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38 条记录 (耗时 0.053 秒)

    Purine nucleoside derivative modified in 8-position and medical use thereof
    9.
    发明授权
    Purine nucleoside derivative modified in 8-position and medical use thereof 失效
    8位修饰的嘌呤核苷衍生物及其用途

    公开(公告)号：US07795236B2

    公开(公告)日：2010-09-14

    申请号：US11717741

    申请日：2007-03-13

    申请人： Kazuya Tatani ,  Yoshinori Nonaka ,  Norihiko Kikuchi

    发明人： Kazuya Tatani ,  Yoshinori Nonaka ,  Norihiko Kikuchi

    IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H19/00 ,  C07H19/16

    CPC分类号： A61K45/06 ,  A61K31/7076 ,  C07H19/167 ,  C07H19/173

    摘要： The present invention provides an 8-modified purinenucleoside derivative which is useful for diseases associated with an abnormality of plasma uric acid level. An 8-modified purinenucleoside derivative represented by the following formula (I), a prodrug thereof or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof, is useful for the prevention or treatment of gout, hyperuricemia, urinary lithiasis, hyperuricemic nephropathy or the like.In the formula, n is 1 or 2; RA is a hydrogen atom or a hydroxyl group; R1 is a hydrogen atom, a hydroxyl group, a thiol group, an amino group or a chlorine atom; ring J represents an optionally substituted 2-naphthyl group, or a group represented by the following general formula (II) wherein Y represents a single bond or a connecting group; ring Z represents an optionally substituted aryl group or heteroaryl group or the like; and R2 to R4, P1 and Q represents a halogen atom, a cyano group or the like.

    摘要翻译： 本发明提供了可用于与血浆尿酸水平异常相关的疾病的8-修饰的嘌呤核苷衍生物。 由下式（I）表示的8-修饰的嘌呤核苷衍生物，其前体药物或其药学上可接受的盐或其水合物或溶剂合物可用于预防或治疗痛风，高尿酸血症，尿结石病，高尿酸性肾病或 类似。 在该式中，n为1或2; RA是氢原子或羟基; R1是氢原子，羟基，硫醇基，氨基或氯原子; 环J表示任选取代的2-萘基，或由以下通式（II）表示的基团，其中Y表示单键或连接基团; 环Z表示任选取代的芳基或杂芳基等; R2和R4，P1和Q表示卤原子，氰基等。

    Clamp device and clamp method for heat-treated article
    10.
    发明申请
    Clamp device and clamp method for heat-treated article 有权
    热处理制品的夹紧装置和夹紧方法

    公开(公告)号：US20060082040A1

    公开(公告)日：2006-04-20

    申请号：US10541331

    申请日：2004-10-04

    申请人： Satoshi Shimizu ,  Norihiko Kikuchi ,  Tatsushi Yurudume ,  Hisao Hoshino ,  Takao Minagawa ,  Hiroyuki Osaka ,  Makoto Noudou ,  Shigeki Kishihara ,  Shingo Shikuwa

    发明人： Satoshi Shimizu ,  Norihiko Kikuchi ,  Tatsushi Yurudume ,  Hisao Hoshino ,  Takao Minagawa ,  Hiroyuki Osaka ,  Makoto Noudou ,  Shigeki Kishihara ,  Shingo Shikuwa

    IPC分类号： B23Q3/02

    CPC分类号： C21D1/42 ,  C21D1/09 ,  C21D1/673 ,  C21D9/0025 ,  C21D9/0068 ,  Y02P10/253

    摘要： A heat treatment operation can be executed, suppressing a wave-shaped deformation at a non heat-treatment region of an article to be heat treated. To an elongated-shaped article to be heat treated (10) to which a raised portion (11) extending in the longitudinal direction is formed, a hardening region as being a heat-treated region defined to be extended in a longitudinal direction at a part of the raised portion (11) and a non-hardening region as being non heat-treated region defined to be extended in the longitudinal direction at flange portion (13) and other parts of the raised portion (11) are arranged side by side in a width direction orthogonal to the longitudinal direction. The flange portion (13) is clamped by a first and a second clamping means (22), (23) arranged in the longitudinal direction, and one first clamping means (22) is a tight clamping means holding fixedly the flange portion (13) and a plurality of second clamping means (23) are loose clamping means clamping loosely the flange portion (13), allowing the article to be heat treated (10) to be convex on the side of the heated hardening region.

    摘要翻译： 可以进行热处理操作，抑制待热处理物品的非热处理区域的波状变形。 对于形成有沿长度方向延伸的凸部（11）进行热处理的细长型制品（10），形成作为热处理区域的硬化区域，其被定义为在纵向方向上延伸的部分 的突出部（11）的非热硬化区域和非凸部（11）的其他部分在长度方向上被限定为非热处理区域的非硬化区域并排配置在 与纵向正交的宽度方向。 凸缘部分（13）由沿纵向布置的第一和第二夹紧装置（22），（23）夹持，一个第一夹紧装置（22）是固定地保持凸缘部分（13）的紧固装置， 并且多个第二夹紧装置（23）是松弛地夹紧凸缘部分（13）的松紧夹紧装置，允许制品在加热硬化区域一侧被热处理（10）凸起。