公开(公告)号：US07141549B2

公开(公告)日：2006-11-28

申请号：US11054281

申请日：2005-02-08

申请人： Peter Mezes ,  Luca Rastelli ,  John Herrmann ,  John MacDougall ,  Haihong Zhong ,  Stacie Casman ,  Ferenc Boldog ,  Richard Shimkets ,  Linda Gorman ,  Andrew Eisen ,  Steven Spaderna ,  Corine Vernet ,  Constance Berghs ,  Kimberly Spytek ,  Vincent DiPippo ,  Bryan Zerhusen ,  John Peyman ,  Karen Ellerman ,  David Stone ,  William Grosse ,  John Alsobrook, II ,  Denise Lepley ,  Daniel Rieger ,  Catherine Burgess ,  Shlomit Edinger ,  Edward Voss ,  Charles Miller

发明人： Peter Mezes ,  Luca Rastelli ,  John Herrmann ,  John MacDougall ,  Haihong Zhong ,  Stacie Casman ,  Ferenc Boldog ,  Richard Shimkets ,  Linda Gorman ,  Andrew Eisen ,  Steven Spaderna ,  Corine Vernet ,  Constance Berghs ,  Kimberly Spytek ,  Vincent DiPippo ,  Bryan Zerhusen ,  John Peyman ,  Karen Ellerman ,  David Stone ,  William Grosse ,  John Alsobrook, II ,  Denise Lepley ,  Daniel Rieger ,  Catherine Burgess ,  Shlomit Edinger ,  Edward Voss ,  Charles Miller

IPC分类号： A61K38/17 ,  C07K14/47

CPC分类号： C12N9/2462 ,  A61K38/00 ,  A61K47/6829 ,  A61K47/6851 ,  A61K47/6869 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  G01N33/6893

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US20060013813A1

公开(公告)日：2006-01-19

申请号：US11054281

申请日：2005-02-08

申请人： Peter Mezes ,  Luca Rastelli ,  John Herrmann ,  John MacDougall ,  Haihong Zhong ,  Stacie Casman ,  Frenc Boldog ,  Richard Shimkets ,  Linda Gorman ,  Andrew Eisen ,  Steven Spaderna ,  Corine Vernet ,  Constance Berghs ,  Kimberly Spytek ,  Vincent DiPippo ,  Bryan Zerhusen ,  John Peyman ,  Karen Ellerman ,  David Stone ,  William Grosse ,  John Alsobrook ,  Denise Lepley ,  Daniel Rieger ,  Catherine Burgess ,  Sholmit Edinger ,  Edward Voss ,  Charles Miller

发明人： Peter Mezes ,  Luca Rastelli ,  John Herrmann ,  John MacDougall ,  Haihong Zhong ,  Stacie Casman ,  Frenc Boldog ,  Richard Shimkets ,  Linda Gorman ,  Andrew Eisen ,  Steven Spaderna ,  Corine Vernet ,  Constance Berghs ,  Kimberly Spytek ,  Vincent DiPippo ,  Bryan Zerhusen ,  John Peyman ,  Karen Ellerman ,  David Stone ,  William Grosse ,  John Alsobrook ,  Denise Lepley ,  Daniel Rieger ,  Catherine Burgess ,  Sholmit Edinger ,  Edward Voss ,  Charles Miller

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  A61K39/395 ,  C07K14/705 ,  C07K16/18

CPC分类号： C12N9/2462 ,  A61K38/00 ,  A61K47/6829 ,  A61K47/6851 ,  A61K47/6869 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  G01N33/6893

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US20060084054A1

公开(公告)日：2006-04-20

申请号：US10455772

申请日：2003-06-04

申请人： John Alsobrook ,  David Anderson ,  Jason Baumgartner ,  Constance Berghs ,  Ferenc Boldog ,  Catherine Burgess ,  Stacie Casman ,  Elina Catterton ,  Mohanraj Dhanabal ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  William Grosse ,  Erik Gunther ,  Xiaojia Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Nikolai Khramtsov ,  William LaRochelle ,  Li Li ,  Hongping Liang ,  Kenneth Low ,  John MacDougall ,  Timothy Maclachlan ,  Uriel Malyankar ,  Kelly McQueeney ,  Amanda Mezick ,  Charles Miller ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  John Peyman ,  Xiaozhong Qian ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Sujatha Sukumaran ,  Edward Szekeres ,  Corine Vernet ,  Edward Voss ,  Adam Wolenc ,  Mei Zhong ,  Haihong Zhong

