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公开(公告)号：US07084322B2
公开(公告)日：2006-08-01
申请号：US10872560
申请日：2004-06-22
申请人： Kyoungwhan Back , Sun-Mi Jang
发明人： Kyoungwhan Back , Sun-Mi Jang
CPC分类号： C12N15/8257
摘要： The present invention relates to a method for biosynthesizing the serotonin derivatives in plants, more particularly, a method for biosynthesizing the serotonin derivatives characterized by treating plants with inducers for serotonin derivative biosynthesis or by inducing over-expression of tyramine N-(hydroxy cinnamoyl)transferase in plants. The method of the present invention facilitates the production of serotonin derivatives such as feruloylserotonin and coumaroylserotonin that have activities of anticancer, anti-oxidation and promoting bone-formation. The serotonin derivatives prepared by the method above can be used either after being purified or as edible plants themselves.
摘要翻译： 本发明涉及植物中5-羟色胺衍生物的生物合成方法，更具体地说，涉及5-羟色胺衍生物的生物合成方法，其特征在于用植物诱导5-羟色胺衍生物生物合成或通过诱导酪胺N-（羟基肉桂酰）转移酶过度表达 在植物中。 本发明的方法促进了具有抗癌，抗氧化和促进骨形成活性的5-羟色胺衍生物如阿魏酰基血清素和香豆酰肌维素的生产。 通过上述方法制备的5-羟色胺衍生物可以在纯化后或作为食用植物本身使用。
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公开(公告)号：US07186891B1
公开(公告)日：2007-03-06
申请号：US09514513
申请日：2000-02-28
申请人： Joseph Chappell , Kyoungwhan Back
发明人： Joseph Chappell , Kyoungwhan Back
CPC分类号： C12N9/88 , C12N9/00 , C12N15/8243
摘要： The invention features plant cells and plants that include a nucleic acid molecule encoding a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned homologous domain. The chimeric isoprenoid synthases of the invention catalyze the production of isoprenoid reaction products that are not produced when the asymmetrically positioned homologous domain is positioned at its naturally-occurring site in an isoprenoid synthase polypeptide.
摘要翻译： 本发明的特征在于植物细胞和植物，其包括编码嵌合型类异戊二烯合酶多肽的核酸分子，其包括不对称定位的同源结构域。 本发明的嵌合类异戊二烯合酶催化产生类异戊二烯反应产物，当不对称定位的同源结构域位于其在异戊二烯合酶多肽中的天然存在位点时不产生。
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公开(公告)号：US5824774A
公开(公告)日：1998-10-20
申请号：US631341
申请日：1996-04-12
申请人： Joseph Chappell , Kyoungwhan Back
发明人： Joseph Chappell , Kyoungwhan Back
IPC分类号： A61K38/00 , C12N15/09 , A01N63/00 , A61K31/00 , A61K31/01 , A61K31/015 , A61P31/00 , A61P31/04 , A61P31/10 , A61P35/00 , C07H21/00 , C07K1/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C12N1/21 , C12N9/00 , C12N9/88 , C12N15/60 , C12N15/82 , C12R1/19
CPC分类号： C12N9/00 , C12N15/8243 , C12N9/88 , C07K2319/00
摘要： Disclosed is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous isoprenoid synthase. Also disclosed is a chimeric isoprenoid synthase polypeptide including an assymetrically positioned homologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide.
摘要翻译： 本发明公开了一种嵌合型类异戊二烯合酶，其包括第一种类型的类异戊二烯合酶的第一结构域，其与第二异源类异戊二烯合酶连接到第二结构域，由此嵌合型类异戊二烯合酶能够催化不产生的类异戊二烯反应产物的产生 不存在第二种异源类异戊二烯合酶的第二结构域。 还公开了嵌合型类异戊二烯合酶多肽，其包括非均衡定位的同源结构域，其中嵌合型类异戊二烯合酶能够催化当该结构域位于其类固醇合成酶多肽的天然存在位点时不产生的类异戊二烯反应产物的产生 。
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公开(公告)号：US08354504B2
公开(公告)日：2013-01-15
申请号：US12927805
申请日：2010-11-23
申请人： Joseph Chappell , Kyoungwhan Back
发明人： Joseph Chappell , Kyoungwhan Back
IPC分类号： C07K14/415
CPC分类号： C12P5/007 , C07K2319/00 , C12N9/00 , C12N9/1003 , C12N9/88 , C12N15/8243
摘要： Provided is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous, isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous, isoprenoid synthase. Also provided is a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned heterologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide.
摘要翻译： 本发明提供了一种嵌合型类异戊二烯合酶，其包含与第二种异戊二烯合成酶连接到第二结构域的第一种类型的类异戊二烯合酶的第一结构域，其中嵌合型类异戊二烯合酶能够催化不产生的类异戊二烯反应产物 不存在第二种异源的类异戊二烯合酶的第二结构域。 还提供了嵌合型类异戊二烯合酶多肽，其包括不对称定位的异源结构域，由此嵌合型类异戊二烯合酶能够催化当该结构域位于类固醇合成酶多肽的天然存在位点时不产生的类异戊二烯反应产物的产生 。
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公开(公告)号：US08106260B2
公开(公告)日：2012-01-31
申请号：US10717500
申请日：2003-11-21
申请人： Joseph Chappell , Kyoungwhan Back
发明人： Joseph Chappell , Kyoungwhan Back
CPC分类号： C12P5/007 , C07K2319/00 , C12N9/00 , C12N9/1003 , C12N9/88 , C12N15/8243
摘要： Disclosed is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous isoprenoid synthase. Also disclosed is a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned homologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide.
