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    Optical resonance analysis system
    6.
    发明申请
    Optical resonance analysis system 审中-公开
    光学共振分析系统

    公开(公告)号：US20050162657A1

    公开(公告)日：2005-07-28

    申请号：US11074604

    申请日：2005-03-07

    申请人： Dar Bahatt ,  Jerry Cahill ,  Koichi Nishikida ,  Enrico Picozza ,  Paul Saviano ,  David Tracy ,  Yongdong Wang

    发明人： Dar Bahatt ,  Jerry Cahill ,  Koichi Nishikida ,  Enrico Picozza ,  Paul Saviano ,  David Tracy ,  Yongdong Wang

    IPC分类号： G01N21/27 ,  G01N21/55

    CPC分类号： G01N21/7703 ,  G01N21/553

    摘要： An optical resonance analysis system comprising a sensor means (60) and an illumination means (400) for generating non-monochromatic illumination. The illumination means (400) further comprises a means for generating illumination at a plurality of angles, a lens system for projecting said illumination at said plurality of angles (390) and a dispersive device (380) for dispersing said illumination at each of said plurality of angles so that there is a correlation between said plurality of angles and the wavelengths of said illumination such that a resonance condition is generated on said sensor mean (60) for all wavelengths generated by said non-monochromatic source simultaneously. The analysis system also comprises a detection means (90) for detecting the reflected or transmitted illumination. Another embodiment comprises an anamorphic imaging means (120).

    摘要翻译： 一种光学共振分析系统，包括传感器装置（60）和用于产生非单色照明的照明装置（400）。 照明装置（400）还包括用于以多个角度产生照明的装置，用于以所述多个角度（390）投射所述照明的透镜系统和用于将所述照明分散在所述多个角度的分散装置（380） 的角度，使得在所述多个角度和所述照明的波长之间存在相关性，使得对于由所述非单色源同时产生的所有波长的所述传感器平均值（60）产生共振条件。 分析系统还包括用于检测反射或透射照明的检测装置（90）。 另一实施例包括变形成像装置（120）。

    Optical Resonance Analysis System
    7.
    发明申请
    Optical Resonance Analysis System 有权
    光学共振分析系统

    公开(公告)号：US20060262313A1

    公开(公告)日：2006-11-23

    申请号：US11460932

    申请日：2006-07-28

    申请人： Dar Bahatt ,  Jerry Cahill ,  Koichi Nishikida ,  Enrico Picozza ,  Paul Saviano ,  David Tracy ,  Yongdong Wang

    发明人： Dar Bahatt ,  Jerry Cahill ,  Koichi Nishikida ,  Enrico Picozza ,  Paul Saviano ,  David Tracy ,  Yongdong Wang

    IPC分类号： G01N21/55

    CPC分类号： G01N21/7703 ,  G01N21/553

    摘要： An optical resonance analysis system comprising a sensor means (60) and an illumination means (400) for generating non-monochromatic illumination. The illumination means (400) further comprises a means for generating illumination at a plurality of angles, a lens system for projecting said illumination at said plurality of angles (390) and a dispersive device (380) for dispersing said illumination at each of said plurality of angles so that there is a correlation between said plurality of angles and the wavelengths of said illumination such that a resonance condition is generated on said sensor mean (60) for all wavelengths generated by said non-monochromatic source simultaneously. The analysis system also comprises a detection means (90) for detecting the reflected or transmitted illumination. Another embodiment comprises an anamorphic imaging means (120).

    摘要翻译： 一种光学共振分析系统，包括传感器装置（60）和用于产生非单色照明的照明装置（400）。 照明装置（400）还包括用于以多个角度产生照明的装置，用于以所述多个角度（390）投射所述照明的透镜系统和用于将所述照明分散在所述多个角度的分散装置（380） 的角度，使得在所述多个角度和所述照明的波长之间存在相关性，使得对于由所述非单色源同时产生的所有波长的所述传感器平均值（60）产生共振条件。 分析系统还包括用于检测反射或透射照明的检测装置（90）。 另一实施例包括变形成像装置（120）。

    In situ PCR amplification system
    9.
    发明授权
    In situ PCR amplification system 失效
    原位PCR扩增系统

    公开(公告)号：US5681741A

    公开(公告)日：1997-10-28

    申请号：US525321

    申请日：1995-09-08

    申请人： John G. Atwood ,  Enrico Picozza

    发明人： John G. Atwood ,  Enrico Picozza

    IPC分类号： B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  C12Q1/68 ,  C40B40/06 ,  G01N1/31 ,  C12M1/40 ,  C12M1/34

    CPC分类号： G01N1/312 ,  B01J19/0046 ,  B01L3/508 ,  B01L7/52 ,  C12Q1/686 ,  B01J2219/00722 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2300/0822 ,  B01L2300/1827 ,  B01L2300/185 ,  B01L9/52 ,  C40B40/06

