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    Method for coating pharmaceutical formulations
    2.
    发明授权
    Method for coating pharmaceutical formulations 失效
    药物制剂的涂敷方法

    公开(公告)号：US4705695A

    公开(公告)日：1987-11-10

    申请号：US744330

    申请日：1985-06-13

    申请人： Klaus Lehmann ,  Dieter Dreher ,  Harry Goetz

    发明人： Klaus Lehmann ,  Dieter Dreher ,  Harry Goetz

    IPC分类号： A61K47/32 ,  A61K9/28 ,  A61K9/32 ,  A61K9/50

    CPC分类号： A61K9/2846 ,  A61K9/5026

    摘要： A method for coating solid pharmaceutical formulations, comprising coating said solid formulation with an aqueous fluid, film forming coating medium comprising a dissolved polymer prepared from acrylic and/or methacrylic monomers having a side group containing a tertiary amine substituent, wherein the amine nitrogen atom is converted to the ammonium salt form; and then drying said coated film.

    摘要翻译： 一种用于涂覆固体药物制剂的方法，包括用水性流体包衣所述固体制剂，成膜包衣介质，其包含由具有含叔胺取代基的侧基的丙烯酸和/或甲基丙烯酸单体制备的溶解聚合物，其中胺氮原子为 转化为铵盐形式; 然后干燥所述涂膜。

    Pharmaceutical coating materials soluble or swellable in gastric juice and pharmaceutical dosage forms coated therewith
    6.
    发明授权
    Pharmaceutical coating materials soluble or swellable in gastric juice and pharmaceutical dosage forms coated therewith 失效
    在胃液中可溶或溶胀的药物包衣材料和用其涂覆的药物剂型

    公开(公告)号：US4452862A

    公开(公告)日：1984-06-05

    申请号：US345478

    申请日：1982-02-03

    申请人： Gerhard Markert ,  Dieter Dreher ,  Klaus Lehmann ,  Werner Siol ,  Hubert Rauch

    发明人： Gerhard Markert ,  Dieter Dreher ,  Klaus Lehmann ,  Werner Siol ,  Hubert Rauch

    IPC分类号： A61K9/58 ,  A61K9/28 ,  A61K9/32 ,  A61K47/32 ,  B32B5/16

    CPC分类号： A61K9/2846 ,  Y10T428/2998

    摘要： Coating materials for pharmaceutical dosage forms contain, besides the conventional liquid or solid additives for pharmaceutical coatings, a binder comprising a synthetic polymer, prepared by emulsion polymerization, having 5 to 100% by weight of units derived from monomers of the formula ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl group, R.sub.2 is an alkylene or aralkylene group having at least 3 carbon atoms in the chain between the amino nitrogen and the ester oxygen atom of which at least one is tertiary or quaternary, and R.sub.3 and R.sub.4 are lower alkyl radicals or together with the amino-nitrogen atom form a heteroaliphatic ring, and, optionally, additional comonomer units.

    摘要翻译： 用于药物剂型的涂层材料除了用于药物涂层的常规液体或固体添加剂外，还包含通过乳液聚合制备的包含合成聚合物的粘合剂，其具有5至100重量％的衍生自下式的单体的单元：其中 R1是氢原子或低级烷基，R2是在氨基氮和酯氧原子之间的链中具有至少3个碳原子的亚烷基或亚芳基，其至少一个是叔或四价，R3和R4 是低级烷基或与氨基 - 氮原子一起形成杂脂族环，和任选的另外的共聚单体单元。

    Time-release laminar pharmaceutical composition
    8.
    发明授权
    Time-release laminar pharmaceutical composition 失效
    时间释放层状药物组成

    公开(公告)号：US06306428B1

    公开(公告)日：2001-10-23

    申请号：US09058951

    申请日：1998-04-13

    申请人： Klaus Lehmann ,  Hans-Ulrich Petereit

    发明人： Klaus Lehmann ,  Hans-Ulrich Petereit

    IPC分类号： A61K900

    CPC分类号： A61K9/2095 ,  A61K9/2072 ,  A61K9/2086 ,  A61K9/7007

    摘要： A time-release laminar pharmaceutical composition, comprised of rolled or folded layers of a polymer film, that contain a pharmaceutically active substance, in which the outer surface area of the polymer film which contains the active substance, and which is accessible to the digestive juices, amounts to at most 25% of the entire surface area in the rolled or folded state, and the rolled or folded layers adhere to one another in such a way that the laminar form of medication maintains its rolled or folded form for a period of at least one hour in the release test according to USP 23, Method A, apparatus 2, at 37° C. and 50 rpm, in artificial gastric juice, and at least 30% of the active substance contained in it is released in the rolled or folded state.

    摘要翻译： 包含聚合物膜的卷曲或折叠层的时间释放层状药物组合物，其含有药物活性物质，其中含有活性物质的聚合物膜的外表面积并且可被消化液接触 相当于轧制或折叠状态下整个表面积的至多25％，并且卷起或折叠的层彼此粘合，使得层状形式的药物保持其卷曲或折叠形式一段时间 根据USP 23，方法A，装置2在37℃和50rpm，在人造胃液中的释放试验中至少1小时，其中含有的至少30％的活性物质被释放在轧制或 折叠状态。

    Unity gain amplifier with high slew rate and high bandwidth
    10.
    发明授权
    Unity gain amplifier with high slew rate and high bandwidth 失效
    具有高压摆率和高带宽的单体增益放大器

    公开(公告)号：US5177451A

    公开(公告)日：1993-01-05

    申请号：US736727

    申请日：1991-07-26

    申请人： Klaus Lehmann

    发明人： Klaus Lehmann

    IPC分类号： H03F3/30

    CPC分类号： H03F3/3076

    摘要： A unity gain amplifier of the diamond follower type provides the combination of negligible input offset voltage, high slew rate, and high bandwidth by providing first and second opposite polarity current mirror circuits which respond to currents flowing through first and second input transistors to boost current available to charge parasitic capacitances during fast rise times and fast fall times of an input pulse. The rapid charging and discharging of the parasitic capacitances eliminates degradation in the rise and fall times of an output pulse produced by the unity gain amplifier. The gains of the first and second current mirror circuits have values that result in critically damped high frequency response of the unity gain amplifier in response to high speed transistions of the input signal. Darlington output stages are used to avoid frequency response peaking due to current gain rolloff of the output transistors at high currents and high frequencies. The unity gain amplifier is used in high performance operational transconductance amplifier.

    摘要翻译： 金刚石跟随器类型的单位增益放大器通过提供响应于流过第一和第二输入晶体管的电流来提升可用电流的第一和第二相反极性电流镜电路，提供可忽略的输入失调电压，高转换速率和高带宽的组合 以在快速上升时间和输入脉冲的快速下降时间期间对寄生电容进行充电。 寄生电容的快速充电和放电消除了由单位增益放大器产生的输出脉冲的上升和下降时间的劣化。 第一和第二电流镜电路的增益具有响应于输入信号的高速转移导致单位增益放大器的严重衰减的高频响应的值。 达林顿输出级用于避免由于高电流和高频下输出晶体管的电流增益而导致的频率响应峰值。 单位增益放大器用于高性能运算跨导放大器。