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    Method for coating metal implants with therapeutic mixtures
    1.
    发明授权
    Method for coating metal implants with therapeutic mixtures 有权
    用治疗性混合物涂覆金属植入物的方法

    公开(公告)号：US08765211B2

    公开(公告)日：2014-07-01

    申请号：US13254569

    申请日：2010-03-31

    申请人： Liam O'Neill ,  Caroline O'Sullivan

    发明人： Liam O'Neill ,  Caroline O'Sullivan

    IPC分类号： A61L33/00

    CPC分类号： A61L27/56 ,  A61L27/04 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/606

    摘要： Disclosed herein are methods of treating an article surface. The method comprises delivering a polymer and drug to a medical implant having a porous surface and using at least one particle stream from at least one fluid jet to subsequently remove the polymer from the outer surface of the metal substrate, thereby retaining the therapeutic agent and polymer within the pores of the implant.

    摘要翻译： 本文公开了处理制品表面的方法。 该方法包括将聚合物和药物递送到具有多孔表面的医用植入物上，并使用至少一种来自至少一种流体射流的颗粒物流，随后从金属基底的外表面除去聚合物，由此保留治疗剂和聚合物 在植入物的孔内。

    METHOD FOR COATING METAL IMPLANTS WITH THERAPEUTIC MIXTURES
    2.
    发明申请
    METHOD FOR COATING METAL IMPLANTS WITH THERAPEUTIC MIXTURES 有权
    用治疗性混合物涂覆金属植入物的方法

    公开(公告)号：US20120135133A1

    公开(公告)日：2012-05-31

    申请号：US13254569

    申请日：2010-03-31

    申请人： Liam O'Neill ,  Caroline O'Sullivan

    发明人： Liam O'Neill ,  Caroline O'Sullivan

    IPC分类号： B05D3/06 ,  B05D3/00

    CPC分类号： A61L27/56 ,  A61L27/04 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/606

    摘要： Disclosed herein are methods of treating an article surface. The method comprises delivering a polymer and drug to a medical implant having a porous surface and using at least one particle stream from at least one fluid jet to subsequently remove the polymer from the outer surface of the metal substrate, thereby retaining the therapeutic agent and polymer within the pores of the implant.

    摘要翻译： 本文公开了处理制品表面的方法。 该方法包括将聚合物和药物递送到具有多孔表面的医用植入物上，并使用至少一种来自至少一种流体射流的颗粒物流，随后从金属基底的外表面除去聚合物，由此保留治疗剂和聚合物 在植入物的孔内。

    Plasma System
    3.
    发明申请
    Plasma System 审中-公开
    等离子体系统

    公开(公告)号：US20090142514A1

    公开(公告)日：2009-06-04

    申请号：US11718610

    申请日：2005-11-03

    申请人： Liam O'Neill ,  Peter Dobbyn ,  Frank Swallow ,  Stuart Leadley

    发明人： Liam O'Neill ,  Peter Dobbyn ,  Frank Swallow ,  Stuart Leadley

    IPC分类号： H05H1/24

    CPC分类号： H05H1/46 ,  H05H2001/466 ,  H05H2001/4697 ,  H05H2240/10 ,  H05H2240/20

    摘要： A non-equilibrium atmospheric pressure plasma incorporating an atomised surface treatment agent is generated by applying a radio frequency high voltage to at least one electrode positioned within a dielectric housing while causing a process gas to flow from the inlet of the housing past the electrode to the outlet. The voltage applied is sufficiently high to generate a non-equilibrium atmospheric pressure plasma extending from the electrode at least to the outlet of the housing. The electrode may be combined with an atomiser for the surface treatment agent within the housing. The electrode may comprise a radioactive material. The surface to be treated can be positioned adjacent to the plasma outlet so that the surface is in contact with the plasma, and moved relative to the plasma outlet.

    摘要翻译： 通过对位于电介质外壳内的至少一个电极施加射频高压来产生包含雾化表面处理剂的非平衡大气压等离子体，同时使处理气体从壳体的入口流过电极至 出口。 施加的电压足够高以产生从电极至少延伸到壳体的出口的非平衡大气压力等离子体。 电极可以与壳体内的表面处理剂的雾化器结合。 电极可以包括放射性材料。 待处理的表面可以位于等离子体出口附近，使得表面与等离子体接触并且相对于等离子体出口移动。

    Coating Compositions
    4.
    发明申请
    Coating Compositions 审中-公开
    涂料组合物

    公开(公告)号：US20080118734A1

    公开(公告)日：2008-05-22

    申请号：US11569100

    申请日：2005-05-13

    申请人： Andrew James Goodwin ,  Stuart Robert Leadley ,  Liam O'Neill ,  Paul John Duffield ,  Malcolm Tom McKechnie ,  Simon Pugh

    发明人： Andrew James Goodwin ,  Stuart Robert Leadley ,  Liam O'Neill ,  Paul John Duffield ,  Malcolm Tom McKechnie ,  Simon Pugh

    IPC分类号： C23C16/513

    CPC分类号： B05D1/62 ,  Y10T428/249921

    摘要： A method for forming an active material containing coating on a substrate, which method comprises the steps of: i) introducing one or more gaseous or atomised liquid and/or solid coating-forming materials which undergo chemical bond forming reactions within a plasma environment and one or more active materials which substantially do not undergo chemical bond forming reactions within a plasma environment, into an atmospheric or low pressure non-thermal equilibrium plasma discharge and/or an excited gas stream resulting therefrom, and ii) exposing the substrate to the resulting mixture of atomised coating-forming and at least one active material which are deposited onto the substrate surface to form a coating; wherein the substrate is not a wipe, cloth or sponge for household care or depilatory care or a water solute household cleaning unit dose product.

