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    System and methods for harvesting mononuclear cells by recirculation of packed red blood cells
    1.
    发明授权
    System and methods for harvesting mononuclear cells by recirculation of packed red blood cells 失效
    通过再循环包装的红细胞收获单核细胞的系统和方法

    公开(公告)号：US5980760A

    公开(公告)日：1999-11-09

    申请号：US886780

    申请日：1997-07-01

    申请人： Kyungyoon Min ,  Richard I Brown ,  Daniel F Bischof ,  William H Cork ,  Robert J Cantu

    发明人： Kyungyoon Min ,  Richard I Brown ,  Daniel F Bischof ,  William H Cork ,  Robert J Cantu

    IPC分类号： A61M1/02 ,  A61M1/36 ,  B01D21/26 ,  B04B5/04 ,  B04B11/02 ,  B04B13/00

    CPC分类号： B01D21/302 ,  A61M1/3696 ,  B01D21/262 ,  B04B13/00 ,  B04B5/0442 ,  B01D2221/10 ,  B04B2005/045

    摘要： A blood separation system operates in a first mode to convey whole blood into the inlet region of a blood processing chamber for centrifugal separation into packed red blood cells, a plasma constituent, and an interface, which carries mononuclear cells, between the packed red blood cells and the plasma constituent. The system removes packed red blood cells and the plasma constituent from the chamber, while maintaining the interface within the chamber. The system operates in a second mode to remove the interface from the chamber by conveying packed red blood cells into the inlet region. An outlet path conveys the removed interface from the chamber. The outlet path includes a first sensing element to locate mononuclear cells in the removed interface and provide a sensed output upon locating mononuclear cells.

    摘要翻译： 血液分离系统以第一模式操作，以将全血输送到血液处理室的入口区域，用于离心分离成装填的红血细胞，血浆成分和携带单核细胞的界面， 和等离子体成分。 该系统在保持室内的界面的同时从腔室中去除填充的红细胞和等离子体成分。 该系统以第二模式操作，以通过将填充的红血细胞输送到入口区域来从腔室去除界面。 出口路径从腔室传送去除的界面。 出口路径包括第一感测元件，以将去除界面中的单核细胞定位，并在定位单核细胞时提供感测输出。

    Systems and methods for collecting diluted mononuclear cells
    3.
    发明授权
    Systems and methods for collecting diluted mononuclear cells 失效
    用于收集稀释的单核细胞的系统和方法

    公开(公告)号：US6027657A

    公开(公告)日：2000-02-22

    申请号：US886732

    申请日：1997-07-01

    申请人： Kyungyoon Min ,  Richard I Brown ,  Robert J Cantu

    发明人： Kyungyoon Min ,  Richard I Brown ,  Robert J Cantu

    IPC分类号： A61K35/14 ,  A61M1/36 ,  A61M1/38 ,  B01D21/26 ,  B04B5/04

    CPC分类号： B01D21/302 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  B01D21/262 ,  B04B5/0442 ,  B01D2221/10 ,  B04B2005/045

    摘要： Systems and methods rotate a chamber, in which whole blood is centrifugally separated into packed red blood cells, a plasma constituent, and an interface between the packed red blood cells and the plasma constituent. The interface carries platelets and mononuclear cells. The systems and methods include an interface control unit. The interface control unit is operative in a first state to enable removal of platelet-poor plasma in a first container for use as a diluting liquid. In a second state, the interface control unit retains mononuclear cells in the chamber, while removing platelet-rich plasma from the chamber, bypassing the platelet-poor collection container, thereby maintaining its platelet-poor character. In a third state, the interface control unit enables the removal of mononuclear cells from the chamber in a path that leads to a second container, where the mononuclear cells are collected. The systems and methods direct platelet-poor plasma from the first container to the second container to dilute the removed mononuclear cells in the second container.

