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公开(公告)号：US20060160836A1
公开(公告)日：2006-07-20
申请号：US11334982
申请日：2006-01-18
申请人： Lidia Mosyak , Zhang Xu , Mark Stahl , Wah-Tung Hum , William Somers , Eric Manas
发明人： Lidia Mosyak , Zhang Xu , Mark Stahl , Wah-Tung Hum , William Somers , Eric Manas
IPC分类号： A61K31/473 , A61K31/416 , C07K14/72 , G06F19/00
CPC分类号： C07K14/721 , C07K2299/00
摘要： Estrogen receptor ligands, estrogen receptor polypeptide/ligand complexes, crystals of estrogen receptor polypeptide/ligand complexes, and related methods and software systems are disclosed.
摘要翻译： 雌激素受体配体，雌激素受体多肽/配体配合物，雌激素受体多肽/配体复合物的晶体以及相关方法和软件系统。
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公开(公告)号：US07555415B2
公开(公告)日：2009-06-30
申请号：US11334982
申请日：2006-01-18
申请人： Lidia Mosyak , Zhang Bao Xu , Mark Stahl , Wah-Tung Hum , William Stuart Somers , Eric Steven Manas
发明人： Lidia Mosyak , Zhang Bao Xu , Mark Stahl , Wah-Tung Hum , William Stuart Somers , Eric Steven Manas
CPC分类号： C07K14/721 , C07K2299/00
摘要： Estrogen receptor ligands, estrogen receptor polypeptide/ligand complexes, crystals of estrogen receptor polypeptide/ligand complexes, and related methods and software systems are disclosed.
摘要翻译： 雌激素受体配体，雌激素受体多肽/配体配合物，雌激素受体多肽/配体复合物的晶体以及相关方法和软件系统。
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公开(公告)号：US20060003431A1
公开(公告)日：2006-01-05
申请号：US11099958
申请日：2005-04-06
申请人： Zhang Xu , Stephane Olland , Scott Wolfrom , Karl Malakian , Laura Lin , Mark Stahl , Julie Lee , Lori Fitz , Rita Greco , Divya Chaudhary , William Somers , Lidia Mosyak
发明人： Zhang Xu , Stephane Olland , Scott Wolfrom , Karl Malakian , Laura Lin , Mark Stahl , Julie Lee , Lori Fitz , Rita Greco , Divya Chaudhary , William Somers , Lidia Mosyak
IPC分类号： G06F19/00 , G01N33/48 , G01N33/50 , C12N9/12 , A61K31/553
CPC分类号： C12N9/1205 , C07K2299/00 , C12Q1/485 , G01N33/564 , G01N33/57426 , G01N2500/04
摘要： A three-dimensional structure of protein kinase C theta (PKCθ) can be used in methods of designing an agent that interacts with PKCθ. The agent can be an inhibitor of PKCθ activity.
摘要翻译： 蛋白激酶Cθ（PKCθ）的三维结构可用于设计与PKCθ相互作用的试剂的方法。 该药物可以是PKCθ活性的抑制剂。
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公开(公告)号：US20070274918A1
公开(公告)日：2007-11-29
申请号：US11701635
申请日：2007-02-01
申请人： Lidia Mosyak , Brian Dwyer , Mark Johnson , Xiaotian Zhong , Eleonora Presman , James Wilhelm , Mark Stahl , William Somers
发明人： Lidia Mosyak , Brian Dwyer , Mark Johnson , Xiaotian Zhong , Eleonora Presman , James Wilhelm , Mark Stahl , William Somers
CPC分类号： C07K14/4703 , C07K14/705 , C07K2299/00
摘要： This disclosure relates to LINGO-1 polypeptides, LINGO-1 polypeptide/ligand complexes, crystals of LINGO-1 polypeptides, crystals of LINGO-1 polypeptide/ligand complexes, and related methods and software systems.
摘要翻译： 本公开涉及LINGO-1多肽，LINGO-1多肽/配体复合物，LINGO-1多肽的晶体，LINGO-1多肽/配体复合物的晶体，以及相关方法和软件系统。
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公开(公告)号：US20070048785A1
公开(公告)日：2007-03-01
申请号：US11149025
申请日：2005-06-09
申请人： Laura Lin , Kevin Parris , Amy Sze Tam , Xiang-Yang Tan , Tania Shane , John Dumas , James Wilhelm , Mark Stahl , Lidia Mosyak , Zhixiang Hu
发明人： Laura Lin , Kevin Parris , Amy Sze Tam , Xiang-Yang Tan , Tania Shane , John Dumas , James Wilhelm , Mark Stahl , Lidia Mosyak , Zhixiang Hu
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Anti-IL-13 antibodies, crystals of anti-IL-13 antibodies, IL-13 polypeptide/anti-IL-13 antibody complexes, crystals of IL-13 polypeptide/anti-IL-13 antibody complexes, IL-13Rα1 polypeptide/IL-13 polypeptide/anti-IL-13 antibody complexes, crystals of IL-13Rα1 polypeptide/IL-13 polypeptide/anti-IL-13 antibody complexes, and related methods and software systems are disclosed.
