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1.发明授权Method and composition for transfer of active tumor-specific immunization from an immunized allogeneic bone marrow donor 失效用于从免疫的同种异体骨髓供体转移活性肿瘤特异性免疫的方法和组合物
公开(公告)号：US5861158A
公开(公告)日：1999-01-19
申请号：US153464
申请日：1993-11-17
申请人： Larry W. Kwak , Dan L. Longo
发明人： Larry W. Kwak , Dan L. Longo
IPC分类号： C12N5/06 , A61K35/12 , A61K35/28 , A61K39/00 , A61K39/395 , A61P35/00 , A61K39/38 , A61K35/14
CPC分类号： A61K35/28 , A61K39/0011 , A61K2035/124 , A61K2039/5158 , A61K2039/55555 , A61K2039/6081
摘要： This invention provides a method of improving a transplantation of hematopoietic cells from a donor to a recipient to treat a hematopoietic cell tumor in the recipient comprising immunizing the donor's hematopoietic cells with an antigen specific for the recipient's hematopoietic cell tumor, and transplanting the donor's immunized hematopoietic cells to the recipient. Also provided is a composition comprising purified hematopoietic cells primed to produce an immunological response to foreign tumor specific antigen. Also provided is a method of treating a tumor by the transplantation of hematopoietic cells from a donor to a recipient to treat the tumor in the recipient comprising immunizing the donor's hematopoietic cells with an antigen specific for the recipient's tumor, and transplanting the donor's immunized hematopoietic cells to the recipient.
摘要翻译： 本发明提供了一种改善造血细胞从供体到接受者移植以治疗受体中的造血细胞肿瘤的方法，包括用接受者的造血细胞肿瘤特异的抗原免疫供体的造血细胞，以及移植供体免疫的造血细胞 细胞到接收者。 还提供了包含引发以产生对外源性肿瘤特异性抗原的免疫应答的纯化造血细胞的组合物。 还提供了通过将供体的造血细胞移植到受体以治疗受体中的肿瘤来治疗肿瘤的方法，包括用对受体肿瘤特异性的抗原免疫供体的造血细胞，以及移植供体免疫的造血细胞 给收件人
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公开(公告)号：US08551936B2
公开(公告)日：2013-10-08
申请号：US13303081
申请日：2011-11-22
申请人： Larry W. Kwak , Bira Arya
发明人： Larry W. Kwak , Bira Arya
IPC分类号： C07K14/00
CPC分类号： A61K47/4833 , A61K31/7088 , A61K38/00 , A61K38/19 , A61K39/0011 , A61K39/39558 , C07K14/005 , C07K14/4723 , C07K2319/00
摘要： The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a defensin fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.
摘要翻译： 本发明涉及用于增加肿瘤抗原的免疫原性的疫苗，从而允许治疗癌症，以及增加病毒抗原的免疫原性的疫苗，从而允许治疗包括免疫缺陷病毒（HIV）感染在内的病毒感染。 特别地，本发明提供一种融合蛋白，其包含与肿瘤抗原或病毒抗原融合的防御素，其作为蛋白质或核酸疫苗施用以引发有效治疗癌症或有效治疗或预防病毒感染的免疫应答 。
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公开(公告)号：US20110110947A1
公开(公告)日：2011-05-12
申请号：US13009572
申请日：2011-01-19
申请人： Larry W. Kwak , Arya Biragyn
发明人： Larry W. Kwak , Arya Biragyn
IPC分类号： A61K39/395 , C07K14/00 , C07H21/04 , C12N15/63 , C12N1/21 , A61K39/00 , A61K31/7088 , A61P35/00
CPC分类号： C07K14/521 , A61K39/39541 , A61K2039/505 , C07K14/005 , C07K14/4727 , C07K14/4748 , C07K14/523 , C07K16/00 , C07K16/2875 , C07K16/2896 , C07K2319/00 , C12N2710/16422 , C12N2740/16122 , Y10S514/885
摘要： The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a viral chemokine fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.
