公开(公告)号：US20130150734A1

公开(公告)日：2013-06-13

申请号：US13817464

申请日：2011-08-31

申请人： Joseph Allen Orr ,  Lara Brewer ,  Dwayne Ronald Westenskow ,  Matthias Goerges

发明人： Joseph Allen Orr ,  Lara Brewer ,  Dwayne Ronald Westenskow ,  Matthias Goerges

IPC分类号： A61B5/00 ,  A61B5/145 ,  A61M16/08 ,  A61M16/04 ,  A61M16/06 ,  A61B5/029 ,  A61M16/00 ,  A61B5/0205

CPC分类号： A61B5/743 ,  A61B5/0004 ,  A61B5/0205 ,  A61B5/029 ,  A61B5/14542 ,  A61B5/4836 ,  A61B5/7225 ,  A61B5/746 ,  A61B5/7475 ,  A61M16/00 ,  A61M16/0057 ,  A61M16/021 ,  A61M16/0465 ,  A61M16/0666 ,  A61M16/085 ,  A61M16/0858 ,  A61M16/0875 ,  A61M2016/0027 ,  A61M2016/0036 ,  A61M2205/18 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/432 ,  G06F19/00 ,  G16H15/00 ,  G16H40/63

摘要： Ventilation information may be presented. Output signals may be received that convey information related to one or more breathing parameters of a subject receiving assisted or controlled mechanical ventilation. Based at least in part on the received output signals, volumetric components of a tidal volume of the subject may be determined. The volumetric components may include an alveolar dead space, an effective alveolar tidal volume, and/or other volumetric components. The alveolar dead space is the volume of inspired gas that occupies alveoli but does not take part in oxygen exchange in the lungs of the subject. The effective alveolar tidal volume is the volume of inspired gas that takes part in oxygen exchange in the lungs of the subject. A visual representation that textually or graphically represents the tidal volume, and/or textually or graphically represents the volumetric components separately from each other may be presented via a user interface.

摘要翻译： 可以呈现通风信息。 可以接收输出信号，其传送与接收辅助或受控机械通气的受试者的一个或多个呼吸参数有关的信息。 至少部分地基于所接收的输出信号，可以确定受试者的潮气量的体积分量。 体积分量可以包括肺泡死空间，有效肺泡潮气量和/或其它体积分量。 肺泡死亡空间是占据肺泡但不参与受试者肺部氧气交换的启发气体的体积。 有效的肺泡潮气量是参与受试者肺部氧气交换的吸入气体的体积。 以文字或图形方式表示潮气量和/或以文字或图形方式表示彼此分开的体积分量的视觉表示可以通过用户界面呈现。

公开(公告)号：US20120289853A1

公开(公告)日：2012-11-15

申请号：US13518955

申请日：2010-12-27

申请人： Lara Brewer ,  Joseph Allen Orr

发明人： Lara Brewer ,  Joseph Allen Orr

IPC分类号： A61B5/091

CPC分类号： A61B5/08 ,  A61B5/082 ,  G06F19/00 ,  G16H40/63

摘要： A system is configured to monitor the dead space fraction of a subject in a substantially ongoing manner, rather than only updating the dead space fraction of the subject if one or more blood gas parameters of the subject are measured. This may facilitate enhanced control over respiratory therapy being provided to the subject, may inform decisions about care of the subject, and/or may provide other enhancements.

摘要翻译： 系统被配置为以基本上持续的方式监视对象的死空间分数，而不是如果测量对象的一个​​或多个血气参数，则仅更新对象的死空间分数。 这可以有助于增强对被提供给对象的呼吸治疗的控制，可以通知关于受试者的照顾的决定和/或可以提供其他增强。

公开(公告)号：US20130013281A1

公开(公告)日：2013-01-10

申请号：US13636526

申请日：2011-03-17

申请人： Joseph Allen Orr ,  Lara Brewer

发明人： Joseph Allen Orr ,  Lara Brewer

IPC分类号： G06G7/60

CPC分类号： A61B5/0836 ,  A61B5/412 ,  A61M16/0003

摘要： Values of components of total carbon dioxide excreted by a subject can be provided. One or more signals may be received conveying information related to a rate of total carbon dioxide excreted by the subject. Based at least in part on the received one or more signals, a first capnometric component and/or a second capnometric component may be determined. The first capnometric component may indicate a rate of metabolic carbon dioxide production. The second capnometric component may indicate a rate of carbon dioxide transfer to or from body compartments of the subject that store carbon dioxide. The first capnometric component and/or the second capnometric component may be presented to a user.

