-
公开(公告)号：US20050234232A1
公开(公告)日：2005-10-20
申请号：US10966174
申请日：2005-04-14
申请人： Leonid Beigelman , Jasenka Matulic-Adamic , Alexander Karpeisky , Peter Haeberli , David Sweedler , Mark Reynolds , Nilabh Chaudhary , John Min
发明人： Leonid Beigelman , Jasenka Matulic-Adamic , Alexander Karpeisky , Peter Haeberli , David Sweedler , Mark Reynolds , Nilabh Chaudhary , John Min
IPC分类号： A61K47/48 , C07C237/06 , C07C237/22 , C07C279/04 , C07C279/12 , C07C279/14 , C07D213/64 , C07H19/06 , C07J1/00 , C07J41/00 , C07J43/00 , C07J51/00 , C12N15/88
CPC分类号： C07D213/64 , A61K47/54 , A61K47/542 , A61K47/543 , C07C237/06 , C07C237/22 , C07C279/04 , C07C279/12 , C07C279/14 , C07H19/06 , C07J1/00 , C07J41/0005 , C07J43/003 , C07J51/00 , C12N15/88
摘要： This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAS, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.
摘要翻译： 本发明的特征在于渗透性增强剂分子和方法，以提高各种分子如核酸，多核苷酸，寡核苷酸，酶核酸分子，反义核酸分子，2-5A反义嵌合体，形成三链体的寡核苷酸，诱饵RNAS， dsRNA，siRNA，适体或含有核酸切割化学基团，肽，多肽，蛋白质，碳水化合物，类固醇，金属和小分子的反义核酸，从而促进这些分子的细胞摄取。
-
公开(公告)号：US07553830B2
公开(公告)日：2009-06-30
申请号：US10966174
申请日：2005-04-14
申请人： Leonid Beigelman , Jasenka Matulic-Adamic , Alexander Karpeisky , Peter Haeberli , David Sweedler , Mark Reynolds , Nilabh Chaudhary , John Min
发明人： Leonid Beigelman , Jasenka Matulic-Adamic , Alexander Karpeisky , Peter Haeberli , David Sweedler , Mark Reynolds , Nilabh Chaudhary , John Min
CPC分类号： C07D213/64 , A61K47/54 , A61K47/542 , A61K47/543 , C07C237/06 , C07C237/22 , C07C279/04 , C07C279/12 , C07C279/14 , C07H19/06 , C07J1/00 , C07J41/0005 , C07J43/003 , C07J51/00 , C12N15/88
摘要： This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAS, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.
摘要翻译： 本发明的特征在于渗透性增强剂分子和方法，以提高各种分子如核酸，多核苷酸，寡核苷酸，酶核酸分子，反义核酸分子，2-5A反义嵌合体，形成三链体的寡核苷酸，诱饵RNAS， dsRNA，siRNA，适体或含有核酸切割化学基团，肽，多肽，蛋白质，碳水化合物，类固醇，金属和小分子的反义核酸，从而促进这些分子的细胞摄取。
-
公开(公告)号：US06972330B2
公开(公告)日：2005-12-06
申请号：US10431739
申请日：2003-05-08
IPC分类号： C07H19/06 , C07H19/16 , C07H21/00 , C07H19/167
CPC分类号： C07H19/06 , C07H19/16 , C07H21/00 , C12N2310/121
摘要： Process for chemical synthesis of methoxy nucleosides.
摘要翻译： 化学合成甲氧基核苷的方法。
-
4.发明申请Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives 审中-公开合成核苷，核苷衍生物和非核苷衍生物的方法公开(公告)号：US20050059817A1
公开(公告)日：2005-03-17
申请号：US10947954
申请日：2004-09-23
IPC分类号： C07H11/04 , C07H15/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/04 , C07H19/04
摘要： The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2′-amino, 2′-N-phthaloyl, 2′-O-methyl, 2′-0-silyl, 2′-O-triisopropylsilyloxymethyl, 2′-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside derivatives.
摘要翻译： 本发明提供核苷及其衍生物的化学合成方法，包括2'-氨基，2'-N-邻苯二甲酰基，2'-O-甲基，2'-O-甲硅烷基，2'-O-三异丙基甲硅烷氧基甲基，2 '-OH核苷，C-核苷，核苷亚磷酰胺，C-核苷亚磷酰胺和非核苷衍生物。
-
公开(公告)号：US5962675A
公开(公告)日：1999-10-05
申请号：US780008
申请日：1996-12-23
IPC分类号： C07H19/167
CPC分类号： C07H19/167
摘要： Several processes for the chemical synthesis of 2'-O-methoxy purine nucleosides are herein disclosed.
摘要翻译： 本文公开了用于化学合成2'-O-甲氧基嘌呤核苷的几种方法。
-
公开(公告)号：US20100036115A1
公开(公告)日：2010-02-11
申请号：US12470382
申请日：2009-05-21
申请人： Leonid Beigelman , Nilabh Chaudhary , Peter Haeberli , Alexander Karpeisky , Jasenka Matulic-Adamic , John Min , Mark Reynolds , David Sweedler
发明人： Leonid Beigelman , Nilabh Chaudhary , Peter Haeberli , Alexander Karpeisky , Jasenka Matulic-Adamic , John Min , Mark Reynolds , David Sweedler
IPC分类号： C07J43/00
CPC分类号： C07D213/64 , A61K47/54 , A61K47/542 , A61K47/543 , C07C237/06 , C07C237/22 , C07C279/04 , C07C279/12 , C07C279/14 , C07H19/06 , C07J1/00 , C07J41/0005 , C07J43/003 , C07J51/00 , C12N15/88
摘要： This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAs, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.