    摘要翻译： 一种在基材上形成含有活性材料的涂层的方法，该方法包括以下步骤：i）在等离子体环境中引入一种或多种经过化学键形成反应的气态或雾化液体和/或固体涂层形成材料， 或更多的活性材料，其基本上不在等离子体环境内经历化学键形成反应，进入大气压或低压非热平衡等离子体放电和/或由其产生的激发气流，以及ii）将基底暴露于所得混合物 的雾化涂层形成和至少一种活性材料，其沉积在基材表面上以形成涂层; 其中所述基底不是用于家庭护理或脱毛护理的擦拭物，布或海绵或水溶性家用清洁单元剂量产品。

    Method for coating a substrate using plasma
    6.
    发明授权
    Method for coating a substrate using plasma 失效
    使用等离子体涂覆基板的方法

    公开(公告)号：US08178168B2

    公开(公告)日：2012-05-15

    申请号：US11577914

    申请日：2005-10-12

    申请人： Liam O'Neill ,  Lesley Ann O'Hare ,  Andrew James Goodwin

    发明人： Liam O'Neill ,  Lesley Ann O'Hare ,  Andrew James Goodwin

    IPC分类号： C08J7/16

    CPC分类号： D06M14/18 ,  B05D1/02 ,  B05D1/62 ,  B05D3/142 ,  B05D3/144 ,  D06M10/025

    摘要： A method for forming a polymeric coating on a substrate surface, by plasma treating a mixture comprising a free-radical initiated polymerisable monomer having one or more free-radical polymerisable groups in the presence of a free radical initiator, wherein said plasma treatment is a soft ionisation plasma process (a process wherein precursor molecules are not fragmented during the plasma process and as a consequence, the resulting polymeric coating has the physical properties of the precursor or bulk polymer) aid depositing the resulting polymeric coating material onto a substrate surface.

    摘要翻译： 通过在自由基引发剂的存在下，通过等离子体处理含有具有一个或多个自由基可聚合基团的自由基引发的可聚合单体的混合物在基材表面上形成聚合物涂层的方法，其中所述等离子体处理是软的 电离等离子体工艺（其中前体分子在等离子体工艺期间不分裂的过程，因此所得聚合物涂层具有前体或本体聚合物的物理性质）有助于将所得聚合物涂层材料沉积到基底表面上。

    Plasma System
    7.
    发明申请
    Plasma System 审中-公开
    等离子体系统

    公开(公告)号：US20090065485A1

    公开(公告)日：2009-03-12

    申请号：US11718618

    申请日：2005-11-03

    申请人： Liam O'Neill ,  Peter Dobbyn ,  Walter Castagna

    发明人： Liam O'Neill ,  Peter Dobbyn ,  Walter Castagna

    IPC分类号： H05H1/24 ,  C23C16/513

    CPC分类号： H05H1/46 ,  H05H2001/466 ,  H05H2001/4697 ,  H05H2240/10 ,  H05H2240/20

    摘要： In a process for plasma treating a surface, a non-equilibrium atmospheric pressure plasma is generated within a dielectric housing having an inlet and an outlet through which a process gas flows from the inlet to the outlet. A tube formed at least partly of dielectric material extends outwardly from the outlet of the housing, whereby the end of the tube forms the plasma outlet. The surface to be treated is positioned adjacent to the plasma outlet so that the surface is in contact with the plasma and is moved relative to the plasma outlet.

    摘要翻译： 在用于等离子体处理表面的过程中，在具有入口和出口的介电壳体内产生非平衡大气压等离子体，工艺气体通过入口和出口从入口流到出口。 至少部分由介电材料形成的管从壳体的出口向外延伸，由此管的端部形成等离子体出口。 待处理的表面位于等离子体出口附近，使得表面与等离子体接触并且相对于等离子体出口移动。

    IMPLANTABLE MEDICAL DEVICES
    10.
    发明申请
    IMPLANTABLE MEDICAL DEVICES 有权
    可植入医疗器械

    公开(公告)号：US20120171354A1

    公开(公告)日：2012-07-05

    申请号：US13315902

    申请日：2011-12-09

    申请人： Liam O'Neill ,  John O'Donoghue

    发明人： Liam O'Neill ,  John O'Donoghue

    IPC分类号： C23C16/50

    CPC分类号： A61L31/14 ,  A61L27/34 ,  A61L27/38 ,  A61L27/50 ,  A61L29/085 ,  A61L29/14 ,  A61L31/10 ,  A61L2400/18 ,  A61L2420/02

    摘要： The present invention is directed to methods for producing a coated substrate, including dissolving at least one biomolecule to form a solution; nebulizing the solution to form a liquid aerosol; combining the liquid aerosol and a plasma to form a coating; and depositing, in the absence of reactive monomers, the coating onto a substrate surface. In an aspect, the substrate can be an implantable medical device.

    摘要翻译： 本发明涉及制备涂覆的基材的方法，包括溶解至少一种生物分子以形成溶液; 将溶液雾化形成液体气溶胶; 组合液体气溶胶和等离子体以形成涂层; 并且在不存在反应性单体的情况下将涂层沉积到基底表面上。 在一方面，基底可以是可植入的医疗装置。