-
公开(公告)号：US07879585B2
公开(公告)日：2011-02-01
申请号：US11865696
申请日：2007-10-01
申请人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
发明人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
CPC分类号： C12P13/002 , C07C253/30 , C12N9/0008 , C12P7/42 , C12P7/62 , C07C255/20
摘要： The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改善的性质的酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，使用工程化酮还原酶合成各种手性纯化合物的方法，以及用其制备的手性纯化合物。
-
2.发明申请COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR 有权用于生产立体纯静止物及其合成中间体的组合物和方法公开(公告)号：US20080248539A1
公开(公告)日：2008-10-09
申请号：US11865696
申请日：2007-10-01
申请人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
发明人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
IPC分类号： C12P7/62 , C12N9/02 , C07H21/04 , C07D207/34 , C07C69/675 , C12N1/21
CPC分类号： C12P13/002 , C07C253/30 , C12N9/0008 , C12P7/42 , C12P7/62 , C07C255/20
摘要： The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改善的性质的酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，使用工程化酮还原酶合成各种手性纯化合物的方法，以及用其制备的手性纯化合物。
-
3.发明申请公开(公告)号：US20130040364A1
公开(公告)日：2013-02-14
申请号：US13571248
申请日：2012-08-09
申请人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
发明人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
CPC分类号： C12P13/002 , C07C253/30 , C12N9/0008 , C12P7/42 , C12P7/62 , C07C255/20
摘要： The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改善的性质的酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，使用工程化酮还原酶合成各种手性纯化合物的方法，以及用其制备的手性纯化合物。
-
4.发明授权Engineered ketoreductases and methods for producing stereoisomerically pure statins 有权工程化的酮还原酶和立体异构体纯的他汀类药物的制备方法公开(公告)号：US08273547B2
公开(公告)日：2012-09-25
申请号：US12978022
申请日：2010-12-23
申请人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
发明人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
CPC分类号： C12P13/002 , C07C253/30 , C12N9/0008 , C12P7/42 , C12P7/62 , C07C255/20
摘要： The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改善的性质的酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，使用工程化酮还原酶合成各种手性纯化合物的方法，以及用其制备的手性纯化合物。
-
5.发明申请Compositions and Methods for Producing Stereoisomerically Pure Statins and Synthetic Intermediates Therefor 有权用于制备立体异构体纯他汀及其合成中间体的组合物和方法公开(公告)号：US20110195465A1
公开(公告)日：2011-08-11
申请号：US12978022
申请日：2010-12-23
申请人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
发明人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
CPC分类号： C12P13/002 , C07C253/30 , C12N9/0008 , C12P7/42 , C12P7/62 , C07C255/20
摘要： The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改善的性质的酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，使用工程化酮还原酶合成各种手性纯化合物的方法，以及用其制备的手性纯化合物。
-
6.发明授权Polynucleotides encoding ketoreductases for producing stereoisomerically pure statins and synthetic intermediates therefor 有权编码用于产生立体异构体纯他汀的酮还原酶的多核苷酸及其合成中间体公开(公告)号：US08617864B2
公开(公告)日：2013-12-31
申请号：US13571248
申请日：2012-08-09
申请人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
发明人： Lorraine Joan Giver , Lisa Marie Newman , Emily Mundorff , Gjalt W. Huisman , Stephane J. Jenne , Jun Zhu , Behnaz Behrouzian , John H. Grate , James Lalonde
CPC分类号： C12P13/002 , C07C253/30 , C12N9/0008 , C12P7/42 , C12P7/62 , C07C255/20
摘要： The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改善的性质的酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，使用工程化酮还原酶合成各种手性纯化合物的方法，以及用其制备的手性纯化合物。
-
公开(公告)号：US20090118130A1
公开(公告)日：2009-05-07
申请号：US12069869
申请日：2008-02-12
CPC分类号： C12Q1/25 , C12N9/00 , C12N15/1093 , C12Q1/00 , C12Q1/26 , C40B10/00 , C40B30/04 , C40B40/02 , C40B40/10 , G01N33/6803 , G01N33/6845 , G16B20/00
摘要： The present disclosure relates to compositions and methods for screening a plurality of polypeptide variants.
