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公开(公告)号：US09828365B2
公开(公告)日：2017-11-28
申请号：US15104584
申请日：2014-12-15
申请人： MERCK SHARP & DOHME CORP. , Joseph Kozlowski , Craig Coburn , Wensheng Yu , Ling Tong , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang , Tao Ji
发明人： Joseph Kozlowski , Craig Coburn , Wensheng Yu , Ling Tong , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang , Tao Ji
IPC分类号： C07D493/04 , C07D405/14 , A61K45/06 , A61K31/4985 , A61K31/7072 , A61K31/4178
CPC分类号： C07D405/14 , A61K31/4155 , A61K31/4178 , A61K31/4985 , A61K31/7072 , A61K45/06 , C07D493/04 , A61K2300/00
摘要： The present invention relates to novel Fused Tetracyclic Heterocyclic Compounds of Formula I: (I), wherein A, A′, R2A, R2B, R7, R8, R9, and R10 are defined herein. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HCV and the prophylaxis, treatment, or delay in the onset of disease caused by HCV. The present invention also relates to pharmaceutical compositions comprising at least one Fused Tetracyclic Heterocyclic Compound, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines, and methods of using the Fused Tetracyclic Heterocyclic Compounds for treating or preventing HCV infection in a patient.
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公开(公告)号：US20170217940A1
公开(公告)日：2017-08-03
申请号：US15104584
申请日：2014-12-15
申请人： Joseph KOZLOWSKI , Craig COBURN , Wensheng YU , Bin HU , Bin ZHONG , Jinglai HAO , Dahai WANG , Tao JI , MERCL SHARP & DOHME CORP.
发明人： Joseph Kozlowski , Craig Coburn , Wensheng Yu , Ling Tong , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang , Tao Ji
IPC分类号： C07D405/14 , A61K31/4178 , A61K31/7072 , A61K45/06 , A61K31/4985
CPC分类号： C07D405/14 , A61K31/4155 , A61K31/4178 , A61K31/4985 , A61K31/7072 , A61K45/06 , C07D493/04 , A61K2300/00
摘要： The present invention relates to novel Fused Tetracyclic Heterocyclic Compounds of Formula I: (I), wherein A, A′, R2A, R2B, R7, R8, R9, and R10 are defined herein. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HCV and the prophylaxis, treatment, or delay in the onset of disease caused by HCV. The present invention also relates to pharmaceutical compositions comprising at least one Fused Tetracyclic Heterocyclic Compound, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines, and methods of using the Fused Tetracyclic Heterocyclic Compounds for treating or preventing HCV infection in a patient.
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3.发明申请公开(公告)号：US20190175602A1
公开(公告)日：2019-06-13
申请号：US16326039
申请日：2017-08-14
申请人： Wensheng Yu , LING Tong , Joseph A. Koziowski , Craig: A Coburn , De-yi J. Yang , Deyou Sha , Jae-Hun. Kim , Michael Dwyer , Kartik M. Keertikar , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
发明人： Wensheng Yu , LING Tong , Joseph A. Koziowski , Craig: A Coburn , De-yi J. Yang , Deyou Sha , Jae-Hun. Kim , Michael Dwyer , Kartik M. Keertikar , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
IPC分类号： A61K31/5365 , C07D498/04 , A61P31/14 , A61K31/4995 , C07D519/00
摘要： The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetra-cyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
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4.发明申请公开(公告)号：US20190185486A1
公开(公告)日：2019-06-20
申请号：US16326043
申请日：2017-08-14
申请人： Wensheng Yu , Joseph A. Kozlowski , Ling Tong , Craig A. Cobum , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
发明人： Wensheng Yu , Joseph A. Kozlowski , Ling Tong , Craig A. Cobum , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
IPC分类号： C07D498/04 , A61K31/5365 , A61K31/496 , A61K45/06 , A61P31/14
摘要： The present invention relates to novel Chromane-Substituted Tetracyclic Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising a Chromane-Substituted Tetracyclic Compound, and methods of using the Chromane-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
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公开(公告)号：US20120316200A1
公开(公告)日：2012-12-13
申请号：US13578653
申请日：2011-04-07
申请人： Linus S. Lin , Richard Soll , Jingchao Dong , Hao Wu , Takao Suzuki , Bin Hu , Dejun Liu , Jinglai Hao , Ming Xu
发明人： Linus S. Lin , Richard Soll , Jingchao Dong , Hao Wu , Takao Suzuki , Bin Hu , Dejun Liu , Jinglai Hao , Ming Xu
IPC分类号： C07D213/69 , C07D401/10 , A61K31/4709 , C07D401/12 , A61P25/22 , A61P3/04 , A61P3/10 , A61P1/16 , A61P25/24 , A61K31/4418 , A61K31/444
CPC分类号： C07D401/12 , C07D213/69
摘要： The present invention is directed to novel phenylpyridone derivative compounds. The compounds act as a melanin concentrating hormone receptor antagonists, and can be useful in preventing, treating or acting as a remedial agent for various circular system diseases, nervous system diseases, metabolic diseases, genital diseases, respiratory diseases and digestive diseases.
