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公开(公告)号：US6139817A
公开(公告)日：2000-10-31
申请号：US10523
申请日：1998-01-21
IPC分类号： A01K67/00 , C07K14/31 , C12N1/15 , C12N1/21 , C12N15/09 , C12N15/113 , C12N15/63 , C12N15/74 , C12Q1/68 , G01N33/53 , G01N33/566 , A61K49/00
CPC分类号： C12N15/113 , C07K14/31 , C12N15/63 , C12N15/74 , C12Q1/6897 , C12N2310/111
摘要： The present invention provides a method for determining pathogen sensitivity to varying levels of reduction of a gene product using an expression vector system having a promoter that is essentially off in vitro and turns on selectively during the infection process in vivo. Genes and gene products identified by this method as essential to growth of infection of a selected pathogen are also provided. In addition, therapeutic compositions designed to target genes identified by this method are provided.
摘要翻译： 本发明提供了一种使用具有在体外基本上关闭的启动子并且在体内感染过程中选择性导通的表达载体系统来确定对不同水平的基因产物的病原体敏感性的方法。 还提供了通过该方法鉴定的对所选病原体的感染生长至关重要的基因和基因产物。 另外，提供了旨在靶向通过该方法鉴定的基因的治疗组合物。
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公开(公告)号：US07422749B2
公开(公告)日：2008-09-09
申请号：US11698250
申请日：2007-01-25
申请人： Michael T. Black , Martin K. Burnham , Jason C. Fedon , John E. Hodgson , David J. Knowles , Michael A. Lonetto , Richard O. Nicholas , Leslie M. Palmer , Julie M. Pratt , Raymond W. Reichard , Martin Rosenberg , Christopher M. Traini , Judith Ward , Richard L. Warren
发明人： Michael T. Black , Martin K. Burnham , Jason C. Fedon , John E. Hodgson , David J. Knowles , Michael A. Lonetto , Richard O. Nicholas , Leslie M. Palmer , Julie M. Pratt , Raymond W. Reichard , Martin Rosenberg , Christopher M. Traini , Judith Ward , Richard L. Warren
CPC分类号： C12N9/0036 , A61K38/00 , A61K39/00 , C07K14/31 , C07K16/1275 , C07K2319/00 , C12N9/78 , C12N15/52 , C12Q1/689 , C12Q2600/158 , C12Y105/0103 , C12Y305/04025
摘要： This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
摘要翻译： 本发明涉及新鉴定的葡萄球菌多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这些多核苷酸和多肽的产生以及用多核苷酸转化的重组宿主细胞。 本发明还涉及抑制这些多核苷酸或多肽的生物合成或作用以及这种抑制剂在治疗中的用途。
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公开(公告)号：US06511839B1
公开(公告)日：2003-01-28
申请号：US09591041
申请日：2000-06-09
申请人： Pan Fong Chan , Sanjoy Biswas , David J. Holmes , Michael A. Lonetto , Leslie M. Palmer , Stephanie Van Horn , Richard L. Warren, Jr. , Magdalena Zalacain
发明人： Pan Fong Chan , Sanjoy Biswas , David J. Holmes , Michael A. Lonetto , Leslie M. Palmer , Stephanie Van Horn , Richard L. Warren, Jr. , Magdalena Zalacain
IPC分类号： C12N1511
CPC分类号： C12N9/1205 , A61K38/00
摘要： The invention provides fucose kinase promoter polynucleotides and methods for producing and using such polynucleotides, as well as their variants, agonists and antagonists, and their uses.
摘要翻译： 本发明提供岩藻糖激酶启动子多核苷酸以及用于产生和使用这些多核苷酸的方法及其变体，激动剂和拮抗剂及其用途。
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公开(公告)号：US06274139B1
公开(公告)日：2001-08-14
申请号：US09340479
申请日：1999-06-30
IPC分类号： A61K3851
摘要： Topoisomerase I polypeptides and DNA and RNA encoding such Topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase I for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase I and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase I and for detecting the polypeptide in a host.