    摘要： A complete in situ PCR system for amplification of nucleic acids contained in a prepared cell or tissue sample. The containment system for the PCR sample comprises a glass microscope slide, a specimen sample containing the target nucleic acid sequence mounted on the slide, a flexible plastic cover over the sample, and a retaining assembly fastened to the slide and to the cover to retain and seal a reaction mixture against the sample during thermal cycling. The retaining assembly includes a rigid ring on a rim portion of the cover, a cross beam having spaced parallel rails joined by opposite flat ends, and a pair of clips which are pressed over the ends and opposite sides of the slide to fasten the cross beam and cover to the slide. In one form the retaining assembly includes a flexible compliant cover member, which is permeable to gas but non-permeable to liquid, for forming a closed liquid space adjacent a flat surface, a cross beam member enclosing the cover member to form a closed gas space therebetween, the periphery of the liquid space and of the gas space being sealed, and a pressure differential being established whereby the pressure in the liquid space is greater than the pressure in the gas space.

    摘要翻译： 用于扩增制备的细胞或组织样品中所含核酸的完整原位PCR系统。 用于PCR样品的容纳系统包括玻璃显微镜载玻片，含有安装在载玻片上的靶核酸序列的样本样本，样品上的柔性塑料盖，以及固定到载玻片和保护盖的保持组件， 在热循环期间将反应混合物密封在样品上。 保持组件包括在盖的边缘部分上的刚性环，具有由相对的平坦端连接的间隔开的平行轨道的横梁和被压在滑块的端部和相对侧上的一对夹子，以将横梁 并覆盖到幻灯片。 在一种形式中，保持组件包括柔性顺应性盖构件，其可透气且不透液体，用于形成邻近平坦表面的封闭液体空间;横梁构件，其围绕盖构件以形成封闭气体空间 在此之间，液体空间和气体空间的周边被密封，并且建立压力差，由此液体空间中的压力大于气体空间中的压力。

    OPTICAL RESONANCE ANALYSIS UNIT
    10.
    发明申请
    OPTICAL RESONANCE ANALYSIS UNIT 审中-公开
    光学谐振分析单元

    公开(公告)号：US20090213382A1

    公开(公告)日：2009-08-27

    申请号：US12330930

    申请日：2008-12-09

    申请人： David H. Tracy ,  Jennifer M. Brockman ,  Keith S. Ferrara ,  Martin Shenker ,  Robert Kersten ,  Steven E. Cohen ,  Gary Bodley ,  Patrick Tuxbury ,  Paul Hetherington ,  Enrico Picozza

    发明人： David H. Tracy ,  Jennifer M. Brockman ,  Keith S. Ferrara ,  Martin Shenker ,  Robert Kersten ,  Steven E. Cohen ,  Gary Bodley ,  Patrick Tuxbury ,  Paul Hetherington ,  Enrico Picozza

    IPC分类号： G01N21/55

    CPC分类号： G01N21/553 ,  G01N21/253 ,  G01N21/7743 ,  Y10T137/86035

    摘要： An array surface plasmon resonance (SPR) analysis instrument comprising a reflective SPR sensor array, a light source assembly arranged to project a collimated beam of light onto the reflective SPR sensor array to provide a reflected array image of the sensor array, and to scan the incident angle of the collimated beam of light over an angular range, and a detector assembly oriented to receive the reflected array image of the sensor array over the angular range, the detector assembly comprises a two-dimensional detector sensing element that is tilted with respect to the optical axis of the lens assembly in accordance with the Scheimpflug condition, and a lens assembly for focusing the reflected array image of said SPR sensor array onto said tilted detector sensing element. The lens assembly comprises an objective section which is arranged to produce a virtual image of the tilted reflected array at infinity, followed by an imaging section arranged to transform the virtual image of the tilted reflected array into a real tilted image on the tilted detector sensing element.

    摘要翻译： 阵列表面等离子体共振（SPR）分析仪器，其包括反射SPR传感器阵列，光源组件，被布置成将准直光束投射到反射SPR传感器阵列上，以提供传感器阵列的反射阵列图像，并扫描 在角度范围内的准直光束的入射角以及定向成在角度范围内接收传感器阵列的反射阵列图像的检测器组件，检测器组件包括二维检测器感测元件，其相对于 根据Scheimpflug条件的透镜组件的光轴，以及用于将所述SPR传感器阵列的反射阵列图像聚焦到所述倾斜检测器感测元件上的透镜组件。 透镜组件包括物镜部分，该物镜部分布置成产生无限远的倾斜反射阵列的虚像，随后是成像部分，被配置为将倾斜的反射阵列的虚像转换成倾斜检测器感测元件上的实际倾斜图像 。