公开(公告)号：US5902885A

公开(公告)日：1999-05-11

申请号：US2513

申请日：1993-01-08

申请人： Kunio Takanohashi ,  Mitsutaka Tanaka ,  Toru Yamano

发明人： Kunio Takanohashi ,  Mitsutaka Tanaka ,  Toru Yamano

IPC分类号： C07D307/62

CPC分类号： C07D307/62

摘要： L-ascorbic acid is produced by allowing an acid to act on 2-keto-L-gulonic acid in a mixture solvent of an inert organic solvent and an aliphatic ketone in the presence of water and a surfactant.The method produces L-ascorbic acid in a high yield 90% or more and is an industrially advantageous method.

摘要翻译： 通过在水和表面活性剂的存在下，在惰性有机溶剂和脂族酮的混合溶剂中使酸作用于2-酮-L-古洛糖酸来制备L-抗坏血酸。 该方法以高产率生产L-抗坏血酸90％以上，是工业上有利的方法。

公开(公告)号：US4845246A

公开(公告)日：1989-07-04

申请号：US205094

申请日：1988-06-10

申请人： Kunio Takanohashi ,  Mitsutaka Tanaka ,  Toru Yamano

发明人： Kunio Takanohashi ,  Mitsutaka Tanaka ,  Toru Yamano

IPC分类号： C07H7/06

CPC分类号： C07H7/06

摘要： 6-O-(2-keto-L-gulonoyl)-L-ascorbate substantially free from 2-keto-L-gulonic acid is produced by allowing an acid to act on 2-keto-L-gulonic acid in an inert organic solvent and recovering 6-O-(2-keto-L-gulonoyl)-L-ascorbate from the reaction mixture.6-O-(2-keto-L-gulonoyl)-L-ascorbate is more fat-soluble than L-ascorbic acid and is expected of the use as a prodrug for L-ascorbic acid that can be absorbed from the intestinal tract.

公开(公告)号：US4794182A

公开(公告)日：1988-12-27

申请号：US073697

申请日：1987-07-14

申请人： Kunio Takanohashi ,  Toru Yamano ,  Mitsutaka Tanaka

发明人： Kunio Takanohashi ,  Toru Yamano ,  Mitsutaka Tanaka

IPC分类号： C07D239/42

CPC分类号： C07D239/42

摘要： A novel 2-lower alkyl-4-amino-5-substituted iminopyrimidine compound represented by the formula: ##STR1## wherein R is a lower alkyl, and Y is hydroxyl or amino which may be protected or a salt thereof is obtainable by allowing a formylpyrimidine compound represented by the formula: ##STR2## wherein R is a lower alkyl to react with a compound represented by the formula H.sub.2 N--Y, wherein Y is hydroxyl or amino which may be protected, or a salts thereof. The iminopyrimidine compound gives the known pyrimidine compound represented by the formula: ##STR3## wherein R is as defined above in high yield. Therefor, the process is very useful as an industrial production method.

摘要翻译： 由下式表示的新型2-低级烷基-4-氨基-5-取代的亚氨基嘧啶化合物：其中R为低级烷基，Y为可被保护的羟基或氨基或其盐可通过使 由下式表示的甲酰嘧啶化合物：其中R是与式H2N-Y表示的化合物反应的低级烷基，其中Y是可被保护的羟基或氨基，或其盐。 亚氨基嘧啶化合物以高产率得到由下式表示的已知嘧啶化合物：其中R如上定义。 因此，该方法作为工业生产方法是非常有用的。

公开(公告)号：US5247095A

公开(公告)日：1993-09-21

申请号：US935105

申请日：1992-08-27

申请人： Toru Yamano ,  Kazuo Nakahama ,  Kunio Takanohashi

发明人： Toru Yamano ,  Kazuo Nakahama ,  Kunio Takanohashi

IPC分类号： C07D495/04 ,  C12P17/18 ,  C12P41/00

CPC分类号： C07D495/04 ,  C12P17/18 ,  C12P41/004

摘要： There are disclosed a compound of the general formula (I): ##STR1## wherein the group R--CO-- is an acyl group and its production. There is also disclosed a process for producing optically active (.+-.)-(3a.alpha., 4.alpha., 6a.alpha.)-tetrahydro-4-acetoxy-1,3-dibenzyl-1H-thieno[3,4-d]imidazol-2(3H)-one by using the compound (I). The compound (I) can be used as an intermediate for producing D-biotin which is useful as medicaments and feed additives for animals.