发明人： John Alsobrook ,  David Anderson ,  Jason Baumgartner ,  Constance Berghs ,  Ferenc Boldog ,  Catherine Burgess ,  Stacie Casman ,  Elina Catterton ,  Mohanraj Dhanabal ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  William Grosse ,  Erik Gunther ,  Xiaojia Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Nikolai Khramtsov ,  William LaRochelle ,  Li Li ,  Hongping Liang ,  Kenneth Low ,  John MacDougall ,  Timothy Maclachlan ,  Uriel Malyankar ,  Kelly McQueeney ,  Amanda Mezick ,  Charles Miller ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  John Peyman ,  Xiaozhong Qian ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Sujatha Sukumaran ,  Edward Szekeres ,  Corine Vernet ,  Edward Voss ,  Adam Wolenc ,  Mei Zhong ,  Haihong Zhong

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N9/00

CPC分类号： C07K16/40 ,  C07K14/47

摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。 公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US20060003323A1

公开(公告)日：2006-01-05

申请号：US10453372

申请日：2003-06-03

申请人： John Alsobrook ,  Enrique Alvarez ,  David Anderson ,  Ferenc Boldog ,  Stacie Casman ,  Elina Catterton ,  Andrei Chapoval ,  Julie Crabtree-Bokor ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  Erik Gunther ,  Xiaojia (Sasha) Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Li Li ,  Xiaohong Liu ,  John MacDougall ,  Timothy Machlachlan ,  Uriel Malyankar ,  Amanda Mezick ,  Isabelle Millet ,  Vishnu Mishra ,  Muralidhara Padigaru ,  Meera Patturajan ,  Carol Pena ,  John Peyman ,  Debasish Raha ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Paul Sciore ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Corine Vernet ,  Edward Voss ,  Mei Zhong ,  Hiahong Zhong

发明人： John Alsobrook ,  Enrique Alvarez ,  David Anderson ,  Ferenc Boldog ,  Stacie Casman ,  Elina Catterton ,  Andrei Chapoval ,  Julie Crabtree-Bokor ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  Erik Gunther ,  Xiaojia (Sasha) Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Li Li ,  Xiaohong Liu ,  John MacDougall ,  Timothy Machlachlan ,  Uriel Malyankar ,  Amanda Mezick ,  Isabelle Millet ,  Vishnu Mishra ,  Muralidhara Padigaru ,  Meera Patturajan ,  Carol Pena ,  John Peyman ,  Debasish Raha ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Paul Sciore ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Corine Vernet ,  Edward Voss ,  Mei Zhong ,  Hiahong Zhong

IPC分类号： C12Q1/68

CPC分类号： C07K14/47 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US20060063200A1

公开(公告)日：2006-03-23

申请号：US11051724

申请日：2005-02-02

申请人： David Anderson ,  Jason Baumgartner ,  Ferenc Boldog ,  Stacie Casman ,  Shlomit Edinger ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  Xiaojia Guo ,  Tord Hjalt ,  Ramesh Kekuda ,  Li Li ,  John MacDougall ,  Uriel Malyankar ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  Carol Pena ,  Luca Rastelli ,  Richard Shimkets ,  David Stone ,  Kimberly Spytek ,  Corine Vernet ,  Edward Voss ,  Bryan Zerhusen

发明人： David Anderson ,  Jason Baumgartner ,  Ferenc Boldog ,  Stacie Casman ,  Shlomit Edinger ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  Xiaojia Guo ,  Tord Hjalt ,  Ramesh Kekuda ,  Li Li ,  John MacDougall ,  Uriel Malyankar ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  Carol Pena ,  Luca Rastelli ,  Richard Shimkets ,  David Stone ,  Kimberly Spytek ,  Corine Vernet ,  Edward Voss ,  Bryan Zerhusen

IPC分类号： G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/18

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00

摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US20050170380A1

公开(公告)日：2005-08-04

申请号：US10971479

申请日：2004-10-21

申请人： Elma Fernandes ,  Corine Vernet ,  Richard Shimkets ,  David Anderson ,  Muralidhara Padigaru ,  Ferenc Boldog ,  Li Li ,  Suresh Shenoy ,  Stacie Casman ,  Luca Rastelli

发明人： Elma Fernandes ,  Corine Vernet ,  Richard Shimkets ,  David Anderson ,  Muralidhara Padigaru ,  Ferenc Boldog ,  Li Li ,  Suresh Shenoy ,  Stacie Casman ,  Luca Rastelli

IPC分类号： C07H21/04 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/68

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/54 ,  C07K14/705 ,  C07K14/70571

摘要： The present invention provides novel isolated SECX polynucleotides and the membrane-associated or secreted polypeptides encoded by the SECX polynucleotides. Also provided are the antibodies that immunospecifically bind to a SECX polypeptide or any derivative, variant, mutant or fragment of the SECX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the SECX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.