摘要翻译： 本发明涉及用于增加肿瘤抗原的免疫原性的疫苗，从而允许治疗癌症，以及增加病毒抗原的免疫原性的疫苗，从而允许治疗包括免疫缺陷病毒（HIV）感染在内的病毒感染。 特别地，本发明提供了融合蛋白，其包含与肿瘤抗原或病毒抗原融合的病毒趋化因子，其作为蛋白质或核酸疫苗施用以引发有效治疗癌症或有效治疗或预防病毒的免疫应答 感染。
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公开(公告)号：US20120276101A1
公开(公告)日：2012-11-01
申请号：US13541997
申请日：2012-07-05
申请人： Larry W. Kwak , Bira Arya
发明人： Larry W. Kwak , Bira Arya
IPC分类号： C07K19/00 , A61K39/395 , A61P37/00 , A61K39/00
CPC分类号： C07K14/521 , A61K39/39541 , A61K2039/505 , C07K14/005 , C07K14/4727 , C07K14/4748 , C07K14/523 , C07K16/00 , C07K16/2875 , C07K16/2896 , C07K2319/00 , C12N2710/16422 , C12N2740/16122 , Y10S514/885
摘要： The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a viral chemokine fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.
摘要翻译： 本发明涉及用于增加肿瘤抗原的免疫原性的疫苗，从而允许治疗癌症，以及增加病毒抗原的免疫原性的疫苗，从而允许治疗包括免疫缺陷病毒（HIV）感染在内的病毒感染。 特别地，本发明提供了融合蛋白，其包含与肿瘤抗原或病毒抗原融合的病毒趋化因子，其作为蛋白质或核酸疫苗施用以引发有效治疗癌症或有效治疗或预防病毒的免疫应答 感染。
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公开(公告)号：US08084250B2
公开(公告)日：2011-12-27
申请号：US13019160
申请日：2011-02-01
申请人： Larry W. Kwak , Bira Arya
发明人： Larry W. Kwak , Bira Arya
CPC分类号： A61K47/4833 , A61K31/7088 , A61K38/00 , A61K38/19 , A61K39/0011 , A61K39/39558 , C07K14/005 , C07K14/4723 , C07K2319/00
摘要： The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a defensin fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.
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公开(公告)号：US07897152B2
公开(公告)日：2011-03-01
申请号：US10380927
申请日：2001-09-17
申请人： Larry W. Kwak , Arya Biragyn
发明人： Larry W. Kwak , Arya Biragyn
CPC分类号： C07K14/521 , A61K39/39541 , A61K2039/505 , C07K14/005 , C07K14/4727 , C07K14/4748 , C07K14/523 , C07K16/00 , C07K16/2875 , C07K16/2896 , C07K2319/00 , C12N2710/16422 , C12N2740/16122 , Y10S514/885
摘要： The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a viral chemokine fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.
摘要翻译： 本发明涉及用于增加肿瘤抗原的免疫原性的疫苗，从而允许治疗癌症，以及增加病毒抗原的免疫原性的疫苗，从而允许治疗包括免疫缺陷病毒（HIV）感染在内的病毒感染。 特别地，本发明提供了融合蛋白，其包含与肿瘤抗原或病毒抗原融合的病毒趋化因子，其作为蛋白质或核酸疫苗施用以引发有效治疗癌症或有效治疗或预防病毒的免疫应答 感染。
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公开(公告)号：US20110135715A1
公开(公告)日：2011-06-09
申请号：US13019160
申请日：2011-02-01
申请人： Larry W. Kwak , Arya Biragyn
发明人： Larry W. Kwak , Arya Biragyn
IPC分类号： A61K9/127 , A61K39/12 , A61K39/00 , A61K39/21 , A61K38/20 , A61K38/21 , A61K38/19 , A61K39/395 , C12N15/63 , A61P37/04 , A61P31/12 , A61P31/18 , A61P35/00
CPC分类号： A61K47/4833 , A61K31/7088 , A61K38/00 , A61K38/19 , A61K39/0011 , A61K39/39558 , C07K14/005 , C07K14/4723 , C07K2319/00
摘要： The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a defensin fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.
