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公开(公告)号：US20240159766A1
公开(公告)日：2024-05-16
申请号：US18545200
申请日：2023-12-19
发明人： Charles M. CLINTON , Eli N. GLEZER , Bandele JEFFREY-COKER , Sandor L. KOVACS , Sudeep M. KUMAR , George SIGAL , Carl STEVENS , Michael VOCK
CPC分类号： G01N33/582 , B01L3/50255 , B01L3/5085 , B67B7/24 , G01N21/6452 , G01N21/66 , G01N33/5302 , G01N35/028 , G01N35/1011 , G01N35/1079 , G01N35/1081 , G01N2035/0405 , G01N35/1002 , G01N35/109 , Y10T83/9314
摘要： We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
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公开(公告)号：US20240347167A1
公开(公告)日：2024-10-17
申请号：US18595584
申请日：2024-03-05
申请人： MESO SCALE TECHNOLOGIES, LLC. , THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
发明人： William F. BLAKELY , Eli N. GLEZER , John H. KENTEN , Sudeep KUMAR , Anu MATHEW , Natalia I. OSSETROVA , George SIGAL
CPC分类号： G16H20/40 , G01N27/3273 , G01N33/6893 , G01N35/00 , G01T1/00 , G01T1/02 , G01N2333/70535 , G01N2333/70578 , G01N2800/40 , G01N2800/60
摘要： The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
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公开(公告)号：US20220341843A1
公开(公告)日：2022-10-27
申请号：US17733036
申请日：2022-04-29
发明人： Nicholas ANDERSON , Jeffery DEBAD , Eli N. GLEZER , Sudeep KUMAR , Noel LAWRENCE , Kenneth PAGE , George SIGAL , Sharon WEST
IPC分类号： G01N21/05 , G01N21/69 , G01N21/76 , B01L3/00 , G01N21/03 , G01F23/02 , G01F23/292 , G01N1/10
摘要： Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, thy reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.
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公开(公告)号：US20240293822A1
公开(公告)日：2024-09-05
申请号：US18436879
申请日：2024-02-08
发明人： Eli N. GLEZER , Stephen HIGGINS , Sandor KOVACS , Sudeep KUMAR , Kenneth PAGE , Kristian ROTH , George SIGAL
CPC分类号： B01L7/525 , B01L3/5027 , B01L2200/027 , B01L2200/0605 , B01L2200/0621 , B01L2200/0631 , B01L2200/10 , B01L2200/146 , B01L2200/16 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0883 , B01L2400/0487 , B01L2400/0688 , B01L2400/0694 , C12Q1/686
摘要： Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.
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公开(公告)号：US20240280786A1
公开(公告)日：2024-08-22
申请号：US18596909
申请日：2024-03-06
发明人： Ian D. CHAMBERLIN , Charles M. CLINTON , Eli N. GLEZER , Bandele JEFFREY-COKER , Manish KOCHAR , Sandor KOVACS , D.T. LE , Aaron LEIMKUEHLER , George SIGAL , Leo TABAKIN , Jon WILLOUGHBY
CPC分类号： G02B7/36 , G01N21/253 , G01N21/6452 , G01N35/028
摘要： Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.
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公开(公告)号：US20220019053A1
公开(公告)日：2022-01-20
申请号：US17492187
申请日：2021-10-01
发明人： Ian CHAMBERLIN , Charles M. CLINTON , Eli N. GLEZER , Bandele JEFFREY-COKER , Manish KOCHAR , Sandor KOVACS , D.T. Le , Aaron LEIMKUEHLER , George SIGAL , Leo TABAKIN , Jon WILLOUGHBY
摘要： Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.
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公开(公告)号：US20180154353A1
公开(公告)日：2018-06-07
申请号：US15882914
申请日：2018-01-29
发明人： Eli N. GLEZER , Bandele JEFFREY-COKER , Jeffery D. DEBAD , Sudeep M. KUMAR , George B. SIGAL , Gisbert SPIELES , Michael TSIONSKY , Michael WARNOCK
IPC分类号： B01L3/00 , G01N33/543
CPC分类号： B01L3/5025 , B01L3/5085 , B01L2200/12 , B01L2200/16 , B01L2300/0636 , B01L2300/0645 , B01L2300/0829 , B01L2300/0851 , B01L2300/0858 , B01L2300/105 , G01N33/54366 , G01N33/54393 , Y10S436/809
摘要： We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.
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公开(公告)号：US20240219307A1
公开(公告)日：2024-07-04
申请号：US18429280
申请日：2024-01-31
发明人： Charles M. CLINTON , Eli N. GLEZER , Sharon WEST , George SIGAL , Carl STEVENS , Michael L. VOCK
CPC分类号： G01N21/76 , G01N21/69 , G01N35/0092 , G01N35/028 , G01N2035/00524 , G01N2035/0425 , G01N35/1079 , Y10T436/114165
摘要： We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
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公开(公告)号：US20220097072A1
公开(公告)日：2022-03-31
申请号：US17492207
申请日：2021-10-01
发明人： Eli N. GLEZER , Bandele JEFFREY-COKER , Kenneth PAGE , Sandor KOVACS , Sudeep KUMAR , Kristian ROTH
IPC分类号： B01L3/00 , F16K11/074
摘要： Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.
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公开(公告)号：US20210291168A1
公开(公告)日：2021-09-23
申请号：US17215962
申请日：2021-03-29
发明人： Eli N. GLEZER , Sudeep KUMAR , Pankaj OBEROI , George SIGAL , Michael TSIONSKY
IPC分类号： B01L3/00 , C12Q1/6804 , G01N33/68 , G01N33/543 , C12Q1/6816 , C12Q1/6876
摘要： The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
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