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    Enzymatic process for the preparation of paliperidone and its intermediate CMHTP
    2.
    发明申请
    Enzymatic process for the preparation of paliperidone and its intermediate CMHTP 审中-公开
    用于制备利培酮及其中间体CMHTP的酶法

    公开(公告)号：US20090035829A1

    公开(公告)日：2009-02-05

    申请号：US12154437

    申请日：2008-05-21

    申请人： Santiago Ini ,  Laszlo Toth ,  Lorant Szabo ,  Ronen Tchelet

    发明人： Santiago Ini ,  Laszlo Toth ,  Lorant Szabo ,  Ronen Tchelet

    IPC分类号： C12P17/16

    CPC分类号： C12P17/00

    摘要： The present invention provides a process for the preparation of a 4H-pyrrido[1,2-a]-pyrimidin-4-one derivative, wherein the 4H-pyrrido[1,2-a]-pyrimidin-4-one derivative is Paliperidone or 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]-pyrimidin-4-one (‘CMHTP’), said process comprising enzymatically hydroxylating Risperidone or 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrrido[1,2-a]-pyrimidin-4-one (‘ClMTTP’), respectively, with at least one oxidoreductase enzyme; and optionally isolating or purifying the Paliperidone or CMHTP, wherein the at least one oxidoreductase enzyme is selected from the group of peroxidases, dioxygenases, monooxygenases and any combination thereof.

    摘要翻译： 本发明提供了制备4H-吡咯并[1,2-a]嘧啶-4-酮衍生物的方法，其中4H-吡啶并[1,2-a]嘧啶-4-酮衍生物是哌啶酮 或3-（2-氯乙基）-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮（'CMHTP'），所述 包括酶促羟基化利培酮或3-（2-氯乙基）-6,7,8,9-四氢-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮（'ClMTTP'）的方法， 分别与至少一种氧化还原酶; 并任选地分离或纯化帕利哌酮或CMHTP，其中所述至少一种氧化还原酶选自过氧化物酶，双加氧酶，单加氧酶及其任何组合。

    Active filter circuit with dynamically modifiable gain
    3.
    发明授权
    Active filter circuit with dynamically modifiable gain 失效
    有源滤波电路具有动态可调增益

    公开(公告)号：US06958644B2

    公开(公告)日：2005-10-25

    申请号：US10450650

    申请日：2002-01-10

    申请人： George Palaskas ,  Yannis Tsividis ,  Laszlo Toth

    发明人： George Palaskas ,  Yannis Tsividis ,  Laszlo Toth

    IPC分类号： H03B1/00 ,  H03F1/00 ,  H03G1/04 ,  H03G3/00 ,  H03G5/00 ,  H03G7/00 ,  H03H11/04 ,  H03H11/12 ,  H03K5/00

    CPC分类号： H03G1/04 ,  H03G3/001 ,  H03G7/00 ,  H03H11/04 ,  H03H11/1252 ,  H03H11/1256 ,  H03H11/126 ,  H03H11/1291

    摘要： A signal processing system (100) comprises an input terminal (102), and a main path having a main filter input gain unit (126) coupled to said input terminal (102), a main filter (132) and an output gain unit (138). An auxiliary path includes an auxiliary filter input gain unit (106) coupled to the input terminal (102), an auxiliary filter (112) and an auxiliary filter output gain unit (118). An adder (144) is coupled to the output gain units (118, 138) for generating an output signal to an output terminal (148). The gains of the gain units are adjusted by a control unit (18) responsive to a detecting signal from a detector (160).

    摘要翻译： 信号处理系统（100）包括输入端（102），以及具有耦合到所述输入端（102）的主滤波器输入增益单元（126）的主路径，主滤波器（132）和输出增益单元 138）。 辅助路径包括耦合到输入端子（102）的辅助滤波器输入增益单元（106），辅助滤波器（112）和辅助滤波器输出增益单元（118）。 加法器（144）耦合到输出增益单元（118,138），用于产生到输出端子（148）的输出信号。 响应于来自检测器（160）的检测信号，控制单元（18）调整增益单元的增益。

    Time encoding and decoding of a signal
    4.
    发明申请
    Time encoding and decoding of a signal 失效
    信号的时间编码和解码

