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公开(公告)号：US09226983B2
公开(公告)日：2016-01-05
申请号：US13081212
申请日：2011-04-06
CPC分类号： C07K16/241 , A61K47/6845 , A61K51/1021 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/7151 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
摘要： Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
摘要翻译： 公开了与肿瘤坏死因子-α（TNF-α）结合的分离的结合蛋白，例如结合肿瘤坏死因子-α（TNF-α）的抗体或其抗原结合部分以及相关的基于抗体的组合物和分子。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。
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公开(公告)号：US20110250130A1
公开(公告)日：2011-10-13
申请号：US13081212
申请日：2011-04-06
IPC分类号： A61K51/10 , A61K39/395 , C07H21/04 , A61K38/20 , A61P43/00 , A61P37/04 , A61P35/00 , A61P29/00 , A61P23/00 , A61P25/24 , A61P25/18 , A61P1/00 , A61P37/08 , A61P33/00 , A61P31/00 , A61P25/04 , C12N15/63 , C12N1/00 , C12N5/10 , C12N1/15 , C12N1/19 , C12N1/11 , C12P21/02 , G01N33/566 , C07K16/18
CPC分类号： C07K16/241 , A61K47/6845 , A61K51/1021 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/7151 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
摘要： Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
摘要翻译： 公开了与肿瘤坏死因子-α（TNF-α）结合的分离的结合蛋白，例如结合肿瘤坏死因子-α（TNF-α）的抗体或其抗原结合部分以及相关的基于抗体的组合物和分子。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。
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公开(公告)号：US09035027B2
公开(公告)日：2015-05-19
申请号：US12477711
申请日：2009-06-03
申请人： Tariq Ghayur , Peter C. Isakson , Lisa M. Olson , Chengbin Wu , Margaret Hugunin , Rajesh V. Kamath , Carolyn A. Cuff , Hamish J. Allen
发明人： Tariq Ghayur , Peter C. Isakson , Lisa M. Olson , Chengbin Wu , Margaret Hugunin , Rajesh V. Kamath , Carolyn A. Cuff , Hamish J. Allen
IPC分类号： A61K39/395 , C07K16/46 , C07K16/22 , C07K16/24 , A61K45/06 , A61K47/48 , G01N33/68 , A61K39/00
CPC分类号： C07K16/2887 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K2039/505 , A61K2039/70 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/247 , C07K16/248 , C07K16/2866 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/64 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , G01N33/6869 , G01N2333/545 , Y02A50/386 , Y02A50/41 , Y02A50/412
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：US20120263722A1
公开(公告)日：2012-10-18
申请号：US13288185
申请日：2011-11-03
申请人： Tariq Ghayur , Junjian Liu , Peter C. Isakson
发明人： Tariq Ghayur , Junjian Liu , Peter C. Isakson
IPC分类号： C07K16/46 , A61K39/395 , A61P29/00 , A61P35/00 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/19 , C12P21/02 , G01N33/53 , G01N21/64 , G01N21/76 , C40B30/04 , G01N27/62 , C12N15/13
CPC分类号： C07K16/468 , C07K16/22 , C07K16/247 , C07K16/248 , C07K16/2803 , C07K16/2809 , C07K16/2827 , C07K16/2851 , C07K16/2863 , C07K16/2878 , C07K16/2887 , C07K16/32 , C07K16/34 , C07K16/44 , C07K2317/31
摘要： Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
摘要翻译： 提供了工程化的多价和多特异性结合蛋白，制备方法及其在预防，诊断和/或治疗疾病中的用途。
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公开(公告)号：US20120034160A1
公开(公告)日：2012-02-09
申请号：US13196138
申请日：2011-08-02
申请人： Tariq Ghayur , Junjian Liu , Peter C. Isakson
发明人： Tariq Ghayur , Junjian Liu , Peter C. Isakson
IPC分类号： A61K51/10 , A61P41/00 , A61P17/06 , A61K39/395 , C12N5/10 , A61P3/10 , A61P9/10 , A61P13/12 , A61P33/00 , A61P11/06 , C12N1/21 , C12N1/15 , C12N1/19 , A61P25/16 , C12N1/11 , C12N15/63 , A61P37/08 , C07K16/24 , A61P1/00 , C07H21/04 , A61P31/16 , A61P25/06 , A61P19/10 , A61P17/00 , A61P25/00 , A61P25/18 , G01N33/566 , A61P31/00 , A61P25/28 , A61P9/00 , A61P15/00 , A61P37/02 , A61P35/02 , A61P35/00 , A61P31/04 , A61P29/00 , A61P17/02 , A61P31/18 , A61K49/00
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K49/00 , A61K51/1021 , C07K16/241 , C07K16/245 , C07K16/468 , C07K2317/35 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/53 , G01N33/56966 , G01N33/6857 , G01N33/6869 , G01N2333/54 , G01N2333/545 , G01N2800/24 , G01N2800/7028
摘要： Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
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公开(公告)号：US20110212094A1
