公开(公告)号：US08303555B2

公开(公告)日：2012-11-06

申请号：US12872990

申请日：2010-08-31

申请人： Luo-Hwa Miau ,  Jhy-Wen Wu ,  Jen-Chien Chien ,  Li-Ling Li ,  Nan-Kuang Yao

发明人： Luo-Hwa Miau ,  Jhy-Wen Wu ,  Jen-Chien Chien ,  Li-Ling Li ,  Nan-Kuang Yao

IPC分类号： A61M1/00

CPC分类号： A61M1/0019 ,  A61M1/0088 ,  A61M1/0094 ,  A61M2205/702 ,  A61M2205/7536

摘要： A collector for a negative pressure wound therapy system has a soft collecting bag with a gas-permeable unit and a liquid absorber. The collecting bag is connected to a wound-dressing unit via an inlet connecting set and is connected to a sensor assembly via a detecting connecting set. With the soft collecting bag, the collector occupies less volume. By the gas-permeable unit and the liquid absorber, the liquid and gas entering into the collecting bag quickly isolate. Moreover, multiple collectors connect in series to form a collector combination to reduce the frequency to replace the collector combination so that a longer usage time of the collector combination is available.

摘要翻译： 用于负压伤口治疗系统的收集器具有带有透气单元和液体吸收器的软收集袋。 收集袋通过入口连接组连接到伤口修整单元，并通过检测连接组连接到传感器组件。 使用软收集袋，收集器占用的体积较小。 通过透气单元和液体吸收器，进入收集袋的液体和气体快速隔离。 此外，多个收集器串联连接以形成收集器组合以减少频率以替换收集器组合，使得收集器组合的更长的使用时间可用。

公开(公告)号：US20130274718A1

公开(公告)日：2013-10-17

申请号：US13445987

申请日：2012-04-13

申请人： Nan-Kuang Yao ,  Jhy-Wen Wu ,  Luo-Hwa Miau ,  Jen-Chien Chien ,  Shi-Fu Chen ,  Li-Ling Li

发明人： Nan-Kuang Yao ,  Jhy-Wen Wu ,  Luo-Hwa Miau ,  Jen-Chien Chien ,  Shi-Fu Chen ,  Li-Ling Li

IPC分类号： A61M27/00

CPC分类号： A61M1/0001 ,  A61M1/0025 ,  A61M1/0031 ,  A61M1/0088 ,  A61M2205/18 ,  A61M2205/3334 ,  A61M2205/3382

摘要： A fluid collector has a container, a T-tube, a first screw unit and a second screw unit. The T-tube is connected to the container and has a main pipe and a branch pipe. The first screw unit is mounted in an outlet end of the main pipe. The second screw unit is mounted in a connecting end of the branch pipe, which is connected to the main pipe. The branch pipe has a detecting opening far from the connecting end and connects to a detecting device. By changing the length of the first and second screw units, different detecting values of the pressure are adjusted according to containers with different capacities. Moreover, with the flowing resistance resulting from the first and second screw units, different pressure variations are performed when liquid or air passes through the T-tube. Therefore, massive hemorrhage is clearly identified to keep the patient safe.

摘要翻译： 流体收集器具有容器，T形管，第一螺丝单元和第二螺钉单元。 T型管与容器连接，并具有主管和分支管。 第一螺杆单元安装在主管的出口端。 第二螺钉单元安装在分支管的连接端上，该分支管连接到主管。 分支管具有远离连接端的检测开口并连接到检测装置。 通过改变第一和第二螺杆单元的长度，根据具有不同容量的容器来调节不同的压力检测值。 此外，由于由第一和第二螺杆单元产生的流动阻力，当液体或空气通过T形管时，执行不同的压力变化。 因此，清楚地确定大量出血以保持患者的安全。

公开(公告)号：US09095644B2

公开(公告)日：2015-08-04

申请号：US13445987

申请日：2012-04-13

申请人： Nan-Kuang Yao ,  Jhy-Wen Wu ,  Luo-Hwa Miau ,  Jen-Chien Chien ,  Shi-Fu Chen ,  Li-Ling Li

发明人： Nan-Kuang Yao ,  Jhy-Wen Wu ,  Luo-Hwa Miau ,  Jen-Chien Chien ,  Shi-Fu Chen ,  Li-Ling Li

IPC分类号： A61M1/00

CPC分类号： A61M1/0001 ,  A61M1/0025 ,  A61M1/0031 ,  A61M1/0088 ,  A61M2205/18 ,  A61M2205/3334 ,  A61M2205/3382

摘要： A fluid collector has a container, a T-tube, a first screw unit and a second screw unit. The T-tube is connected to the container and has a main pipe and a branch pipe. The first screw unit is mounted in an outlet end of the main pipe. The second screw unit is mounted in a connecting end of the branch pipe, which is connected to the main pipe. The branch pipe has a detecting opening far from the connecting end and connects to a detecting device. By changing the length of the first and second screw units, different detecting values of the pressure are adjusted according to containers with different capacities. Moreover, with the flowing resistance resulting from the first and second screw units, different pressure variations are performed when liquid or air passes through the T-tube. Therefore, massive hemorrhage is clearly identified to keep the patient safe.

