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公开(公告)号：US6121041A
公开(公告)日：2000-09-19
申请号：US695067
申请日：1996-07-31
申请人： M. William Mirsch, II , Richard F. Schroeder , Barbara Illingworth , William H. Borner , Susan I. Montoya
发明人： M. William Mirsch, II , Richard F. Schroeder , Barbara Illingworth , William H. Borner , Susan I. Montoya
IPC分类号： C12N15/09 , A61L27/00 , A61L27/36 , A61L27/38 , C12N1/21 , C12N5/06 , C12R1/265 , C07G17/00 , C07G15/00 , C14C1/00
CPC分类号： A61L27/3687 , A61L2430/40
摘要： A method is disclosed for processing tissue by inoculating the tissue with a solution having microorganisms, where the microorganisms are selected to produce compounds that process the tissue. The tissue is incubated with the inoculated microorganisms under conditions that are effective for processing the tissue by the chemicals produced by the microorganisms. The tissue may be subsequently treated to substantially remove or inactivate the microorganisms.
摘要翻译： 公开了一种通过用具有微生物的溶液接种组织来处理组织的方法，其中选择微生物以产生加工组织的化合物。 将组织与接种的微生物在通过微生物产生的化学品有效处理组织的条件下温育。 随后处理组织以基本上除去或灭活微生物。
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公开(公告)号：US06531310B1
公开(公告)日：2003-03-11
申请号：US09609443
申请日：2000-07-03
IPC分类号： C07G1700
CPC分类号： A61L27/3687 , A01N1/02 , A61F2/24 , A61L27/36 , A61L27/38 , A61L2430/40 , C08L89/00
摘要： A method is disclosed for processing tissue by inoculating the tissue with a solution having microorganisms, where the microorganisms are selected to produce compounds that process the tissue. The tissue is incubated with the inoculated microorganisms under conditions that are effective for processing the tissue by the chemicals produced by the microorganisms. The tissue maybe subsequently treated to substantially remove or inactivate the microorganisms.
摘要翻译： 公开了一种通过用具有微生物的溶液接种组织来处理组织的方法，其中选择微生物以产生加工组织的化合物。 将组织与接种的微生物在通过微生物产生的化学品有效处理组织的条件下温育。 随后处理组织以基本上除去或灭活微生物。
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公开(公告)号：US06190407B1
公开(公告)日：2001-02-20
申请号：US09224178
申请日：1998-12-31
申请人： Matthew F. Ogle , William R. Holmberg , Richard F. Schroeder , Donald S. Guzik , M. William Mirsch, II , Darrin J. Bergman , Hallie A. Finucane , Katherine S. Tweden
发明人： Matthew F. Ogle , William R. Holmberg , Richard F. Schroeder , Donald S. Guzik , M. William Mirsch, II , Darrin J. Bergman , Hallie A. Finucane , Katherine S. Tweden
IPC分类号： A61F206
CPC分类号： A61L31/16 , A01N59/16 , A61F2/2412 , A61L15/18 , A61L15/44 , A61L15/46 , A61L27/30 , A61L27/306 , A61L27/54 , A61L29/10 , A61L29/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/45 , Y10S623/901 , Y10T428/31692 , Y10T428/31707 , A01N2300/00
摘要： A variety of new ways can be used for associating antimicrobial elemental metal with a medical article. The associated antimicrobial metal reduces the risk of infection associated with the medical use of the medical article. New medical articles are produced by some of these new approaches. Some of the methods involve ways of adjusting the dissociation rate of associated elemental metal such that desired degrees of antimicrobial activity can be achieved over selected periods of time.
摘要翻译： 可以使用各种新的方法将抗微生物元素金属与医疗制品相关联。 相关的抗微生物金属降低与医疗用品的医疗用途相关的感染的风险。 新的医疗用品是通过其中一些新方法生产的。 一些方法涉及调节相关元素金属的解离速率的方法，使得可以在选定的时间段内实现所需程度的抗微生物活性。
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公开(公告)号：US06267782B1
公开(公告)日：2001-07-31
申请号：US09143989
申请日：1998-08-31
申请人： Matthew F. Ogle , William R. Holmberg , Richard F. Schroeder , Donald S. Guzik , M. William Mirsch, II , Darrin J. Bergman , Hallie A. Finucane , Katherine S. Tweden
发明人： Matthew F. Ogle , William R. Holmberg , Richard F. Schroeder , Donald S. Guzik , M. William Mirsch, II , Darrin J. Bergman , Hallie A. Finucane , Katherine S. Tweden
IPC分类号： A61F204
CPC分类号： A61L31/16 , A01N59/16 , A61F2/2412 , A61L15/18 , A61L15/44 , A61L15/46 , A61L27/30 , A61L27/306 , A61L27/54 , A61L29/10 , A61L29/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/45 , Y10S623/901 , Y10T428/31692 , Y10T428/31707 , A01N2300/00
摘要： A variety of new ways can be used for associating antimicrobial elemental metal with a medical article. The associated antimicrobial metal reduces the risk of infection associated with the medical use of the medical article. New medical articles are produced by some of these new approaches. Some of the methods involve ways of adjusting the dissociation rate of associated elemental metal such that desired degrees of antimicrobial activity can be achieved over selected periods of time.