    摘要翻译： 系统和方法旋转室，其中全血离心分离成包装的红细胞，血浆成分以及填充的红细胞和血浆成分之间的界面。 界面携带血小板和单核细胞。 系统和方法包括接口控制单元。 界面控制单元在第一状态下操作以使得能够在用作稀释液体的第一容器中移除贫血小血浆。 在第二状态下，界面控制单元在腔室中保留单核细胞，同时从腔室中除去富含血小板的血浆，绕过血小板收集容器，从而维持其血小板减少的特征。 在第三状态下，界面控制单元能够在通向收集单核细胞的第二容器的路径中从腔室去除单核细胞。 系统和方法将血小板从第一容器直接引导到第二容器，以稀释第二容器中去除的单核细胞。

    Blood processing systems and methods
    6.
    发明授权
    Blood processing systems and methods 失效
    血液处理系统和方法

    公开(公告)号：US06899666B2

    公开(公告)日：2005-05-31

    申请号：US10337486

    申请日：2003-01-07

    申请人： Richard I Brown

    发明人： Richard I Brown

    IPC分类号： A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B7/08 ,  B04B13/00

    CPC分类号： B04B13/00 ,  A61M1/025 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D17/0217 ,  B01D21/0003 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/32 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B2005/045 ,  A61M2202/0071

    摘要： Systems and methods centrifugally separate whole blood into red blood cells, plasma, and a platelet concentrate. The systems and methods rotate a first rotating separation zone about a rotational axis, to separate whole blood into red blood cells and plasma constituent carrying platelets. Red blood cells separated are directed in a first circumferential flow direction toward a terminal wall, where blood flow is halted. Surface hematocrit is successively increased in the first circumferential flow direction by separating the plasma constituent from the red blood cells. Separated red blood cells are directed from the first rotating separation zone through a path where the surface hematocrit is the most. Plasma constituent separated is directed in a second circumferential flow direction opposite to the first circumferential flow direction toward a different region in the first rotating separation zone, where the surface hematocrit is the least. The systems and methods separate the plasma constituent into platelet concentrate and plasma in a second rotating separation zone.

    摘要翻译： 系统和方法将全血离心分离成红细胞，血浆和血小板浓缩物。 系统和方法围绕旋转轴旋转第一旋转分离区，以将全血分离成红细胞和携带血小板的血浆成分。 分离的红细胞在朝向终止壁的第一周向流动方向上被引导，其中血液流动停止。 通过将等离子体成分与红细胞分离，在第一周向流动方向上依次增加表面血细胞比容。 分离的红细胞从第一旋转分离区通过表面血细胞比容最多的路径引导。 分离的等离子体成分在与第一圆周流动方向相反的第二圆周流动方向上朝向第一旋转分离区中的不同区域，其中表面血细胞比容最小。 系统和方法在第二旋转分离区中将等离子体成分分离成血小板浓缩物和血浆。

    Systems and methods for control of pumps employing gravimetric sensing
    7.
    发明授权
    Systems and methods for control of pumps employing gravimetric sensing 有权
    使用重力感应控制泵的系统和方法

    公开(公告)号：US06296450B1

    公开(公告)日：2001-10-02

    申请号：US09390269

    申请日：1999-09-03

    申请人： Tom Westberg ,  Richard E Mullen ,  Clement Lim Yu ,  Richard I Brown

    发明人： Tom Westberg ,  Richard E Mullen ,  Clement Lim Yu ,  Richard I Brown

    IPC分类号： F04B4900

    CPC分类号： F04B49/06 ,  F04B49/12 ,  F04B2205/09

    摘要： Systems and related methods pump fluid through a pump having a stroke volume. The systems and methods employ gravimetric control measures to monitor fluid flow through the pump. An actuator interacts with the pump during a stroke interval (TStroke) to pump fluid through the pump. The systems and methods couple a receptacle to the pump, to either dispense fluid into the pump or to receive fluid from the pump. The systems and methods detect changes in weight of the receptacle over a sample time period. The systems and methods achieve a desired flow rate (QDesired) by deriving an actual flow rate (QActual) by sensing changes in weight of the receptacle over the sample time period, taking into account the density of the fluid, and adjusting the stroke interval based upon QActual so that QDesired is achieved.

    摘要翻译： 系统和相关方法通过具有行程体积的泵来泵送流体。 系统和方法采用重力控制措施来监测通过泵的流体流量。 执行器在行程间隔（TStroke）期间与泵相互作用以泵送流体通过泵。 系统和方法将容器连接到泵，以将流体分配到泵中或从泵接收流体。 系统和方法在一个采样时间段内检测容器的重量变化。 系统和方法通过在考虑到流体的密度的基础上感测容器在采样时间段内的重量变化并通过调节基于行程间隔的方式获得实际流量（QActual）来实现期望的流量（QDesire） 在QActual上实现QDesired。