摘要翻译： 流体收集器具有容器，T形管，第一螺丝单元和第二螺钉单元。 T型管与容器连接，并具有主管和分支管。 第一螺杆单元安装在主管的出口端。 第二螺钉单元安装在分支管的连接端上，该分支管连接到主管。 分支管具有远离连接端的检测开口并连接到检测装置。 通过改变第一和第二螺杆单元的长度，根据具有不同容量的容器来调节不同的压力检测值。 此外，由于由第一和第二螺杆单元产生的流动阻力，当液体或空气通过T形管时，执行不同的压力变化。 因此，清楚地确定大量出血以保持患者的安全。

公开(公告)号：US20120053543A1

公开(公告)日：2012-03-01

申请号：US12872990

申请日：2010-08-31

申请人： Luo-Hwa Miau ,  Jhy-Wen Wu ,  Jen-Chien Chien ,  Li-Ling Li ,  Nan-Kuang Yao

发明人： Luo-Hwa Miau ,  Jhy-Wen Wu ,  Jen-Chien Chien ,  Li-Ling Li ,  Nan-Kuang Yao

IPC分类号： A61M1/00

CPC分类号： A61M1/0019 ,  A61M1/0088 ,  A61M1/0094 ,  A61M2205/702 ,  A61M2205/7536

摘要： A collector for a negative pressure wound therapy system has a soft collecting bag with a gas-permeable unit and a liquid absorber. The collecting bag is connected to a wound-dressing unit via an inlet connecting set and is connected to a sensor assembly via a detecting connecting set. With the soft collecting bag, the collector occupies less volume. By the gas-permeable unit and the liquid absorber, the liquid and gas entering into the collecting bag quickly isolate. Moreover, multiple collectors connect in series to form a collector combination to reduce the frequency to replace the collector combination so that a longer usage time of the collector combination is available.

摘要翻译： 用于负压伤口治疗系统的收集器具有带有透气单元和液体吸收器的软收集袋。 收集袋通过入口连接组连接到伤口修整单元，并通过检测连接组连接到传感器组件。 使用软收集袋，收集器占用的体积较小。 通过透气单元和液体吸收器，进入收集袋的液体和气体快速隔离。 此外，多个收集器串联连接以形成收集器组合以减少频率以替换收集器组合，使得收集器组合的更长的使用时间可用。

公开(公告)号：US08148596B2

公开(公告)日：2012-04-03

申请号：US12497607

申请日：2009-07-03

申请人： Luo-Hwa Miau ,  Jhy-Wen Wu ,  Nan-Kuang Yao

发明人： Luo-Hwa Miau ,  Jhy-Wen Wu ,  Nan-Kuang Yao

IPC分类号： A61F13/00

CPC分类号： A61M27/00 ,  A61F13/0206 ,  A61F13/0216 ,  A61F13/0226 ,  A61F13/0246 ,  A61M1/0088

摘要： A wound treatment apparatus is disclosed, which comprises: a first portion, a second portion and a porous matrix. In an exemplary embodiment of the invention, the first portion, being an adhesive film, is formed with at least a first hole; and the second portion, being made of a flexible, water-resistant material, is formed with at least a second hole and at least a third hole in a manner that the at least one second hole and the at least one third hole are capable of communicating with each other and thus causes an accommodation space to be formed inside the second portion while the at least one second hole is arranged at a position corresponding to the at least one first hole as the second portion is connected to the first portion. Moreover, the porous matrix is received inside the accommodation space of the second portion.

