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    Fluorescent NIRF activatable probes for disease detection
    8.
    发明授权
    Fluorescent NIRF activatable probes for disease detection 有权
    用于疾病检测的荧光NIRF可激活探针

    公开(公告)号：US08834846B2

    公开(公告)日：2014-09-16

    申请号：US13101370

    申请日：2011-05-05

    申请人： Tao Ji ,  Warren M. Leevy ,  William E. McLaughlin ,  Yawfui Yong

    发明人： Tao Ji ,  Warren M. Leevy ,  William E. McLaughlin ,  Yawfui Yong

    IPC分类号： A61B5/00

    CPC分类号： G01N33/587 ,  A61K49/0485 ,  B82Y5/00 ,  B82Y15/00 ,  C12Q1/34 ,  G01N33/542

    摘要： Fluorescent activatable probes for imaging biological processes and disease detection in vitro and in vivo. There is also described a method for detecting the presence of an enzyme. A sample is contacted with a nanoparticle including a monomer, at least one cleavable spacer comprising at least one fluorescence activation site, and at least two dyes of at least two types. The cleavable spacer is attached at one end to the nanoparticle. The at least two types comprise an energy donor type and an energy acceptor type. At least one dye of one type is embedded in the nanoparticle and the cleavable spacer has at least one dye of the other type attached. The at least two dyes comprise at least one matched pair capable of fluorescence resonance energy transfer. Fluorescence is detected by exposing the sample to a light source, and detecting emitted light with a detector.

    摘要翻译： 用于成像生物过程和体外和体内疾病检测的荧光可激活探针。 还描述了检测酶的存在的方法。 将样品与包含单体的纳米颗粒，至少一个可切割间隔基包含至少一个荧光活化位点和至少两种至少两种类型的染料接触。 可切割间隔物的一端连接到纳米颗粒。 至少两种类型包括能量供体类型和能量受体类型。 至少一种一种染料被包埋在纳米颗粒中，并且可切割间隔物具有至少一种所连接的另一种类型的染料。 所述至少两种染料包含能够进行荧光共振能量转移的至少一个匹配对。 通过将样品暴露于光源并用检测器检测发射光来检测荧光。

    FIRE EXTINGUISHING COMPOSITION OF COPPER SALTS
    9.
    发明申请
    FIRE EXTINGUISHING COMPOSITION OF COPPER SALTS 有权
    铜销售灭火组合物

    公开(公告)号：US20140183400A1

    公开(公告)日：2014-07-03

    申请号：US14239118

    申请日：2012-08-14

    申请人： Tao Ji ,  Tao Wei

    发明人： Tao Ji ,  Tao Wei

    IPC分类号： A62D1/00 ,  A62D1/06

    CPC分类号： A62D1/0007 ,  A62D1/06

    摘要： Disclosed is a fire extinguishing composition of copper salts, which comprises a compound of copper salts and a fire retardant component with the content of 30 wt %--95 wt % for the former and 5 wt %-70 wt % for the latter respectively. A pyrotechnic agent in the composition serves as heat source and power source, and through being ignited, the pyrotechnic agent is burnt to generate high temperature to enable the composition to perform decomposition reaction so that a large quantity of the resulting fire extinguishing substances can be spouted out with the pyrotechnic agent to achieve an object of fire extinguishing. The fire extinguishing composition of copper salts can decrease the quantity of heat released by combustion of the pyrotechnic agent rapidly and efficiently, thus greatly reducing the nozzle temperature of a fire extinguishing apparatus and a sprayed substance, avoiding use of a complicated cooling system of the fire extinguishing apparatus, and also eliminating the danger of a secondary fire. the fire extinguishing composition releases a great deal of an effective fire extinguishing substance at the moment of being heated, through the synergistic effect of various particles, the fire extinguishing time is greatly shortened.

    摘要翻译： 公开了一种铜盐灭火组合物，其包含铜盐和阻燃组分的化合物，其中前者分别为30重量％-95重量％，后者分别为5重量％-70重量％。 组合物中的烟火剂用作热源和动力源，并通过点燃，燃烧烟火以产生高温，使得组合物能够进行分解反应，从而可以喷出大量所得的灭火物质 与烟火代理商达成灭火对象。 铜盐灭火组合物可以快速有效地减少烟火剂燃烧释放的热量，从而大大降低灭火装置和喷雾物质的喷嘴温度，避免使用复杂的火灾冷却系统 灭火装置，也消除二次火灾的危险。 灭火组合物在加热时释放大量有效的灭火物质，通过各种颗粒的协同效应，大大缩短了灭火时间。

    High capacity non-viral vectors
    10.
    发明授权
    High capacity non-viral vectors 失效
    高容量非病毒载体

    公开(公告)号：US08202544B2

    公开(公告)日：2012-06-19

    申请号：US12562184

    申请日：2009-09-18

    申请人： Rao Papineni ,  Tao Ji ,  William E. McLaughlin

    发明人： Rao Papineni ,  Tao Ji ,  William E. McLaughlin

    IPC分类号： C12N15/87 ,  C07H21/02 ,  C07K2/00

    CPC分类号： C12N15/87 ,  A61K48/00

    摘要： Non-viral vectors for delivering agents to a site within the body of an animal comprise a biocompatible nanoparticle conjugated to an avidin/biotin complex and a water soluble linear polymer comprising multiple binding sites. The agents to be delivered are conjugated to each of the multiple binding sites, thereby increasing the loading capacity of the system. Where the agents comprise siRNA, each biotin/avidin complex may carry greater than four siRNA. The biocompatible nanoparticle may also comprise a fluorescent dye for in vivo imaging.

    摘要翻译： 用于将药剂递送到动物体内的部位的非病毒载体包含与抗生物素蛋白/生物素复合物缀合的生物相容纳米颗粒和包含多个结合位点的水溶性线性聚合物。 要递送的试剂与多个结合位点中的每一个缀合，从而增加系统的负载能力。 当试剂包含siRNA时，每个生物素/抗生物素蛋白复合物可携带大于4个siRNA。 生物相容纳米颗粒还可以包含用于体内成像的荧光染料。