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公开(公告)号：US20170253921A1
公开(公告)日：2017-09-07
申请号：US15518016
申请日：2015-10-13
Inventor： Chunmei LIU , Shoulian DONG , Junko STEVENS
IPC: C12Q1/68
CPC classification number: C12Q1/6851 , C12Q1/6853 , C12Q1/686 , C12Q1/6883 , C12Q2537/16 , C12Q2537/161 , C12Q2545/107 , C12Q2545/113 , C12Q2600/16
Abstract: The present specification relates to methods, compositions, and kits for determining the presence of the number of copies of a gene. The present disclosure provides methods and compositions to determine zygosity in transgenic plants, number of transgenes in a plant or animal, karyotyping, determine CNV in human and animal samples, diagnose and detect diseases and conditions that are characterized by having variations in the number of copies of one or more genes.
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公开(公告)号：US20250116628A1
公开(公告)日：2025-04-10
申请号：US18922656
申请日：2024-10-22
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Wolfgang HINZ , John DONOHUE , Daniel BEACHMAN
IPC: G01N33/543 , G01N27/30 , G03G5/02
Abstract: Various cell analysis systems of the present teachings can measure the electrical and metabolic activity of single, living cells with subcellular addressability and simultaneous data acquisition for between about 10 cells to about 500,000 cells in a single analysis. Various sensor array devices of the present teachings can have sensor arrays with between 20 million to 660 million ChemFET sensors built into a massively paralleled array and can provide for simultaneous measurement of cells with data acquisition rates in the kilohertz (kHz) range. As various ChemFET sensor arrays of the present teachings can detect chemical analytes as well detect changes in cell membrane potential, various cell analysis systems of the present teachings also provide for the controlled chemical and electrical interrogation of cells.
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公开(公告)号：US12272538B2
公开(公告)日：2025-04-08
申请号：US17755179
申请日：2020-11-10
Applicant: Thermo Fisher Scientific (Bremen) GmbH , Life Technologies Corporation , FEI Deutschland GmbH
Inventor： Alexander Makarov , Michael Ward , Rainer Daum
Abstract: Disclosed herein are systems for imaging and ablating a sample. An imaging/ablating device (110) includes an optical assembly (112), a sample stage (114), and a receiver (116). The optical assembly (112) is disposed in an inverted position below the sample stage (114) and the receiver (116) is positioned above the sample stage (112). The optical assembly enables imaging of a sample disposed on the sample stage (114). The optical assembly (112) also enables ablation of a region of interest within the sample. The laser light propagated from the optical assembly during ablation propagates substantially in the same direction as the direction of travel of the ablation plume (20) toward the receiver (116).
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公开(公告)号：US12271043B2
公开(公告)日：2025-04-08
申请号：US17729480
申请日：2022-04-26
Applicant: Life Technologies Corporation
Inventor： Derek Robinson , Wesley Smith , Keith Kearsley
IPC: G02B6/42 , G01N15/1434
Abstract: Provided are optical fiber alignment assemblies, comprising: a plurality of fiber channel members being arranged along a first vertical axis, each fiber channel member comprising a fiber channel configured to accommodate an optical fiber disposed therein, the plurality of fiber channels being parallel to one another, fiber channels adjacent to one another defining a spacing therebetween, the spacing being measured along the first vertical axis; a plurality of resilient members, a resilient member being disposed between adjacent fiber channel members; and an adjustment element, the adjustment element being configured to effect a force oriented along the first vertical axis, and the adjustment member being configured such that actuation of the adjustment member changes a compression of the plurality of resilient members so as to effect an essentially linear variation in the spacing between adjacent fiber channels. Also provided are related methods.
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5.发明申请公开(公告)号：US20250109412A1
公开(公告)日：2025-04-03
申请号：US18911619
申请日：2024-10-10
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Xavier De Mollerat Du Jeu
Abstract: The present invention is directed to non-naturally occurring peptides containing a membrane-penetrating amino acid sequence and further at least one polycationic moiety or peptide sequence. The peptides are suitable for use in delivery a cargo to the interior of a cell. Suitable cargo includes nucleic acid molecules (including DNA, RNA or PNA), polypeptides, or other biologically active molecules. The present invention is further directed to transfection complexes containing the non-naturally occurring peptides of the present invention in non-covalent association with at least one cationic lipid and a cargo to be delivered to the interior of a cell. The invention further relates to methods for the preparation and use of the non-naturally occurring peptides for the formation of transfection complexes and the delivery of a cargo to the interior of a cell in culture, an animal or a human. The invention also relates to compositions and kits useful for transfecting cells.
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Patent Agency Ranking
公开(公告)号：US12263475B2
公开(公告)日：2025-04-01
申请号：US17970202
申请日：2022-10-20
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Jonathan Schultz , Todd Roswech
Abstract: An apparatus for preparing a reagent solution includes an enclosure and a container disposed within the enclosure. The container defines an internal cavity having a compressible volume and defines a passage providing fluidic communication between the internal cavity and the exterior of the container. Optionally, a compressible member is disposed within the internal cavity. A reagent is disposed within the internal cavity.
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公开(公告)号：USD1065210S1
公开(公告)日：2025-03-04
申请号：US29761746
申请日：2020-12-11
Applicant: LIFE TECHNOLOGIES CORPORATION
Designer： Jing Gao , Alexander Roemer , Vrunda Sheth , Vidya Kudlingar , Dhirendrakumar Rai , Prateek Kumar
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公开(公告)号：US12226561B2
公开(公告)日：2025-02-18
申请号：US17671353
申请日：2022-02-14
Applicant: Life Technologies Corporation , Life Technologies AS
Inventor： Lars Norderhaug , Angel Varela-Rohena , Nephi D. Jones
IPC: A61M1/36 , B01L3/00 , B03C1/01 , B03C1/28 , B03C1/30 , C07K16/28 , C12M1/00 , C12M1/12 , C12M1/26 , C12M3/00
Abstract: A magnetic particle separation system includes a magnetic field generating device having an upper surface with a receiving area formed thereon; and a magnetic field generating element disposed beneath the upper surface, the magnetic field generating element being configured to produce a magnetic field above the upper surface. A container assembly is disposed on the upper surface and includes: a flexible container having an outer wall with an interior surface that at least partially bounds an internal compartment, the outer wall having a front side and an opposing back side with the internal compartment disposed therebetween; a fluid inlet extending through the outer wall at the front side; a fluid outlet extending through the outer wall at the front side; and a first partition projecting into the internal compartment from the front side between the fluid inlet and the fluid outlet.
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公开(公告)号：US12209239B2
公开(公告)日：2025-01-28
申请号：US17320572
申请日：2021-05-14
Inventor： Todd Peterson , Axel Trefzer , Thomas Poehmerer
Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
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公开(公告)号：US20250019864A1
公开(公告)日：2025-01-16
申请号：US18606205
申请日：2024-03-15
Applicant: Life Technologies Corporation
Inventor： Timothy Looney , Geoffrey Lowman , Lifeng Lin
IPC: C40B50/06 , C07K14/725 , C12Q1/6811 , C12Q1/6844 , C12Q1/6869 , C12Q1/6876 , C12Q1/6881 , C12Q1/6883
Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.
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