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    CELL CULTURE MEDIUM COMPRISING SMALL PEPTIDES
    1.
    发明申请
    CELL CULTURE MEDIUM COMPRISING SMALL PEPTIDES 审中-公开
    包含小细胞的细胞培养基

    公开(公告)号：US20170058256A1

    公开(公告)日：2017-03-02

    申请号：US15349791

    申请日：2016-11-11

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Shawn BARRETT ,  Scott JACOBIA

    IPC: C12N5/00

    Abstract: Cell culture media, concentrated media and feeds, methods of manufacturing cell culture media and feeds, and methods of culturing cells are provided. One or more small peptides, including dipeptides are added to the cell culture media to provide improved stability and improved conditions for culturing cells.

    Abstract translation: 提供细胞培养基，浓缩培养基和饲料，制备细胞培养基和饲料的方法，以及培养细胞的方法。 将一种或多种小肽，包括二肽加入到细胞培养基中，以提供培养细胞的改善的稳定性和改善的条件。

    CELL CULTURE MEDIA AND METHODS
    4.
    发明申请
    CELL CULTURE MEDIA AND METHODS 审中-公开

    公开(公告)号：US20200332250A1

    公开(公告)日：2020-10-22

    申请号：US16918838

    申请日：2020-07-01

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Richard FIKE ,  Shawn BARRETT ,  Zhou JIANG ,  David JUDD

    IPC: C12N5/00 ,  B29C67/24 ,  B01J13/06 ,  B01J13/22

    Abstract: Compositions and methods are described for preparing media, feeds, and supplements. Such methods and medias may display increased stability of labile components and may use, for example, microsuspension and/or encapsulation technologies, chelation, and optionally, coating and/or mixing the labile compounds with anti-oxidants. The compositions may withstand thermal and/or irradiation treatment and have reduced virus number. These techniques may result in product with extended shelf-life, extended release of their internal components into culture, or in product that can be added aseptically into a bioreactor using minimal volumes. The compositions and methods may optimize the bioproduction workflow and increase efficiency.

    COMPOSITIONS AND METHODS FOR STABILIZING SUSCEPTIBLE COMPOUNDS
    6.
    发明申请
    COMPOSITIONS AND METHODS FOR STABILIZING SUSCEPTIBLE COMPOUNDS 有权

    公开(公告)号：US20210269767A1

    公开(公告)日：2021-09-02

    申请号：US17307234

    申请日：2021-05-04

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Richard FIKE ,  Bruce BRANCHAUD ,  Shawn BARRETT

    IPC: C12N5/00

    Abstract: Methods for increasing the stability of, or protecting, labile components, such as ethanolamine, growth factors, vitamins, etc., in compositions such as a cell culture medium, are described. Stability of the labile compound is increased either, by derivatization or by sequestering the labile compound. Sequestering can be done either by encapsulation within a microcapsule or by the use of sequestering agents. Encapsulation can provide controlled release of the susceptible compound being protected. These methods may improve or extend the storage conditions, the shipping and handling of media compositions comprising the labile compounds at room temperature rather than at lower temperatures, thereby decreasing shipping costs.

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