摘要翻译： 可以提供受试者排出的总二氧化碳的成分的值。 可以接收一个或多个信号，其传送与被摄体排出的总二氧化碳的速率有关的信息。 至少部分地基于所接收的一个或多个信号，可以确定第一测量分量和/或第二测量分量。 第一个测量组分可能表示代谢二氧化碳产生的速率。 第二测量组分可以指示存储二氧化碳的物体的二氧化碳转移到或来自身体隔室的速率。 可以向用户呈现第一测量分量和/或第二测量分量。

公开(公告)号：US10117599B2

公开(公告)日：2018-11-06

申请号：US13518913

申请日：2010-12-10

申请人： Joseph Allen Orr ,  Soeren Hoehne ,  Lara Brewer

发明人： Joseph Allen Orr ,  Soeren Hoehne ,  Lara Brewer

IPC分类号： A61M16/06 ,  A61B5/097 ,  A61M16/08

摘要： A subject interface appliance (10) configured to deliver a breathable substance to a subject. The subject interface appliance includes a primary interface (12) configured to deliver a breathable substance to the subject, and a secondary interface (14) configured to obtain gas samples from the airway of the subject. The secondary interface is resiliently held at a default position with respect to the primary interface. The default position is located such that installation of the primary and secondary interfaces on the subject results in the application of a bias force to the secondary interface that holds the secondary interface in place.

公开(公告)号：US09763601B2

公开(公告)日：2017-09-19

申请号：US13636526

申请日：2011-03-17

申请人： Joseph Allen Orr ,  Lara Brewer

发明人： Joseph Allen Orr ,  Lara Brewer

IPC分类号： A61B5/083 ,  A61M16/00 ,  A61B5/00

CPC分类号： A61B5/0836 ,  A61B5/412 ,  A61M16/0003

摘要： Values of components of total carbon dioxide excreted by a subject can be provided. One or more signals may be received conveying information related to a rate of total carbon dioxide excreted by the subject. Based at least in part on the received one or more signals, a first capnometric component and/or a second capnometric component may be determined. The first capnometric component may indicate a rate of metabolic carbon dioxide production. The second capnometric component may indicate a rate of carbon dioxide transfer to or from body compartments of the subject that store carbon dioxide. The first capnometric component and/or the second capnometric component may be presented to a user.

公开(公告)号：US09675300B2

公开(公告)日：2017-06-13

申请号：US13817464

申请日：2011-08-31

申请人： Joseph Allen Orr ,  Lara Brewer ,  Dwayne Ronald Westenskow ,  Matthias Goerges

发明人： Joseph Allen Orr ,  Lara Brewer ,  Dwayne Ronald Westenskow ,  Matthias Goerges

IPC分类号： A61B5/00 ,  A61M16/00 ,  G06F19/00 ,  A61B5/0205 ,  A61B5/029 ,  A61B5/145 ,  A61M16/04 ,  A61M16/06 ,  A61M16/08

CPC分类号： A61B5/743 ,  A61B5/0004 ,  A61B5/0205 ,  A61B5/029 ,  A61B5/14542 ,  A61B5/4836 ,  A61B5/7225 ,  A61B5/746 ,  A61B5/7475 ,  A61M16/00 ,  A61M16/0057 ,  A61M16/021 ,  A61M16/0465 ,  A61M16/0666 ,  A61M16/085 ,  A61M16/0858 ,  A61M16/0875 ,  A61M2016/0027 ,  A61M2016/0036 ,  A61M2205/18 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/432 ,  G06F19/00 ,  G16H15/00 ,  G16H40/63

摘要： Ventilation information may be presented. Output signals may be received that convey information related to one or more breathing parameters of a subject receiving assisted or controlled mechanical ventilation. Based at least in part on the received output signals, volumetric components of a tidal volume of the subject may be determined. The volumetric components may include an alveolar dead space, an effective alveolar tidal volume, and/or other volumetric components. The alveolar dead space is the volume of inspired gas that occupies alveoli but does not take part in oxygen exchange in the lungs of the subject. The effective alveolar tidal volume is the volume of inspired gas that takes part in oxygen exchange in the lungs of the subject. A visual representation that textually or graphically represents the tidal volume, and/or textually or graphically represents the volumetric components separately from each other may be presented via a user interface.

公开(公告)号：US09549690B2

公开(公告)日：2017-01-24

申请号：US13518955

申请日：2010-12-27

申请人： Lara Brewer ,  Joseph Allen Orr

发明人： Lara Brewer ,  Joseph Allen Orr

IPC分类号： A61B5/08 ,  G06F19/00

CPC分类号： A61B5/08 ,  A61B5/082 ,  G06F19/00 ,  G16H40/63

摘要： A system is configured to monitor the dead space fraction of a subject in a substantially ongoing manner, rather than only updating the dead space fraction of the subject if one or more blood gas parameters of the subject are measured. This may facilitate enhanced control over respiratory therapy being provided to the subject, may inform decisions about care of the subject, and/or may provide other enhancements.

