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    Microfluidic system having monolithic nanoplasmonic structures
    3.
    发明授权
    Microfluidic system having monolithic nanoplasmonic structures 有权
    具有单片纳米结构的微流体系统

    公开(公告)号：US09291567B2

    公开(公告)日：2016-03-22

    申请号：US14005347

    申请日：2012-03-12

    申请人： Lidija Malic ,  Keith Morton ,  Teodor Veres

    发明人： Lidija Malic ,  Keith Morton ,  Teodor Veres

    IPC分类号： G01N1/30 ,  G01N21/65 ,  B82Y30/00 ,  C12M3/06 ,  G01N21/552 ,  B01L3/00

    CPC分类号： G01N21/65 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/12 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0822 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/0896 ,  B01L2300/12 ,  B01L2400/086 ,  B82Y30/00 ,  C12M23/16 ,  G01N21/554 ,  G01N21/658 ,  Y10T137/8593

    摘要： A microfluidic system has a monolithic biocompatible substrate with both a surface having an ordered array of nano-scale elements for plasmonic response monitoring and a network of microchannels. Advantageously, low-volume consumption, rapid low-cost fabrication of molds with easily interchangeable microfluidic channel layouts, mass production, and in situ label-free real-time detection of cellular response, viability, behavior and biomolecular binding using plasmonic techniques can be provided. A ratio of greater than 0.2 of the cross-sectional dimension and the spacing between the nano-scale elements is useful for plasmonic response monitoring. Producing such a system involves a master mold with the nano-scale elements etched into a hard substrate, and the network provided in a soft membrane bonded to the hard substrate. A stamp may be created by setting a settable liquid polymer or metal placed in the master mold. Features of the intended device can be transferred to a polymeric substrate using the stamp.

    摘要翻译： 微流体系统具有整体生物相容性基底，其具有具有用于等离子体响应监测的纳米级元件的有序阵列的表面和微通道网络。 有利地，可以提供低体积消耗，快速低成本地制造具有易于互换的微流体通道布局的模具，批量生产和使用等离子体激元技术的细胞响应，活力，行为和生物分子结合的原位无标记实时检测 。 大于0.2的横截面尺寸和纳米级元件之间的间距可用于等离子体响应监测。 生产这样的系统包括将纳米级元素蚀刻到硬质基底中的母模，并且网络设置在粘结到硬质基底上的软膜中。 可以通过设置放置在主模具中的可固化液体聚合物或金属来形成印章。 可以使用印模将预期装置的特征转移到聚合物基材。

    Microfluidic System Having Monolithic Nanoplasmonic Structures
    4.
    发明申请
    Microfluidic System Having Monolithic Nanoplasmonic Structures 有权
    具有单片纳米结构的微流体系统

    公开(公告)号：US20140004507A1

    公开(公告)日：2014-01-02

    申请号：US14005347

    申请日：2012-03-12

    申请人： Lidija Malic ,  Keith Morton ,  Teodor Veres

    发明人： Lidija Malic ,  Keith Morton ,  Teodor Veres

    IPC分类号： G01N21/65

    CPC分类号： G01N21/65 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/12 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0822 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/0896 ,  B01L2300/12 ,  B01L2400/086 ,  B82Y30/00 ,  C12M23/16 ,  G01N21/554 ,  G01N21/658 ,  Y10T137/8593

    摘要： A microfluidic system, particularly suited as a cell culture system, is provided having a single monolithic biocompatible substrate with both a surface having an ordered array of nano-scale elements required for plasmonic response monitoring and a network of microchannels for precisely controlling cellular environment. The system has the additional advantages of low-volume consumption, rapid low-cost fabrication of molds with easily interchangeable microfluidic channel layouts, amenability to mass production, and in situ label-free real-time detection of cellular response, viability, behavior and biomolecular binding using plasmonic techniques. A ratio of greater than 0.2 between the cross-sectional dimension and the spacing distance of the nano-scale elements is useful for plasmonic response monitoring. A process for producing such a system involves fabrication of a master mold containing the nano-scale elements etched into a hard substrate, and the micro-scale and meso-scale features, such as channels and chambers, provided in a soft membrane bonded to the hard substrate. A stamp may be created by setting a settable liquid polymer or metal placed in the master mold and then the features of the intended device transferred to a polymeric substrate using the stamp.

    摘要翻译： 提供了特别适合作为细胞培养系统的微流体系统，其具有单个整体生物相容性基底，其具有具有等离子体激发响应监测所需的纳米级元件的有序阵列的表面和用于精确控制细胞环境的微通道网络。 该系统具有低体积消耗，快速低成本制造具有易于互换的微流体通道布局的模具，大规模生产的易于使用以及原位无标签的实时检测细胞反应，活力，行为和生物分子的附加优点 使用等离子体激元技术进行结合。 横截面尺寸与纳米级元件的间距之间的比值大于0.2对等离子体响应监测是有用的。 制造这种系统的方法包括制造含有蚀刻到硬质基底中的纳米级元素的母模，以及提供在粘合到该柔性膜的软膜中的微尺度和中尺度特征，例如通道和室 硬质基材。 可以通过设置放置在母模中的可固化液体聚合物或金属，然后使用印模将预期装置的特征转移到聚合物基底来形成印模。