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1.发明授权公开(公告)号：US08518642B2
公开(公告)日：2013-08-27
申请号：US12684345
申请日：2010-01-08
申请人： Kyung-hee Park , Myo-yong Lee , Kyu-sang Lee , Jong-suk Chung
发明人： Kyung-hee Park , Myo-yong Lee , Kyu-sang Lee , Jong-suk Chung
CPC分类号： C12Q1/6837 , C12Q2545/101
摘要： Provided are a method of analyzing a sequence of a first probe nucleic acid using a substrate on which a second probe nucleic acid is immobilized, and a microarray and a kit for the same.
摘要翻译： 提供了使用其上固定有第二探针核酸的底物和微阵列及其用于分析第一探针核酸的试剂盒的方法来分析第一探针核酸的序列。
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2.发明授权Method and compositions for detecting respiratory disease-causing bacterial species 有权用于检测呼吸道性疾病的细菌物种的方法和组合物公开(公告)号：US07659388B2
公开(公告)日：2010-02-09
申请号：US11862758
申请日：2007-09-27
申请人： Ji-young Oh , Sang-hyun Paek , Kyung-hee Park , Jung-nam Lee , Jong-suk Chung , Ah-gi Kim
发明人： Ji-young Oh , Sang-hyun Paek , Kyung-hee Park , Jung-nam Lee , Jong-suk Chung , Ah-gi Kim
CPC分类号： C12Q1/689 , C12Q2600/16 , Y02A50/451
摘要： Provided are a primer set for specifically amplifying target sequence(s) of twelve respiratory disease-causing bacterial species, a probe set specifically hybridizing with target sequence(s) of twelve respiratory disease-causing bacterial species, a microarray comprising the probe set, and a method of detecting a respiratory disease-causing bacterial species using the probe set.
摘要翻译： 提供了用于特异性扩增十二种呼吸道性疾病的细菌种类的靶序列的引物组，与12种呼吸道性疾病致细菌物种的靶序列特异性杂交的探针组，包含探针组的微阵列和 使用探针组检测呼吸系统疾病的细菌物种的方法。
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3.发明授权Method of predicting risk of lung cancer recurrence, and a composition, kit and microarray for the same 有权预测肺癌复发风险的方法，以及组合物，试剂盒和微阵列公开(公告)号：US07585634B2
公开(公告)日：2009-09-08
申请号：US11971585
申请日：2008-01-09
申请人： Byung-chul Kim , Jhin-gook Kim , Nam Hur , Kyu-sang Lee , Dae-soon Son , Kyung-hee Park , Tae-jin Ahn
发明人： Byung-chul Kim , Jhin-gook Kim , Nam Hur , Kyu-sang Lee , Dae-soon Son , Kyung-hee Park , Tae-jin Ahn
CPC分类号： C40B40/06 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C40B30/04 , Y10S977/792
摘要： Provided is a method of predicting risk of lung cancer recurrence in a lung cancer patient or after a patient has lung cancer treatment, the method including: obtaining a biological sample from a lung cancer patient; measuring an expression level of at least one marker gene from the biological sample, the marker gene being selected from the group consisting of marker genes of Table 1, 2 or 3, to obtain data for the expression level of the marker gene; and determining whether the expression level of the marker gene corresponds to an expression level of a recurrence group or an expression level of a non-recurrence group.
摘要翻译： 本发明提供一种预测肺癌患者的肺癌复发风险或患者进行肺癌治疗后的方法，该方法包括从肺癌患者获得生物样品; 测定来自生物样品的至少一种标记基因的表达水平，所述标记基因选自表1,2或3的标记基因，以获得标记基因表达水平的数据; 确定标记基因的表达水平是否符合复发组的表达水平或非复发组的表达水平。
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4.发明授权Polynucleotide associated with a colon cancer comprising single nucleotide polymorphism, microarray and diagnostic kit comprising the same and method for diagnosing a colon cancer using the polynucleotide 有权与包含单核苷酸多态性的结肠癌相关的多核苷酸，微阵列和包含其的诊断试剂盒和使用多核苷酸诊断结肠癌的方法公开(公告)号：US07914996B2
公开(公告)日：2011-03-29
申请号：US12627022
申请日：2009-11-30
申请人： Kyung-hee Park , Kyu-sang Lee , Yeon-su Lee , Jae-Heup Kim , Yeon-a Park , Ji-young Cho , Ok-kyoung Son , Byung-chul Kim , Min-sun Kim
发明人： Kyung-hee Park , Kyu-sang Lee , Yeon-su Lee , Jae-Heup Kim , Yeon-a Park , Ji-young Cho , Ok-kyoung Son , Byung-chul Kim , Min-sun Kim
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/172
摘要： Provided is a polynucleotide including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID NOS: 1-12 and including a nucleotide at position 101 of the nucleotide sequence, or a complementary polynucleotide thereof.