摘要翻译： 公开了一种伤口治疗装置，其包括：第一部分，第二部分和多孔基质。 在本发明的示例性实施例中，作为粘合膜的第一部分至少形成有第一孔; 并且由柔性防水材料制成的第二部分形成有至少第二孔和至少第三孔，使得所述至少一个第二孔和所述至少一个第三孔能够 彼此连通，从而在第二部分内部形成容纳空间，同时当第二部分连接到第一部分时，至少一个第二孔布置在与至少一个第一孔相对应的位置。 此外，多孔基质容纳在第二部分的容纳空间的内部。

公开(公告)号：US08173078B2

公开(公告)日：2012-05-08

申请号：US10835101

申请日：2004-04-28

申请人： Nan-Kuang Yao ,  Jhy-Wen Wu

发明人： Nan-Kuang Yao ,  Jhy-Wen Wu

IPC分类号： B01L3/00

CPC分类号： F04B19/006

摘要： A microfluidic chip with a built-in gravity-driven micropump is provided. The gravity-driven micropump comprises a winding channel, an inert fluidic material placed inside the winding channel, and a suction channel that links the winding channel to the microfluidic chip. The winding channel is for the inert fluidic material to flow in. A fixed volume of high density, inert fluidic material is placed in the winding channel to act as a micropump in the bio chip. When the microfluidic chip is placed in a declining or standing position, the inert fluidic material flows along the winding channel due to the gravity. The invention provides a simple, convenient, and robust microfluid pumping source. With the built-in micropump, this invention is free-of-pollution and saves the manufacturing cost for the pipe link between the bio chip and peripheral devices.

摘要翻译： 提供具有内置重力驱动微型泵的微流控芯片。 重力驱动的微型泵包括绕组通道，放置在绕组通道内部的惰性流体材料以及将绕组通道连接到微流体芯片的抽吸通道。 卷绕通道用于惰性流体材料流入。固定体积的高密度惰性流体材料被放置在绕组通道中以用作生物芯片中的微型泵。 当微流体芯片处于下降或静止位置时，惰性流体材料由于重力而沿着缠绕通道流动。 本发明提供了一种简单，方便，可靠的微流体泵浦源。 利用内置的微型泵，本发明无污染，节省了生物芯片与外围设备之间管路连接的制造成本。

公开(公告)号：US20090053106A1

公开(公告)日：2009-02-26

申请号：US12007931

申请日：2008-01-17

申请人： Jhy-Wen Wu ,  Hung-Jen Yang ,  Nan-Kuang Yao

发明人： Jhy-Wen Wu ,  Hung-Jen Yang ,  Nan-Kuang Yao

IPC分类号： G01N33/00

CPC分类号： B01L3/502746 ,  B01L3/502738 ,  B01L2200/0621 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0457 ,  B01L2400/0688 ,  B01L2400/084

摘要： The present invention relates to an autonomous microfluidic apparatus. The autonomous microfluidic apparatus is substantially a substrate having a microchannel structure arranged thereon. As a microfluid is being filled in a loading well situated upstream of the microchannel structure, the microfluid is affected by interactions between gravity, adhesive force and surface tension and thus driven to flow downstream in the microchannel structure while filling a plurality of manifolds formed in a area situated downstream of the microchannel structure, so that accurate and autonomous quantification and separation of the microfluid using the plural manifolds, each having a specific length, can be achieved and provided for biomedical inspection and analysis.

摘要翻译： 本发明涉及自主微流体装置。 自主微流体装置基本上是其上布置有微通道结构的基板。 当微流体填充在位于微通道结构上游的装载井中时，微流体受到重力，粘附力和表面张力之间的相互作用的影响，因此被驱动在微通道结构的下游流动，同时填充形成在微通道结构中的多个歧管 位于微通道结构下游的区域，从而可以实现使用多个歧管（每个具有特定长度）的微流体的精确和自主的定量和分离，并提供用于生物医学检查和分析。

公开(公告)号：US07097811B2

公开(公告)日：2006-08-29

申请号：US11253981

申请日：2005-10-19

申请人： Nan-Kuang Yao ,  Jhy-Wen Wu

发明人： Nan-Kuang Yao ,  Jhy-Wen Wu

IPC分类号： B01L3/00

CPC分类号： B01L3/50273 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0457 ,  B01L2400/0694 ,  B01L2400/084 ,  Y10T436/2575

摘要： A gravity-driven apparatus and method control the flow order of reactants in microfluidic devices which are employed in a microfluidic chip. The gravity-driven apparatus flow order control mainly comprises a plurality of reactant chambers arranged at different heights, a plurality of flow-control microchannels, and a reaction chamber having a winding collection microchannel. Each reactant chamber has an air-in vent. Each pair of neighboring flow-control microchannels has a U-shaped structure connecting the pair of neighboring flow-control microchannels. To activate the microfluidic device, the device is placed in an inclining or standing position and the air-in vents are unsealed. This method enhances the reliability of flow order control for multiple reactants. It can be built in a microfluidic chip, and does not use any actuating power or element. Therefore, it is low in energy-consumption, low in manufacturing cost and free of pollution.