公开(公告)号：US07084278B2

公开(公告)日：2006-08-01

申请号：US10506309

申请日：2003-03-05

申请人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

发明人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

IPC分类号： C07D213/16 ,  C07D213/28 ,  C07D233/64

CPC分类号： C07D233/64 ,  C07D213/55

摘要： The present invention provides a method for producing an optically active β-hydroxy ester compound represented by the general formula: wherein R1 represents an optionally substituted hydrocarbon group and the like, R2 represents a nitrogen-containing heterocyclic group different from R1, which is represented by the general formula: wherein the ring may be substituted and the like, R3 represents an optionally substituted hydrocarbon group and the like, R4 and R5 represent, the same or different, a hydrogen atom, a halogen atom and the like, the symbol “*” represents an optically active center, which comprises reacting in the presence of a cinchona alkaloid and the like a compound represented by the general formula: wherein R1 and R2 are as defined above with a compound represented by the general formula: wherein R3, R4 and R5 are as defined above, and X is a halogen atom.

摘要翻译： 本发明提供一种制备由以下通式表示的光学活性β-羟基酯化合物的方法：其中R 1表示任选取代的烃基等，R 2 O >表示不同于R 1的含氮杂环基，其由以下通式表示：其中该环可以被取代等，R 3表示任选地 取代烃基等，R 4和R 5表示相同或不同的氢原子，卤素原子等，符号“*”表示 光学活性中心，其包括在cinchona生物碱等存在下反应，由通式表示的化合物：其中R 1和R 2如上定义 与下列通式表示的化合物：其中R 3，R 4和R 5如上所定义，X是卤代基 n原子。

公开(公告)号：US20050107433A1

公开(公告)日：2005-05-19

申请号：US10506309

申请日：2003-03-05

申请人： Toru Yamano ,  Naohiro Taya

发明人： Toru Yamano ,  Naohiro Taya

IPC分类号： C07D233/64 ,  C07B53/00 ,  C07B61/00 ,  C07D213/55 ,  C07D233/54 ,  C07D43/02 ,  A61K31/4025 ,  A61K31/454

CPC分类号： C07D233/64 ,  C07D213/55

摘要： The present invention provides a method for producing an optically active β-hydroxy ester compound represented by the general formula: wherein R1 represents an optionally substituted hydrocarbon group and the like, R2 represents a nitrogen-containing heterocyclic group different from R1, which is represented by the general formula: wherein the ring may be substituted and the like, R3 represents an optionally substituted hydrocarbon group and the like, R4 and R5 represent, the same or different, a hydrogen atom, a halogen atom and the like, the symbol “*” represents an optically active center, which comprises reacting in the presence of a cinchona alkaloid and the like a compound represented by the general formula: wherein R1 and R2 are as defined above with a compound represented by the general formula: wherein R3, R4 and R5 are as defined above, and X is a halogen atom.

摘要翻译： 本发明提供一种制备由以下通式表示的光学活性β-羟基酯化合物的方法：其中R 1表示任选取代的烃基等，R 2 O >表示不同于R 1的含氮杂环基，其由以下通式表示：其中该环可以被取代等，R 3表示任选地 取代烃基等，R 4和R 5表示相同或不同的氢原子，卤素原子等，符号“*”表示 光学活性中心，其包括在cinchona生物碱等存在下反应，由通式表示的化合物：其中R 1和R 2如上定义 与下列通式表示的化合物：其中R 3，R 4和R 5如上所定义，X是卤代基 n原子。

公开(公告)号：US07629472B2

公开(公告)日：2009-12-08

申请号：US11812052

申请日：2007-06-14

申请人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

发明人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

IPC分类号： C07D233/54 ,  C07D211/80

CPC分类号： C07D233/64 ,  C07D213/55

摘要： The present invention provides a method for producing an optically active β-hydroxy ester compound represented by the general formula: wherein R1 represents an optionally substituted hydrocarbon group and the like, R2 represents a nitrogen-containing heterocyclic group different from R1, which is represented by the general formula: wherein the ring may be substituted and the like, R3 represents an optionally substituted hydrocarbon group and the like, R4 and R5 represent, the same or different, a hydrogen atom, a halogen atom and the like, the symbol “*” represents an optically active center, which comprises reacting in the presence of a cinchona alkaloid and the like a compound represented by the general formula: wherein R1 and R2 are as defined above with a compound represented by the general formula: wherein R3, R4 and R5 are as defined above, and X is a halogen atom.

