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    CHEMICAL DETECTION DEVICE HAVING MULTIPLE FLOW CHANNELS
    3.
    发明申请
    CHEMICAL DETECTION DEVICE HAVING MULTIPLE FLOW CHANNELS 审中-公开

    公开(公告)号：US20180224393A1

    公开(公告)日：2018-08-09

    申请号：US15943668

    申请日：2018-04-02

    Applicant: Life Technologies Corporation

    Inventor： Kim L. JOHNSON ,  Jeremy JORDAN ,  Peter M. LEVINE ,  Mark James MILGREW

    IPC: G01N27/414 ,  H04N5/374 ,  G01R29/26 ,  C12Q1/6869 ,  H01L29/66 ,  H01L27/146 ,  G01N33/00 ,  G01J1/46

    Abstract: The described embodiments may provide a chemical detection circuit that may comprise a plurality of first output circuits at a first side and a plurality of second output circuits at a second side of the chemical detection circuit. The chemical detection circuit may further comprise a plurality of tiles of pixels each placed between respective pairs of first and second output circuits. Each tile may include four quadrants of pixels. Each quadrant may have columns with designated first columns interleaved with second columns. Each first column may be coupled to a respective first output circuit in first and second quadrants, and to a respective second output circuit in third and fourth quadrants. Each second column may be coupled to a respective second output circuit in first and second quadrants, and to a respective first output circuit in third and fourth quadrants.

    Chemical Detection Device Having Multiple Flow Channels
    5.
    发明申请
    Chemical Detection Device Having Multiple Flow Channels 审中-公开
    具有多个流通道的化学检测装置

    公开(公告)号：US20150241387A1

    公开(公告)日：2015-08-27

    申请号：US14597507

    申请日：2015-01-15

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Kim L. JOHNSON ,  Jeremy JORDAN ,  Peter M. LEVINE ,  Mark James MILGREW

    IPC: G01N27/414

    Abstract: The described embodiments may provide a chemical detection circuit that may comprise a plurality of first output circuits at a first side and a plurality of second output circuits at a second side of the chemical detection circuit. The chemical detection circuit may further comprise a plurality of tiles of pixels each placed between respective pairs of first and second output circuits. Each tile may include four quadrants of pixels. Each quadrant may have columns with designated first columns interleaved with second columns. Each first column may be coupled to a respective first output circuit in first and second quadrants, and to a respective second output circuit in third and fourth quadrants. Each second column may be coupled to a respective second output circuit in first and second quadrants, and to a respective first output circuit in third and fourth quadrants.

    Abstract translation: 所描述的实施例可以提供化学检测电路，其可以包括在第一侧的多个第一输出电路和在化学检测电路的第二侧的多个第二输出电路。 化学检测电路还可以包括多个像素瓦片，每个瓷砖分别放置在相应的第一和第二输出电路对之间。 每个瓦片可以包括四个像素象限。 每个象限可以具有与第二列交错的指定的第一列的列。 每个第一列可以耦合到第一和第二象限中的相应的第一输出电路，以及耦合到第三和第四象限中的相应的第二输出电路。 每个第二列可以耦合到第一和第二象限中的相应的第二输出电路，以及耦合到第三和第四象限中的相应的第一输出电路。

    CHEMICALLY-SENSITIVE SAMPLE AND HOLD SENSORS
    6.
    发明申请
    CHEMICALLY-SENSITIVE SAMPLE AND HOLD SENSORS 有权
    化学敏感样品和保持传感器

    公开(公告)号：US20130292743A1

    公开(公告)日：2013-11-07

    申请号：US13923282

    申请日：2013-06-20

    Applicant: Life Technologies Corporation

    Inventor： Jonathan M. ROTHBERG ,  Wolfgang HINZ ,  Kim L. JOHNSON ,  James BUSTILLO

    IPC: H01L27/088

    CPC classification number: G01N27/4148 ,  C12Q1/6818 ,  C12Q1/6874 ,  G01N27/4145 ,  G01N33/54373 ,  G01N33/5438 ,  H01L27/088 ,  H01L29/42324 ,  H01L29/78 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01073 ,  H01L2924/14 ,  H01L2924/1433 ,  Y10T436/22 ,  C12Q2565/607 ,  C12Q2565/301 ,  C12Q2533/101

    Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

    Abstract translation: 与用于分析物测量的非常大规模的FET阵列相关的方法和装置。 可以使用基于提高测量灵敏度和精度的改进的FET像素和阵列设计的传统CMOS处理技术来制造ChemFET（例如，ISFET）阵列，并且同时促进显着小的像素尺寸和致密阵列。 改进的阵列控制技术提供了从大型和密集阵列的快速数据采集。 可以使用这样的阵列来检测各种化学和/或生物过程中各种分析物类型的存在和/或浓度变化。 在一个实例中，chemFET阵列基于监测氢离子浓度（pH），其他分析物浓度变化和/或与DNA合成相关的化学过程相关联的结合事件的变化来促进DNA测序技术。

    Semiconductor-Based Chemical Detection Device
    7.
    发明申请
    Semiconductor-Based Chemical Detection Device 有权

    公开(公告)号：US20210172907A1

    公开(公告)日：2021-06-10

    申请号：US17064948

    申请日：2020-10-07

    Applicant: Life Technologies Corporation

    Inventor： Kim L. JOHNSON ,  Jeremy JORDAN ,  Peter M LEVINE ,  Mark James MILGREW

    IPC: G01N27/414 ,  H01L27/146 ,  H04N5/374 ,  G01R29/26 ,  H01L29/66 ,  G01N33/00 ,  C12Q1/6869

    Abstract: The described embodiments may provide a chemical detection circuit that may comprise a plurality of first output circuits at a first side and a plurality of second output circuits at a second side of the chemical detection circuit. The chemical detection circuit may further comprise a plurality of tiles of pixels each placed between respective pairs of first and second output circuits. Each tile may include four quadrants of pixels. Each quadrant may have columns with designated first columns interleaved with second columns. Each first column may be coupled to a respective first output circuit in first and second quadrants, and to a respective second output circuit in third and fourth quadrants. Each second column may be coupled to a respective second output circuit in first and second quadrants, and to a respective first output circuit in third and fourth quadrants.

    CHEMICALLY-SENSITIVE SENSOR ARRAY CALIBRATION CIRCUITRY
    8.
    发明申请
    CHEMICALLY-SENSITIVE SENSOR ARRAY CALIBRATION CIRCUITRY 有权

    公开(公告)号：US20210109060A1

    公开(公告)日：2021-04-15

    申请号：US17067538

    申请日：2020-10-09

    Applicant: Life Technologies Corporation

    Inventor： Jonathan M. ROTHBERG ,  Wolfgang HINZ ,  Kim L. JOHNSON ,  James BUSTILLO

    IPC: G01N27/414 ,  C12Q1/6874 ,  H01L29/78 ,  H01L27/088 ,  C12Q1/6818 ,  G01N33/543

    Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

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