摘要翻译： 本公开涉及用于筛选多种多肽变体的组合物和方法。
-
8.发明授权Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives 有权用于生产4-取代的3-羟基丁酸衍生物的酶法公开(公告)号：US07807423B2
公开(公告)日：2010-10-05
申请号：US11502745
申请日：2006-08-10
申请人： S. Christopher Davis , John H. Grate , David R. Gray , John M. Gruber , Gjalt W. Huisman , Steven K. Ma , Lisa M. Newman , Roger Sheldon , Li A Wang
发明人： S. Christopher Davis , John H. Grate , David R. Gray , John M. Gruber , Gjalt W. Huisman , Steven K. Ma , Lisa M. Newman , Roger Sheldon , Li A Wang
CPC分类号： C12P13/002 , C12N9/14 , C12P7/62 , C12P13/02
摘要： The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.
摘要翻译： 本发明提供了通过卤代醇脱卤酶催化的4-卤代-3-羟基丁酸衍生物的转化来制备4-取代的3-羟基丁酸衍生物的方法和组合物。 本发明还提供了通过酮还原酶催化转化4-卤代-3-酮丁酸衍生物来制备4-卤代-3-羟基丁酸衍生物的方法和组合物。本发明还提供了用于制备邻位氰基，羟基取代的羧酸的方法和组合物 酸酯。
-
9.发明授权Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters 有权用于生产4-取代的3-羟基丁酸衍生物和连位氰基羟基取代的羧酸酯的酶法公开(公告)号：US07132267B2
公开(公告)日：2006-11-07
申请号：US10782258
申请日：2004-02-18
申请人： S. Christopher Davis , John H. Grate , David R. Gray , John M. Gruber , Gjalt W. Huisman , Steven K. Ma , Lisa M. Newman , Roger Sheldon , Li A Wang
发明人： S. Christopher Davis , John H. Grate , David R. Gray , John M. Gruber , Gjalt W. Huisman , Steven K. Ma , Lisa M. Newman , Roger Sheldon , Li A Wang
IPC分类号： C12P13/00
CPC分类号： C12P13/002 , C12N9/14 , C12P7/62 , C12P13/02
摘要： The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.
摘要翻译： 本发明提供了通过卤代醇脱卤酶催化的4-卤代-3-羟基丁酸衍生物的转化来制备4-取代的3-羟基丁酸衍生物的方法和组合物。 本发明还提供了通过酮还原酶催化转化4-卤代-3-酮丁酸衍生物来制备4-卤代-3-羟基丁酸衍生物的方法和组合物。本发明还提供了用于制备邻位氰基，羟基取代的羧酸的方法和组合物 酸酯。
-
10.发明授权Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives 有权用于生产4-取代的3-羟基丁酸衍生物的酶法公开(公告)号：US07125693B2
公开(公告)日：2006-10-24
申请号：US10639159
申请日：2003-08-11
申请人： S. Christopher Davis , John H. Grate , David R. Gray , John M. Gruber , Gjalt W. Huisman , Steven K. Ma , Lisa M. Newman , Roger Sheldon , Li A Wang
发明人： S. Christopher Davis , John H. Grate , David R. Gray , John M. Gruber , Gjalt W. Huisman , Steven K. Ma , Lisa M. Newman , Roger Sheldon , Li A Wang
IPC分类号： C12P13/00
CPC分类号： C12P13/002 , C12N9/14 , C12P13/02
摘要： The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives.
摘要翻译： 本发明提供了通过卤代醇脱卤酶催化的4-卤代-3-羟基丁酸衍生物的转化来制备4-取代的3-羟基丁酸衍生物的方法和组合物。 本发明还提供了通过酮还原酶催化转化4-卤代-3-酮丁酸衍生物制备4-卤代-3-羟基丁酸衍生物的方法和组合物。
-
-
-
-
-
-
-
-
-
搜索结果
26 条记录 (耗时 0.062 秒)