摘要翻译： 公开了拓扑异构酶I多肽和编码这种拓扑异构酶I多肽的DNA和RNA以及通过重组技术产生这种多肽的方法。 还公开了利用这种拓扑异构酶I来治疗感染，特别是细菌感染的方法。 还公开了抗这种拓扑异构酶I的拮抗剂及其用作治疗感染，特别是细菌感染的治疗剂。 还公开了用于检测与宿主中拓扑异构酶I核酸序列和多肽的存在相关的疾病的诊断测定。 还公开了用于检测编码葡萄球菌拓扑异构酶I的多核苷酸并用于检测宿主中的多肽的诊断测定。
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公开(公告)号：US6156310A
公开(公告)日：2000-12-05
申请号：US310669
申请日：1999-05-12
IPC分类号： G01N33/50 , A61K38/00 , A61K38/45 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/04 , C07K16/40 , C12N9/90 , C12N15/00 , C12N15/09 , C12N15/61 , C12Q1/68 , C12R1/445 , G01N33/566 , G01N33/573 , A61K38/51 , C07K1/00
CPC分类号： C12N9/90 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Topoisomerase III polypeptides and DNA and RNA encoding such Topoisomerase III polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase III for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase III and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase III nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase III and for detecting the polypeptide in a host.
摘要翻译： 拓扑异构酶III多肽和编码这种拓扑异构酶III多肽的DNA和RNA以及通过重组技术产生此类多肽的方法。 还公开了利用这种拓扑异构酶III来治疗感染，特别是细菌感染的方法。 还公开了抗这种拓扑异构酶III的拮抗剂及其用作治疗感染，特别是细菌感染的治疗剂。 还公开了用于检测与宿主中拓扑异构酶III核酸序列和多肽的存在相关的疾病的诊断测定。 还公开了用于检测编码葡萄球菌拓扑异构酶III的多核苷酸并用于检测宿主中的多肽的诊断测定法。
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公开(公告)号：US6025156A
公开(公告)日：2000-02-15
申请号：US949588
申请日：1997-10-14
IPC分类号： G01N33/50 , A61K38/00 , A61K38/45 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/04 , C07K16/40 , C12N9/90 , C12N15/00 , C12N15/09 , C12N15/61 , C12Q1/68 , C12R1/445 , G01N33/566 , G01N33/573 , C07H21/04
CPC分类号： C12N9/90 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Topoisomerase III polypeptides and DNA and RNA encoding such Topoisomerase III polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase III for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase III and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase III nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase III and for detecting the polypeptide in a host.
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公开(公告)号：US6013505A
公开(公告)日：2000-01-11
申请号：US946475
申请日：1997-10-07
IPC分类号： G01N33/53 , A61K38/00 , A61K38/45 , A61K38/55 , A61K39/00 , A61K48/00 , A61P31/04 , C07K14/81 , C12N5/00 , C12N5/10 , C12N9/90 , C12N15/09 , C12N15/61 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/531 , G01N33/566 , C07H21/04
摘要： Topoisomerase I polypeptides and DNA and RNA encoding such Topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase I for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase I and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase I and for detecting the polypeptide in a host.
摘要翻译： 公开了拓扑异构酶I多肽和编码这种拓扑异构酶I多肽的DNA和RNA以及通过重组技术产生这种多肽的方法。 还公开了利用这种拓扑异构酶I来治疗感染，特别是细菌感染的方法。 还公开了抗这种拓扑异构酶I的拮抗剂及其用作治疗感染，特别是细菌感染的治疗剂。 还公开了用于检测与宿主中拓扑异构酶I核酸序列和多肽的存在相关的疾病的诊断测定。 还公开了用于检测编码葡萄球菌拓扑异构酶I的多核苷酸并用于检测宿主中的多肽的诊断测定。
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