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公开(公告)号：US5910170A
公开(公告)日：1999-06-08
申请号：US992595
申请日：1997-12-17
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , Y10S623/90
摘要： The present invention includes a prosthetic heart valve having a stent and a piece of biocompatible material. The stent includes an inflow ring and a plurality of posts, each post extending from the ring to a post tip. The piece of material extends over the stent and substantially conforms to a profile of the stent. The piece of material includes a portion which extends adjacent a post tip. A clip is provided which has a shape generally conforming to the post tip to thereby clamp the portion of the piece of material to the post tip.
摘要翻译： 本发明包括具有支架和一片生物相容性材料的假体心脏瓣膜。 支架包括流入环和多个柱，每个柱从环延伸到后端。 该块材料在支架上延伸并且基本上符合支架的轮廓。 材料片包括一个邻近一个后端延伸的部分。 提供了一种夹子，其具有大致与柱塞顶端相符的形状，从而将该部分材料夹紧到后端。
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公开(公告)号：US20090270980A1
公开(公告)日：2009-10-29
申请号：US12498956
申请日：2009-07-07
申请人： Richard F. Schroeder , Robert Vidlund , Jason Kalgreen , Cyril Schweich, JR. , Todd Mortier , Marc Simmon , Peter Keith
发明人： Richard F. Schroeder , Robert Vidlund , Jason Kalgreen , Cyril Schweich, JR. , Todd Mortier , Marc Simmon , Peter Keith
CPC分类号： A61F2/2487 , A61B17/00234 , A61B17/1227 , A61B2017/00243 , A61B2017/0404 , A61B2017/048 , A61B2017/0496 , A61F2/2481
摘要： The various aspects of the invention pertain to devices and related methods for treating heart conditions, including, for example, dilatation, valve incompetencies, including mitral valve leakage, and other similar heart failure conditions. The devices and related methods of the present invention operate to assist in the apposition of heart valve leaflets to improve valve function. According to one aspect of the invention, a method improves the function of a valve of a heart by placing an elongate member transverse a heart chamber so that each end of the elongate member extends through a wall of the heart, and placing first and second anchoring members external the chamber. The first and second anchoring members are attached to first and second ends of the elongate member to fix the elongate member in a position across the chamber so as to reposition papillary muscles within the chamber. Also described herein is a method for placing a splint assembly transverse a heart chamber by advancing an elongate member through vasculature structure and into the heart chamber.
摘要翻译： 本发明的各个方面涉及用于治疗心脏病症的装置和相关方法，包括例如扩张，瓣膜无能力，包括二尖瓣渗漏和其它类似的心力衰竭病症。 本发明的装置和相关方法用于协助心脏瓣膜小叶的安置以改善瓣膜功能。 根据本发明的一个方面，一种方法通过将细长构件横向放置在心室中来改善心脏瓣膜的功能，使得细长构件的每个端部延伸穿过心脏的壁，并且将第一和第二锚定 会员外部室。 第一和第二锚固构件附接到细长构件的第一和第二端部，以将细长构件固定在穿过腔室的位置，以便重新定位腔室内的乳头肌肉。 本文还描述了通过使细长构件通过脉管系统结构并进入心脏腔室来放置夹板组件横向于心室的方法。
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公开(公告)号：US06302909B1
公开(公告)日：2001-10-16
申请号：US08690661
申请日：1996-07-31
IPC分类号： A61F202
CPC分类号： A61L27/3687 , A61L27/3604 , A61L27/50 , A61L2400/02 , Y10S623/901 , Y10S623/925
摘要： The invention involves a bioprosthetic article including a biocompatible material having at least one bound exogenous storage structure, the storage structures having collectively greater than about 0.5 mg metal cations per gram of biocompatible material. The calcification inhibitors preferably decrease calcium deposition by greater than 95% relative to untreated tissue. The calcification inhibitors are bonded to the bioprosthetic material preferably at a pH between about 6.0 and 8.5.