摘要翻译： 本发明涉及用于增加肿瘤抗原的免疫原性的疫苗，从而允许治疗癌症，以及增加病毒抗原的免疫原性的疫苗，从而允许治疗包括免疫缺陷病毒（HIV）感染在内的病毒感染。 特别地，本发明提供一种融合蛋白，其包含与肿瘤抗原或病毒抗原融合的防御素，其作为蛋白质或核酸疫苗施用以引发有效治疗癌症或有效治疗或预防病毒感染的免疫应答 。
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公开(公告)号：US07915040B2
公开(公告)日：2011-03-29
申请号：US12786334
申请日：2010-05-24
申请人： Larry W. Kwak , Arya Biragyn
发明人： Larry W. Kwak , Arya Biragyn
CPC分类号： A61K47/4833 , A61K31/7088 , A61K38/00 , A61K38/19 , A61K39/0011 , A61K39/39558 , C07K14/005 , C07K14/4723 , C07K2319/00
摘要： The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a defensin fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.
摘要翻译： 本发明涉及用于增加肿瘤抗原的免疫原性的疫苗，从而允许治疗癌症，以及增加病毒抗原的免疫原性的疫苗，从而允许治疗包括免疫缺陷病毒（HIV）感染在内的病毒感染。 特别地，本发明提供一种融合蛋白，其包含与肿瘤抗原或病毒抗原融合的防御素，其作为蛋白质或核酸疫苗施用以引发有效治疗癌症或有效治疗或预防病毒感染的免疫应答 。
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公开(公告)号：US20100260793A1
公开(公告)日：2010-10-14
申请号：US12786334
申请日：2010-05-24
申请人： Larry W. Kwak , Arya Biragyn
发明人： Larry W. Kwak , Arya Biragyn
CPC分类号： A61K47/4833 , A61K31/7088 , A61K38/00 , A61K38/19 , A61K39/0011 , A61K39/39558 , C07K14/005 , C07K14/4723 , C07K2319/00
摘要： The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a defensin fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.
摘要翻译： 本发明涉及用于增加肿瘤抗原的免疫原性的疫苗，从而允许治疗癌症，以及增加病毒抗原的免疫原性的疫苗，从而允许治疗包括免疫缺陷病毒（HIV）感染在内的病毒感染。 特别地，本发明提供一种融合蛋白，其包含与肿瘤抗原或病毒抗原融合的防御素，其作为蛋白质或核酸疫苗施用以引发有效治疗癌症或有效治疗或预防病毒感染的免疫应答 。
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公开(公告)号：US08460675B2
公开(公告)日：2013-06-11
申请号：US13541997
申请日：2012-07-05
申请人： Larry W. Kwak , Bira Arya
发明人： Larry W. Kwak , Bira Arya
CPC分类号： C07K14/521 , A61K39/39541 , A61K2039/505 , C07K14/005 , C07K14/4727 , C07K14/4748 , C07K14/523 , C07K16/00 , C07K16/2875 , C07K16/2896 , C07K2319/00 , C12N2710/16422 , C12N2740/16122 , Y10S514/885
摘要： The present invention relates to a vaccine for increasing the immunogenicity of a tumor antigen thus allowing treatment of cancer, as well as a vaccine that increases the immunogenicity of a viral antigen, thus allowing treatment of viral infection, including immunodeficiency virus (HIV) infection. In particular, the present invention provides a fusion protein comprising a viral chemokine fused to either a tumor antigen or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune response effective in treating cancer or effective in treating or preventing viral infection.
摘要翻译： 本发明涉及用于增加肿瘤抗原的免疫原性的疫苗，从而允许治疗癌症，以及增加病毒抗原的免疫原性的疫苗，从而允许治疗包括免疫缺陷病毒（HIV）感染在内的病毒感染。 特别地，本发明提供了融合蛋白，其包含与肿瘤抗原或病毒抗原融合的病毒趋化因子，其作为蛋白质或核酸疫苗施用以引发有效治疗癌症或有效治疗或预防病毒的免疫应答 感染。
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