摘要翻译： 重力驱动装置和方法控制在微流体芯片中使用的微流体装置中的反应物的流动顺序。 重力驱动装置流程顺序控制主要包括布置在不同高度的多个反应物室，多个流量控制微通道和具有卷绕收集微通道的反应室。 每个反应物室都有一个进气口。 每对相邻的流量控制微通道具有连接该对相邻的流量控制微通道的U形结构。 为了激活微流体装置，将装置置于倾斜或站立位置，并且将通风口开封。 这种方法提高了多种反应物流顺序控制的可靠性。 它可以内置在微流控芯片中，不使用任何驱动电源或元件。 因此，能源消耗低，制造成本低，无污染。

公开(公告)号：US20070297949A1

公开(公告)日：2007-12-27

申请号：US11524372

申请日：2006-09-21

申请人： Jhy-Wen Wu ,  Hung-Jen Yang ,  Nan-Kuang Yao

发明人： Jhy-Wen Wu ,  Hung-Jen Yang ,  Nan-Kuang Yao

IPC分类号： B01L11/00

CPC分类号： B01L3/502753 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0457 ,  B01L2400/0487 ,  B01L2400/049

摘要： The present invention relates to a gravity-driven fraction separator and method thereof. The gravity-driven fraction separator is substantially a substrate having a microchannel structure arranged thereon, in which the microchannel structure is extending longitudinally on the substrate while sloping with respect to the level of the substrate by a specific angle. As a micro fluidics is being filled in a loading well situated upstream of the microchannel structure, the micro fluidics is driven by gravity to flow downstream in the microchannel structure while filling a plurality of manifolds formed in a area situated downstream of the microchannel structure, so that accurate quantification and separation of the micro fluidics using the plural manifolds, each having a specific length, can be achieved and provided for posterior inspection and analysis.

摘要翻译： 本发明涉及一种重力驱动级分分离器及其方法。 重力驱动级分分离器基本上是其上布置有微通道结构的基板，其中微通道结构在基板上纵向延伸，同时相对于基板的高度以特定角度倾斜。 由于微流体被填充在位于微通道结构上游的装载井中，微流体通过重力驱动以在微通道结构的下游流动，同时填充形成在位于微通道结构下游的区域中的多个歧管，因此 可以实现使用具有特定长度的多个歧管的微流体学的精确定量和分离，并提供用于后验检查和分析。

公开(公告)号：US20050255004A1

公开(公告)日：2005-11-17

申请号：US10836011

申请日：2004-04-29

申请人： Nan-Kuang Yao ,  Jhy-Wen Wu

发明人： Nan-Kuang Yao ,  Jhy-Wen Wu

IPC分类号： G01N35/08 ,  B01J19/00 ,  B01L3/00 ,  B81B1/00 ,  G01N37/00

CPC分类号： B01L3/50273 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0457 ,  B01L2400/0694 ,  B01L2400/084 ,  Y10T436/2575

摘要： A gravity-driven apparatus and method for controlling the flow order of reactants in microfluidic devices are provided, which are employed in a microfluidic chip. The gravity-driven apparatus flow order control mainly comprises a plurality of reactant chambers arranged in a stepwise pattern, a plurality of separate microchannels, and a reaction chamber having a winding converged microchannel. Each said reactant chamber has an air vent channel. Each pair of neighboring separate microchannels has a U-shaped structure connecting the pair of neighboring separate microchannels. To activate the microfluidic chip, the microfluidic chip is placed in a declining or standing position and the air vents are unsealed. This invention enhances the reliability of flow order control for multiple reactants. It can be built in a microfluidic chip, and needs not use any activate power or element. Therefore, it is low in energy-consumption, low in manufacturing cost and free-of-pollution.

摘要翻译： 提供了一种用于控制微流体装置中的反应物的流顺序的重力驱动装置和方法，其用于微流体芯片。 重力驱动装置流程顺序控制主要包括以逐步模式布置的多个反应物室，多个单独的微通道，以及具有卷绕收敛微通道的反应室。 每个所述反应物室具有排气通道。 每对相邻的单独微通道具有连接该对相邻的单独微通道的U形结构。 为了激活微流体芯片，微流控芯片被放置在下降或站立的位置，并且通气口是非密封的。 本发明提高了多种反应物流动顺序控制的可靠性。 它可以内置在微流控芯片中，不需要使用任何激活电源或元件。 因此，能源消耗低，制造成本低，污染自由。