摘要翻译： 本发明提供一种制备由以下通式表示的光学活性β-羟基酯化合物的方法：其中R 1表示任选取代的烃基等，R 2表示与R 1不同的含氮杂环基，其表示为 通式：其中环可以被取代等，R 3表示任选取代的烃基等，R 4和R 5表示相同或不同的氢原子，卤素原子等，符号“* “表示光学活性中心，其包括在cinchona生物碱等存在下反应，由通式表示的化合物：其中R 1和R 2如上所定义，与通式表示的化合物反应：其中R 3，R 4和 R5如上所定义，X为卤素原子。

公开(公告)号：US20070276143A1

公开(公告)日：2007-11-29

申请号：US11812052

申请日：2007-06-14

申请人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

发明人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

IPC分类号： C07D233/54 ,  C07D211/80

CPC分类号： C07D233/64 ,  C07D213/55

摘要： The present invention provides a method for producing an optically active β-hydroxy ester compound represented by the general formula: wherein R1 represents an optionally substituted hydrocarbon group and the like, R2 represents a nitrogen-containing heterocyclic group different from R1, which is represented by the general formula: wherein the ring may be substituted and the like, R3 represents an optionally substituted hydrocarbon group and the like, R4 and R5 represent, the same or different, a hydrogen atom, a halogen atom and the like, the symbol “*” represents an optically active center, which comprises reacting in the presence of a cinchona alkaloid and the like a compound represented by the general formula: wherein R1 and R2are as defined above with a compound represented by the general formula: wherein R3, R4and R5 are as defined above, and X is a halogen atom.

摘要翻译： 本发明提供一种制备由以下通式表示的光学活性β-羟基酯化合物的方法：其中R 1表示任选取代的烃基等，R 2 O >表示不同于R 1的含氮杂环基，其由以下通式表示：其中该环可以被取代等，R 3表示任选地 取代烃基等，R 4和R 5表示相同或不同的氢原子，卤素原子等，符号“*”表示 光学活性中心，其包括在cinchona生物碱等存在下反应，由通式表示的化合物：其中R 1和R 2如上定义 与由下列通式表示的化合物：其中R 3，R 4和R 5如上定义，X​​是卤素 原子。

公开(公告)号：US07247732B2

公开(公告)日：2007-07-24

申请号：US11451051

申请日：2006-06-12

申请人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

发明人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

IPC分类号： C07D213/46 ,  C07D233/60

CPC分类号： C07D233/64 ,  C07D213/55

摘要： The present invention provides a method for producing an optically active β-hydroxy ester compound represented by the general formula: wherein R1 represents an optionally substituted hydrocarbon group and the like,R2 represents a nitrogen-containing heterocyclic group different from R1, which is represented by the general formula: wherein the ring may be substituted and the like, R3 represents an optionally substituted hydrocarbon group and the like,R4 and R5 represent, the same or different, a hydrogen atom, a halogen atom and the like,the symbol “*” represents an optically active center, which comprises reacting in the presence of a cinchona alkaloid and the like a compound represented by the general formula: wherein R1 and R2 are as defined above with a compound represented by the general formula: wherein R3, R4 and R5 are as defined above, and X is a halogen atom.

摘要翻译： 本发明提供一种制备由以下通式表示的光学活性β-羟基酯化合物的方法：其中R 1表示任选取代的烃基等，R 2 O >表示不同于R 1的含氮杂环基，其由以下通式表示：其中该环可以被取代等，R 3表示任选地 取代烃基等，R 4和R 5表示相同或不同的氢原子，卤素原子等，符号“*”表示 光学活性中心，其包括在cinchona生物碱等存在下反应，由以下通式表示的化合物：其中R 1和R 2如上定义 与下列通式表示的化合物：其中R 3，R 4和R 5如上所定义，X是卤代基 n原子。

公开(公告)号：US20060229457A1

公开(公告)日：2006-10-12

申请号：US11451051

申请日：2006-06-12

申请人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

发明人： Toru Yamano ,  Naohiro Taya ,  Akio Ojida

IPC分类号： C07D233/61

CPC分类号： C07D233/64 ,  C07D213/55

摘要： The present invention provides a method for producing an optically active β-hydroxy ester compound represented by the general formula: wherein R1 represents an optionally substituted hydrocarbon group and the like, R2 represents a nitrogen-containing heterocyclic group different from R1, which is represented by the general formula: wherein the ring may be substituted and the like, R3 represents an optionally substituted hydrocarbon group and the like, R4 and R5 represent, the same or different, a hydrogen atom, a halogen atom and the like, the symbol “*” represents an optically active center, which comprises reacting in the presence of a cinchona alkaloid and the like a compound represented by the general formula: wherein R1 and R2 are as defined above with a compound represented by the general formula: wherein R3, R4 and R5 are as defined above, and X is a halogen atom.

摘要翻译： 本发明提供一种制备由以下通式表示的光学活性β-羟基酯化合物的方法：其中R 1表示任选取代的烃基等，R 2 O >表示不同于R 1的含氮杂环基，其由以下通式表示：其中该环可以被取代等，R 3表示任选地 取代烃基等，R 4和R 5表示相同或不同的氢原子，卤素原子等，符号“*”表示 光学活性中心，其包括在cinchona生物碱等存在下反应，由通式表示的化合物：其中R 1和R 2如上定义 与下列通式表示的化合物：其中R 3，R 4和R 5如上所定义，X是卤代基 n原子。