摘要翻译： 本发明涉及一种生物假体制品，其包括具有至少一种结合的外源储存结构的生物相容性材料，所述储存结构具有大于约0.5mg金属阳离子/克生物相容性材料。 钙化抑制剂相对于未处理的组织优选减少钙沉积大于95％。 钙化抑制剂优选在约6.0-8.5之间的pH下结合到生物假体材料上。
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公开(公告)号：US06206917B1
公开(公告)日：2001-03-27
申请号：US08850812
申请日：1997-05-02
IPC分类号： A61F210
CPC分类号： A61F2/2415 , A61F2/062
摘要： An apparatus is disclosed for differentially treating a medical device. One portion of the device is treated with a first fluid and a separate portion is treated with a second fluid. The second fluid generally is substantially different from the first fluid. The first fluid can be contacted with an flow region of the medical device. The apparatus can include a conduit system, where fluid flowing through the conduit system flows through the flow region. Sheet material can be treated differentially on the opposite surfaces of the sheet. The medical device can include vascular tissue.
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公开(公告)号：US6132473A
公开(公告)日：2000-10-17
申请号：US86193
申请日：1998-05-28
CPC分类号： A61F2/2415 , A61F2/062
摘要： An apparatus is disclosed for differentially treating a medical device. One portion of the device is treated with a first fluid and a separate portion is treated with a second fluid. The second fluid generally is substantially different from the first fluid. The first fluid can be contacted with an flow region of the medical device. The apparatus can include a conduit system, where fluid flowing through the conduit system flows through the flow region. Sheet material can be treated differentially on the opposite surfaces of the sheet. The medical device can include vascular tissue.
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公开(公告)号：US06616684B1
公开(公告)日：2003-09-09
申请号：US09679550
申请日：2000-10-06
申请人： Robert M. Vidlund , Marc A. Simmon , Todd J. Mortier , Cyril J. Schweich, Jr. , Peter T. Keith , Richard F. Schroeder , Jason Kalgreen
发明人： Robert M. Vidlund , Marc A. Simmon , Todd J. Mortier , Cyril J. Schweich, Jr. , Peter T. Keith , Richard F. Schroeder , Jason Kalgreen
IPC分类号： A61B1708
CPC分类号： A61F2/2487 , A61B17/00234 , A61B17/064 , A61B17/0682 , A61B90/39 , A61B2017/00243 , A61B2017/003 , A61B2017/00557 , A61B2017/00907 , A61B2017/0404 , A61B2017/0409 , A61B2017/0412 , A61B2017/0437 , A61B2017/0464 , A61B2017/048 , A61B2017/0496
摘要： A method for placing a splint assembly transverse a heart chamber includes providing an elongate member having a first end and a second end and a deployable heart-engaging assembly connected to at least the first end. The method includes advancing the elongate member through vasculature structure and into the heart chamber such that the first end of the elongate member extends through a first location of a wall surrounding the heart chamber and the second end extends through a second location of the heart chamber wall substantially opposite the first location. A deployable heart-engaging assembly is deployed such that it engages with a first exterior surface portion of the heart chamber wall adjacent the first location. The elongate member is secured with respect to the heart with a second heart-engaging assembly connected to the second end. The second heart-engaging assembly engages with a second exterior surface portion of the heart chamber wall adjacent the second location. A splint assembly includes an expandable heart-engaging assembly formed partially from portions forming the elongate member of the splint assembly. A delivery tool includes a tubular member configured to be advanced through vasculature structure and has a curved distal end.
摘要翻译： 用于将夹板组件放置在心室上的方法包括提供具有第一端和第二端的细长构件以及连接到至少第一端的可展开的心脏接合组件。 该方法包括使细长构件通过脉管系统结构推进并进入心室，使得细长构件的第一端延伸穿过围绕心室的壁的第一位置，并且第二端延伸通过心室壁的第二位置 基本上与第一位置相对。 展开的心脏接合组件被布置成使得其与邻近第一位置的心室壁的第一外表面部分接合。 细长构件相对于心脏固定，第二心脏接合组件连接到第二端。 第二心脏接合组件与邻近第二位置的心室壁的第二外表面部分接合。 夹板组件包括可部分地由形成夹板组件的细长构件的部分形成的可膨胀心脏接合组件。 输送工具包括构造成通过脉管系统结构前进并具有弯曲远端的管状构件。
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