    公开(公告)号：US20050190865A1

    公开(公告)日：2005-09-01

    申请号：US11049401

    申请日：2005-02-02

    申请人： Aurel Lazar ,  Laszlo Toth

    发明人： Aurel Lazar ,  Laszlo Toth

    IPC分类号： H03M1/84 ,  H03M3/02 ,  H03M7/32 ,  H04L27/06

    CPC分类号： H03M1/125 ,  H03M1/50 ,  H03M1/82 ,  H03M3/432 ,  H03M3/504

    摘要： Analog signals can be fully encoded as an asynchronous time sequence generated by a time encoding machine (TEM). With knowledge of the parameters of the time encoding machine, the asynchronous time sequence can be decoded using a non-linear time decoding machine. In one embodiment, the non-linear time decoding machine generates a set of weighted Dirac delta functions centered in the intervals of the asynchronous time sequence of the time encoding machine output. The weighting of each of the delta functions is determined by the parameters of the TEM as well as the values of the time sequence. The generation of the series of delta functions is a nonlinear operation (500, 510, 520). The input signal can be recovered from the series of weighted delta functions by (530) applying this series through an impulse response filter.

    摘要翻译： 模拟信号可以被完全编码为由时间编码机（TEM）生成的异步时间序列。 利用时间编码机的参数知识，可以使用非线性时间解码机对异步时序进行解码。 在一个实施例中，非线性时间解码机器生成以时间编码机器输出的异步时间序列的间隔为中心的一组加权的Dirac delta函数。 每个delta函数的加权由TEM的参数以及时间序列的值确定。 一系列delta函数的生成是非线性运算（500,510,520）。 通过（530）通过脉冲响应滤波器应用该系列，可以从一系列加权的增量函数中恢复输入信号。

    Local heating installation
    5.
    发明授权
    Local heating installation 失效
    本地采暖设备

    公开(公告)号：US4526319A

    公开(公告)日：1985-07-02

    申请号：US440291

    申请日：1982-11-09

    申请人： Laszlo Toth

    发明人： Laszlo Toth

    IPC分类号： F24H3/06 ,  F24B1/02 ,  F24B5/02 ,  F24B7/02 ,  F24H1/36 ,  F24H7/04 ,  F24D5/00

    CPC分类号： F24H7/0475 ,  F24B1/02 ,  F24B5/02 ,  F24B7/02

    摘要： A heating installation for local use is disclosed which is to be operated by aggregate fuel having both direct and indirect thermal emission, with a reactor receiving the combustion chamber, and a waste-heat flue above the reactor as well as an outer heat accumulator case, wherein a waste-heat flue is disposed in the space above the reactor and which flue is essentially developed by having a helical elevation between an outer heat accumulator case and an inner heat accumulator case, while air channels are formed opening into the inner space of the air space to be heated between the reactor case which is made of metal encircling directly the reactor case and the outer heat accumulator case which is connected with at least one, adherent part of the combustion chamber, while it is also connected with the air space to be heated, wherein both the outer and inner heat accumulator cases are of hollow walls, and are fitted together from ring-shaped ceramic modular elements, wherein the modular elements have section-shaped distance rings arranged fitted together in pairs and filled with sand and provided with interruptions for the continuous elevation of the waste-heat flue without change of direction.

    摘要翻译： 公开了一种用于局部使用的加热装置，其由具有直接和间接热发射的聚集燃料，接收燃烧室的反应器和反应器上方的废热烟道以及外部蓄热器壳体操作， 其中废热烟道设置在反应器上方的空间中，并且烟道基本上通过在外部蓄热器壳体和内部蓄热器壳体之间具有螺旋形高度而形成，而空气通道形成为开口到内部空间 在由直接由反应器壳体包围的金属构成的反应器壳体和与燃烧室的至少一个附着部分连接的外部蓄热器壳体之间加热的空气空间，同时其还与空气空间连接 被加热，其中外部和内部蓄热器壳都是中空壁，并且由环形陶瓷模块元件装配在一起，其中模块化 元件具有成对安装在一起并且填充有沙子的断面形距离环，并且在不改变方向的情况下为废热烟道的连续升高提供中断。

    Mushroom growing process
    6.
    发明授权
    Mushroom growing process 失效
    蘑菇生长过程

