-
1.发明申请公开(公告)号：US20190175602A1
公开(公告)日：2019-06-13
申请号：US16326039
申请日：2017-08-14
申请人： Wensheng Yu , LING Tong , Joseph A. Koziowski , Craig: A Coburn , De-yi J. Yang , Deyou Sha , Jae-Hun. Kim , Michael Dwyer , Kartik M. Keertikar , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
发明人： Wensheng Yu , LING Tong , Joseph A. Koziowski , Craig: A Coburn , De-yi J. Yang , Deyou Sha , Jae-Hun. Kim , Michael Dwyer , Kartik M. Keertikar , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
IPC分类号： A61K31/5365 , C07D498/04 , A61P31/14 , A61K31/4995 , C07D519/00
摘要： The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetra-cyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
-
公开(公告)号：US09828365B2
公开(公告)日：2017-11-28
申请号：US15104584
申请日：2014-12-15
申请人： MERCK SHARP & DOHME CORP. , Joseph Kozlowski , Craig Coburn , Wensheng Yu , Ling Tong , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang , Tao Ji
发明人： Joseph Kozlowski , Craig Coburn , Wensheng Yu , Ling Tong , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang , Tao Ji
IPC分类号： C07D493/04 , C07D405/14 , A61K45/06 , A61K31/4985 , A61K31/7072 , A61K31/4178
CPC分类号： C07D405/14 , A61K31/4155 , A61K31/4178 , A61K31/4985 , A61K31/7072 , A61K45/06 , C07D493/04 , A61K2300/00
摘要： The present invention relates to novel Fused Tetracyclic Heterocyclic Compounds of Formula I: (I), wherein A, A′, R2A, R2B, R7, R8, R9, and R10 are defined herein. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HCV and the prophylaxis, treatment, or delay in the onset of disease caused by HCV. The present invention also relates to pharmaceutical compositions comprising at least one Fused Tetracyclic Heterocyclic Compound, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines, and methods of using the Fused Tetracyclic Heterocyclic Compounds for treating or preventing HCV infection in a patient.
-
3.发明申请公开(公告)号：US20190185486A1
公开(公告)日：2019-06-20
申请号：US16326043
申请日：2017-08-14
申请人： Wensheng Yu , Joseph A. Kozlowski , Ling Tong , Craig A. Cobum , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
发明人： Wensheng Yu , Joseph A. Kozlowski , Ling Tong , Craig A. Cobum , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
IPC分类号： C07D498/04 , A61K31/5365 , A61K31/496 , A61K45/06 , A61P31/14
摘要： The present invention relates to novel Chromane-Substituted Tetracyclic Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising a Chromane-Substituted Tetracyclic Compound, and methods of using the Chromane-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
-
公开(公告)号：US20170217940A1
公开(公告)日：2017-08-03
申请号：US15104584
申请日：2014-12-15
申请人： Joseph KOZLOWSKI , Craig COBURN , Wensheng YU , Bin HU , Bin ZHONG , Jinglai HAO , Dahai WANG , Tao JI , MERCL SHARP & DOHME CORP.
发明人： Joseph Kozlowski , Craig Coburn , Wensheng Yu , Ling Tong , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang , Tao Ji
IPC分类号： C07D405/14 , A61K31/4178 , A61K31/7072 , A61K45/06 , A61K31/4985
CPC分类号： C07D405/14 , A61K31/4155 , A61K31/4178 , A61K31/4985 , A61K31/7072 , A61K45/06 , C07D493/04 , A61K2300/00
摘要： The present invention relates to novel Fused Tetracyclic Heterocyclic Compounds of Formula I: (I), wherein A, A′, R2A, R2B, R7, R8, R9, and R10 are defined herein. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HCV and the prophylaxis, treatment, or delay in the onset of disease caused by HCV. The present invention also relates to pharmaceutical compositions comprising at least one Fused Tetracyclic Heterocyclic Compound, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines, and methods of using the Fused Tetracyclic Heterocyclic Compounds for treating or preventing HCV infection in a patient.