摘要翻译： 提供了包含选自SEQ ID NO：1-12的核苷酸序列并且包含核苷酸序列的101位的核苷酸的核苷酸序列的至少10个连续核苷酸或其互补多核苷酸的多核苷酸。
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5.发明申请POLYNUCLEOTIDE ASSOCIATED WITH A COLON CANCER COMPRISING SINGLE NUCLEOTIDE POLYMORPHISM, MICROARRAY AND DIAGNOSTIC KIT COMPRISING THE SAME AND METHOD FOR DIAGNOSING A COLON CANCER USING THE POLYNUCLEOTIDE 有权与包含单核苷酸多态性，微阵列和包含其的诊断试剂盒相关的多核苷酸和使用多核苷酸诊断结肠癌的方法相关的多核苷酸公开(公告)号：US20100093549A1
公开(公告)日：2010-04-15
申请号：US12627022
申请日：2009-11-30
申请人： Kyung-hee Park , Kyu-sang Lee , Yeon-su Lee , Jae-Heup Kim , Yeon-a Park , Ji-young Cho , Ok-kyoung Son , Byung-chul Kim , Min-sun Kim
发明人： Kyung-hee Park , Kyu-sang Lee , Yeon-su Lee , Jae-Heup Kim , Yeon-a Park , Ji-young Cho , Ok-kyoung Son , Byung-chul Kim , Min-sun Kim
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/172
摘要： Provided is a polynucleotide including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID NOS: 1-12 and including a nucleotide at position 101 of the nucleotide sequence, or a complementary polynucleotide thereof.
摘要翻译： 提供了包含选自SEQ ID NO：1-12的核苷酸序列并且包含核苷酸序列的101位的核苷酸的核苷酸序列的至少10个连续核苷酸或其互补多核苷酸的多核苷酸。
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6.发明申请METHOD OF PREDICTING RISK OF LUNG CANCER RECURRENCE, AND A COMPOSITION, KIT AND MICROARRAY FOR THE SAME 审中-公开预测肺癌复发风险的方法及其组合物，包装及其微生物公开(公告)号：US20090291853A1
公开(公告)日：2009-11-26
申请号：US12512401
申请日：2009-07-30
申请人： Byung-Chul Kim , Jhin-gook Kim , Nam Hur , Kyu-Sang Lee , Dae-soon Son , Kyung-hee Park , Tae-jin Ahn
发明人： Byung-Chul Kim , Jhin-gook Kim , Nam Hur , Kyu-Sang Lee , Dae-soon Son , Kyung-hee Park , Tae-jin Ahn
CPC分类号： C40B40/06 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C40B30/04 , Y10S977/792
摘要： Provided is a method of predicting risk of lung cancer recurrence in a lung cancer patient or after a patient has lung cancer treatment, the method including: obtaining a biological sample from a lung cancer patient; measuring an expression level of at least one marker gene from the biological sample, the marker gene being selected from the group consisting of marker genes of Table 1, 2 or 3, to obtain data for the expression level of the marker gene; and determining whether the expression level of the marker gene corresponds to an expression level of a recurrence group or an expression level of a non-recurrence group.
摘要翻译： 本发明提供一种预测肺癌患者的肺癌复发风险或患者进行肺癌治疗后的方法，该方法包括从肺癌患者获得生物样品; 测定来自生物样品的至少一种标记基因的表达水平，所述标记基因选自表1,2或3的标记基因，以获得标记基因表达水平的数据; 确定标记基因的表达水平是否符合复发组的表达水平或非复发组的表达水平。
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公开(公告)号：US20100169107A1
公开(公告)日：2010-07-01
申请号：US12623893
申请日：2009-11-23
申请人： Tae-jin Ahn , Kyu-sang Lee , Dae-soon Son , Kyung-hee Park
发明人： Tae-jin Ahn , Kyu-sang Lee , Dae-soon Son , Kyung-hee Park
摘要： Provided are a method and an apparatus for managing data indicating personal genome data. The method includes obtaining property information of a first personal genome data, which indicates genome information of an individual, by analyzing a first personal genome data, and generating integrated data by integrating the first personal genome data and a second personal genome data indicating genome data of the individual based on the obtained property information.