公开(公告)日：2011-09-01
申请号：US12914614
申请日：2010-10-28
申请人： Tariq Ghayur , Jochen G. Salfeld , Michael J. McPherson , Maria C. Harris , Junjian Liu , Peter C. Isakson , Jijie Gu
发明人： Tariq Ghayur , Jochen G. Salfeld , Michael J. McPherson , Maria C. Harris , Junjian Liu , Peter C. Isakson , Jijie Gu
IPC分类号： A61K39/395 , C07K16/46 , C12N9/96 , C07H21/04 , C12N15/63 , C12N1/00 , C12N1/21 , C12N5/10 , C12N1/15 , C12N1/19 , C12P21/08 , A61P29/00 , A61P19/06 , A61P19/02 , A61P17/00 , A61P37/06 , A61P1/16 , A61P13/12 , A61P31/12 , A61P11/00 , A61P37/08 , A61P25/00 , A61P31/00 , A61P35/00 , A61P5/00 , A61P5/14 , A61P9/00 , A61P3/00 , A61P7/00
CPC分类号： C07K16/241 , C07K16/22 , C07K16/2803 , C07K16/2875 , C07K16/44 , C07K16/468 , C07K2317/31 , C07K2317/73
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译： 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。
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7.发明授权公开(公告)号：US08822645B2
公开(公告)日：2014-09-02
申请号：US12499652
申请日：2009-07-08
申请人： Tariq Ghayur , Jijie Gu , Peter C. Isakson
发明人： Tariq Ghayur , Jijie Gu , Peter C. Isakson
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , C07H21/04 , G01N33/53 , C12P21/06 , C12N1/20 , C12N15/00 , C12N5/00 , C12N5/16 , C07K1/00
CPC分类号： C07K16/468 , A61K38/00 , A61K45/06 , A61K47/6879 , A61K51/109 , C07K16/22 , C07K16/24 , C07K16/26 , C07K16/2863 , C07K16/2866 , C07K16/44 , C07K2317/31 , C07K2317/64 , C07K2317/73 , C07K2317/732 , C07K2317/734 , G01N33/6869 , G01N33/74 , G01N33/88 , G01N2333/4709 , G01N2333/48 , G01N2333/525 , G01N2333/5443 , G01N2333/545 , G01N2333/7155 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/463 , Y02A50/478 , Y02A50/481
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译： 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。
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公开(公告)号：US08735546B2
公开(公告)日：2014-05-27
申请号：US13196138
申请日：2011-08-02
申请人： Tariq Ghayur , Junjian Liu , Peter C. Isakson
发明人： Tariq Ghayur , Junjian Liu , Peter C. Isakson
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K49/00 , A61K51/1021 , C07K16/241 , C07K16/245 , C07K16/468 , C07K2317/35 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/53 , G01N33/56966 , G01N33/6857 , G01N33/6869 , G01N2333/54 , G01N2333/545 , G01N2800/24 , G01N2800/7028
摘要： Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
摘要翻译： 提供了工程化的多价和多特异性结合蛋白，制备方法及其在预防，诊断和/或治疗疾病中的用途。
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公开(公告)号：US08722855B2
公开(公告)日：2014-05-13
申请号：US12914614
申请日：2010-10-28
申请人： Tariq Ghayur , Jochen G. Salfeld , Michael J. McPherson , Maria C. Harris , Junjian Liu , Peter C. Isakson , Jijie Gu
发明人： Tariq Ghayur , Jochen G. Salfeld , Michael J. McPherson , Maria C. Harris , Junjian Liu , Peter C. Isakson , Jijie Gu
CPC分类号： C07K16/241 , C07K16/22 , C07K16/2803 , C07K16/2875 , C07K16/44 , C07K16/468 , C07K2317/31 , C07K2317/73
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：US20090311253A1
公开(公告)日：2009-12-17
申请号：US12477711
申请日：2009-06-03
申请人： Tariq Ghayur , Peter C. Isakson , Lisa M. Olson , Chengbin Wu , Margaret Hugunin , Rajesh V. Kamath , Carolyn A. Cuff , Hamish J. Allen
发明人： Tariq Ghayur , Peter C. Isakson , Lisa M. Olson , Chengbin Wu , Margaret Hugunin , Rajesh V. Kamath , Carolyn A. Cuff , Hamish J. Allen
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N15/63 , C12N1/21 , C12N1/10 , C12N5/10 , C12N1/15 , C12P21/06
CPC分类号： C07K16/2887 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K2039/505 , A61K2039/70 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/247 , C07K16/248 , C07K16/2866 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/64 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , G01N33/6869 , G01N2333/545 , Y02A50/386 , Y02A50/41 , Y02A50/412
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译： 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。
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