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    Phytase variants
    5.
    发明授权
    Phytase variants 有权
    植酸酶变体

    公开(公告)号：US08460656B2

    公开(公告)日：2013-06-11

    申请号：US12294526

    申请日：2007-03-19

    申请人： Leonardo De Maria ,  Carsten Andersen ,  Lars Kobberoee Skov ,  Mikael Blom Soerensen

    发明人： Leonardo De Maria ,  Carsten Andersen ,  Lars Kobberoee Skov ,  Mikael Blom Soerensen

    IPC分类号： A61K38/46 ,  C12N9/00

    CPC分类号： C12N9/16 ,  A23K20/189 ,  C12Y301/03

    摘要： The present invention relates to a phytase which has at least 80% identity to a phytase derived from Citrobacter braakii and comprises at least one alteration when compared to this phytase. These phytase variants have amended, preferably improved, properties, such as thermostability, temperature profile, pH profile, specific activity, performance in animal feed, reduced protease sensitiliby, and/or an amended glycosylation pattern. The invention also relates to DNA encoding these phytases, methods of their production, as well as the use thereof, e.g. in animal feed and animal feed additives.

    摘要翻译： 本发明涉及一种植酸酶，其与来自柠檬酸杆菌的植酸酶具有至少80％的同一性，并且与该植酸酶相比包含至少一个变化。 这些植酸酶变体具有修饰，优选改进的性质，例如热稳定性，温度曲线，pH曲线，比活性，动物饲料中的性能，降低的蛋白酶敏感性和/或修饰的糖基化模式。 本发明还涉及编码这些植酸酶的DNA，其生产方法及其用途，例如， 在动物饲料和动物饲料添加剂中。

    PHYTASE VARIANTS
    6.
    发明申请
    PHYTASE VARIANTS 有权

    公开(公告)号：US20110258714A1

    公开(公告)日：2011-10-20

    申请号：US12294526

    申请日：2007-03-19

    申请人： Leonardo De Maria ,  Carsten Andersen ,  Lars Kobberoee Skov ,  Mikael Blom Soerensen

    发明人： Leonardo De Maria ,  Carsten Andersen ,  Lars Kobberoee Skov ,  Mikael Blom Soerensen

    IPC分类号： A01K67/00 ,  C12N15/63 ,  C12N5/10 ,  C07H21/00 ,  A23L1/304 ,  A01H5/00 ,  A23K1/16 ,  A23K1/18 ,  A23L1/29 ,  A23L1/302 ,  C12N9/16 ,  C12N1/00

    CPC分类号： C12N9/16 ,  A23K20/189 ,  C12Y301/03

    摘要： The present invention relates to a phytase which has at least 74% identity to a phytase derived from Citrobacter braakii and comprises at least one alteration as compared to this phytase. These phytase variants have amended, preferably improved, properties, such as thermostability, temperature profile, pH profile, specific activity, performance in animal feed, reduced protease sensitiliby, and/or an amended glycosylation pattern. The invention also relates to DNA encoding these phytases, methods of their production, as well as the use thereof, e.g. in animal feed and animal feed additives.

    摘要翻译： 本发明涉及一种植酸酶，其与来自柠檬酸杆菌的植酸酶具有至少74％的同一性，并且与该植酸酶相比包含至少一个改变。 这些植酸酶变体具有修饰，优选改进的性质，例如热稳定性，温度曲线，pH曲线，比活性，动物饲料中的性能，降低的蛋白酶敏感性和/或修饰的糖基化模式。 本发明还涉及编码这些植酸酶的DNA，其生产方法及其用途，例如， 在动物饲料和动物饲料添加剂中。

    Method of providing fast relief to a user of a nicotine chewing gum
    9.
    发明授权
    Method of providing fast relief to a user of a nicotine chewing gum 有权
    向尼古丁口香糖使用者提供快速释放的方法

    公开(公告)号：US08858919B2

    公开(公告)日：2014-10-14

    申请号：US13963480

    申请日：2013-08-09

    申请人： Carsten Andersen

    发明人： Carsten Andersen

    IPC分类号： A61K9/58 ,  A61K31/465 ,  A61K9/68

    CPC分类号： A61K31/465 ,  A61K9/0058

    摘要： The invention relates to a method of relieving nicotine craving comprising the steps of providing at least one chewing gum comprising tobacco alkaloid to a user, providing relief of nicotine craving to said user by transferring of tobacco alkaloid from the chewing gum to the human body of said user by chewing of said chewing gum, said chewing of said chewing gum comprising a chewing process involving a transfer of tobacco alkaloid from said chewing gum above a threshold transfer rate in the period of about ½ minute to about 2½ minutes from initiation of said chewing process.

    摘要翻译： 本发明涉及一种减轻尼古丁渴望的方法，包括以下步骤：向使用者提供包含烟草生物碱的至少一种口香糖，通过将烟草生物碱从口香糖转移到所述口腔内的人体，使所述使用者缓解尼古丁渴望 所述咀嚼口咀嚼所述口香糖，所述咀嚼口香糖包括咀嚼方法，所述咀嚼方法涉及在所述咀嚼过程开始之后约1/2分钟至约2.5分钟的时间内从所述口香糖转移烟草生物碱高于阈值转移速率 。

    Nicotine delivery product and method for producing it
    10.
    发明授权
    Nicotine delivery product and method for producing it 有权
    尼古丁递送产品及其生产方法

    公开(公告)号：US08741935B2

    公开(公告)日：2014-06-03

    申请号：US10581628

    申请日：2004-12-02

    申请人： Carsten Andersen

    发明人： Carsten Andersen

    IPC分类号： A61K9/68 ,  A61K31/4439 ,  A61P25/34

    CPC分类号： A24B15/10 ,  A24B15/287 ,  A61K9/0058 ,  A61K31/465 ,  A61K47/10 ,  A61K47/585

    摘要： A nicotine delivery product comprising the reaction product of a nicotine/cation exchange resin complex and an organic polyol; and a method for preparing it comprising (a) mixing an aqueous suspension of a nicotine/cation exchange resin complex with an organic polyol or an aqueous solution thereof, and (b) removing water from the mixture to produce said nicotine delivery product. The nicotine delivery product has a nicotine release rate of at least 80% over a 10 minute period. It is particularly suited for use in smoking substitution devices delivering nicotine such as chewing gum, patches, lozenges, melting tablets and tablets for chewing.

    摘要翻译： 尼古丁输送产物，其包含尼古丁/阳离子交换树脂复合物和有机多元醇的反应产物; 及其制备方法，包括（a）将尼古丁/阳离子交换树脂配合物的水悬浮液与有机多元醇或其水溶液混合，和（b）从混合物中除去水以产生所述尼古丁递送产物。 尼古丁递送产品在10分钟内具有至少80％的尼古丁释放率。 它特别适用于提供尼古丁的吸烟替代装置，例如口香糖，贴剂，锭剂，熔化片和片剂用于咀嚼。