摘要翻译： 提供了一种用于管理表示个人基因组数据的数据的方法和装置。 该方法包括：通过分析第一个人基因组数据来获得指示个体的基因组信息的第一个人基因组数据的属性信息，以及通过整合第一个人基因组数据和指示基因组数据的第二个人基因组数据来生成综合数据 个人基于获得的财产信息。
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8.发明授权Method of selecting optimized SNP marker sets from multiple SNP markers associated with a complex disease 有权从与复杂疾病相关的多个SNP标记中选择优化的SNP标记组的方法公开(公告)号：US07627436B2
公开(公告)日：2009-12-01
申请号：US11063513
申请日：2005-02-23
申请人： Kyung-hee Park , Kyoung-a Kim , Kyu-sang Lee
发明人： Kyung-hee Park , Kyoung-a Kim , Kyu-sang Lee
IPC分类号： G06F19/00
CPC分类号： G06F19/18 , C12Q1/6883 , C12Q2600/156
摘要： Provided is a method of selecting an optimized SNP marker set from a plurality of SNP markers. The method includes selecting an SNP marker set having a high association from a plurality of SNP markers using set-association, selecting SNP markers having a high association by performing discrimination analysis on arbitrary combinations of the markers included in the SNP marker set, and selecting an optimized SNP marker combination satisfying predetermined selection criteria by using receiver operating characteristics (ROC) curve analysis of arbitrary combinations of the selected SNP markers.
摘要翻译： 提供了从多个SNP标记中选择优化的SNP标记集的方法。 该方法包括使用设置关联从多个SNP标记中选择具有高关联的SNP标记组，通过对包括在SNP标记组中的标记的任意组合进行鉴别分析来选择具有高关联的SNP标记，并选择 通过使用所选SNP标记的任意组合的接收器操作特性（ROC）曲线分析来满足预定选择标准的优化的SNP标记组合。
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9.发明申请Method of selecting optimized SNP marker sets from multiple SNP markers associated with a complex disease 有权从与复杂疾病相关的多个SNP标记中选择优化的SNP标记组的方法公开(公告)号：US20050192763A1
公开(公告)日：2005-09-01
申请号：US11063513
申请日：2005-02-23
申请人： Kyung-hee Park , Kyoung-a Kim , Kyu-sang Lee
发明人： Kyung-hee Park , Kyoung-a Kim , Kyu-sang Lee
CPC分类号： G06F19/18 , C12Q1/6883 , C12Q2600/156
摘要： Provided is a method of selecting an optimized SNP marker set from a plurality of SNP markers. The method includes selecting an SNP marker set having a high association from a plurality of SNP markers using set-association, selecting SNP markers having a high association by performing discrimination analysis on arbitrary combinations of the markers included in the SNP marker set, and selecting an optimized SNP marker combination satisfying predetermined selection criteria by using receiver operating characteristics (ROC) curve analysis of arbitrary combinations of the selected SNP markers.
摘要翻译： 提供了从多个SNP标记中选择优化的SNP标记集的方法。 该方法包括使用设置关联从多个SNP标记中选择具有高关联的SNP标记组，通过对包括在SNP标记组中的标记的任意组合进行鉴别分析来选择具有高关联的SNP标记，并选择 通过使用所选SNP标记的任意组合的接收器操作特性（ROC）曲线分析来满足预定选择标准的优化的SNP标记组合。
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10.发明申请Breast cancer related protein, gene encoding the same, and method of diagnosing breast cancer using the protein and gene 审中-公开乳腺癌相关蛋白，编码相同的基因，以及使用蛋白质和基因诊断乳腺癌的方法公开(公告)号：US20050186610A1
公开(公告)日：2005-08-25
申请号：US11061694
申请日：2005-02-18
申请人： Yeon-su Lee , Kyung-hee Park , Tae-jin Ahn , Jong-hoon Park
发明人： Yeon-su Lee , Kyung-hee Park , Tae-jin Ahn , Jong-hoon Park
IPC分类号： G01N33/53 , C07H21/04 , C07K14/47 , C07K14/82 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/574 , G01N37/00 , C07K16/30
CPC分类号： C07H21/04 , C07K14/47 , C12Q1/6886 , C12Q2600/158 , G01N33/57415
摘要： An isolated protein having an amino acid sequence of SEQ ID No. 4 and having an activity inducing apoptosis, and a gene encoding the same are provided. Also, a microarray having a substrate on which the gene or fragment thereof is immobilized is provided. Also, a method of diagnosing breast cancer using an antibody specifically binding to the protein and a method of diagnosing breast cancer by determining whether the gene is expressed in a cell or not, are provided.
摘要翻译： 提供了具有SEQ ID No.4的氨基酸序列并且具有诱导细胞凋亡的活性的分离的蛋白质和编码该蛋白质的基因。 另外，提供了具有固定基因或其片段的底物的微阵列。 此外，提供了使用特异性结合蛋白质的抗体诊断乳腺癌的方法和通过确定该基因是否在细胞中表达来诊断乳腺癌的方法。
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