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公开(公告)号:US20220341923A1
公开(公告)日:2022-10-27
申请号:US17728292
申请日:2022-04-25
Applicant: Meso Scale Technologies, LLC.
Inventor: John H. KENTEN , Galina NIKOLENKO
IPC: G01N33/543 , G01N21/76 , G01N33/53 , G01N33/569 , G01N33/58
Abstract: Described herein is a method of preparing a bifunctional assay surface. In particular, a method is provided for preparing an assay surface that includes a primary reagent and a secondary reagent. In one aspect, the primary and secondary reagents are immobilized on the assay surface by different surface chemistries. In one aspect, a method is provided for preparing an assay surface that includes a proteinaceous primary reagent and a thiol-containing secondary reagent. In one aspect, a method is provided for preparing an assay surface that includes a capture-target hybrid and a thiol-containing secondary reagent.
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公开(公告)号:US20240347167A1
公开(公告)日:2024-10-17
申请号:US18595584
申请日:2024-03-05
Applicant: MESO SCALE TECHNOLOGIES, LLC. , THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
Inventor: William F. BLAKELY , Eli N. GLEZER , John H. KENTEN , Sudeep KUMAR , Anu MATHEW , Natalia I. OSSETROVA , George SIGAL
CPC classification number: G16H20/40 , G01N27/3273 , G01N33/6893 , G01N35/00 , G01T1/00 , G01T1/02 , G01N2333/70535 , G01N2333/70578 , G01N2800/40 , G01N2800/60
Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
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公开(公告)号:US20240287572A1
公开(公告)日:2024-08-29
申请号:US18555331
申请日:2022-04-15
Applicant: MESO SCALE TECHNOLOGIES, LLC.
Inventor: John H. KENTEN , Jacob N. WOHLSTADTER
Abstract: The invention relates to methods, compositions, and kits for detection of hydrolase enzyme activity in a sample.
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公开(公告)号:US20230073180A1
公开(公告)日:2023-03-09
申请号:US17930196
申请日:2022-09-07
Applicant: Meso Scale Technologies, LLC.
Inventor: John H. KENTEN , George SIGAL
IPC: G01N1/18
Abstract: A sample collection device having a sample container, a solid phase binding material, and a container sealing component is presented. The sample container may have a housing that forms an opening for receiving a sample, and that encloses a space for holding the sample. The solid phase binding material may be disposed within the space enclosed by the housing of the sample container and may be adapted, when the sample contains an analyte, to bind specifically to the analyte. The container sealing component may be removably attachable to the sample container at the opening thereof, and may be adapted, when attached to the sample container, to form a seal around the opening of the sample container.
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公开(公告)号:US20240368676A1
公开(公告)日:2024-11-07
申请号:US18043275
申请日:2021-09-02
Applicant: Meso Scale Technologies, LLC.
Inventor: John H. KENTEN , Galina NIKOLENKO , Seth B. HARKINS , Timothy J. BREAK
IPC: C12Q1/682
Abstract: Oligonucleotides, methods and kits are provided for detecting, identifying or quantifying one or more target analytes in a sample as well as methods for immobilizing oligonucleotides onto a support surface.
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公开(公告)号:US20230407380A1
公开(公告)日:2023-12-21
申请号:US18320411
申请日:2023-05-19
Applicant: MESO SCALE TECHNOLOGIES, LLC.
Inventor: Eli N. GLEZER , John H. KENTEN
IPC: C12Q1/6844 , G01N33/543 , C12Q1/682 , C12Q1/6837 , C12Q1/6848 , C12Q1/6804 , G01N33/542
CPC classification number: C12Q1/6844 , G01N33/54306 , C12Q1/682 , C12Q1/6837 , G01N2458/10 , C12Q1/6804 , G01N33/542 , C12Q2531/125 , C12Q2533/107 , C12Q1/6848
Abstract: The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays.
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