-
5.发明申请SILYL-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 审中-公开含有SILYL的杂环化合物及其用于治疗病毒性疾病的方法公开(公告)号：US20140378416A1
公开(公告)日：2014-12-25
申请号：US14345114
申请日：2012-09-11
申请人： Michael P. Dwyer , Kartik M. Keertikar , Qingbei Zeng , Robert D. Mazzola, JR. , Wensheng Yu , Haiqun Tang , Seong Heon Kim , Ling Tong , Stuart B. Rosenblum , Joseph A. Kozlowski , Anilkumar Gopinadhan Nair
发明人： Michael P. Dwyer , Kartik M. Keertikar , Qingbei Zeng , Robert D. Mazzola, JR. , Wensheng Yu , Haiqun Tang , Seong Heon Kim , Ling Tong , Stuart B. Rosenblum , Joseph A. Kozlowski , Anilkumar Gopinadhan Nair
IPC分类号： C07F7/10 , A61K45/06 , A61K31/695
CPC分类号： C07F7/10 , A61K31/695 , A61K45/06 , A61K2201/094 , A61K2300/00 , C07F7/0816
摘要： The present invention relates to novel Silyl-Containing Heterocyclic Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, C, D, E, F and L are as defined herein. The present invention also relates to compositions comprising at least one Silyl-Containing Heterocyclic Compound, and methods of using the Silyl-Containing Heterocyclic Compounds for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式（I）的新的含甲硅烷基的杂环化合物及其药学上可接受的盐，其中A，B，C，D，E，F和L如本文所定义。 本发明还涉及包含至少一种含甲硅烷基的杂环化合物的组合物，以及使用含有甲硅烷基的杂环化合物治疗或预防患者HCV感染的方法。
-
6.发明授权Fused tricyclic silyl compounds and methods of use thereof for the treatment of viral diseases 有权稠合的三环甲硅烷基化合物及其用于治疗病毒性疾病的方法公开(公告)号：US08609635B2
公开(公告)日：2013-12-17
申请号：US13041082
申请日：2011-03-04
申请人： Anilkumar Gopinadhan Nair , Kartik M. Keertikar , Seong Heon Kim , Joseph A. Kozlowski , Stuart Rosenblum , Oleg B. Selyutin , Michael Wong , Wensheng Yu , Qingbei Zeng
发明人： Anilkumar Gopinadhan Nair , Kartik M. Keertikar , Seong Heon Kim , Joseph A. Kozlowski , Stuart Rosenblum , Oleg B. Selyutin , Michael Wong , Wensheng Yu , Qingbei Zeng
IPC分类号： A61K31/695 , C07F7/10
CPC分类号： C07F7/0816
摘要： The present invention relates to novel Fused Tricyclic Silyl Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, C, D, M1, X1 and X2 are as defined herein. The present invention also relates to compositions comprising at least one Fused Tricyclic Silyl Compound, and methods of using the Fused Tricyclic Silyl Compounds for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式（I）的新型稠合三环甲硅烷基化合物及其药学上可接受的盐，其中A，B，C，D，M1，X1和X2如本文所定义。 本发明还涉及包含至少一种熔融三环甲硅烷基化合物的组合物，以及使用融合的三环甲硅烷基化合物治疗或预防患者HCV感染的方法。
-
公开(公告)号：US08178553B2
公开(公告)日：2012-05-15
申请号：US12690633
申请日：2010-01-20
申请人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Shankar B. Bandarpalle , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Aneta Maria Kosinski , Seong-Heon Kim , De-Yi Yang , Razia K. Rizvi
发明人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Shankar B. Bandarpalle , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Aneta Maria Kosinski , Seong-Heon Kim , De-Yi Yang , Razia K. Rizvi
IPC分类号： A61K31/4178 , A61K31/437 , A61K31/4439 , A61P3/00 , A61P29/00 , A61P11/00 , C07D491/048 , C07D471/04 , C07D401/14 , C07D403/06
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症 。
-
公开(公告)号：US20120010181A1
公开(公告)日：2012-01-12
申请号：US13127952
申请日：2009-11-09
申请人： Joseph A. Kozlowski , Wensheng Yu , Michael K.C. Wong , Seong Heon Kim , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , De-Yi Yang , Robert Feltz , Aneta Maria Kosinski , Guowei Zhou , Razia K. Rizvi , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristen E. Rosner , M. Arshad Siddiqui , Liping Yang
发明人： Joseph A. Kozlowski , Wensheng Yu , Michael K.C. Wong , Seong Heon Kim , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , De-Yi Yang , Robert Feltz , Aneta Maria Kosinski , Guowei Zhou , Razia K. Rizvi , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristen E. Rosner , M. Arshad Siddiqui , Liping Yang
IPC分类号： A61K31/4178 , C07D401/14 , C07D491/052 , C07D413/14 , C07D417/14 , C07D403/14 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/436 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P29/00 , A61P19/02 , A61P1/02 , A61P35/00 , A61P35/04 , A61P25/00 , A61P27/06 , A61P1/00 , A61P17/06 , A61P9/00 , A61P31/18 , A61P31/04 , C07D403/06
CPC分类号： C07D403/14
摘要： This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF—or combinations thereof.
摘要翻译： 本发明涉及式（I）的化合物：（化学式应该插在这里，它以纸的形式出现）（I）或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗 由MMP，ADAM，TACE，聚蛋白聚糖蛋白聚糖酶，TNF-或其组合介导的疾病或病症。
-
公开(公告)号：US20090156586A1
公开(公告)日：2009-06-18
申请号：US12364845
申请日：2009-02-03
申请人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong Heon Kim
发明人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong Heon Kim
IPC分类号： A61K31/4178 , C07D403/06 , C07D401/14 , C07D403/14 , C07D409/14 , C07D417/14 , C07D413/14 , A61K31/427 , A61K31/517 , A61K31/54 , A61K31/5377 , A61K31/4725 , A61K31/4709 , A61K31/4439 , A61K31/506
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症 。
-
公开(公告)号：US20090111803A1
公开(公告)日：2009-04-30
申请号：US12338353
申请日：2008-12-18
申请人： Wensheng Yu , Ling Tong , Lei Chen , Joseph A. Kozlowski , Brian J. Lavey , Neng-Yang Shih , Vincent S. Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael K.C. Wong , De-Yi Yang , Seong Heon Kim , Bandarpalle B. Shankat
发明人： Wensheng Yu , Ling Tong , Lei Chen , Joseph A. Kozlowski , Brian J. Lavey , Neng-Yang Shih , Vincent S. Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael K.C. Wong , De-Yi Yang , Seong Heon Kim , Bandarpalle B. Shankat
IPC分类号： A61K31/5377 , C07D233/02 , A61K31/4178 , C07D403/02 , C07D277/20 , A61K31/426 , C07D401/14 , A61K31/4709 , A61P19/02 , A61P37/00 , A61P9/00 , A61P29/00 , A61K31/4545 , C07D215/00 , A61K31/4439 , C07D403/14 , A61K31/506 , A61K31/497 , C07D413/14
CPC分类号： C07D401/14 , C07D403/06 , C07D409/14 , C07D413/14 , C07D417/14
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF—or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，TNF-或其组合介导的疾病或病症。
-
-
-
-
-
-
-
-
-
搜索结果
63 条记录 (耗时 0.067 秒)
