公开(公告)号：US20240201126A1

公开(公告)日：2024-06-20

申请号：US18536131

申请日：2023-12-11

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： James BUSTILLO ,  Mark J. MILGREW ,  Wolfgang HINZ ,  John LEAMON ,  John DAVIDSON ,  Martin HUBER ,  Antoine M. VAN OIJEN ,  Jonathan ROTHBERG

IPC: G01N27/414 ,  C12Q1/6869 ,  C12Q1/6874 ,  H01L21/82

CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/4148 ,  H01L21/82

Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

公开(公告)号：US20240201127A1

公开(公告)日：2024-06-20

申请号：US18530075

申请日：2023-12-05

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Kim L. JOHNSON ,  Jeremy JORDAN ,  Mark J. MILGREW ,  Peter M. LEVINE

IPC: G01N27/414 ,  C12Q1/6869 ,  G01J1/46 ,  G01N33/00 ,  G01R29/26 ,  H01L27/146 ,  H01L29/66 ,  H04N25/76

CPC classification number: G01N27/4148 ,  C12Q1/6869 ,  G01N27/4143 ,  G01N27/4145 ,  G01N33/00 ,  G01R29/26 ,  H01L27/14609 ,  H01L27/14632 ,  H01L29/66 ,  H04N25/76 ,  G01J1/46 ,  H01L27/14643 ,  H01L2924/0002 ,  Y10T436/25875

Abstract: The described semiconductor device can include a two-transistor pixel array. Each pixel in the two-transistor pixel array can include a chemical detection pixel comprising a chemically-sensitive transistor and a row-selection transistor connected between a current source and a chemically-sensitive transistor. The source of the chemically-sensitive transistor can be coupled to a column line, and the drain of the chemically-sensitive transistor can be coupled to the source of the row selection transistor. The gate of the row selection transistor can be couple to a row line. When a row line is activated, the row selection transistor can couple the chemically-sensitive transistor to the column line.

公开(公告)号：US20140194303A1

公开(公告)日：2014-07-10

申请号：US14206473

申请日：2014-03-12

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Mark J. MILGREW

IPC: C12Q1/68

CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/27 ,  G01N27/414 ,  Y10T29/49002

Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

Abstract translation: 与用于监测化学和/或生物反应的FET阵列相关的方法和装置，例如核酸序列合成反应。 本文提供的一些方法涉及在核酸测序反应期间从释放的氢离子改进信号（以及信噪比）。

公开(公告)号：US20150168344A1

公开(公告)日：2015-06-18

申请号：US14541041

申请日：2014-11-13

Applicant: Life Technologies Corporation

Inventor： Mark J. MILGREW

IPC: G01N27/414 ,  C12Q1/68

CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/27 ,  G01N27/414 ,  Y10T29/49002

Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

Abstract translation: 与用于监测化学和/或生物反应的FET阵列相关的方法和装置，例如核酸序列合成反应。 本文提供的一些方法涉及在核酸测序反应期间从释放的氢离子改进信号（以及信噪比）。

公开(公告)号：US20140194302A1

公开(公告)日：2014-07-10

申请号：US14206386

申请日：2014-03-12

Applicant: Life Technologies Corporation

Inventor： Mark J. MILGREW

IPC: C12Q1/68

CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/27 ,  G01N27/414 ,  Y10T29/49002

Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

Abstract translation: 与用于监测化学和/或生物反应的FET阵列相关的方法和装置，例如核酸序列合成反应。 本文提供的一些方法涉及在核酸测序反应期间从释放的氢离子改进信号（以及信噪比）。

公开(公告)号：US20140194301A1

公开(公告)日：2014-07-10

申请号：US14206326

申请日：2014-03-12

Applicant: Life Technologies Corporation

Inventor： Mark J. MILGREW

IPC: C12Q1/68

CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/27 ,  G01N27/414 ,  Y10T29/49002

Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

Abstract translation: 与用于监测化学和/或生物反应的FET阵列相关的方法和装置，例如核酸序列合成反应。 本文提供的一些方法涉及在核酸测序反应期间从释放的氢离子改进信号（以及信噪比）。