摘要翻译： 本发明的特征在于渗透性增强剂分子和方法，以增加各种分子如核酸，多核苷酸，寡核苷酸，酶核酸分子，反义核酸分子，2-5A反义嵌合体，形成三链体的寡核苷酸，诱饵RNA， dsRNA，siRNA，适体或含有核酸切割化学基团，肽，多肽，蛋白质，碳水化合物，类固醇，金属和小分子的反义核酸，从而促进这些分子的细胞摄取。
-
7.发明授权Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives 有权合成核苷，核苷衍生物和非核苷衍生物的方法公开(公告)号：US06686463B2
公开(公告)日：2004-02-03
申请号：US09944554
申请日：2001-08-31
IPC分类号： C07H1916
摘要： The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2′-amino, 2′-N-phthaloyl, 2′-O-methyl, 2′-O-silyl, 2′-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside derivatives.
摘要翻译： 本发明提供了用于化学合成核苷及其衍生物的方法，包括2'-氨基，2'-N-邻苯二甲酰基，2'-O-甲基，2'-O-甲硅烷基，2'-OH核苷，C- 核苷亚磷酰胺，核苷亚磷酰胺和非核苷衍生物。
-
公开(公告)号：US20050176018A1
公开(公告)日：2005-08-11
申请号：US10715285
申请日：2003-11-17
申请人： James Thompson , Leonid Beigelman , James McSwiggen , Alexander Karpeisky , Laurent Bellon , Mark Reynolds , Michael Zwick , Thale Jarvis , Tod Woolf , Peter Haeberli , Jasenka Matulic-Adamic
发明人： James Thompson , Leonid Beigelman , James McSwiggen , Alexander Karpeisky , Laurent Bellon , Mark Reynolds , Michael Zwick , Thale Jarvis , Tod Woolf , Peter Haeberli , Jasenka Matulic-Adamic
IPC分类号： C12N15/09 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P5/30 , A61P35/00 , C12N5/10 , C12N9/00 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , A61K38/00 , C12N15/1135 , C12N15/1138 , C12N2310/15 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/332 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3521 , C12N2310/3527
摘要： This invention relates to novel chemically-modified nucleic acid molecules having specified formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using the novel chemically modified nucleic acid molecules, and compositions and cells comprising said molecules.
摘要翻译： 本发明涉及具有特异性结构的新型化学修饰的核酸分子，其表现出对核酸酶的增加的抗性并增加与靶核酸分子的结合亲和力。 本发明还涉及使用新的化学修饰的核酸分子调节基因表达的方法，以及包含所述分子的组合物和细胞。
-
9.发明授权Nucleic acid molecules with novel chemical compositions capable of modulating gene expression 有权具有能够调节基因表达的新化学成分的核酸分子公开(公告)号：US06673611B2
公开(公告)日：2004-01-06
申请号：US09866316
申请日：2001-05-25
申请人： James Thompson , Leonid Beigelman , James McSwiggen , Alexander Karpeisky , Laurent Bellon , Mark Reynolds , Michael Zwick , Thale Jarvis , Tod Woolf , Peter Haeberli , Jasenka Matulic-Adamic
发明人： James Thompson , Leonid Beigelman , James McSwiggen , Alexander Karpeisky , Laurent Bellon , Mark Reynolds , Michael Zwick , Thale Jarvis , Tod Woolf , Peter Haeberli , Jasenka Matulic-Adamic
IPC分类号： C12Q168
CPC分类号： C12N15/113 , A61K38/00 , C12N15/1135 , C12N15/1138 , C12N2310/15 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/332 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3521 , C12N2310/3527
摘要： This invention relates to novel chemically-modified nucleic acid molecules having specific formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using the novel chemically modified nucleic acid molecules, and compositions and cells comprising said molecules.
摘要翻译： 本发明涉及具有特异性结构的新化学修饰的核酸分子，其表现出对核酸酶的增加的抗性和增加的对靶核酸分子的结合亲和力。 本发明还涉及使用新的化学修饰的核酸分子调节基因表达的方法，以及包含所述分子的组合物和细胞。
-
公开(公告)号：US06395713B1
公开(公告)日：2002-05-28
申请号：US09120520
申请日：1998-07-21
申请人： Leonid Beigelman , Jasenka Matulic-Adamic , Alex Karpeisky , Peter Haeberli , David Sweedler , Mark Reynolds , Nilabh Chaudhary , John Min
发明人： Leonid Beigelman , Jasenka Matulic-Adamic , Alex Karpeisky , Peter Haeberli , David Sweedler , Mark Reynolds , Nilabh Chaudhary , John Min
IPC分类号： A01N4304
CPC分类号： C07D213/64 , A61K47/54 , A61K47/542 , A61K47/543 , C07C237/06 , C07C237/22 , C07C279/04 , C07C279/12 , C07C279/14 , C07H19/06 , C07J41/0005 , C07J43/003 , C07J51/00 , C12N15/88
摘要： This invention features permeability enhancer molecules, and methods, to increase membrane permeability of negatively charged polymers thereby facilitating cellular uptake of such polymers.
摘要翻译： 本发明的特征在于渗透性增强剂分子和方法，以提高带负电荷的聚合物的膜渗透性，从而促进这些聚合物的细胞摄取。
-
-
-
-
-
-
-
-
-
搜索结果
56 条记录 (耗时 0.028 秒)
