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公开(公告)号：US20230183760A1
公开(公告)日：2023-06-15
申请号：US18172594
申请日：2023-02-22
申请人： MANUS BIO INC.
发明人： Ryan N. PHILIPPE , Ajikumar PARAYIL KUMARAN , Christine Nicole S. SANTOS , Jason DONALD , Stephen SARRIA
CPC分类号： C12P7/26 , C12N9/0006 , C12N9/0071 , C12N9/1085 , C12N9/88 , C12N15/52 , C12Y205/0101 , C12Y402/03087
摘要： The present disclosure provides methods and compositions for producing rotundone. In various aspects, the present disclosure provides enzymes, polynucleotides encoding said enzymes, and recombinant microbial host cells (or microbial host strains) for the production of rotundone. In some embodiments, the present disclosure provides microbial host cells for producing rotundone at high purity and/or yield, from either enzymatic transformation of α-guaiene, or from sugar or other carbon source. The present disclosure further provides methods of making products containing rotundone, including flavor or fragrance products, among others.
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公开(公告)号：US20230146484A1
公开(公告)日：2023-05-11
申请号：US17981671
申请日：2022-11-07
申请人： MANUS BIO INC.
IPC分类号： C12P19/56
CPC分类号： C12P19/56 , C12N1/205 , C12Y114/14 , C12Y114/13079 , C12Y204/01 , C12Y402/03019
摘要： The present invention provides engineered cells and methods for making high purity steviol glycosides, including RebM. In some aspects, the present invention provides host cells, such as bacterial cells (including but not limited to E. coli), that are engineered to overexpress and/or delete or inactivate one or more steviol glycoside transport proteins. The bacterial cells selectively export RebM, or other specific combination of steviol glycosides, out of the cell to increase productivity and reduce production costs associated with downstream purification. Non-target steviol glycosides are not transported to the extracellular medium in significant amounts.
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公开(公告)号：US20230313249A1
公开(公告)日：2023-10-05
申请号：US18023912
申请日：2021-08-26
申请人： Manus Bio Inc.
发明人： Ajikumar PARAYIL KUMARAN , Christine Nicole S. SANTOS , Stephen SARRIA , Jason Eric DONALD , Yiying ZHENG , Liwei LI , Eric NIEMINEN , Michelle N. GOETTGE
CPC分类号： C12P17/181 , C12N15/52 , C12N9/001 , C12Y103/01092 , C12N9/0042 , C12N9/88 , C12Y402/03024
摘要： The present disclosure provides methods and compositions for producing artemisinic acid, dihydroartemisinic acid or artemisinin. In various aspects, the present disclosure provides enzymes, polynucleotides encoding said enzymes, and recombinant microbial host cells (or microbial host strains) for the production of artemisinic acid, dihydroartemisinic acid or artemisinin. The present disclosure further provides methods of making pharmaceutical products containing artemisinic acid, dihydroartemisinic acid or artemisinin.
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公开(公告)号：US20230180691A1
公开(公告)日：2023-06-15
申请号：US17981867
申请日：2022-11-07
CPC分类号： A01H3/04 , C12N1/12 , C12N1/14 , C12N1/16 , C12N1/20 , C12N15/1079 , C12Q1/025 , G01N33/5082 , G01N33/5097
摘要： The present invention relates to systems and methods for screening natural products such as secondary metabolites produced by engineered microbial strains.
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公开(公告)号：US20240093258A1
公开(公告)日：2024-03-21
申请号：US18038067
申请日：2021-11-24
申请人： Manus Bio Inc.
发明人： Ajikumar PARAYIL KUMARAN , Christine Nicole S. SANTOS , Jason DONALD , Aaron LOVE , Yiying ZHENG , Adel GHADERI , Vineet SHASTRY , Lu CHEN , Christopher TOOMEY , Hannah LYNCH , Eric NIEMINEN
CPC分类号： C12P19/60 , C12N9/1051 , C12N9/90 , C12Y204/01017 , C12Y503/01009
摘要： In various aspects and embodiments, the present disclosure provides methods for making glycosylated products, as well as bacterial cells and uridine diphosphate (UDP)-dependent glycosyltransferase (UGT) enzymes useful for the same. In other aspects and embodiments, the disclosure provides methods for high yield and/or high purity recovery of such glycoside products from microbial cultures or cell free reactions. In various aspects and embodiments, the disclosure provides for whole cell bioconversion processes involving the glycosylation of a desired substrate, and/or the recovery of the glycosylated product at high yield and/or high purity.
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公开(公告)号：US20230323314A1
公开(公告)日：2023-10-12
申请号：US18161938
申请日：2023-01-31
申请人： MANUS BIO INC.
发明人： Jason DONALD , Christopher PIRIE , Liwei LI , Huey-Ming MAK , Srishti TIBREWALA , Ajikumar PARAYIL KUMARAN
CPC分类号： C12N9/0079 , C12N9/00 , C12N15/52 , C12N15/70 , C12P5/007 , C12P19/56 , C07K2319/03
摘要： The present invention relates to the production of chemical species in bacterial host cells. Particularly, the present invention provides for the production of chemical species in Escherichia coli (E. coli) host cells that functionally express engineered P450 enzymes.
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