    公开(公告)号：US3996038A

    公开(公告)日：1976-12-07

    申请号：US448948

    申请日：1974-03-07

    申请人： Erno Toth ,  Laszlo Toth ,  Imre Heltay

    发明人： Erno Toth ,  Laszlo Toth ,  Imre Heltay

    IPC分类号： A01G1/04 ,  C05F11/08 ,  C05F11/00

    CPC分类号： A01G1/04 ,  C05F11/08

    摘要： A cellulosic starting material, substantially devoid of nitrogen values is moistened to bring its water content to at least 50%, pasteurized by steam treatment during which the temperature is increased to a maximum of about 70.degree. C and maintained at such temperature for about 12 hours during which time a relative humidity of about 100% is likewise maintained whereby the starting material is digested. The material is cooled to about 55.degree. C to proliferate thermophilic metabolite producing microorganisms. This temperature is maintained for about 36 hours and is then lowered to about 40.degree.-45.degree. C and maintained at that level for about 24 hours whereby another group of microorganisms is proliferated. The substrate so produced is cooled to 25.degree. C or less. The process provides the substrate with metabolites that protect it against microorganisms which compete for substrate carbon sources with the macrofungi to be cultivated on the substrate.

    摘要翻译： 将基本上没有氮值的纤维素起始材料润湿以使其含水量达到至少50％，通过蒸汽处理进行巴氏杀菌，其中将温度升至最高约70℃，并在该温度下保持约12小时 在此期间同样保持约100％的相对湿度，从而使原料消化。 将材料冷却至约55℃以增殖产生嗜热代谢物的微生物。 该温度保持约36小时，然后降至约40-45℃，并保持该水平约24小时，由此另一组微生物增殖。 将如此制造的基板冷却至25℃以下。 该方法为底物提供了保护其免受微生物代谢的代谢物，这些微生物与基质上培养的大型真菌竞争底物碳源。

    Beet juice purification system
    9.
    发明授权
    Beet juice purification system 失效
    甜菜汁净化系统

    公开(公告)号：US4795494A

    公开(公告)日：1989-01-03

    申请号：US167845

    申请日：1988-03-14

    申请人： Laszlo Toth ,  Michael R. Conway

    发明人： Laszlo Toth ,  Michael R. Conway

    IPC分类号： C13B20/06 ,  C13B20/12 ,  C07C53/00 ,  C07C55/00 ,  C13D3/12

    CPC分类号： C13B20/06 ,  C13B20/12

    摘要： A process for the removal of non-sugar impurities from beet diffusion juice having essentially no beet tissue particles therein and comprising water, sugar, and dissolved and colloidal non-sugar impurities. The diffusion juice is subjected to a progressive preliming procedure to thereby produce a limed first juice fraction containing non-sugar flocs and a limed, floc-free second juice fraction. The fractions are separated and the floc-free fraction is subjected to cold and hot main liming. Subsequently, and without substantial mechanical or chemical degradation, at least a portion of the first juice fraction containing at least a portion of the non-sugar flocs is united with the main-limed second juice fraction in a first carbonation procedure wherein carbon dioxide reacts with the lime present to produce calcium carbonate precipitate which, in addition to being an adsorption filter aid, forms protective scales around the floc particles. The resulting single juice fraction is separated, further treated in a second carbonation procedure, and filtered for subsequent sugar crystallization.

    摘要翻译： 一种从甜菜扩散汁除去非糖杂质的方法，其中基本上没有甜菜组织颗粒，并且包含水，糖和溶解的胶体非糖杂质。 使扩散汁进行逐步预处理，从而产生含有非糖絮状物和无絮状的无絮状第二榨汁部分的有色的第一果汁部分。 分离各部分，使无絮状部分经受冷和热主要的灰分。 随后，并且没有实质的机械或化学降解，含有至少一部分非糖絮状物的第一汁液部分的至少一部分在主要碳酸化程序中与主要的第二汁液部分结合，其中二氧化碳与 石灰存在以产生碳酸钙沉淀物，除了作为吸附助滤剂之外，其还形成围绕絮状物颗粒的保护垢。 分离得到的单汁液部分，在第二次碳酸化程序中进一步处理，并过滤以用于随后的糖结晶。