摘要翻译： 系统被配置为以基本上持续的方式监视对象的死空间分数，而不是如果测量对象的一个​​或多个血气参数，则仅更新对象的死空间分数。 这可以有助于增强对被提供给对象的呼吸治疗的控制，可以通知关于受试者的照顾的决定和/或可以提供其他增强。

公开(公告)号：US20130131533A1

公开(公告)日：2013-05-23

申请号：US13518913

申请日：2010-12-10

申请人： Joseph Allen Orr ,  Soeren Hoehne ,  Lara Brewer

发明人： Joseph Allen Orr ,  Soeren Hoehne ,  Lara Brewer

IPC分类号： A61B5/097

CPC分类号： A61B5/097 ,  A61M16/06 ,  A61M16/0616 ,  A61M16/0666 ,  A61M16/0683 ,  A61M16/085 ,  A61M2205/0216 ,  A61M2210/0618 ,  A61M2210/0625 ,  A61M2230/43

摘要： A subject interface appliance (10) configured to deliver a breathable substance to a subject. The subject interface appliance includes a primary interface (12) configured to deliver a breathable substance to the subject, and a secondary interface (14) configured to obtain gas samples from the airway of the subject. The secondary interface is resiliently held at a default position with respect to the primary interface. The default position is located such that installation of the primary and secondary interfaces on the subject results in the application of a bias force to the secondary interface that holds the secondary interface in place.

摘要翻译： 被摄体界面装置（10），被配置为将可透气物质输送到对象。 所述主题界面装置包括被配置为将物品传送到所述对象的主界面（12）以及被配置为从所述对象的气道获得气体样本的次级界面（14）。 辅助接口弹性地保持在相对于主界面的默认位置。 默认位置的位置使得主题和辅助界面在主题上的安装导致向保持辅助界面就位的辅助界面施加偏置力。

公开(公告)号：US20110245705A1

公开(公告)日：2011-10-06

申请号：US13133299

申请日：2009-11-30

申请人： Joseph Allen Orr ,  Lara Brewer

发明人： Joseph Allen Orr ,  Lara Brewer

IPC分类号： A61B5/08

CPC分类号： A61M16/161 ,  A61B5/083 ,  A61B5/091 ,  A61M16/024 ,  A61M2016/0027 ,  A61M2016/0036 ,  A61M2016/102 ,  A61M2016/1025 ,  A61M2205/3368 ,  A61M2205/52 ,  A61M2230/43

摘要： A system and method that determine the functional residual capacity of a subject in an automated manner. The determination of the functional residual capacity of the subject is made by analyzing the washout and/or wash-in of one or more molecular species present in gas breathed by the subject. The determination of the functional residual capacity can be made without a determination of oxygen consumption.

摘要翻译： 以自动方式确定受试者的功能残余能力的系统和方法。 通过分析由受试者呼吸的气体中存在的一种或多种分子种类的冲洗和/或洗涤来进行受试者的功能残留能力的确定。 功能残留容量的测定可以在不测定氧消耗的情况下进行。

公开(公告)号：US08398559B2

公开(公告)日：2013-03-19

申请号：US11483460

申请日：2006-07-10

申请人： Kai Kück ,  Joseph A. Orr ,  Lara Brewer

发明人： Kai Kück ,  Joseph A. Orr ,  Lara Brewer

IPC分类号： A61B5/08

CPC分类号： A61B5/0836 ,  A61B5/029 ,  G01N33/497 ,  G01N2001/2244

摘要： Methods for estimating the volume of the carbon dioxide stores of an individual's respiratory tract include determining a carbon dioxide store volume at which a correlation between corresponding signals of carbon dioxide elimination and an indicator of the content of carbon dioxide in blood of the individual is optimized. The estimate of the volume of carbon dioxide stores, which comprises a model of the respiratory tract, or lungs, of the individual, may be used as a transformation to improve the accuracy of one or both of the carbon dioxide elimination and carbon dioxide content signals. Transformation, or filtering, algorithms are also disclosed, as are systems in which the methods and algorithms may be used. The methods, algorithms, and systems may be used to accurately and noninvasively determine one or both of the pulmonary capillary blood flow and cardiac output of the individual.

摘要翻译： 用于估计个体呼吸道二氧化碳储存体积的方法包括确定二氧化碳储存容积，其中二氧化碳消除的相应信号与个体血液中二氧化碳含量的指标被优化之间的相关性。 包括个人呼吸道或肺的模型的二氧化碳储存量的估算可以用作改善二氧化碳消除和二氧化碳含量信号中的一种或两种的准确性的转化 。 还公开了转换或滤波算法，以及可以使用方法和算法的系统。 方法，算法和系统可用于精确地和非侵入性地确定个体的肺毛细血管血流量和心输出量中的一个或两个。