Tanaka ,  Shigeyuki Iijima

    发明人： Kiyotaka Nakano ,  Izumi Sugo ,  Masamichi Sugimoto ,  Takahiro Ishiguro ,  Megumi Tanaka ,  Shigeyuki Iijima

    IPC分类号： A61K39/395 ,  C07K16/18 ,  A61P43/00 ,  C12P21/04

    CPC分类号： C07K16/303 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/72 ,  C07K2317/732

    摘要： An anti-glypican 3 antibody with modified sugar chains, more specifically, an anti-glypican 3 antibody lacking fucose is provided. The anti-glypican 3 antibody with modified sugar chains of the present invention may be produced by a process comprising introducing a nucleic acid encoding an anti-glypican 3 antibody into host cells with reduced fucose addition capability, such as YB2/0 cells and cells lacking a fucose transporter. The anti-glypican 3 antibody with modified sugar chains of the present invention has a high level of cytotoxic activity and therefore is useful as a cell growth inhibitor such as an anticancer agent.

    摘要翻译： 提供了具有修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体，更具体地，提供了缺乏岩藻糖的磷脂酰肌醇蛋白聚糖3抗体。 具有本发明的修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体可以通过包括将编码抗磷脂酰肌醇蛋白聚糖3抗体的核酸引入具有降低的岩藻糖加成能力的宿主细胞中的方法来生产，例如YB2 / 0细胞和缺乏细胞的细胞 岩藻糖转运蛋白 具有本发明的修饰的糖链的磷脂酰肌醇蛋白聚糖3抗体具有高水平的细胞毒活性，因此可用作细胞生长抑制剂如抗癌剂。

    Method of manufacturing an article of footwear having a direct attach sole component
    8.
    发明授权
    Method of manufacturing an article of footwear having a direct attach sole component 失效
    制造具有直接附着鞋底部件的鞋类物品的方法

    公开(公告)号：US08557157B2

    公开(公告)日：2013-10-15

    申请号：US12496177

    申请日：2009-07-01

    申请人： Kiyotaka Nakano

    发明人： Kiyotaka Nakano

    IPC分类号： B29C45/14

    CPC分类号： B29D35/148 ,  A43B1/0072 ,  A43B7/144 ,  A43B7/1465 ,  A43B7/148 ,  A43B13/186 ,  B29D35/06 ,  B29D35/10

    摘要： A method of manufacturing an article of footwear having a direct attach sole component includes providing an upper and a receptacle shell that defines a receptacle adapted to receive a cushion insert. A molding insert is placed into the receptacle, and the upper is joined with the receptacle shell. A mold is closed about the receptacle shell and at least a portion of the upper to form a mold cavity corresponding to the direct attach sole component. Material is introduced into the mold cavity to form the direct attach sole component. The mold insert protects the shell from deformation during the molding process. The mold insert is removed and replaced with a cushioning insert after the molding process. The footwear can optionally include a partially transparent shell that supports a sole component that receives a cushion insert, such that the cushion insert and/or sole component are visible through the shell.

    摘要翻译： 制造具有直接附着鞋底部件的鞋类制品的方法包括提供限定适于容纳缓冲垫片的容器的上部和容器壳体。 将模制插入件放置在容器中，并且上部与容器壳体连接。 模具围绕容器壳体和上部的至少一部分封闭以形成对应于直接附着鞋底部件的模腔。 将材料引入模腔中以形成直接附着鞋底部件。 模具插入件在模制过程中保护壳体免受变形。 在模制过程之后，移除模具插件并用缓冲插入件代替。 鞋类可以可选地包括部分透明的外壳，其支撑容纳缓冲垫片的鞋底部件，使得衬垫插入件和/或鞋底部件通过壳体可见。

    Anti-Muc 17 antibody
    9.
    发明授权
    Anti-Muc 17 antibody 有权
    抗粘蛋白17抗体

    公开(公告)号：US08546546B2

    公开(公告)日：2013-10-01

    申请号：US12667595

    申请日：2008-07-03

    申请人： Kiyotaka Nakano

    发明人： Kiyotaka Nakano

    IPC分类号： C07K1/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  A61K35/14 ,  A61K38/16 ,  C12P21/08

    CPC分类号： G01N33/57438 ,  A61K2039/505 ,  C07K16/3092 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/732 ,  G01N33/57446 ,  G01N2333/4725

    摘要： An antibody that binds to Mucin17 (Muc17) is disclosed. The antibody of the present invention preferably binds to the peptide of SEQ ID NO:3 and does not bind to the peptide of SEQ ID NO:4 or the peptide of SEQ ID NO:5. Also disclosed are an anti-cancer agent, preferably an anti-cancer agent for pancreatic cancer, which comprises the antibody of the present invention, as well as a method of diagnosing cancer using the antibody of the present invention, preferably the antibody of the present invention that does not bind to the secreted-form of Muc17.

    摘要翻译： 公开了结合粘蛋白17（Muc17）的抗体。 本发明的抗体优选与SEQ ID NO：3的肽结合，不与SEQ ID NO：4的肽或SEQ ID NO：5的肽结合。 还公开了包含本发明的抗体的抗癌剂，优选为胰腺癌的抗癌剂，以及使用本发明的抗体诊断癌症的方法，优选本发明的抗体 本发明不结合Muc17的分泌型。