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    Immune-derived moieties reactive against lysophosphatidic acid
    3.
    发明授权
    Immune-derived moieties reactive against lysophosphatidic acid 有权
    对溶血磷脂酸具有反应性的免疫衍生部分

    公开(公告)号：US09217749B2

    公开(公告)日：2015-12-22

    申请号：US11755721

    申请日：2007-05-30

    申请人： Roger A. Sabbadini ,  William A. Garland ,  Genevieve Hansen

    发明人： Roger A. Sabbadini ,  William A. Garland ,  Genevieve Hansen

    IPC分类号： G01N33/92 ,  C07K16/18 ,  C07K16/30 ,  C12P21/08 ,  A61K47/48 ,  A61K39/00

    CPC分类号： G01N33/92 ,  A61K47/544 ,  A61K47/60 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/74

    摘要： Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1-phosphate) in which a carbon atom has been derivatized with a pendant reactive group; immunogens made by linking a derivatized lipid to a carrier moiety (e.g., a carrier protein, polyethylene glycol, colloidal gold, alginate, or a silicone bead); monoclonal antibodies and derivatives produced by immunizing an animal with such an immunogen; and therapeutic and diagnostic compositions containing such antibodies and antibody derivatives. Methods for making such derivatized lipids, immunogens, and monoclonal antibodies and derivatives, methods for detecting such antibodies once generated, and therapeutic and diagnostic methods for using such antibodies and derivatives, are also described.

    摘要翻译： 描述了用于产生针对生物活性脂质靶标的反应性的单克隆抗体及其衍生物的组合物和方法。 这些组合物包括衍生的脂质，其各自包含具有极性头基团和至少一个烃链的生物活性脂质（例如溶血磷脂酸或鞘氨醇-1-磷酸酯等溶血磷脂酸或鞘氨醇-1-磷酸酯），其中碳原子已被衍生化， 吊坠反应组; 通过将衍生的脂质与载体部分（例如载体蛋白，聚乙二醇，胶体金，藻酸盐或硅酮珠）连接而制备的免疫原; 通过用这种免疫原免疫动物产生的单克隆抗体和衍生物; 以及含有此类抗体和抗体衍生物的治疗和诊断组合物。 还描述了制备这种衍生化脂质，免疫原和单克隆抗体及其衍生物的方法，一旦产生的检测此类抗体的方法，以及使用这些抗体和衍生物的治疗和诊断方法。

    Immune-Derived Moieties Reactive Against Bioactive Lipids, and Methods of Making and Using Same
    4.
    发明申请
    Immune-Derived Moieties Reactive Against Bioactive Lipids, and Methods of Making and Using Same 审中-公开
    对生物活性脂类有反应活性的免疫衍生物及其制备和使用方法

    公开(公告)号：US20080138334A1

    公开(公告)日：2008-06-12

    申请号：US11755485

    申请日：2007-05-30

    申请人： Roger A. SABBADINI ,  William A. Garland ,  Genevieve Hansen

    发明人： Roger A. SABBADINI ,  William A. Garland ,  Genevieve Hansen

    IPC分类号： A61K39/395 ,  C07K16/18

    CPC分类号： G01N33/92 ,  A61K47/544 ,  A61K47/60 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/74

    摘要： Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1-phosphate) in which a carbon atom has been derivatized with a pendant reactive group; immunogens made by linking a derivatized lipid to a carrier moiety (e.g., a carrier protein, polyethylene glycol, colloidal gold, alginate, or a silicone bead); monoclonal antibodies and derivatives produced by immunizing an animal with such an immunogen; and therapeutic and diagnostic compositions containing such antibodies and antibody derivatives. Methods for making such derivatized lipids, immunogens, and monoclonal antibodies and derivatives, methods for detecting such antibodies once generated, and therapeutic and diagnostic methods for using such antibodies and derivatives, are also described.

    摘要翻译： 描述了用于产生针对生物活性脂质靶标的反应性的单克隆抗体及其衍生物的组合物和方法。 这些组合物包括衍生的脂质，其各自包含具有极性头基团和至少一个烃链的生物活性脂质（例如溶血磷脂酸或鞘氨醇-1-磷酸酯等溶血磷脂酸或鞘氨醇-1-磷酸酯），其中碳原子已被衍生化， 吊坠反应组; 通过将衍生的脂质与载体部分（例如载体蛋白，聚乙二醇，胶体金，藻酸盐或硅酮珠）连接而制备的免疫原; 通过用这种免疫原免疫动物产生的单克隆抗体和衍生物; 以及含有此类抗体和抗体衍生物的治疗和诊断组合物。 还描述了制备这种衍生化脂质，免疫原和单克隆抗体及其衍生物的方法，一旦产生的检测此类抗体的方法，以及使用这些抗体和衍生物的治疗和诊断方法。

    In vitro screening and evolution of proteins
    6.
    发明申请
    In vitro screening and evolution of proteins 审中-公开
    蛋白质的体外筛选和进化

    公开(公告)号：US20090099033A1

    公开(公告)日：2009-04-16

    申请号：US11890345

    申请日：2007-08-06

    申请人： Jeffrey Rogers ,  Genevieve Hansen

    发明人： Jeffrey Rogers ,  Genevieve Hansen

    IPC分类号： C40B30/04 ,  C12Q1/68

    CPC分类号： C12N15/1055 ,  C12N15/1075

    摘要： The present invention provides a composition which links genotype and phenotype and provides a method for in vitro protein evolution and screening using said composition. The invention also facilitates the identification and isolation of proteins with selected properties from large pools of proteins. The composition and method of the invention can be used with eukaryotic (both mammalian and plant) and prokaryotic translation systems.

    摘要翻译： 本发明提供了一种组合物，其连接基因型和表型，并提供使用所述组合物进行体外蛋白质进化和筛选的方法。 本发明还有助于鉴定和分离来自大量蛋白质的选定性质的蛋白质。 本发明的组合物和方法可以与真核生物（哺乳动物和植物）和原核翻译系统一起使用。