摘要翻译： 本发明涉及新的苯基吡啶酮衍生物化合物。 该化合物作为黑色素浓缩激素受体拮抗剂起作用，可用于预防，治疗或作为各种循环系统疾病，神经系统疾病，代谢疾病，生殖器疾病，呼吸系统疾病和消化系统疾病的补救剂。
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6.发明申请HETEROCYCLE-SUBSTITUTED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权杂环取代的四环化合物及其用于治疗病毒性疾病的方法公开(公告)号：US20150335648A1
公开(公告)日：2015-11-26
申请号：US14761256
申请日：2013-12-31
发明人： Wensheng Yu , Ling Tong , Joseph A. Kozlowski , Oleg Selyutin , Lei Chen , Jae-Hun Kim , Deyou Sha , Razia Rizvi , Bandarpalle Shankar , Bin Hu , Bin Zhong , Dahai Wang , Jinglai Hao , Wei Wei , Tao Ji , Shuai Zan
IPC分类号： A61K31/5365 , C07D498/04 , C07D513/04 , A61K45/06
CPC分类号： A61K31/5365 , A61K31/4985 , A61K31/7056 , A61K31/7072 , A61K45/06 , C07D498/04 , C07D513/04 , Y02A50/385 , Y02A50/389 , A61K2300/00
摘要： The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3, R4 and R are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetracyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式（I）的新型杂环取代的四环化合物：（I）及其药学上可接受的盐，其中A，A'，R 2 R3，R4和R如本文所定义。 本发明还涉及包含至少一种杂环取代的四环化合物的组合物，以及使用杂环取代的四环化合物治疗或预防患者HCV感染的方法。
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公开(公告)号：US20190269679A1
公开(公告)日：2019-09-05
申请号：US16462344
申请日：2017-12-11
发明人： John S. Debenham , Jason M. Cox , Ping Lan , Zhongxiang Sun , Zhe Feng , Chunrui Sun , Michael W. Seganish , Zhong Lai , Cheng Zhu , Thomas Bara , Murali Rajagopalan , Qun Dang , Hyunjin M. Kim , Bin Hu , Jinglai Hao
IPC分类号： A61K31/497 , A61K31/4439 , A61K31/42 , A61K31/444 , C07D417/14 , C07D413/04 , C07D413/14 , C07D231/20
摘要： The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.
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公开(公告)号：US10787441B2
公开(公告)日：2020-09-29
申请号：US16094621
申请日：2017-04-17
发明人： Joseph A. Kozlowski , Wensheng Yu , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang , Zhixin Lei
IPC分类号： A61K31/4178 , C07D405/14 , A61K38/21 , A61K38/19 , A61K45/06
摘要： A compound of Formula (I) or (II), for treating or preventing an HCV infection in a subject.
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9.发明授权公开(公告)号：US10738062B2
公开(公告)日：2020-08-11
申请号：US16326043
申请日：2017-08-14
发明人： Wensheng Yu , Joseph A. Kozlowski , Ling Tong , Craig A. Coburn , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
IPC分类号： C07D498/04 , A61K45/06 , A61K31/496 , A61K31/5365 , A61P31/14
摘要： The present invention relates to novel Chromane-Substituted Tetracyclic Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising a Chromane-Substituted Tetracyclic Compound, and methods of using the Chromane-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
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公开(公告)号：US09527875B2
公开(公告)日：2016-12-27
申请号：US14418147
申请日：2013-07-31
发明人： William K. Hagmann , Ravi P. Nargund , Timothy A. Blizzard , Hubert Josien , Purakkattle Biju , Christopher W. Plummer , Qun Dang , Bing Li , Derun Li , Linus S. Lin , Mingxiang Cui , Bin Hu , Jinglai Hao , Zhengxia Chen
IPC分类号： C07D417/12 , A61K31/4353 , C07F9/58 , C07D401/14 , C07D221/16 , C07D401/12 , A61K31/435 , A61K31/444 , A61K45/06 , A61K31/4412 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/496 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/675 , C07D405/12 , C07D409/14
CPC分类号： C07F9/58 , A61K31/435 , A61K31/4412 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D221/16 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D417/12
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要翻译： 结构式（I）的新型化合物及其药学上可接受的盐是G蛋白偶联受体40（GPR40）的激动剂，可用于治疗，预防和抑制G蛋白偶联受体 受体40.本发明的化合物可用于治疗2型糖尿病，以及通常与该疾病相关的病症，包括肥胖症和脂质疾病，例如混合或糖尿病性血脂异常，高脂血症，高胆固醇血症和 高甘油三酯血症
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