摘要翻译： 本发明公开了一种嵌合型类异戊二烯合酶，其包括第一种类型的类异戊二烯合酶的第一结构域，其与第二异源类异戊二烯合酶连接到第二结构域，由此嵌合型类异戊二烯合酶能够催化不产生的类异戊二烯反应产物的产生 不存在第二种异源类异戊二烯合酶的第二结构域。 还公开了嵌合型类异戊二烯合酶多肽，其包括不对称定位的同源结构域，其中嵌合型类异戊二烯合酶能够催化产生类异戊二烯反应产物，当该结构域位于其在类异戊二烯合酶多肽的天然存在位点时不产生 。
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公开(公告)号：US20130071877A1
公开(公告)日：2013-03-21
申请号：US13694098
申请日：2012-10-26
申请人： Joseph Chappell , Kyoungwhan Back
发明人： Joseph Chappell , Kyoungwhan Back
IPC分类号： C12N9/88
CPC分类号： C12P5/007 , C07K2319/00 , C12N9/00 , C12N9/1003 , C12N9/88 , C12N15/8243
摘要： Provided is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous, isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous, isoprenoid synthase. Also provided is a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned heterologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide.
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公开(公告)号：US20110081703A1
公开(公告)日：2011-04-07
申请号：US12927805
申请日：2010-11-23
申请人： Joseph Chappell , Kyoungwhan Back
发明人： Joseph Chappell , Kyoungwhan Back
CPC分类号： C12P5/007 , C07K2319/00 , C12N9/00 , C12N9/1003 , C12N9/88 , C12N15/8243
摘要： Provided is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous, isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous, isoprenoid synthase. Also provided is a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned heterologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide.
摘要翻译： 本发明提供了一种嵌合型类异戊二烯合酶，其包含与第二种异戊二烯合成酶连接到第二结构域的第一种类型的类异戊二烯合酶的第一结构域，其中嵌合型类异戊二烯合酶能够催化不产生的类异戊二烯反应产物 不存在第二种异源的类异戊二烯合酶的第二结构域。 还提供了嵌合型类异戊二烯合酶多肽，其包括不对称定位的异源结构域，由此嵌合型类异戊二烯合酶能够催化当该结构域位于类固醇合成酶多肽的天然存在位点时不产生的类异戊二烯反应产物的产生 。
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公开(公告)号：US20140242660A1
公开(公告)日：2014-08-28
申请号：US14120177
申请日：2014-05-02
申请人： Joseph Chappell , Kyoungwhan Back
发明人： Joseph Chappell , Kyoungwhan Back
CPC分类号： C12P5/007 , C07K2319/00 , C12N9/00 , C12N9/1003 , C12N9/88 , C12N15/8243
摘要： Provided is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous, isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous, isoprenoid synthase. Also provided is a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned heterologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide.
摘要翻译： 本发明提供了一种嵌合型类异戊二烯合酶，其包含与第二种异戊二烯合成酶连接到第二结构域的第一种类型的类异戊二烯合酶的第一结构域，其中嵌合型类异戊二烯合酶能够催化不产生的类异戊二烯反应产物 不存在第二种异源的类异戊二烯合酶的第二结构域。 还提供了嵌合型类异戊二烯合酶多肽，其包括不对称定位的异源结构域，由此嵌合型类异戊二烯合酶能够催化当该结构域位于类固醇合成酶多肽的天然存在位点时不产生的类异戊二烯反应产物的产生 。
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公开(公告)号：US08741651B2
公开(公告)日：2014-06-03
申请号：US13694098
申请日：2012-10-26
申请人： Joseph Chappell , Kyoungwhan Back
发明人： Joseph Chappell , Kyoungwhan Back
CPC分类号： C12P5/007 , C07K2319/00 , C12N9/00 , C12N9/1003 , C12N9/88 , C12N15/8243
摘要： Provided is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous, isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous, isoprenoid synthase. Also provided is a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned heterologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide.
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公开(公告)号：US06072045A
公开(公告)日：2000-06-06
申请号：US134699
申请日：1998-08-14
申请人： Joseph Chappell , Kyoungwhan Back
发明人： Joseph Chappell , Kyoungwhan Back
IPC分类号： A61K38/00 , C12N15/09 , A01N63/00 , A61K31/00 , A61K31/01 , A61K31/015 , A61P31/00 , A61P31/04 , A61P31/10 , A61P35/00 , C07H21/00 , C07K1/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C12N1/21 , C12N9/00 , C12N9/88 , C12N15/60 , C12N15/82 , C12R1/19 , C07H21/02
CPC分类号： C12N9/00 , C12N15/8243 , C12N9/88 , C07K2319/00
摘要： Disclosed is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous isoprenoid synthase. Also disclosed is a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned homologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide.
摘要翻译： 本发明公开了一种嵌合型类异戊二烯合酶，其包括第一种类型的类异戊二烯合酶的第一结构域，其与第二异源类异戊二烯合酶连接到第二结构域，由此嵌合型类异戊二烯合酶能够催化不产生的类异戊二烯反应产物的产生 不存在第二种异源类异戊二烯合酶的第二结构域。 还公开了嵌合型类异戊二烯合酶多肽，其包括不对称定位的同源结构域，其中嵌合型类异戊二烯合酶能够催化产生类异戊二烯反应产物，当该结构域位于其在类异戊二烯合酶多肽的天然存在位点时不产生 。
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