摘要翻译： 本发明提供新的分离的SECX多核苷酸和由SECX多核苷酸编码的膜相关或分泌的多肽。 还提供免疫特异性结合SECX多肽或SECX多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。 本发明还提供了其中SECX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

公开(公告)号：US20050153305A1

公开(公告)日：2005-07-14

申请号：US10851438

申请日：2004-05-21

申请人： Corine Vernet ,  Catherine Burgess ,  Elma Fernandes ,  Raymond Taupier ,  Kerry Quinn ,  Kimberly Spytek ,  Luca Rastelli ,  John Herrmann

发明人： Corine Vernet ,  Catherine Burgess ,  Elma Fernandes ,  Raymond Taupier ,  Kerry Quinn ,  Kimberly Spytek ,  Luca Rastelli ,  John Herrmann

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/705 ,  C07K16/30 ,  G01N33/574

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C12Q1/6886

摘要： Disclosed herein are novel human nucleic acid sequences which encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本文公开了编码多肽的新型人核酸序列。 还公开了由这些核酸序列编码的多肽，以及与多肽免疫特异性结合的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US20080171046A1

公开(公告)日：2008-07-17

申请号：US10844295

申请日：2004-05-12

申请人： Corine Vermet ,  Elma Fernandes ,  Richard Shimkets ,  John Herrmann ,  Kumud Majumder ,  John MacDougall ,  Vishnu Mishra ,  Peter S. Mezes ,  Luca Rastelli

发明人： Corine Vermet ,  Elma Fernandes ,  Richard Shimkets ,  John Herrmann ,  Kumud Majumder ,  John MacDougall ,  Vishnu Mishra ,  Peter S. Mezes ,  Luca Rastelli

IPC分类号： A61K39/395 ,  C07K14/435 ,  C07H21/00 ,  C12N15/00 ,  C07K16/18 ,  C12N5/00 ,  A61K38/17 ,  A61P25/00 ,  A61P11/00 ,  A61P37/00 ,  A61P15/00 ,  A61P35/04 ,  A61K31/70 ,  G01N33/566 ,  C12Q1/68 ,  G01N33/00 ,  C12Q1/02

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/47 ,  C07K14/54 ,  C07K14/70571 ,  Y02A50/423 ,  Y10T436/143333

摘要： Disclosed herein are novel human nucleic acid sequences which encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本文公开了编码多肽的新型人核酸序列。 还公开了由这些核酸序列编码的多肽，以及与多肽免疫特异性结合的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US06653448B1

公开(公告)日：2003-11-25

申请号：US09625634

申请日：2000-07-26

申请人： Corine Vernet ,  Luca Rastelli ,  John Herrmann

发明人： Corine Vernet ,  Luca Rastelli ,  John Herrmann

IPC分类号： C07K1400

CPC分类号： C07K14/475 ,  A61K38/00

摘要： The present invention provides novel isolated Wnt-7B-like polynucleotides and the membrane-associated or secreted polypeptides encoded by the Wnt-7B-like polynucleotides. Also provided are the antibodies that immunospecifically bind to a Wnt-7B-like polypeptide or any derivative, variant, mutant or fragment of the Wnt-7B-like polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the Wnt-7B-like polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.

摘要翻译： 本发明提供新的分离的Wnt-7B样多核苷酸和由Wnt-7B样多核苷酸编码的膜相关或分泌的多肽。 还提供了免疫特异性结合Wnt-7B样多肽或Wnt-7B样多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。 本发明另外提供了Wnt-7B样多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

公开(公告)号：US20050014687A1

公开(公告)日：2005-01-20

申请号：US10391939

申请日：2003-03-19

申请人： David Anderson ,  Loic Giot ,  Xiaojia Guo ,  Denise Lepley ,  Mehdi Mesri ,  Chean Ooi ,  Luca Rastelli ,  Daniel Rieger ,  Glennda Smithson ,  Gary Starling ,  Kam-Fai Tse

发明人： David Anderson ,  Loic Giot ,  Xiaojia Guo ,  Denise Lepley ,  Mehdi Mesri ,  Chean Ooi ,  Luca Rastelli ,  Daniel Rieger ,  Glennda Smithson ,  Gary Starling ,  Kam-Fai Tse

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K38/17 ,  A61K39/395 ,  A61P29/00 ,  A61P35/00 ,  C07K14/47 ,  C07K16/18 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/567 ,  G01N33/68

CPC分类号： C07K14/47 ,  G01N33/6893 ,  G01N2800/042

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.