摘要翻译： 抗IL-13抗体，抗IL-13抗体晶体，IL-13多肽/抗IL-13抗体复合物，IL-13多肽/抗IL-13抗体复合物的结晶，IL-13Rα1多肽/ IL -13多肽/抗IL-13抗体复合物，IL-13Rα1多肽/ IL-13多肽/抗IL-13抗体复合物的晶体，以及相关方法和软件系统。
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6.发明授权Method for identifying or designing a candidate agent that interacts with LINGO-1 polypeptide using a LINGO-1 three-dimensional structure 失效使用LINGO-1三维结构识别或设计与LINGO-1多肽相互作用的候选试剂的方法公开(公告)号：US07693698B2
公开(公告)日：2010-04-06
申请号：US11701635
申请日：2007-02-01
申请人： Lidia Mosyak , Brian Dwyer , Mark Johnson , Xiaotian Zhong , Eleonora Presman , James M. Wilhelm , Mark Stahl , William Stuart Somers
发明人： Lidia Mosyak , Brian Dwyer , Mark Johnson , Xiaotian Zhong , Eleonora Presman , James M. Wilhelm , Mark Stahl , William Stuart Somers
CPC分类号： C07K14/4703 , C07K14/705 , C07K2299/00
摘要： This disclosure relates to LINGO-1 polypeptides, LINGO-1 polypeptide/ligand complexes, crystals of LINGO-1 polypeptides, crystals of LINGO-1 polypeptide/ligand complexes, and related methods and software systems.
摘要翻译： 本公开涉及LINGO-1多肽，LINGO-1多肽/配体复合物，LINGO-1多肽的晶体，LINGO-1多肽/配体复合物的晶体，以及相关方法和软件系统。
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公开(公告)号：US20070100560A1
公开(公告)日：2007-05-03
申请号：US11635186
申请日：2006-12-06
申请人： Kevin Parris , Kathryn Underwood , Mark Stahl , Lidia Mosyak , Kristine Svenson , Tania Shane , Meggin Taylor
发明人： Kevin Parris , Kathryn Underwood , Mark Stahl , Lidia Mosyak , Kristine Svenson , Tania Shane , Meggin Taylor
CPC分类号： C12N9/1205 , C07H21/04 , C07K2299/00 , Y02A90/26
摘要： This invention is directed to the crystal structures of MK2, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of MK2 proteins. Such agents may be useful as therapeutic agents.
摘要翻译： 本发明涉及MK2的晶体结构，以及在合理的药物设计方法中使用这些结构来鉴定可能与MK2蛋白的活性位点相互作用的试剂。 这样的试剂可用作治疗剂。
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公开(公告)号：US07584087B2
公开(公告)日：2009-09-01
申请号：US11099958
申请日：2005-04-06
申请人： Zhang Bao Xu , Stephane Olland , Scott Wolfrom , Karl Malakian , Laura Lin , Mark Stahl , Julie Lee , Lori Fitz , Rita Greco , Divya Chaudhary , William Stuart Somers , Lidia Mosyak
发明人： Zhang Bao Xu , Stephane Olland , Scott Wolfrom , Karl Malakian , Laura Lin , Mark Stahl , Julie Lee , Lori Fitz , Rita Greco , Divya Chaudhary , William Stuart Somers , Lidia Mosyak
CPC分类号： C12N9/1205 , C07K2299/00 , C12Q1/485 , G01N33/564 , G01N33/57426 , G01N2500/04
摘要： A three-dimensional structure of human protein kinase C theta (PKCθ) can be used in methods of designing an agent that interacts with PKCθ. The agent can be an inhibitor of PKCθ activity.
摘要翻译： 人蛋白激酶Cθ（PKCθ）的三维结构可用于设计与PKCθ相互作用的试剂的方法中。 该药物可以是PKCθ活性的抑制剂。
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9.发明申请Crystal structure of E.coli GDP-fucose synthetase (and complexes thereof) and methods of identifying agonists and antagonists using same 审中-公开大肠杆菌GDP-岩藻糖合成酶（及其复合物）的晶体结构以及使用其鉴定激动剂和拮抗剂的方法公开(公告)号：US20070038380A1
公开(公告)日：2007-02-15
申请号：US10090879
申请日：2002-03-04
申请人： William Somers , Mark Stahl , Francis Sullivan
发明人： William Somers , Mark Stahl , Francis Sullivan
IPC分类号： C07K14/475 , G06F19/00
CPC分类号： C12N9/0006 , C12N9/90
摘要： The present invention provides for crystalline GFS. The crystal structure of GFS has also been solved using such material. Models based upon such crystal structure are also provided. Methods of identifying inhibitors of GFS activity using such models are also disclosed.
摘要翻译： 本发明提供了结晶GFS。 GFS的晶体结构也使用这种材料得到解决。 还提供了基于这种晶体结构的模型。 还公开了使用这些模型鉴定GFS活性抑制剂的方法。
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公开(公告)号：US10081843B2
公开(公告)日：2018-09-25
申请号：US12856434
申请日：2010-08-13
申请人： Mark Stahl , John Stahl , Richard Stahl
发明人： Mark Stahl , John Stahl , Richard Stahl
CPC分类号： C12Q1/701
摘要： Animal husbandry has always been susceptible to the ravages of pathogenic infections. Poultry flus and cattle diseases are but two examples that have dire consequences for animals and adversely affect the economic fortunes of farmers. A testing and culling methodology is presented that can eliminate pathogens from an infected herd. The sensitivity of PCR to detect very low levels of nucleic acid of an infecting pathogen is utilized to identify infected animals. In addition, it has been discovered that PCR analysis of manure samples can accurately identify infected animals and offspring for those species that consume placental remains after birth. Mink Aleutian Disease Virus (mADV) is one of several deadly DNA parvoviruses that can quickly reach epidemic proportions in a mink herd. PCR primers have been developed that generate amplicons to detect and identify the mADV. In addition, a previously unidentified strain of mADV has been discovered, genomically sequenced, and substantially detailed.
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